The Efficacy Of Baricitinib As A Treatment Option For Alopecia, In Terms Of Promoting Hair Regrowth And Improving Patient Reported Outcomes, Bhaumik Patel, Abhiram Gollapudi, Samrat Gollapudi, Srinidhi Banala, Brian Joseph Mathew, Prince Patel

Rowan-Virtua Research Day

Background: Alopecia, an autoimmune condition characterized by hair loss, significantly impacts millions globally, often leading to psychological distress such as anxiety and depression. Current treatments are variably effective and frequently associated with adverse effects that restrict long-term use. This study evaluates the efficacy of Baricitinib, a Janus Kinase inhibitor, in treating severe alopecia, focusing on hair regrowth and patient-reported outcomes.

Methods: This research synthesized data from recent publications (2018-2023) including clinical trials, reviews, meta-analyses, and systematic reviews, sourced from databases such as PubMed, Springer, and Elsevier. The inclusion criteria focused on recent studies in English evaluating Baricitinib's effectiveness in severe …

Review Of Psychogenic Nonepileptic Seizures And Patient-Centered Approaches To Care, Rabeel Ahmad, Rebekah Dietrich, Munaza Khan

Rowan-Virtua Research Day

Psychogenic nonepileptic seizures (PNES) are defined as involuntary experiential and behavioral responses to internal or external stimuli. They are behaviors, not associated with pathological alterations in the physiology of the brain. Although some of them mimic syncope, they have historically been regarded to clinically resemble epileptic episodes.

There is a multiplicity of different names for this condition. PNES is the most widely used term, though the term "functional seizures" is increasingly used. Alternatives such as "psychogenic seizures," "dissociative seizures," "psychogenic nonepileptic attacks" (PNEA), and "nonepileptic seizures" are also used.

Utilization Of Depression Screening In Patients With Type 2 Diabetes Mellitus, John T. Norris Bsn, Rn, Dnp-Pmhnp Student, Robin Gordon Bsn, Rn, Dnp-Pmhnp Student, Margaret Harvey Phd, Aprn-Bc, Acnp, Chfn, Laura Reed Dnp, Fnp-Bc

Doctor of Nursing Practice Projects

Purpose/Background

Type 2 diabetes is a chronic metabolic disorder affecting millions of individuals worldwide. Research has shown that individuals with diabetes are at a higher risk of developing depression in comparison to those of the general population. Depression affects the individual's emotional well-being and has a significant impact on the management and outcomes of diabetes (Mather, 2022). This research study aims to investigate the feasibility and effectiveness of implementing the Patient Health Questionnaire-9 (PHQ-9). The PHQ-9 is one the most effective assessment tools available to identify symptoms of depression (Celik, 2020).

Methods

In this retrospective chart review, at least 50 …

Social Media Addiction Affecting Mental Health Of College Women, Praneetha Rajkumar, Don D. Shamilov, David F. Lo

Rowan-Virtua Research Day

In our digital society, many teenagers and young adults use the many forms of social media, which are applications that enable users to create, share, and view content. Addiction to sites such as Instagram, TikTok, and Snapchat is a rising concern due to the impact it has on the mental health of young women, particularly those aged 18-25. Addiction can result in spending an unreasonable amount of time on social media, being overly preoccupied with social media content, or having day-to-day activities that revolve around social media usage. Different sources of data were reviewed to understand why mental health concerns …

Tailoring Treatment Approaches With Supplemental Screening: Homeostatic Model Assessment Of Insulin Resistance (Homa-Ir) In An Obese Population, Christine Ruvaclaba

Cohort XII

Background: This quality improvement project, conducted in the Texas-Mexico border region with high obesity rates, aimed to explore the utility of the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) as a screening tool for insulin resistance (IR) among overweight and obese individuals. The study focused on patients with a Body Mass Index (BMI) greater than 25 who exhibited normal blood sugar levels or Hemoglobin A1c (HbA1c) levels less than 5.7%.

Aim/Methods: The aim is to identify early intervention strategies for metabolic disorders, particularly in obese populations. Obesity is often the precursor to comorbid conditions such as diabetes and cardiovascular disease. …

The Effects Of Mediterranean Diet On The Epileptic Population With Depression, Celina Navarro

Cohort XII

Background: People with epilepsy often develop depression during the course of their disease progression. This condition is multifactorial, often related to the unpredictability of their disease, the lack of control on their symptoms, and the medications they use to treat their seizures. Mental health services continue to be insufficient for our growing border region, and patients with epilepsy, often will lack the proper mental health management due to mental health provider shortage. Multiple medications can be used to successfully treat depression in the general population, however people with epilepsy often will struggle as anti-seizure drugs can interact with antidepressants. Also, …

Improving Bipolar Diagnosis With The Rapid Mood Screener, Leslie Richard

Cohort XII

Background: Bipolar disorder is a chronic, debilitating mental illness that affects individuals globally. It is characterized by significant challenges in diagnosis, often leading to delays in receiving appropriate treatment. This condition can mirror the symptoms of unipolar depression, leading to frequent misdiagnoses and hindering timely intervention that could improve functional outcomes and quality of life.

Aims/Methods: This project aims to enhance the accuracy of bipolar disorder diagnoses in clinical settings, specifically bipolar disorder type 1 (BPT1), at the earliest possible stage of the illness. By doing so, it seeks to improve symptom management, reduce the duration of episodes, and enhance …

Physical Activity And Depression: Nationwide Evaluation Of Depression And Physical Activity In South Korea, Kwang Jun Kim, Jin Soo Kim, Dong Hyun Yoon

Research outputs 2022 to 2026

Purpose: The relationship between depression and physical activity levels in adults in Korea was determined using data from the National Health and Nutrition Survey (K-NAESE). METHODS: Data collected from K-NAESE between 2014 and 2020, comprising 29,716 (male: 13,416, female: 16,300) participants, were analyzed using a complex sample statistical analysis by applying differential weight to the variables to analyze the relationship between depression and physical activity levels in an estimated South Korean population (50,881,242). Demographic factors were used as control variables while constructing an independent variable-by-variable fit model for the zero-inflated Poison Regression analysis of PHQ-9 depression scores, and a meaningfully …

Stimulate The Senses: How The Great Outdoors Affects Mental Health, Kayleigh Hite

University Honors College

Mental health disorders and illnesses are a majority concern in societies across the globe in our current age. This paper examines the impacts and the benefits of the outdoors in relation to mental health. Various aspects of the outdoors, such as connection, nature-based therapies, and specific elements, will be addressed to see what kind of an impact the outdoors can have. Studies on these aspects will be reviewed and compared to determine if it is hugely beneficial and worth trying before starting new medications with a long list of side effects for mental health disorders. The findings have shown that …

An Examination Of Benefits Between Massage Therapy And Mental Health, Alexis Fears

University Honors College

Mental health affects millions of people every year, which is why finding effective treatment methods are important. This paper goes into a deep dive into the practice of massage therapy and its promising intervention for treated mental health disorders. Studies on the physiology of psychiatric disorders on the mental and physical states of the body will be reviewed. Following the examination of the effect the disorders have on the body, an examination of the effects of massage therapy on the physical and mental aspects of a psychiatric disorder will be provided. The findings show that massage therapy works to reduce …

A Systematic Review Of Mental Health Of Women In Fragile And Humanitarian Settings Of The Eastern Mediterranean Region, Fauziah Rabbani, Aysha Zahidie, Amna Siddiqui, Sanam Shah, Zul Merali, Khalid Saeed, Mohamed Afifi

Brain and Mind Institute

Background: The increasing emergencies and humanitarian challenges have worsened the mental health condition of women in the Eastern Mediterranean Region.

Aim: To assess the prevalence, determinants and interventions to address mental health among women in fragile and humanitarian settings in the Eastern Mediterranean Region.

Methods: Using the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines, we reviewed 59 peer-reviewed published studies (PubMed, IMEMR) and grey literature (WHO/IRIS) from January 2001 to February 2023, focusing on women's mental health in the Eastern Mediterranean Region. We then conducted a descriptive analysis of the sociodemographic characteristics.

Results: Among …

Implementation Of Prenatal And Postpartum Depression Screening For A Telehealth Company, Allison Herrmann, Lori Deibel

Doctor of Nursing Practice Projects

Abstract

Depression is a leading mental health disorder. Depression occurring during the perinatal and postpartum periods has become highly prevalent throughout the world, impacting 5-10% of women during (van de Loo et al., 2018) and 9-23.5% postpartum (Bauman et al., 2020). Proper diagnosis and treatment of perinatal and postpartum depression (PPD) is crucial, as depression can lead to poor outcomes including relationship complications and negatively affect child development (Slomain, 2019). The implementation of screening tools can help identify women at risk based on their signs and symptoms of PPD (Bauman et al., 2020). The primary goal of this project was …

Association Between Depression And Coronary Heart Disease: A Cross-Sectional Study Using Behavioral Risk Factor Surveillance System (Brfss), 2022, Juliana Monono

Capstone Experience: Master of Public Health

Objectives: To examine the association of depression and coronary heart disease in U.S. adults.

Methods: This cross-sectional study uses the Behavioral Risk Factor Surveillance System (BRFSS), 2022 data for non-institutionalized U.S adults aged 18 and older. The exposure variable is depression, the outcome is coronary heart disease (CHD), and covariates are age, race, education, and physical activity. Performed univariate, bivariate, and multivariate analyses to assess the association between depression and CHD.

Results: The analytical sample size consisted of 427,217 individuals. A total of 88,841(20.7%) of the population reported having coronary heart disease, while 338,376(70.3%) reported having no …

Heartache Beyond The Physical: Unraveling The Nexus Between Myocardial Infarction History And Depressive Disorders In Us Adults, Sonika Khanal

Capstone Experience: Master of Public Health

Objective: To estimate the prevalence of depressive disorders among US adults and explore the association between a history of Myocardial Infarction (MI) and depressive disorders, considering potential risk factors and demographic variables.

Methods: A cross-sectional study was conducted from 2022 Behavioral Risk Factor Surveillance System data, including 390,429 US adults. Logistic regression was used to estimate the association between the history of MI and depressive disorders, adjusting for age, gender, race, smoking status, health insurance, education level, and BMI. Effect modification by age was assessed.

Results: The prevalence of depressive disorders was 21.19%, with 4.46% reporting a …

Exploring The Impact Of A History Of Depression On Physical Activity In The United States: A Cross-Sectional Study, Behavioral Risk Factor Surveillance System (Brfss), 2022, Maxime Kwizera

Capstone Experience: Master of Public Health

Objective: To determine the association between a history of depression and engagement in physical activity among U.S. adults.

Method: Data were from the 2022 Behavioral Risk Factor Surveillance System survey (N=441,348). Univariate and bivariate analyses were performed to determine the distribution of sample characteristics and crude prevalence odds ratios. Weighted multivariate logistic regression stratified by age group assessed the relationship between physical activity engagement and covariates.

Results: In our sample, 20.63% had a history of depression, and 23.89% of adults reported not exercising within the past 30 days. Adults with a history of depression had 1.42 times the odds …

Fatigue Impacts Quality Of Life In People With Spinocerebellar Ataxias, Ruo-Yah Lai, Christian Rummey, Christian J Amlang, Chi-Ying R Lin, Tiffany X Chen, Susan Perlman, George Wilmot, Christopher M Gomez, Jeremy D Schmahmann, Henry Paulson, Sarah H Ying, Chiadi U Onyike, Theresa A Zesiewicz, Khalaf O Bushara, Michael D Geschwind, Karla P Figueroa, Stefan M Pulst, Sub H Subramony, Matthew R Burns, Puneet Opal, Antoine Duquette, Tetsuo Ashizawa, Ali G Hamedani, Marie Y Davis, Sharan R Srinivasan, Lauren R Moore, Vikram G Shakkottai, Liana S Rosenthal, Sheng-Han Kuo

Faculty, Staff and Students Publications

Background: Fatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated.

Objectives: To study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life.

Methods: Fatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi-variable linear regression models to examine the factors contributing to fatigue as …

A Randomized Trial Of Two Remote Health Care Delivery Models On The Uptake Of Genetic Testing And Impact On Patient-Reported Psychological Outcomes In Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, And Testing (Generate) Study, Nicolette J Rodriguez, C Sloane Furniss, Matthew B Yurgelun, Chinedu Ukaegbu, Pamela E Constantinou, Ileana Fortes, Alyson Caruso, Alison N Schwartz, Jill E Stopfer, Meghan Underhill-Blazey, Barbara Kenner, Scott H Nelson, Sydney Okumura, Alicia Y Zhou, Tara B Coffin, Hajime Uno, Miki Horiguchi, Allyson J Ocean, Florencia Mcallister, Andrew M Lowy, Alison P Klein, Lisa Madlensky, Gloria M Petersen, Judy E Garber, Scott M Lippman, Michael G Goggins, Anirban Maitra, Sapna Syngal

Faculty, Staff and Student Publications

Background & aims: Genetic testing uptake for cancer susceptibility in family members of patients with cancer is suboptimal. Among relatives of patients with pancreatic ductal adenocarcinoma (PDAC), The GENetic Education, Risk Assessment, and TEsting (GENERATE) study evaluated 2 online genetic education/testing delivery models and their impact on patient-reported psychological outcomes.

Methods: Eligible participants had ≥1 first-degree relative with PDAC, or ≥1 first-/second-degree relative with PDAC with a known pathogenic germline variant in 1 of 13 PDAC predisposition genes. Participants were randomized by family, between May 8, 2019, and June 1, 2021. Arm 1 participants underwent a remote interactive telemedicine session …

Single Case Experimental Design Examining Cognitive Behavioural Therapy For Post-Stroke Depression, Liam Alexander Mackenzie Myles, Emma Jones

Journal of Mind and Medical Sciences

Background. Post-stroke depression (PSD) is common in older-age adults and is typically treated with cognitive-behavioural therapy (CBT). However, research has ascertained mixed findings regarding the efficacy of CBT for PSD in older-age adults, with limited evidence in people from global majority backgrounds. Materials and Methods. This case study used single case experimental design methodology to examine the effectiveness of CBT for PSD in a black, older-age man. The effects of health conditions, cohort beliefs, transitions in role investments, socio-cultural context and early experiences on the client’s thoughts, emotions, physical sensations and behaviours were formulated, before behavioural activation was used to …

Nurse Suicide: Examining Depression And Anxiety In Critical Care Settings, Arianna Bernardine Barata

Nursing | Student Research Posters

Nurses play a critical role in healthcare, yet the demanding work environment often exposes them to stressors, leading to the development of depression and anxiety. According to the National Library of Medicine (NLM) (2021), 50.8% of nurses have stress, 74% have anxiety, 70.8% have depression, and 79.1% have at least one of them. Burnout, understaffing, COVID fatigue, alarm fatigue, patient ratios, and disrupted sleep patterns are some of the stressors nurses contend with in every shift. While some nurses may cope and overcome these challenges, many face more severe issues, such as suicide. Nurse suicide is an issue that has …

Examining The Effect Of Genes On Depression As Mediated By Smoking And Modified By Sex, Kirsten Voorhies, Julian Hecker, Sanghun Lee, Georg Hahn, Dmitry Prokopenko, Merry-Lynn Mcdonald, Alexander C Wu, Ann Wu, John E Hokanson, Michael H Cho, Christoph Lange, Karin F Hoth, Sharon M Lutz

Faculty, Staff and Student Publications

Depression is heritable, differs by sex, and has environmental risk factors such as cigarette smoking. However, the effect of single nucleotide polymorphisms (SNPs) on depression through cigarette smoking and the role of sex is unclear. In order to examine the association of SNPs with depression and smoking in the UK Biobank with replication in the COPDGene study, we used counterfactual-based mediation analysis to test the indirect or mediated effect of SNPs on broad depression through the log of pack-years of cigarette smoking, adjusting for age, sex, current smoking status, and genetic ancestry (via principal components). In secondary analyses, we adjusted …

Educational Campaign: Using Exercise To Prevent Postpartum Depression, Ruth Platt

MSN Capstone Projects

Postpartum depression is one of the most common medical ailments surrounding childbirth. It affects up to 20% of postpartum women and has detrimental effects not only on the mother but her infant and family as well (Navas et al., 2021). Currently, the medical community takes a reactive approach to postpartum depression by screening and treating cases of postpartum depression as they occur. An evidence-based search of peer-reviewed articles found that exercise in the perinatal period had a positive effect on maternal mental health and decreased postpartum depression scores. This is especially true for women who have a history of depression …

Statistical Genetic Approaches To Investigate Genotype-By-Environment Interaction: Review And Novel Extension Of Models, Vincent P. Diego, Eron G. Manusov, Marcio Almeida, Sandra Laston, David Ortiz, John Blangero, Sarah Williams-Blangero

School of Medicine Publications

Statistical genetic models of genotype-by-environment (G×E) interaction can be divided into two general classes, one on G×E interaction in response to dichotomous environments (e.g., sex, disease-affection status, or presence/absence of an exposure) and the other in response to continuous environments (e.g., physical activity, nutritional measurements, or continuous socioeconomic measures). Here we develop a novel model to jointly account for dichotomous and continuous environments. We develop the model in terms of a joint genotype-by-sex (for the dichotomous environment) and genotype-by-social determinants of health (SDoH; for the continuous environment). Using this model, we show how a depression variable, as measured by the …

Brain Matters: Cognitive-Behavioral Therapy And Antidepressants For Post-Stroke Depression, Lindsey Anne Smith

MSN Capstone Projects

Stroke is the leading cause of death and disability in the United States, and approximately one-third of these patients will develop post-stroke depression, which is associated with higher rates of morbidity and mortality (American Stroke Association, 2022). Even though post-stroke depression is prevalent, it often goes undertreated. The combination of antidepressants and cognitive-behavioral therapy has shown to be an effective method of treating post-stroke depression. There are cognitive-behavioral exercises that nurses can implement, such as group therapy, acceptance therapy, and cognitive retraining, a method of coaching the patient to replace negative thoughts with positive ones (Byun et al., 2021). With …

The Role Of Occupational Therapy, Community Reintegration And Cultural Responsiveness Among African American/Black Adults With Major Clinical Depression, Walter Akoh, Felecia Banks

Howard University, Department of Occupational Therapy Capstone and Faculty Research

Walter Akoh

The Role of Occupational Therapy, Community Reintegration and Cultural Responsiveness Among African American/Black Adults with Major Clinical Depression

Felecia M. Banks, PhD, MEd, OTR/L, FAOTA

Abstract:

This project explores the pivotal role of occupational therapy in fostering successful community reintegration outcomes among African American/Black adults grappling with major clinical depression. Depression, a prevalent mental health ailment, often impairs individuals' ability to carry out daily tasks, resulting in reduced engagement in preferred activities and diminished community participation (American Psychiatric Association, 2013). Consequently, occupational therapy, renowned for its focus on empowering individuals to partake in meaningful occupations, holds promise for …

The Role Of Occupational Therapy, Community Reintegration And Cultural Responsiveness Among African American/Black Adults With Major Clinical Depression, Walter Akoh, Felecia Banks

Howard University, Department of Occupational Therapy Capstone and Faculty Research

Date: 4/14/2025

Student Name: Walter Akoh

Capstone Project Title: The Role of Occupational Therapy, Community Reintegration and Cultural Responsiveness Among African American/Black Adults with Major Clinical Depression

Capstone Faculty Advisor: Felecia M. Banks, PhD, MEd, OTR/L, FAOTA

Abstract:

This project explores the pivotal role of occupational therapy in fostering successful community reintegration outcomes among African American/Black adults grappling with major clinical depression. Depression, a prevalent mental health ailment, often impairs individuals' ability to carry out daily tasks, resulting in reduced engagement in preferred activities and diminished community participation (American Psychiatric Association, 2013). Consequently, occupational therapy, renowned for its focus on …

Evaluating The Efficacy Of Universal Depression Screenings In The High School Setting, Telisha Anthony Msn, Fnp-Bc, Jennifer Thorsen Bsn, Rn, Jackie Sharp Dnp, Pmhnp-Bc, Sharon Little Dnp, Fnp-Bc

Doctor of Nursing Practice Projects

Purpose/Background

Depression in adolescents is rising each year. Early detection of depression has been shown to result in better health outcomes and success in school. This scoping review aims to evaluate the implementation of universal depression screenings in the high school setting and how this detection of depression and initiation of treatment.

Methods

From August 2022 to November 2023, we used the Medline, PubMed, Elsevier, Google Scholar, and PsycINFO databases, using specific keywords related to depression in adolescents. Of the 38 articles found, 10 were chosen after extensive article critique. The publication dates ranged from 2014-2023, were full-text, and from …

Implementing Universal Adult Depression Screening In A Rural Maine Free Medical Clinic, Karen Hussion

Doctor of Nursing Practice Scholarly Projects

Abstract

BACKGROUND: Depression in adults is a leading cause of disability, morbidity and mortality worldwide with an estimated prevalence of 20% in the US population. Despite estimates that one out of every five Americans suffers from depression, less than 50% of adult primary care patients with depression are identified, and less than 5% of all adult primary care patients are screened. To increase early detection and management of depression, the United States Protective Service Task Force (USPSTF) recommends routine depression screening for adults older than 18 years in primary care settings.

LOCAL PROBLEM: This project site was a rural, free, …

When They Just Don’T Sleep: Differential Impacts Of Reduced Child Sleep On Depression, Anxiety, And Stress Among Caregivers Of Children With And Without Neurogenetic Syndromes, Kimberly Galvez-Ortega, Kristine Marceau, Dan Foti, Bridgette Kelleher

Purdue University Libraries Open Access Publishing Fund

Introduction: Children with neurogenetic syndromes commonly experience significant and pervasive sleep disturbances, however, associations with caregiver mental health remains unclear. Previous studies have linked sleep disturbances with increased caregiver depression in typically developing populations, and heightened caregiver stress among neurogenetic populations. The present study expands on findings by exploring the longitudinal association between child sleep duration and caregiver mental health (depression, anxiety, stress) throughout development (infancy to school-aged children) in dyads with and without a child affected by a neurogenetic syndrome.

Methods: Participants were drawn from the Purdue Early Phenotype Study, including 193 caregivers (Age: M = 34.40 years, SD …

Preparatory Program For Women During Pregnancy/Postpartum And Transitioning Back To Work Or School, Bria Runnels, Rebecca King

Spring 2024 Virtual OTD Capstone Symposium

Despite the importance of maternal health during the prenatal, postnatal, and parenting stages, there is a lack of research on the role of occupational therapists (OTs) in addressing the occupational challenges faced by women during this transitional phase. This dissertation aims to develop a program that raises awareness of the role of occupational therapy in maternal health and promotes occupational therapists as part of an interdisciplinary team within the scope of maternal health care. By adapting co-occupation for mothers, occupational therapists can play an important role in individualizing occupations for enhanced transitioning and overall quality of life. The study highlights …

Depression And Other Risk Factors Of Suicide, Mckenna Newnam, Jaeyong Choi

Criminal Justice Student Work

Substance abuse, other mental disorders, and individual characteristics all play a role in the risk of suicide when concurrent with depression. Far more research exists on depression as it effects suicide alone. Future research needs to focus on depression as it effects suicide and explore the other possible factors that can impact the outcome. Understanding the different aspects of depression as it effects suicide will provide a template for scholars and individuals involved in the mental health system to enhance treatment.