Medicine and Health Sciences Commons^™

Achievements Of The Covid-19 Turkey Platform In Vaccine And Drug Development Withan Approach Of "Co-Creation And Succeeding Together", Hasan Mandal

Turkish Journal of Medical Sciences

Mobilizing the research ecosystem for accelerating vaccine and drug development has been an important reality of the pandemic. This article reviews the scientific advances that are attained by the COVID-19 Turkey Platform for vaccine and drug development against the SARS-CoV-2 virus. The platform that is coordinated by the Scientific and Technological Research Council of Turkey is established with a "co-creation and succeeding together" approach, which involves 436 researchers across 49 different institutions working on 17 vaccine and drug development projects in total. Recent advances of the COVID-19 Turkey Platform include the fourth virus-like particle-based vaccine candidate in the world to …

Turkey's Response To Covid-19 Pandemic: Strategy And Key Actions, Gülşen Barlas, Harun Öztürk, Gülen Pehli̇vantürk, Sabahatti̇n Aydin

Turkish Journal of Medical Sciences

COVID-19 emerged at the end of 2019 in Wuhan, China, and spread rapidly around the world causing many deaths. Due to the intercontinental escalation in the epidemic, while WHO declared a pandemic on March 11, 2020, our country's first case was diagnosed. Before this, the MoH established the Operations Center against possible risks regarding the Pandemic Influenza Preparedness Plan on January 10, 2020 and formed the Scientific Committee, which has a critical importance in epidemic management. National and Provincial Pandemic Coordination Boards were established within the scope of this plan. Fast, effective and frequently updated decisions were implemented. The epidemic …

One And A Half Years Into The Covid-19 Pandemic - Exit Strategies And Efficacy Of Sarscov-2 Vaccines For Holistic Management And Achieving Global Control, Eskild Petersen, Ayşe Deni̇z Gökengi̇n, Asma Al Balushi, Alimuddin Zumla

Turkish Journal of Medical Sciences

One and a half years into the pandemic, SARS-CoV-2 is still here to stay. Whilst rapid several effective COVID-19 vaccines have been developed and are being rolled out, the critical questions remain whether vaccines provide widespread protection against infection and reinfection, and what the duration of protection is. Community wide control cannot be obtained until almost everyone is immune. Vaccine production must be ramped up to cover the world population. The price of herd immunity through natural infection is high mortality in the elderly and morbidity in other age groups including children and Long-COVID. We must expect a new wave …

Going Back To Normal, But How? Re-Opening Policies And The Standards For A New Normal, Levent Akin

Turkish Journal of Medical Sciences

Governments implemented to nonpharmacological methods and various limitation policies such as closing nonessential businesses, schools and limiting group gatherings, promoting social distancing, use of personal protective equipment, advising staying at home. These policies have caused various problems in social and economic life and gradual increase in psychosocial well-being problems. All societies yearningly are waiting for the COVID-19 pandemic to be brought under control and the measures to be lifted in order to return to their previous lives. Indicators are needed to assess the burden of disease in the country while lifting measures to control the COVID-19 pandemic. When using these …

Epidemiology Of Covid-19: What Changed In One Year?, Cemal Bulut, Yasuyuki̇ Kato

Turkish Journal of Medical Sciences

A coronavirus brought the first pandemic attack of this century as a flu virus did a hundred years ago. This greatest pandemic of the century brings us new opportunities to understand and explore the dynamics of a contagious disease. Nearly two years later, we are still collecting the evidence to understand the disease. Some basic epidemiological properties are still urgently needed. Not only the origin of the virus but also Ro value, possible transmission routes, epidemiologic curves, case fatality rates, seasonality, severity and mortality risk factor, effects on the risk groups, differences between countries and so on still require strong …

From Asymptomatic To Critical Illness - Different Clinical Manifestations Of Covid-19 Inchildren, Hasan Tezer, Meli̇s Deni̇z

Turkish Journal of Medical Sciences

The global pandemic infectious disease that was named the new coronavirus disease (COVID 19), spread throughout the world, causing a major public health emergency. The causative virus of COVID-19, called SARS CoV-2, can infect all age groups. Various clinical signs and symptoms have been observed in neonates, children, and adolescents during the COVID-19 outbreak. The clinical manifestations of COVID-19 might be different due to the medical conditions and comorbid status in elderly and pediatric patients. The rise in cases among children has been reported during the COVID-19 pandemic. Although infected children generally appear to be asymptomatic or have only mild …

Multisystem Inflammatory Syndrome In Children, Selda Hançerli̇ Törün, Di̇lek Yilmaz Çi̇ftdoğan, Ateş Kara

Turkish Journal of Medical Sciences

As the COVID-19 pandemic continues, children can be infected with the virus that causes COVID-19. Clinical symptoms of children with COVID from China, where the disease was first reported, generally were less severe than adults. However, at the end of April 2020 in Europe, it was observed that some children with SARS-CoV-2 infection developed fever, abdominal pain, shock, myocardial insufficiency and they needed to be taken care of in intensive care unit. This new disease has been called multisystem inflammatory syndrome in children (MIS-C). Although the pathogenesis of MIS-C is unclear, it progresses with signs of multiorgan involvement as a …

From Asymptomatic To Critical Illness: Decoding Various Clinical Stages Of Covid-19, İlhami̇ Çeli̇k, Recep Öztürk

Turkish Journal of Medical Sciences

The clinical course of COVID-19 is variable, with clinical manifestation ranging from 81% mild course to 14% severe course along with 5% critical course in patients. The asymptomatic course is reported to potentially range between 20% and 70% (avg. 33%). A more severe course is seen in the elderly, those with various chronic diseases, and the immunosuppressed, where the case fatality rate is higher in these risk groups. The disease progresses with various symptoms, such as fever, cough, shortness of breath, malaise, myalgia, taste and smell disorders, diarrhea, sore throat, headache, and conjunctivitis. The disease begins with shortness of breath, …

Covid-19 And Sepsis, Zeli̇ha Koçak Tufan, Bi̇rcan Kayaaslan, Mervyn Mer

Turkish Journal of Medical Sciences

The COVID-19 pandemic has created a major alteration in the medical literature including the sepsis discussion. From the outset of the pandemic, various reports have indicated that although there are some unique features pertinent to COVID-19, many of its acute manifestations are similar to sepsis caused by other pathogens. As a consequence, the old definitions now require consideration of this new etiologic agent, namely SARS-CoV-2. Although the pathogenesis of COVID-19 has not been fully explained, the data obtained so far in hospitalized patients has revealed that serum cytokine and chemokine levels are high in severe COVID-19 patients, similar to those …

Pregnancy And Covid-19: Prevention, Vaccination, Therapy, And Beyond, Di̇lek Şahi̇n, Atakan Tanaçan, Sophia Ne Webster, Özlem Moraloğlu Teki̇n

Turkish Journal of Medical Sciences

: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has alarmed the world since its first emergence. As pregnancy is characterized by significant changes in cardiovascular, respiratory, endocrine, and immunological systems, there are concerns on issues like the course of disease in pregnant women, safety of medications, route of delivery and risk of obstetric complications. The aim of this review is to summarize the current literature in the management of pregnant women during the COVID-19 pandemic. Although more than 90% of pregnant women with COVID-19 recover without serious morbidity, rapid deterioration of disease and higher …

The Radiological Findings Of Covid-19, Alper Karacan, Yakup Ersel Aksoy, Mehmet Hali̇l Öztürk

Turkish Journal of Medical Sciences

Background/aim: Available information on the radiological findings of the 2019 novel coronavirus disease (COVID-19) is constantly updated. Ground glass opacities (GGOs) and consolidation with bilateral and peripheral distribution have been reported as the most common CT findings, but less typical features can also be identified. According to the reported studies, SARS-CoV-2 infection is not limited to the respiratory system, and it can also affect other organs. Renal dysfunction, gastrointestinal complications, liver dysfunction, cardiac manifestations, and neurological abnormalities are among the reported extrapulmonary features. This review aims to provide updated information for radiologists and all clinicians to better understand the radiological …

Immune Dysfunction In Covid-19 And Judicious Use Of Antirheumatic Drugs For Thetreatment Of Hyperinflammation, Abdurrahman Tufan, Marco Matucci-Cerinic

Turkish Journal of Medical Sciences

: In the Wuhan province of China, almost two years ago, in December 2019, the novel Coronavirus 2019 has caused a severe involvement of the lower respiratory tract leading to an acute life-threatening respiratory syndrome, coronavirus disease-19 (COVID-19). Subsequently, coronavirus 2 (SARS-CoV-2) rapidly spread to the entire world causing a pandemic and affected every single person on earth either directly or indirectly with destroying all facets of social life and economy. Since the announcement of COVID-19 as a global pandemic, we have witnessed tremendous scientific work on all aspects of COVID-19 across the globe, which has never been witnessed before. …

An Update Of Anti-Viral Treatment Of Covid-19, Serap Yavuz, Feri̇de İpek Komsuoğlu Çeli̇kyurt

Turkish Journal of Medical Sciences

Background/aim: Currently there is not an effective antiviral treatment for COVID-19, but a large number of drugs have been evaluated since the beginning of the pandemic, and many of them have been used for the treatment of COVID-19 despite the preliminary or conflicting results of the clinical trials. We aimed to review and summarize all of the current knowledge on the antivirals for COVID-19. Results: There are 2 main drug groups for SARS-CoV-2: agents that target proteins or RNA of the virus or interfere with proteins or biological processes in the host that support the virus. The main drug groups …

Consensus Recommendations For Botulinum Toxin Injections In The Spasticitymanagement Of Children With Cerebral Palsy During Covid-19 Outbreak, Ebru Yilmaz Yalçinkaya, Nai̇me Evri̇m Karadağ Saygi, Özden Özyemi̇şci̇ Taşkiran, Nalan Çapan, Şehi̇m Kutlay, Bi̇rkan Sonel Tur, Özlem El, Ece Ünlü Akyüz, Süda Teki̇n, Demet Ofluoğlu, Murat Zi̇nnuroğlu, Pinar Akpinar, Tuğçe Özekli̇ Misirlioğlu, Berri̇n Hüner, Ahmet Hakan Nur

Turkish Journal of Medical Sciences

Spasticity is the most common motor disturbance in cerebral palsy (CP). Lockdown in the COVID-19 outbreak has profoundly changed daily routines, and similarly caused the suspension of spasticity treatment plans. Besides, the delay in botulinum toxin (BoNT) injection, which is important in the management of focal spasticity, led to some problems in children. This consensus report includes BoNT injection recommendations in the management of spasticity during the COVID-19 pandemic in children with CP. In order to develop the consensus report, physical medicine and rehabilitation (PMR) specialists experienced in the field of pediatric rehabilitation and BoNT injections were invited by Pediatric …

Outcome Of Noncritical Covid-19 Patients With Early Hospitalization And Early Antiviraltreatment Outside The Icu, Nursel Çalik Başaran, Oğuz Abdullah Uyaroğlu, Gülçi̇n Telli̇ Di̇zman, Lale Özişik, Taha Koray Şahi̇n, Zahi̇t Taş, Ahmet Çağkan İnkaya, Sevi̇lay Karahan, Şehnaz Özyavuz Alp, Alpaslan Alp, Gökhan Metan, Işkin Pinar Zarakol, Gülay Sai̇n Güven, Şeri̇fe Gül Öz, Arzu Topeli̇ İski̇t

Turkish Journal of Medical Sciences

Background/aim: Despite the fact that the COVID-19 pandemic has been going on for over 5 months, there is yet to be a standard management policy for all patients including those with mild-to-moderate cases. We evaluated the role of early hospitalization in combination with early antiviral therapy with COVID-19 patients in a tertiary care university hospital. Materials and methods: This was a prospective, observational, single-center study on probable/confirmed COVID-19 patients hospitalized in a tertiary care hospital on COVID-19 wards between March 20 and April 30, 2020. The demographic, laboratory, and clinical data were collected. Results: We included 174 consecutive probable/confirmed COVID-19 …

Clinical Course Of Covid-19 Disease In Immunosuppressed Renal Transplant Patients, Hamad Dhei̇r, Savaş Si̇pahi̇, Selçuk Yaylaci, Esma Seda Çeti̇n, Ahmed Bi̇lal Genç, Necatti̇n Firat, Mehmet Köroğlu, Gürkan Muratdaği, Yakup Tomak, Kezban Özmen Süner, Ömer Faruk Ateş, Oğuz Karabay

Turkish Journal of Medical Sciences

Background/aim: We aimed to identify clinical settings of renal transplant patients with COVID-19. Materials and methods: In this retrospective study, we included kidney transplant inpatients with laboratory confirmed COVID-19 who had been discharged or had died by October 1st, 2020. Characteristics of the patients, including basal and last outpatient biochemical parameters were recorded. Discontinuation or dosage reduction of immunosuppressives and other treatment information was documented. Results: Twenty patients were included in this study, of whom 18 were discharged and 2 died in hospital. The mean duration of hospitalization and follow-up were 9.7 ± 6.4 days and 4.5 ± 2.0 months, …

Characteristics And Mortality Determinants Of Covid-19 Patients Undergoinghemodialysis, Savaş Si̇pahi̇, Hamad Dhei̇r, Aysel Toçoğlu, Meli̇ke Bektaş, Seyyi̇d Bi̇lal Açikgöz, Ahmed Ci̇had Genç, Fuldem Mutlu, Mehmet Köroğlu, Ali̇ Fuat Erdem, Oğuz Karabay

Turkish Journal of Medical Sciences

Background/aim: The COVID-19 infection, which started in Wuhan City, China, in December 2019, turned into a pandemic in a very short time, affecting mainly the elderly and those with serious chronic illnesses. COVID-19 infections have been observed to have a high mortality rate, especially in patients undergoing maintenance hemodialysis. Materials and methods: Forty-two patients over 18 years of age who underwent a maintenance hemodialysis program at our unit, who tested positive for COVID-19 by PCR from nasopharyngeal swabs, and/or who were observed to have disease-related signs in their CTs were included in the study. Results: In this study, 23 of …

Ua19/16/2 Track & Field Press Releases, Wku Athletic Media Relations

WKU Administration Documents

Press releases, photos and meet statistics for WKU track & field team in 2021.

Investigation Of A Sars-Cov-2 B.1.1.529 (Omicron) Variant Cluster - Nebraska, November-December 2021, Lauren Jansen, Bryan Tegomoh, Kate Lange, Kimberly Showalter, Jon Figliomeni, Baha Abdalhamid, Peter C. Iwen, Joseph R. Fauver, Bryan Buss, Matthew Donahue

Journal Articles: Epidemiology

The B.1.1.529 (Omicron) variant of SARS-CoV-2 (the virus that causes COVID-19) was first detected in specimens collected on November 11, 2021, in Botswana and on November 14 in South Africa;* the first confirmed case of Omicron in the United States was identified in California on December 1, 2021 (1). On November 29, the Nebraska Department of Health and Human Services was notified of six probable cases^† of COVID-19 in one household, including one case in a man aged 48 years (the index patient) who had recently returned from Nigeria. Given the patient's travel history, Omicron infection was suspected. Specimens …

Community Health Workers And Covid-19 In New York State: Adaptable And Resilient, But Strained, Annis Golden, Amy Williams

Understanding and eliminating minority health disparities in a 21st-century pandemic: A White Paper Collection

This report summarizes findings from an interview-based study conducted in October and November 2020, and inferences that may be drawn from those findings with respect to the contributions of CHWs to eliminating disparities in the impact of COVID-19, and resources needed by CHW-based programs going forward. Findings are reported in the following areas: New connection strategies with clients used by CHWs in response to physical distancing requirements, barriers to connections; new areas of support CHWs provided; socioemotional impact of the pandemic and adaptations on CHWs; resources needed going forward; CHW support for efforts to eliminate disparities in COVID-19 impact on …

The Impact Of Covid-19 On Minority Disparities In Sexual And Reproductive Health Care In New York State, Elise Andaya, Rajani Bhatia

Understanding and eliminating minority health disparities in a 21st-century pandemic: A White Paper Collection

This report presents the findings from a qualitative study of the impact of COVID-19 on the provision of sexual and reproductive health (SRH) care to minority groups in New York State from March to October 2020. Drawing on interview material with frontline SRH providers and advocates, we illustrate the deepening inequalities in access to, and quality of, SRH care during the first surge of the pandemic, as well as their implications for future policy and practice. Key findings include: 1) Negative birthing conditions experienced disproportionately by women most vulnerable to poor maternal and birth outcomes; 2) delays and avoidance of …

Identifying Critical Psychological Characteristics Related To Successful Performance As A Contact Tracer: A Job Analysis, Dev Dalal, Jason G. Randall Phd, Gabrielle Danna, Joshua Ash

Understanding and eliminating minority health disparities in a 21st-century pandemic: A White Paper Collection

The COVID-19 pandemic highlighted the need for a massive workforce of contact tracers to help end the global pandemic. Rapidly accelerating the recruitment, selection, and training of contact tracers proved to be difficult due in part to the lack of a valid, structured, and systematic approach to hiring and training contact tracers. This demonstration presents the results of the first step in developing a systematic selection and training program: a worker-oriented job analysis of the contact tracer job. Using archival records and structured interviews with 15 subject matter experts, we identified 26 unique characteristics related to successful performance as a …

Food Insecurity In Ny State. Solutions To Address The Multifaceted Problem, Janine Jurkowski, Tomoko Udo, Angela Hackstadt

Understanding and eliminating minority health disparities in a 21st-century pandemic: A White Paper Collection

Food is an essential determinant of health; the challenges in meeting nutritional needs for all are complex. Food insecurity involves the availability of enough safe and nutritious food, having access to that food, and being able to effectively utilize that food for household consumption. Availability has to do with the supply chain, which is affected directly by the social and physical environment. Access is related to the social and economic factors that determine individuals and households’ socioeconomic opportunities. Utilization has to do with having the ability, storage and tools for food preparation. Food insecurity is a growing social problem with …

Ua19/16/2 Tennis Press Releases, Wku Athletic Media Relations

WKU Administration Documents

Press releases, photos and game statistics for WKU tennis team in 2021.

The Effect Of School Return During The Covid-19 Pandemic On Children’S Physical And Mental Health, Kaitlynn Craig

Mahurin Honors College Capstone Experience/Thesis Projects

Flashback to midnight on January 1st, 2020. It was New Year’s Day, the beginning of a new decade. Many were filled with excitement and hope to make this year the best one yet. Little did they know that their entire world would be turned upside down a short two months later with a worldwide pandemic, the coronavirus. COVID-19 has affected people in many ways. Some lost their jobs, others struggled to maintain their education virtually, and unfortunately, too many lost their lives. As a nursing student, fear grew while imagining the role of becoming one of the frontline workers battling …

Use Of Chest Ct To Diagnose Covid-19, Ryan Gilgallon

Student Research Poster Presentations 2021

Use of Computed Tomography (CT) to Diagnose COVID-19

Ryan Gilgallon

Dr. Elaine Halesey, Ed.D., R.T.(R)(QM)

This project explains COVID-19 and the role Computed Tomography (CT) can play in diagnosing patients who have infections. General equipment used, symptoms, findings and abnormalities, methods of early detection, rates of misdiagnosis, advantages of CT, and a case study are also discussed. COVID-19 originated in Wuhan, China and rapidly spread throughout the world being transmitted from human to human, affecting the respiratory system. The most common findings in this project consisted of ground-glass opacities (GGO), fibrous stripes, interlobular septal thickening, and consolidation. Computed Tomography is …

Covid-19 In The Computed Tomography (Ct) Department, Jannelle Perla

Student Research Poster Presentations 2021

This research will discuss how Coronavirus (COVID-19) has severely impacted the world and the role of computed tomography (CT) department as a whole. COVID-19 is an infectious disease that is fast spreading caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outbreak began in December of 2019 in the city of Wuhan, China. COVID-19 has been declared a pandemic since March of 2020 due to the rapid spreading of the virus. The most common way to confirm coronavirus is the reverse transcription polymerase chain reaction (RT-PCR) nasal swab. X-ray and CT are the two main imaging modalities that help …

2021-01-01_Michiganoverview_Covidtestingtimes, Michigan Department Of Health & Human Services

Michigan COVID-19 Testing Turnaround Data

The COVID Testing Turnaround Time page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-545615--,00.html.

This report was created by the Michigan Department of Health & Human Services, providing data for the past 14 days on the average time it takes for a diagnostic COVID-19 laboratory test to be reported to the state health department. Testing turnaround time data will be updated weekly on Friday mornings.

MDHHS receives results from commercial labs, hospitals, and public health labs. However, public health laboratories perform limited diagnostic testing and disease surveillance for infectious diseases. Total turnaround time is calculated from the difference of …

Individual Versus Sequential: The Potential Of Comic Creation In Art Therapy, Christine Phang

Art Therapy | Theses and Dissertations

This research study explored the potential of comics within an art therapy and narrative therapy framework. The process of depicting a past problem as a single image was compared to the process of depicting the same problem as a comic. This study worked with 15 normally functioning adults to compare the effectiveness of the two formats (comics vs. single image) in processing a past problem or challenge. Participants evaluated these two formats through a survey and a brief verbal interview. The quantitative data from the survey and the qualitative data from the interview were analyzed to determine the effectiveness of …

Ua19/16/2 Golf Press Releases, Wku Athletic Media Relations

WKU Administration Documents

Press releases, photos and game statistics for WKU golf teams in 2021.