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Articles 1681 - 1710 of 2573

Full-Text Articles in Medicine and Health Sciences

A Novel Biosimulation Task Trainer For The Deliberate Practice Of Resuscitative Hysterotomy., Lawrence Lau, Dimitrios Papanagnou, Elaine Smith, Crystal Waters, Elizabeth Teixeira, Xiao Chi Zhang Jan 2018

A Novel Biosimulation Task Trainer For The Deliberate Practice Of Resuscitative Hysterotomy., Lawrence Lau, Dimitrios Papanagnou, Elaine Smith, Crystal Waters, Elizabeth Teixeira, Xiao Chi Zhang

Department of Emergency Medicine Faculty Papers

Resuscitative hysterotomy is a daunting and rarely performed procedure in the emergency department (ED). Given the paucity of clinical exposure to this intervention, resuscitative hysterotomy is an ideal opportunity for simulation-mediated deliberate practice. The authors propose a novel training program using a homegrown, realistic, simulation device as a means to practice resuscitative hysterotomy. Two high-fidelity, tissue-based task-trainer models were constructed and tested on a convenience sample of 14 emergency medicine (EM) residents. The simulated human placenta, bladder, amniotic sac, and uterus were constructed through the use of porcine skin, porcine stomach, transparent plastic bag, Foley tubing, and squid mantle, all …


Evaluating Outcomes Of Education On Waste Management In The Hospital Setting, Taryn N. Schlather Jan 2018

Evaluating Outcomes Of Education On Waste Management In The Hospital Setting, Taryn N. Schlather

Honors Undergraduate Theses

With advancements in healthcare, we continue to find new needs that must be addressed. Hospitals generate a substantial amount of medical waste, and proper disposal is important for patient and staff safety, environmental protection, and cost efficiency. A series of studies show there is a need for further education on hospital waste management policies. This thesis aims to evaluate education interventions to improve knowledge and healthcare waste disposal practices. This literature review was conducted using multiple databases, including MedLINE, CINAHL, GreenFILE, Google Scholar, EBSCOhost, and NCBI, to find qualifying research articles in the English language from 2005-2018. Key terms for …


Appreciating The Golden Hour: A Comparative Interdisciplinary Study, Taylor Tachon Jan 2018

Appreciating The Golden Hour: A Comparative Interdisciplinary Study, Taylor Tachon

Honors Undergraduate Theses

Within the health care, many medical professionals know about the critical time restraints for provisions of care within their discipline, but do not know the term "The Golden Hour". The Golden Hour is a term indicating the universal time restraint found within every area of health care and more specifically, every area of nursing. The term and concept represented by it should be recognized to better the outcomes of our patients. Although the Golden Hour typically indicates a 60-minute period of time, various settings recognize shorter and longer periods during which specific actions must be taken to assure positive patient …


Insights And Evidence Gaps In Girl-Centered Programming: A Systematic Review, Nicole Haberland, Katharine Mccarthy, Martha Brady Jan 2018

Insights And Evidence Gaps In Girl-Centered Programming: A Systematic Review, Nicole Haberland, Katharine Mccarthy, Martha Brady

Poverty, Gender, and Youth

Increased attention to the needs of adolescent girls has led to a growing number of programs in low- and middle-income countries. Questions remain, however, about what aspects of program design are most effective. This hinders efforts to effectively allocate resources, scale up programs, and replicate results across settings. This review looks at how the number of program components, involvement of supporting actors who influence the lives of girls, supplemental “booster” activities, intervention exposure level, and community saturation level influenced outcomes for girls. While findings suggest the importance of multicomponent programs and longer program exposure, each area requires further rigorous research …


Delivering Impact For Adolescent Girls: Emerging Findings From Population Council Research, Population Council Jan 2018

Delivering Impact For Adolescent Girls: Emerging Findings From Population Council Research, Population Council

Poverty, Gender, and Youth

Despite numerous global commitments to invest in improving the lives of adolescent girls, questions remain as to what package of interventions can deliver the best outcomes. This report synthesizes findings from nine recent Population Council impact evaluations, conducted around the world, which indicate that empowerment and asset-building interventions for adolescent girls can improve education, health, economic, social capital, gender-equitable attitude, and violence outcomes for girls. The report includes implications for programs and investment, and identifies open questions for further research and evaluation.


Academically Resistant Athletes: Victims Of Aces Or Commodities Of The System, Melnee Berry Jan 2018

Academically Resistant Athletes: Victims Of Aces Or Commodities Of The System, Melnee Berry

Department of Conflict Resolution Studies Theses and Dissertations

Fans of college sports embrace the idea of athletes playing sport and, in turn, receiving tuition scholarships that provide them an opportunity to trade athletic talent for a free education. A contradictory body of research using internal colonization theory posits that the trade of education for playing sports is not a fair exchange but is fraught with exploitation that continues to perpetuate subjugation. An accepted narrative in athletic competition is that the recruiting pipeline draws athletes from impoverished inner-city areas engaging young athletes who experience difficulties keeping up scholastically becoming academically resistant as they focus on their sport at the …


Use Of Antipsychotic Medications In Individuals With Alzheimer's Disease In Nursing Facilities, Michelle M. Dionne-Vahalik Jan 2018

Use Of Antipsychotic Medications In Individuals With Alzheimer's Disease In Nursing Facilities, Michelle M. Dionne-Vahalik

Walden Dissertations and Doctoral Studies

Patients with Alzheimer's disease or other types of dementia often require long-term care in nursing facilities (NF) where they may display out-of-character behaviors complicating their care. While antipsychotic medications are sometimes prescribed for NF residents, their use is considered inappropriate for the control of dementia behaviors. The Centers for Medicare and Medicaid Services have rated Texas the worst state in the country for the inappropriate use of antipsychotic medications for NF residents with dementia. This project was guided by the star model of knowledge transformation with the goal to reduce inappropriate use of antipsychotic medications through NF staff education. The …


Diabetes Management Protocol In The Rehabilitation Setting, Hannah Mottel Jan 2018

Diabetes Management Protocol In The Rehabilitation Setting, Hannah Mottel

Walden Dissertations and Doctoral Studies

Diabetes mellitus is a growing healthcare problem in the United States. Diabetes affects 1.4 million Americans yearly, impacting the lives of individuals of all ages. One of the most challenging aspects about diabetes is that many individuals are not aware of the impact of the disease on multiple organs until the progression of the disease has reached latter stages. Prevention and early detection of diabetes is a key component of lifesaving interventions including proper nutrition counseling, exercise regimens, management, and patient compliance with a treatment plan. The purpose of this doctoral project was to create a standardized diabetes management protocol …


A Chronic Obstructive Pulmonary Disease Self-Management Packet To Reduce 30-Day Readmissions, Josette Askratni Jan 2018

A Chronic Obstructive Pulmonary Disease Self-Management Packet To Reduce 30-Day Readmissions, Josette Askratni

Walden Dissertations and Doctoral Studies

Chronic obstructive pulmonary disease (COPD) signifies a significant public health challenge that is both avoidable and treatable. There was no standardized education offered to the COPD population at the practice location. The scope of the project encompassed standardizing education by developing a self-management packet for the COPD patients. The goal of this project was to examine how the development of a standardized COPD self-management packet enhances the quality of care and strategizes reducing 30-day readmissions compared to nonstandardized delivery of education. Orem's self-care theory and Bandura's self-efficacy concept were used to explain the principle of self-management, while Rosswurm and Larrabee's …


Factors That Influence Whether Mexican Americans With Depression Seek Treatment, Irene Rodriguez Jan 2018

Factors That Influence Whether Mexican Americans With Depression Seek Treatment, Irene Rodriguez

Walden Dissertations and Doctoral Studies

Mexican Americans, the largest Hispanic subgroup in the United States, tend to underuse mental health services. Grounded in Andersen's behavioral model of health services use, the purpose of this nonexperimental study was to examine the likelihood of birth country, education, income, and insurance predicting which respondents would report seeking mental health services to treat depression. The Mini International Neuropsychiatric Interview was used to diagnose depression in 203 Mexican Americans whose data was archived from the primary study. This archived data was analyzed within this study. The results of the 2 x 2 chi-square tests of independence indicated a significant association …


Association Between Type Of Diabetes Education And Health Status, Limitations, And Healthcare, Starr Michelle Seip Jan 2018

Association Between Type Of Diabetes Education And Health Status, Limitations, And Healthcare, Starr Michelle Seip

Walden Dissertations and Doctoral Studies

Diabetes is an epidemic that has started to capture political attention in the United States because of the devastating health care costs associated with the disease. Researchers in other studies have concluded that additional education face-to-face (FTF) and FTF with alternative forms of diabetes communication (FTF plus) have been beneficial. However, there is very little information on the comparison of the two groups as mentioned above when comparing chronic limitations, self-perception, health status, and healthcare satisfaction as circumscribed by specific demographic population. This study was an investigation of the above variables and explored how specific demographic characteristics (age, gender, educational …


The Impact Of Classroom Instruction On Cultural Awareness And Sensitivity In Occupational Therapy Students, Sierra Grady, Kym Brungardt, Joy Doll Jan 2018

The Impact Of Classroom Instruction On Cultural Awareness And Sensitivity In Occupational Therapy Students, Sierra Grady, Kym Brungardt, Joy Doll

Journal of Occupational Therapy Education

As the population in the United States increases, it is essential that occupational therapy students and practitioners be aware of, respond to, and effectively interact with clients from diverse cultural backgrounds. Current literature identifies a gap in the cultural competence education for occupational therapy students and has demonstrated the importance of developing a culturally sensitive curriculum that will prepare students for today’s work environment. This study employed a quasi-experimental approach with a one group pretest-posttest design to explore the development of cultural awareness in occupational therapy students with classroom instruction on culturally sensitive practice. Data was collected from 43 students …


Improving Breastfeeding Education Among Hospital Nurses, Kara R. Connelly Jan 2018

Improving Breastfeeding Education Among Hospital Nurses, Kara R. Connelly

Graduate Dissertations and Theses

Breastfeeding is well-documented as the most beneficial method of infant feeding worldwide. There are numerous national initiatives present to improve breastfeeding outcomes. Despite knowledge and health care organization efforts, the recommendations of exclusive breastfeeding through six months of life with continued breastfeeding through one year of age are not being met. The purpose of this DNP project is to determine if a structured self-study educational program on breastfeeding recommendations, the 4th Edition of the Lactation Management Self-Study Modules created by Wellstart International™, provided to hospital nurses on a maternity unit in Central, New York with a Level One nursery, …


Pain Medicine Content, Teaching And Assessment In Medical School Curricula In Australia And New Zealand, Elspeth E. Shipton, Frank Bate, Raymond Garrick, Carole Steketee, Eric J. Visser Jan 2018

Pain Medicine Content, Teaching And Assessment In Medical School Curricula In Australia And New Zealand, Elspeth E. Shipton, Frank Bate, Raymond Garrick, Carole Steketee, Eric J. Visser

Medical Papers and Journal Articles

Background: The objective of pain medicine education is to provide medical students with opportunities to develop their knowledge, skills and professional attitudes that will lead to their becoming safe, capable, and compassionate medical practitioners who are able to meet the healthcare needs of persons in pain. This study was undertaken to identify and describe the delivery of pain medicine education at medical schools in Australia and New Zealand.

Method: All 23 medical schools in Australia and New Zealand in 2016 were included in this study. A structured curriculum audit tool was used to obtain information on pain medicine curricula including …


Systematic Review Of Pain Medicine Content, Teaching, And Assessment In Medical School Curricula Internationally, Elspeth E. Shipton, Frank Bate, Raymond Garrick, Carole Steketee, Edward A. Shipton, Eric J. Visser Jan 2018

Systematic Review Of Pain Medicine Content, Teaching, And Assessment In Medical School Curricula Internationally, Elspeth E. Shipton, Frank Bate, Raymond Garrick, Carole Steketee, Edward A. Shipton, Eric J. Visser

Medical Papers and Journal Articles

Introduction: Pain management is a major health care challenge in terms of the significant prevalence of pain and the negative consequences of poor management. Consequently, there have been international calls to improve pain medicine education for medical students. This systematic review examines the literature on pain medicine education at medical schools internationally, with a particular interest in studies that make reference to: a defined pain medicine curriculum, specific pain medicine learning objectives, dedicated pain education modules, core pain topics, medical specialties that teach pain medicine, elective study opportunities, hours allocated to teaching pain medicine during the curriculum, the status of …


How To Prepare Interprofessional Teams In Two Weeks: An Innovative Education Program Nested In Telehealth, Tina S. Haney, Karen Kott, Carolyn M. Rutledge, Bruce Britton, Christianne N. Fowler, Rebecca D. Poston Jan 2018

How To Prepare Interprofessional Teams In Two Weeks: An Innovative Education Program Nested In Telehealth, Tina S. Haney, Karen Kott, Carolyn M. Rutledge, Bruce Britton, Christianne N. Fowler, Rebecca D. Poston

Ellmer School of Nursing Faculty Publications

PROBLEM:

Preparing health professional students for interprofessional collaborative practice, especially at a distance where provider shortages prevail remains difficult.

APPROACH:

A two-week interprofessional education (IPE) immersion experience preparing students from 11 disciplines and four universities was implemented. Week-one, using online technology, students develop/present an interprofessional careplan for a complex patient. Students then meet face-to-face to conduct group interviews with two standardized patient dyads. Week-two, students develop a website for use of the patient dyads. Websites are presented to faculty and fellow students via an online virtual meeting space.

OUTCOMES:

To date, 594 students have participated demonstrating capacity to: 1.effectively engage …


Exploring The Preparedness Of Novice (Student) Paramedics For The Mental Health Challenges Of The Paramedic Profession: Using The Wisdom Of The Elders, Lisa Holmes Jan 2018

Exploring The Preparedness Of Novice (Student) Paramedics For The Mental Health Challenges Of The Paramedic Profession: Using The Wisdom Of The Elders, Lisa Holmes

Theses: Doctorates and Masters

This study investigates the preparedness of novice (student) paramedics for the mental health challenges of the paramedic profession and identifies the coping strategies used by veteran paramedics to successfully meet these challenges. The lived experience of veteran paramedics is utilised to provide this important assistance.

Initially, two surveys were developed and administered to 16 course coordinators and 302 students of the 16 accredited undergraduate degree paramedicine courses across Australia and New Zealand, to identify the perceived need (for preparation) within the curriculum. In addition, the anticipations, confidence and fears of novice (student) paramedics, course coordinators and veteran paramedics were also …


Predictors Of Noncompliance To Antihypertensive Therapy Among Hypertensive Patients Ghana: Application Of Health Belief Model, Yaa Obirikorang, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Daniel Gyamfi, Selorm Philip Segbefia, Michael Opoku Boateng, Dari Pascal Dapilla, Peter Kojo Brenya, Bright Amankwaa, Evans Asamoah Adu, Emmanuel Nsenbah Batu, Adjei Gyimah Akwasi, Beatrice Amoah Jan 2018

Predictors Of Noncompliance To Antihypertensive Therapy Among Hypertensive Patients Ghana: Application Of Health Belief Model, Yaa Obirikorang, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Daniel Gyamfi, Selorm Philip Segbefia, Michael Opoku Boateng, Dari Pascal Dapilla, Peter Kojo Brenya, Bright Amankwaa, Evans Asamoah Adu, Emmanuel Nsenbah Batu, Adjei Gyimah Akwasi, Beatrice Amoah

Research outputs 2014 to 2021

This study determined noncompliance to antihypertensive therapy (AHT) and its associated factors in a Ghanaian population by using the health belief model (HBM). This descriptive cross-sectional study conducted at Kintampo Municipality in Ghana recruited a total of 678 hypertensive patients. The questionnaire constituted information regarding sociodemographics, a five-Likert type HBM questionnaire, and lifestyle-related factors. The rate of noncompliance to AHT in this study was 58.6%. The mean age (SD) of the participants was 43.5 (±5.2) years and median duration of hypertension was 2 years. Overall, the five HBM constructs explained 31.7% of the variance in noncompliance to AHT with a …


An Ehealth Program For Patients Undergoing A Total Hip Arthroplasty: Protocol For A Randomized Controlled Trial, Rosemary Saunders, Karla Seaman, Catherine Ashford, Trudy Sullivan, Judith Mcdowall, Lisa Whitehead, Bev Ewens, Kathryn Pedler, Karen Gullick Jan 2018

An Ehealth Program For Patients Undergoing A Total Hip Arthroplasty: Protocol For A Randomized Controlled Trial, Rosemary Saunders, Karla Seaman, Catherine Ashford, Trudy Sullivan, Judith Mcdowall, Lisa Whitehead, Bev Ewens, Kathryn Pedler, Karen Gullick

Research outputs 2014 to 2021

Background: Total hip arthroplasty is an effective surgical procedure commonly used worldwide for patients suffering the disabling effects of osteoarthritis when medical therapy is unsuccessful. Traditionally pre- and postoperative information for patients undergoing a hip arthroplasty has been provided by paper-based methods. Electronic health (eHealth) programs to support individualized patient education on preoperative preparation, in-patient care, and home rehabilitation have the potential to increase patient engagement, enhance patient recovery, and reduce potential postoperative complications.

Objective: The aim of this study is to compare the addition of an eHealth program versus standard care for pre- and postoperative education on patient outcomes …


Exploring Incivility Among Nursing And Health Science Students: A Descriptive Study, Diane Louise Smith Dec 2017

Exploring Incivility Among Nursing And Health Science Students: A Descriptive Study, Diane Louise Smith

Student Theses, Dissertations and Capstones

Incivility has infiltrated our institutions of higher learning as well as the world of nursing. All too familiar in nursing is the phrase “eating their young,” which aptly describes how nurses treat other nurses, even though they should be nurturing and caring professionals.

The investigator explored nursing and health science students’ perceptions of student and faculty uncivil behaviors within the academic environment, seeking the levels and frequency of the problem. Bandura’s social learning theory presents a sound theoretical framework for this dissertation. The research methodology consisted of a quantitative descriptive approach. The Incivility in Higher Education-Revised (IHE-R) Survey was used …


Effects Of An Alcohol Education Program On Improving Knowledge, Attitudes And Satisfaction Of Registered Nurses Caring For Patients Undergoing Alcohol Withdrawal, Luis Medina Dec 2017

Effects Of An Alcohol Education Program On Improving Knowledge, Attitudes And Satisfaction Of Registered Nurses Caring For Patients Undergoing Alcohol Withdrawal, Luis Medina

Seton Hall University DNP Final Projects

Managing and caring for patients who are undergoing alcohol withdrawal presents challenges for nurses in an inpatient setting. These challenges are influenced by factors such as negative attitudes, lack of knowledge and poor satisfaction. The purpose of this quality improvement initiative was to determine whether the effects of implementing an alcohol educational program would improve knowledge and satisfaction while reducing negative attitudes. This program implemented education on alcoholism, alcohol withdrawal and the Clinical Institute Withdrawal Assessment of Alcohol Scale, Revised (CIWA-Ar) monitoring tool which would be incorporated into the everyday practice of nurses caring for patients undergoing alcohol withdrawal. The …


Preventing Obesity And Cardiovascular Disease In At-Risk Youth, Allison Patricia Woolf, Nicole Ashley Bauernfeind, Rachel Katharine Civale, Elizabeth Rose Spellman Dec 2017

Preventing Obesity And Cardiovascular Disease In At-Risk Youth, Allison Patricia Woolf, Nicole Ashley Bauernfeind, Rachel Katharine Civale, Elizabeth Rose Spellman

Senior Honors Projects, 2010-2019

The literature review that was conducted focuses on exploring the most effective way to prevent development of Cardiovascular Disease (CVD) as a late effect of childhood obesity or risk thereof. Our research focused on the 8-10 year old at-risk and obese pediatric populations and whether the use of interactive educational interventions in the community setting can be of use to reduce CVD development and improve overall health status. Our findings determined that interactive educational interventions early in childhood can improve health outcomes for these populations and prevent subsequent development of CVD. We minimized the inclusion of all research whose evidence …


Pregnancy Loss In The Emergency Department, Gudrun Reiterhiltebrand Dec 2017

Pregnancy Loss In The Emergency Department, Gudrun Reiterhiltebrand

Master's Projects and Capstones

Abstract

The aim of this project is to improve the care for patients experiencing pregnancy loss in the emergency department (ED). Objectives are to enhance understanding of staff about the patients’ experience and their knowledge on how to best care for emotional needs, thus improving quality of patient care, work satisfaction, knowledge, confidence and comfort levels, while decreasing experienced stress. The project was implemented in a midsized community hospital with 117 beds, which discharged 74 patients with “interrupted pregnancies” over the previous year from the ED. The project was directed toward nurses, doctors, care partners, chaplains, and social workers. The …


Reflections From The Road: Vincentian Hospitality Principles In Healthcare Education For The Indigent, John M. Conry Dec 2017

Reflections From The Road: Vincentian Hospitality Principles In Healthcare Education For The Indigent, John M. Conry

Journal of Vincentian Social Action

Hospitality and health care are clearly connected, both etymologically and practically. Health care has traditionally been delivered in hospitals. Vincent de Paul and Louise de Marillac developed the concept and practice of Vincentian health care, demonstrating a preferential option for the poor. It is important that those who work in healthcare understand and remain committed to Vincentian and hospitality based health care, particularly for the indigent and marginalized. The need for Vincentian and hospitality-based health care remains relevant and necessary in contemporary society, as there remains health inequity, particularly for the poor.


The Use Of Culturally Sensitive Education On Organ Donation And Its Impact On Attitudes And Willingness To Donate Organs, James Winters Dec 2017

The Use Of Culturally Sensitive Education On Organ Donation And Its Impact On Attitudes And Willingness To Donate Organs, James Winters

Doctoral Projects

In regards to transplantation, ethnic minorities are disproportionately affected by the donor shortage. The high morbidity rates and decreased willingness to donate commonplace among these demographics has created a devastating imbalance. Increasing minority donor presence will make the allocation process more favorable for minority candidates. The current study entailed the provision of a culturally sensitive educational intervention to sixty-five (n=65) students at the University of Southern Mississippi. Surveys were administered pre/post intervention to assess knowledge and attitudes towards donation. Pre-intervention data reflected findings from prior research, post-intervention data showed that the intervention was able to mitigate these findings and that …


Improving Discharge Planning Using The Re-Engineered Discharge (Red) Program, Sterling L. Roberts, Leslie C. Moore, Brian Jack Dec 2017

Improving Discharge Planning Using The Re-Engineered Discharge (Red) Program, Sterling L. Roberts, Leslie C. Moore, Brian Jack

Doctor of Nursing Practice (DNP) Translational and Clinical Research Projects

The 12-actionable items of the Re-Engineered Discharge Program (RED) are equipped to address essential areas to prevent hospital re-visits. Evidence supports the use of nurses to complete these essential components of hospital interventions. The aims of this project were to: 1) assess nurses’ readiness to learn prior to receiving education on the RED Program, and 2) measure the utilization of the RED discharge process from patient chart reviews following an educational intervention focused on the RED 12-actionable items. Participants (N = 69) scored high M = 219.8 (SD 23.7) on the Self-Directed Learning Readiness – Adult Scale, indicating the nurses …


High School Seniors' Educational Experience Lnfluencing The Decision To Pursue A Career In Nursing, Ryan L. Rowe Dec 2017

High School Seniors' Educational Experience Lnfluencing The Decision To Pursue A Career In Nursing, Ryan L. Rowe

Dissertations

Many high school students interested in nursing as an occupation choose to engage in a Career and Technical Education (CTE) program and subsequently progress through the exploration stage of Super’s Career Development Theory in a succinct, deliberate, and intentional manner. While CTE continues to serve as an educational option for many high school students interested in nursing, its value as a means for students to crystallize, specify, and implement the choice to pursue the high-wage, high-skill, and high-demand career of nursing is not understood to the extent possible. CTE is regularly overlooked as a viable educational option by high school …


Program Evaluation Of A Bundled Educational Intervention To Enhance Implementation Of Professional Exchange Report, Luanne M. Shaw Dec 2017

Program Evaluation Of A Bundled Educational Intervention To Enhance Implementation Of Professional Exchange Report, Luanne M. Shaw

Doctoral Projects

Communication handover is a source of potential error and risk to patient safety. Electronic-based tools may reduce errors and mitigate risks to patient safety. Electronic tools have been successfully implemented using multiple methods of education and training. Electronic tools vary in functionality and integration with the electronic health record (EHR). A large West Michigan Regional Health System (RHS) implemented a new EHR containing an embedded tool for communication handover called Professional Exchange Report (PER). There was inconsistency in the practice of bedside report by nurses. The RHS planned to use a bundled approach of educational interventions to implement the new …


A License To Kill: Understanding Natural Killer Cell Licensing To Fight Cancer, Jolie Schafer Dec 2017

A License To Kill: Understanding Natural Killer Cell Licensing To Fight Cancer, Jolie Schafer

Dissertations and Theses (Open Access)

Natural killer (NK) cell education is an essential developmental process for NK cell effector function, that renders some NK cells “licensed” and others “unlicensed” (with heightened or lowered effector function potential, respectively) against tumor and targets lacking self-molecules. However, the underlying mechanisms responsible for the heightened effector responses of licensed cells remain unknown. Using NK cells derived from humans and expanded ex vivo we performed high-throughput protein expression analysis, and identified multiple proteins that are differentially regulated in licensed and unlicensed human NK cells before and after inhibition by killer-cell immunoglobulin-like receptors (KIRs) and activation by the NKp46 natural cytotoxicity …


A Blueprint For Life And Love, Marilyn Todd Dec 2017

A Blueprint For Life And Love, Marilyn Todd

The Texas Heart Institute Journal

No abstract provided.