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Full-Text Articles in Embryonic Structures
Use Of Umbilical Cord Mesencymal Stem Cells In The Treatment Of Severe Covid-19 Pneumonia, Michelle Joy De Vera, Marc Joseph Buensalido, Jan Jorge Francisco, Jia An Bello, Alan Olavere, Alma Calavera, Josephine Ramos, Norma Ona, Eyreka Escalambre, Marvin Delos Santos, Samuel Bernal, Vasiliki E. Kalodimou
Use Of Umbilical Cord Mesencymal Stem Cells In The Treatment Of Severe Covid-19 Pneumonia, Michelle Joy De Vera, Marc Joseph Buensalido, Jan Jorge Francisco, Jia An Bello, Alan Olavere, Alma Calavera, Josephine Ramos, Norma Ona, Eyreka Escalambre, Marvin Delos Santos, Samuel Bernal, Vasiliki E. Kalodimou
Ateneo School of Medicine and Public Health Publications
A proposed mechanism of severe Corona virus Disease-2019 (COVID-19) is a deregulated innate immune response to an infection with SARS-CoV-2 resulting in cytokine release syndrome (CRS). Mesencymal stem cells (MSC) have been shown to have immunomodulatory effects and may attenuate the CRS. We present 11 cases of severe COVID-19 pneumonia treated with umbilical cord-derived, non-HLA matched MSC administered as four separate intravenous doses, 5×105 cells/kg. Clinical symptoms, measurements of inflammatory mediators and cytokines (IL6, IL10, IFN-γ, TNF-α), and radiological results were recorded for each patient. Although there were large variations in baseline cytokine pattern elevation, all cytokine levels decreased in …