Investigative Techniques Commons^™

An Innovative Testing Protocol To Study Foot And Ankle Kinetics During Early Stance Phase Of Gait, Thomas E. Stewart

Theses and Dissertations (ETD)

The objective of this study was to improve upon existing testing platform limitations with respect to foot and ankle mechanics in the sagittal plane during dorsiflexion and plantar flexion. The intent was to develop a multi-loading protocol that simulated aspects of early stance phase of walking gait. This data were used to evaluate the influence an Achilles load has on the kinematic profile of the ankle complex. Also, resulting kinematic profile data can be used to evaluate ligament/tendon effects, ankle arthroplasty, and various surgical techniques.

A pair of cadaveric human feet, from the same donor, 50 years of age were …

N-Glycosylation Dictates Proper Processing Of Organic Anion Transporting Polypeptide 1b1, Juan Yao, Weifang Hong, Jiujiu Huang, Kai Zhan, Hong Huang, Mei Hong

School of Information Faculty Publications

Organic anion transporting polypeptides (OATPs) have been extensively recognized as key determinants of absorption, distribution, metabolism and excretion (ADME) of various drugs, xenobiotics and toxins. Putative N-glycosylation sites located in the extracellular loops 2 and 5 is considered a common feature of all OATPs and some members have been demonstrated to be glycosylated proteins. However, experimental evidence is still lacking on how such a post-translational modification affect the transport activity of OATPs and which of the putative glycosylation sites are utilized in these transporter proteins. In the present study, we substituted asparagine residues that are possibly involved in N-glycosylation with …

Investigating Axonal Biology Using Microfluidic Devices, James Deyling, Brittany Kastan

Undergraduate Research Posters 2012

During nervous system development, various diffusing biomolecules play a critical role in neurite outgrowth and guidance, resulting in the formation of a complex circuitry. However, the precise mechanism by which these molecules are spatio-temporally delivered to the growing tip of the neurites is unclear. Overall, the results suggest to the utility of this device for studying neurobiology, tissue engineering and cell migration.

Evaluation Of Smoking Cessation Services In Ireland: Design And Pilot Of A Smoking Cessation Treatment Database, Sheila Keogan

Masters

A reduction in tobacco use is one of the stated aims of the National Health Promotion Strategy
(2000-2005) (Department of Health and Children, 2000a) as well being the core activity of
membership for all health promoting hospitals (HPH).
AIMS OF THE STUDY

1. To develop a database of smoking cessation services in Ireland.

2. Do a census of the smoking cessation services in Ireland and evaluate the range and
availability of them.
3. Develop a database for use in smoking cessation treatment services which would schedule
consultations with patients and gather all relevant demographics, treatments and their outcomes,
(cessation treatment …

A Consensus Model For Electroencephalogram Data Via The S-Transform, Andrew Coady Young

Electronic Theses and Dissertations

A consensus model combines statistical methods with signal processing to create a better picture of the family of related signals. In this thesis, we will consider 32 signals produced by a single electroencephalogram (EEG) recording session. The consensus model will be produced by using the S-Transform of the individual signals and then normalized to unit energy. A bootstrapping process is used to produce a consensus spectrum. This leads to the consensus model via the inverse S-Transform of the consensus spectrum. The method will be applied to both a control and experimental EEG to show how the results can be used …

The Influence Of Sample Volume Applied To The Makler Sperm Counting Chamber Upon The Measured Concentration Of Latex Beads: A Multi-Centre Study, Melanie Walls, Emily Zuvela, Cheryl Ayres, Deborah Sherrin, Asma Chhotani, Liz Butler, Kelli Peirce, Jenny Krapez, Renae Parker, Cherise Mooy, Patrick Mohan, Sally Catt, Matthew Wiltshire, Hassan W. Bakos, Mary Whyte, Phillip Matson

Research outputs 2012

Objective: To undertake a multi-centre study to maximize the number of Makler chambers used.

Methods: A total of 15 laboratories participated with 31 Makler chambers. A suspension of latex beads was prepared to a concentration of 20 millions per milliliter, and 0.5 mL aliquots distributed to each participating laboratory. They measured the concentration on their Makler chamber(s) used for routine semen analysis by adding 3, 4, 5, 7 and 10 μL volumes of bead suspension to the chamber.

Results: There was no difference in within-chamber analysis of the bead concentration according to the volume of bead suspension …

Comparing Functional Outcomes On Open Reduction And Internal Fixation For Acute Perilunate Dislocation And Fracture-Dislocations: A Systematic Review, Melissa Mundy Allen

MUSC Theses and Dissertations

Introduction: Outcomes based research on trauma-related orthopaedic injuries is imperative for gauging the effectiveness of current surgical procedures and thereby maximizing the patient's functional status. In patients sustaining perilunate dislocations (PLD) and fracture-dislocations (PLFD) following a traumatic fall on an outstretched hand, early open reduction and internal fixation (ORIF) is widely considered the standard of care for acute cases, but evidence supporting optimal techniques and materials is limited in a body of literature consisting mainly of small retrospective case series and expert opinion. The aims of this study were to compare functional outcomes of PLD and PLFD by surgical technique …

A Voice-Based Automated System For Ptsd Screening And Monitoring, Roger Xu, Gang Mei, Guangfan Zhang, Pan Gao, Timothy Judkins, Michael Cannizzaro, Jiang Li, James D. Westwood (Ed.), Susan W. Westwood (Ed.), Li Felländer-Tsai (Ed.), Randy S. Haluck (Ed.), Richard A. Robb (Ed.), Steven Senger (Ed.), Kirby G. Vosburgh (Ed.)

Electrical & Computer Engineering Faculty Publications

Comprehensive evaluation of PTSD includes diagnostic interviews, self-report testing, and physiological reactivity measures. It is often difficult and costly to diagnose PTSD due to patient access and the variability in symptoms presented. Additionally, potential patients are often reluctant to seek help due to the stigma associated with the disorder. A voice-based automated system that is able to remotely screen individuals at high risk for PTSD and monitor their symptoms during treatment has the potential to make great strides in alleviating the barriers to cost effective PTSD assessment and progress monitoring. In this paper we present a voice-based automated Tele-PTSD Monitor …

Eae/Ase Recommendations For Image Acquisition And Display Using Three-Dimensional Echocardiography., Roberto M. Lang, Luigi P. Badano, Wendy Tsang, David H. Adams, Eustachio Agricola, Thomas Buck, Francesco F. Faletra, Andreas Franke, Judy Hung, Leopoldo Pérez De Isla, Otto Kamp, Jaroslaw D. Kasprzak, Patrizio Lancellotti, Thomas H. Marwick, Marti L. Mcculloch, Mark J. Monaghan, Petros Nihoyannopoulos, Natesa G. Pandian, Patricia A. Pellikka, Mauro Pepi, David A. Roberson, Stanton K. Shernan, Girish S. Shirali, Lissa Sugeng, Folkert J. Ten Cate, Mani A. Vannan, Jose Luis Zamorano, William A. Zoghbi, American Society Of Echocardiography, European Association Of Echocardiography

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

The Fate Of Frozen Human Embryos When Transferred Either On The Day Ofthawing Or After Overnight Culture, Yanhe Liu, Kellie Peirce, Kailin Yap, Kate Mckenzie, Jay Natalwala, Vince Chapple, Margo Norman, Phillip Matson

Research outputs 2012

Objective: To study the performance of thawed zygotes and cleavage stage embryos transferred either on the day of thaw or after overnight culture. Methods: A retrospective study of 864 frozen embryo transfer cycles. Cryosurvival rates per thawed embryo and implantation rates were analysed for embryos frozen on Day 1, Day 2 or Day 3 relative to oocyte collection (Day 0) and transferred on the day of thaw or after overnight culture, together with clinical pregnancy rates and prevalence of multiple gestations. Results: Survival of Day 3 embryos was significantly lower than those frozen on Day 1 (P=0.017) or Day 2 …

Does Mucosal Or Serosal Side Approximation Affect The Efficacy Of Native Small Intestinal Submucosa Graft Repair Of Neurotmesis?, Ferro Nguyen

PCOM Biomedical Studies Student Scholarship

FDA approved, commercial, modified porcine small intestinal submucosa (SIS) is utilized clinically for peripheral nerve repair. However, if measures can be put in place to insure its safety, native SIS prepared from locally available porcine resources would provide easy access to an inexpensive alternative. Both forms of this material lack antigenicity, have inherit properties which provides a favorable growth environment, and have been successfully used experimentally as a natural conduit in peripheral nerve repair. Successful recovery from a peripheral nerve injury is dependent on the efficiency and speed of axonal regeneration to the point of distal interruption of the nerve. …

Eae/Ase Recommendations For Image Acquisition And Display Using Three-Dimensional Echocardiography., Roberto M. Lang, Luigi P. Badano, Wendy Tsang, David H. Adams, Eustachio Agricola, Thomas Buck, Francesco F. Faletra, Andreas Franke, Judy Hung, Leopoldo Pérez De Isla, Otto Kamp, Jaroslaw D. Kasprzak, Patrizio Lancellotti, Thomas H. Marwick, Marti L. Mcculloch, Mark J. Monaghan, Petros Nihoyannopoulos, Natesa G. Pandian, Patricia A. Pellikka, Mauro Pepi, David A. Roberson, Stanton K. Shernan, Girish S. Shirali, Lissa Sugeng, Folkert J. Ten Cate, Mani A. Vannan, Jose Luis Zamorano, William A. Zoghbi, American Society Of Echocardiography, European Association Of Echocardiography

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Association Between The G-Protein Β3 Subunit C825t Polymorphism With Essential Hypertension: A Meta-Analysis In Han Chinese Population, Jaipeng Lu, Q Guo, Ling Zhang, Wei Wang

Research outputs 2012

We aimed to evaluate the contribution of the G-protein β3 subunit C825T (GNB3-C825T) polymorphism to essential hypertension (EH) in Han Chinese population by performing meta-analysis. A meta-analysis was performed in 12 case–control genetic association studies including 3,020 hypertension patients and 2,790 controls from MEDLINE (PubMed) and the China National Knowledge Infrastructure platforms. The STATA 10.0 software was used in analysis. Overall, there was no significant association between the GNB3-C825T polymorphism and EH in neither additive [TT vs. CC: OR (95 % CI) = 1.11 (0.74–1.69), P = 0.61; TC vs. CC: OR (95 % CI) = 1.08 (0.89–1.31), P = …