Medicine and Health Sciences Commons^™

Defining Breast Cryoablation Treatment Success: A Guide For The Curative And Palliative Treatment Of Breast Cancer, Monica L Huang, Deanna L Lane, Lauren Q Chang Sen, Rosalind P Candelaria, Henry M Kuerer, Kelly K Hunt, Catherine Akay, Bora Lim, Simona Shaitelman, Rosa F Hwang, Hui Chen, Rajani Katta, Lumarie Santiago

Faculty, Staff and Student Publications

Rationale and objectives: Recent ICE3 trial of breast cryoablation for breast cancer demonstrated 98% success rate, similar to breast-conserving surgery. However, ICE3 and other published studies did not differentiate curative from palliative treatment nor define patient-specific treatment objectives. We sought to define treatment success of curative and palliative breast cryoablation for breast cancer in meeting procedure objectives and patient-specific treatment objectives.

Materials and methods: We conducted a retrospective analysis of breast cancer patients who underwent breast cryoablation during 2021-2024. Breast radiologists performed outpatient cryoablation using local anesthesia and argon gas cryoprobes under ultrasound or MRI guidance. Patient demographics, referral indications, …

Sleep Disturbances Based On Patient Reported Outcomes In Patients With Breast Cancer, Saadia A Faiz, Ashley S Knox, Bryan Fellman, Bibi Aneesah Jaumally, G Nancy Pacheco, Aneesa Das, Reeba Mathew, Rashmi Murthy, Jennifer K Litton, Diwakar D Balachandran, Lara Bashoura

Faculty, Staff and Student Publications

Purpose: Sleep disturbances are common in patients with breast cancer, but comprehensive evaluations with patient-reported outcomes (PRO) and sleep evaluation with polysomnography (PSG) are lacking. This study describes sleep disruption using PROs and PSG to identify underlying sleep disorders.

Methods: A retrospective review of patients with breast cancer undergoing formal sleep evaluation from 4/1/2009 to 7/31/2014 was performed. Clinical characteristics, PROs using Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS), and PSG data were reviewed.

Results: 404 patients were identified with 43% early, 30% locally advanced and 17% metastatic disease. PSQI revealed poor sleep in 75%, and ESS …

Excess Risk Of Chronic Health Conditions In Black Adolescent And Young Adult Cancer Survivors, Amy M Berkman, Eunju Choi, Christabel K Cheung, John M Salsman, Susan K Peterson, Clark R Andersen, Qian Lu, J A Livingston, Aryce Battle, Michelle A T Hildebrandt, Susan K Parsons, Michael E Roth

Faculty, Staff and Student Publications

Background: The US population of adolescent and young adult (age 15-39 years at diagnosis) cancer survivors is growing. Previous studies have identified racial and ethnic disparities in survival and health outcomes in racially minoritized survivors, including Black survivors, compared with White survivors. However, comparisons should be made between those of the same race or ethnicity with and without a history of AYA cancer to fully understand the association of a cancer diagnosis with socioeconomic status (SES) and health outcomes within a minoritized population.

Methods: Non-Hispanic Black AYA cancer survivors and non-Hispanic Black age- and sex-matched controls were identified from self-reported …

Association Between Chronotype And Chronic Neuropathic Pain Sensitivity: A Pilot Prospective, Observational, Single-Center, Cross-Sectional Study, Michael Kim, Yuri C Martins, Kishan Patel, Chiu-Hsieh Hsu, Mohab Ibrahim, Vasudha Goel, Amol M Patwardhan, Sejal Jain

Faculty, Staff and Student Publications

Background: Chronotype defines an organism's biological preference for timing of activity and sleep. Being a morning chronotype (i.e., tending to wake up early and go to bed earlier at night) is associated with protection against chronic musculoskeletal pain and headaches, but the relationship between chronotype and neuropathic pain sensitivity remains unclear.

Objectives: The aim of this pilot study was to explore the relationship among chronotype, neuropathic pain sensitivity, and pain interference in patients with chronic neuropathic pain disorders.

Study design: This was a prospective, observational, single-center, cross-sectional study.

Setting: Patients were recruited from pain management clinics.

Methods: The Morningness-Eveningness Questionnaire …

Datopotamab-Deruxtecan In Early-Stage Breast Cancer: The Sequential Multiple Assignment Randomized I-Spy22 Phase 2 Trial, Katia Khoury, Jane L Meisel, Christina Yau, Hope S Rugo, Rita Nanda, Marie Davidian, Butch Tsiatis, A Jo Chien, Anne M Wallace, Mili Arora, Mariya Rozenblit, Dawn L Hershman, Alexandra Zimmer, Amy S Clark, Heather Beckwith, Anthony D Elias, Erica Stringer-Reasor, Judy C Boughey, Chaitali Nangia, Christos Vaklavas, Coral Omene, Kathy S Albain, Kevin M Kalinsky, Claudine Isaacs, Jennifer Tseng, Evanthia T Roussos Torres, Brittani Thomas, Alexandra Thomas, Amy Sanford, Ronald Balassanian, Cheryl Ewing, Kay Yeung, Candice Sauder, Tara Sanft, Lajos Pusztai, Meghna S Trivedi, Ashton Outhaythip, Wen Li, Natsuko Onishi, Adam L Asare, Philip Beineke, Peter Norwood, Lamorna Brown-Swigart, Gillian L Hirst, Jeffrey B Matthews, Brian Moore, W Fraser Symmans, Elissa Price, Carolyn Beedle, Jane Perlmutter, Paula Pohlmann, Rebecca A Shatsky, Angela Demichele, Douglas Yee, Laura J Van 'T Veer, Nola M Hylton, Laura J Esserman

Faculty, Staff and Student Publications

Among the goals of patient-centric care are the advancement of effective personalized treatment, minimising toxicity. The phase-2 I-SPY2.2 trial uses a neoadjuvant sequential therapy approach in breast cancer to further these goals, testing promising new agents while optimising individual outcomes. Here we tested datopotamab-deruxtecan (Dato-Dxd) in the I-SPY2.2 trial for patients with high-risk stage 2/3 breast cancer. I-SPY2.2 uses a sequential multiple assignment randomisation trial (SMART) design that includes three sequential blocks of biologically targeted neoadjuvant treatment: the experimental agent (Block A), a taxane-based regimen tailored to the tumour subtype (Block B), and doxorubicin/cyclophosphamide (Block C). Patients are randomised into …

Keratinocyte Carcinomas In Survivors Of Childhood Cancer: A Report From The Childhood Cancer Survivor Study, Christina Boull, Yan Chen, Cindy Im, Alan Geller, Yadav Sapkota, James E Bates, Rebecca Howell, Michael A Arnold, Miriam Conces, Louis S Constine, Leslie Robison, Yutaka Yasui, Gregory T Armstrong, Joseph P Neglia, Lucie M Turcotte

Faculty, Staff and Student Publications

Background: Childhood cancer survivors (CCS) are at increased risk for keratinocyte carcinomas (KC) however, the long-term incidence of single and multiple KC is not well established.

Objective: Identify risk factors and quantify KC cumulative incidence and multiple-incidence burden in CCS.

Methods: KC were identified among Childhood Cancer Survivor Study participants, a cohort of 5-year cancer survivors diagnosed < 21 years of age between 1970 and 1999 in North America. Cumulative incidence was estimated and multivariable models assessed relative rates of KC associated with survivor and treatment characteristics.

Results: Among 25,658 participants, 1446 developed 5363 KC (93.5% basal cell carcinoma, 6.7% squamous cell carcinoma; mean age 37.0 years (range 7.3-67.4), mean latency 25.7 years; 95.3% White and 88.4% with radiotherapy). Mean lesion count was 3.7 with 26.1% experiencing ≥4. Radiotherapy imparted …

Sitravatinib In Patients With Solid Tumors Selected By Molecular Alterations: Results From A Phase Ib Study, Lyudmila Bazhenova, Dong-Wan Kim, Byoung Chul Cho, Sanjay Goel, Rebecca Heist, Theresa L Werner, Keith D Eaton, Judy S Wang, Shubham Pant, Douglas R Adkins, Collin M Blakely, Xiaohong Yan, Saskia Neuteboom, James G Christensen, Richard Chao, Todd Bauer

Faculty, Staff and Student Publications

No abstract provided.

Explainable Artificial Intelligence And Domain Adaptation For Predicting Hiv Infection With Graph Neural Networks, Evan Yu, Jingcheng Du, Yang Xiang, Xinyue Hu, Jingna Feng, Xi Luo, John A Schneider, Degui Zhi, Kayo Fujimoto, Cui Tao

Faculty, Staff and Student Publications

OBJECTIVE: Investigation of explainable deep learning methods for graph neural networks to predict HIV infections with social network information and performing domain adaptation to evaluate model transferability across different datasets.

METHODS: Network data from two cohorts of younger sexual minority men (SMM) from two U.S. cities (Chicago, IL, and Houston, TX) were collected between 2014 and 2016. Feature importance from graph attention network (GAT) models were determined using GNNExplainer. Domain adaptation was performed to examine model transferability from one city dataset to the other dataset, training with 100% of the source dataset with 30% of the target dataset and prediction …

Chronic Illness Education 2024: A Guide To Navigating Chronic Obstructive Pulmonary Disease, Polina Chuikov, Bilal Ahmed, Brennan Smith, Karina Medina, Masoud Harati

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Better Sleep In Improved Cardiovascular Health, Jenna Brokaw, Kalyyanee Nanaaware, Mikhail Salnikov, Nicholas Daher, Timothy Page, Zoha Rizvi

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Capturing Undiagnosed Hypertension In Ophthalmology Clinics, Alexander Hayes, Dominic Sacca, Indrea Joplin, Owen Stratton, Whitney Bowyer

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Beating Hearts: Navigating Cardiovascular Disease Resources, Julia Tenbusch, Kaelan Patel, Maxim Jani, Nand Ganesh, Nicole Flores, Venkata Patchigolla

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Resources For The Providers To Improve Adult Hiv Outcome, Amolak Jhand, Ariana Cho, Brayden Bitterman, Jhonny Avila Mendoza, Madeline Evans, Sabrina Khan

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Cardiovascular Disease In Adults, Amber Jackson, Hayat Bazzi, Raina Awdish, Timothy Chalom, Tobias Cox

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Diet And Excersize Education To Improve Adult Obesity, David Elyas, Dhwani Krishnan, Joseph Overway, Melissa Connop, Swathi Srikantan, Zahira Malik

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Prevention And Management Of Copd, Alexander Sonaglia, Anagha Srivatsa, Hunter Cohn, Kendall Conway, Laith Fakhouri, Parmida Abdoli

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Addressing Cardiovascular Disease Through Diet Education, Alexander Restum, Alexandra Stone, Anna Lundh, Bradley Libs, Caitlin Alindogan, Jaylin Jones

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Tips And Resources For Optimal Heart Health, Genevieve Murray, Jeswin David, Matthew George, Raghav Rajesh, Simran Qureshi, Ward Hedges

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Educational Resources To Reduce Hiv Stigma, Joshua Sternberg, Akash Gopal, Anna Karle, Derek Zahnleuter, Gloria Fung, Surbhi Neole

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Improving Depression And Anxiety In Detroit, Aneesh Cherukuri, Ashlee Perry, Ethan Dunn, Grace Chen, Philip Riendeau, Sarah Qureshi

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Chronic Kidney Disease Resources, Abigail Schuch, Bamdad Tayyari, Cassidy Kamrada, Sen Gao, Solen Tadesse, Sophia Braun

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Strategies For Improving Adult Cardiovascular Health, Riley St. Amour, Sarah Rehman, Tanyeem Shaik, Yasmeen Berry, Youssef Salama, Yusuf Kashlan

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Causes, Impacts, And Approaches To Adult Obesity, Alexandra Crawford, Heather Sun, Hyeok Jun Lee, Kenneth Jackson, Kyle Mastalerz, Mannat Bedi

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Evaluating Psychological Barriers To Treating Cardiovascular Disease, Ameen Khan, Aria Hutchinson, Caitlin Ann Benitez, Daniel Poe, Dawson Sloan, Shivani Bongu

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Enhancing Patient Communication With Visual Effect In Cardiovascular Disease Management, Brendan Dolan, Candace Marquette, Diana Duque, Hyun Kyu Park, Kendra Juliette, Mohull Mehta

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Strategies And Resources To Identify Adult Depression And Anxiety In Medical Students, Arianna Afonso, Douglas Nefcy, Kelly Chen, Ken Huynh, Louie Mekani, Megan Clare Carulla

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Macro Environmental Factors That Impact Upstream Management Of Hypertension: Extending Supplemental Nutrition Assistance Program (Snap), Camden Gardner, Dina Saban, Hasan Sawan, Kaitlyn Zablock, Nikesh Thadani, Nishith Sagubadi

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Resources To Address Obesity And Improve Dietary Management, Alexa Atty, Halah Keramane, Nazeh Saad, Nishant Kumar, Sukhanjit Kaur, Zachary Wojcik

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Strategies To Improve Hiv Management, Fabiola Cuellar, Farheen Vali, Hana Jiang, Kevin Chau, Rahul Babu

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Resources To Improve Comorbidities Of Copd, Ariana Afrakhteh, Christian Versin, Joseph Kananen, Meghna Duvoor, Mitchell Rits, Natalie Aulicino

Patient Education Projects

No abstract provided.