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Full-Text Articles in Embryonic Structures
The Role Of Sox9 In Epicardial-Mediated Cardiovascular Development And Valve Homeostasis, Andrew Brantley Harvey
The Role Of Sox9 In Epicardial-Mediated Cardiovascular Development And Valve Homeostasis, Andrew Brantley Harvey
MUSC Theses and Dissertations
Congenital heart defects (CHDs) are the most common birth defects in humans, affecting as many as 1% of live births, thereby representing a major public health burden. These defects arise when signaling pathways and mechanical forces guiding heart development are disrupted, either by genetic mutations, aneuploidies, environmental influences, or any combination of these factors. The vast majority of CHDs have undetermined etiologies. Understanding the molecular and cellular mechanisms of normal heart development is critical for unraveling the origins of CHDs and for developing more effective diagnostics and interventional treatments for those affected by cardiovascular diseases of developmental origin.
The epicardium …