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Articles 1 - 5 of 5
Full-Text Articles in Embryonic Structures
Regulation Of Müllerian Duct Mesenchyme Transcription During Mammalian Sex Differentiation, Haowen Li, Richard R Behringer, Rachel D Mullen
Regulation Of Müllerian Duct Mesenchyme Transcription During Mammalian Sex Differentiation, Haowen Li, Richard R Behringer, Rachel D Mullen
Dissertations and Theses (Open Access)
Sp7/Osterix (Osx) encodes a zinc-finger transcription factor of the Specificity-protein family discovered by Nakashima et al. at the MD Anderson Cancer Center. While primarily recognized for its role in osteogenesis, Osx has also been implicated in mammalian reproductive development, particularly in male sex differentiation, where Müllerian Duct (MD) regression occurs, mediated by anti-Müllerian hormone (AMH) signaling. AMH-induced regression signals are transduced by the mesenchymal tissue surrounding the ductal structure, known as the Müllerian Duct mesenchyme (MDM). It was discovered that AMH signaling is necessary and sufficient for driving Osx expression in MDM. A previous transgenic mouse reporter …
The Effects Of Body Mass Index On Fertility And In Vitro Fertilization, Morgan R. Kidd
The Effects Of Body Mass Index On Fertility And In Vitro Fertilization, Morgan R. Kidd
Honors College Theses
In-vitro fertilization (IVF) is the most widely used type of assisted reproductive technology for treating infertility arising from a number of conditions. As obesity rates continue to climb in the United States, infertility has been discovered to have a direct correlation. Individuals that fall below or above the healthy body mass index range are found to have disrupted regulation of the hypothalamic-pituitary-gonadal axis, resulting in diminished reproductive health. Those that are diagnosed as infertile due to conditions caused by the effects of low body mass index or high body mass index may seek assisted reproductive technologies to intervene in achieving …
Variant Superficial Epigastric Supply To The Anterior Abdominal Wall Arising From Inferior Epigastric Perforators: A Neonatal Case Report, Daniël J. Van Tonder, Natalie Keough, Martin Louis Van Niekerk, Albert Van Schoor
Variant Superficial Epigastric Supply To The Anterior Abdominal Wall Arising From Inferior Epigastric Perforators: A Neonatal Case Report, Daniël J. Van Tonder, Natalie Keough, Martin Louis Van Niekerk, Albert Van Schoor
COM Scholarship
Introduction: Understanding superficial epigastric vessel anatomy is crucial for abdominal surgeries like laparoscopy, especially in neonates, to prevent injury. While standard courses are described, variations occur. This case report highlights a unique anatomical variation in the superficial epigastric artery found during the dissection of a stillborn neonatal cadaver. Case Report: In contrast to the usual origin from the femoral artery, this variation features the inferior epigastric artery penetrating the anterior abdominal wall near the umbilicus and branching superiorly to supply the superficial abdominal wall. Conclusions: This distinctive vascular configuration, which to the best of our knowledge has not been previously …
Dose-Dependent Developmental Toxicity Of Cisplatin In Zebrafish Embryos, Reagan D. Sellers, Katherine T. Doucet, Jinhee Park, Andrea Florian
Dose-Dependent Developmental Toxicity Of Cisplatin In Zebrafish Embryos, Reagan D. Sellers, Katherine T. Doucet, Jinhee Park, Andrea Florian
SPARK Symposium Presentations
Cisplatin is a widely used chemotherapy drug for treating various types of cancer. Although cisplatin is effective in killing cancer, it can also cause toxic side effects in normal tissues. Because cisplatin can cross the placental barrier, its use during pregnancy is generally avoided, particularly during early embryonic stages of fetal development. Exposure to cytotoxic drugs during embryogenesis may lead to developmental abnormalities, birth defects, or pregnancy complications. Understanding how cisplatin affects early development is therefore important.
Zebrafish (Danio rerio) are an established model for studying developmental toxicity due to their rapid external development, transparent embryos, and genetic similarity to …
Intersections Of Art And Medicine, Lina Adwer