Medicine and Health Sciences Commons^™

A Stronger Impact On Career Development For Early- And Mid-Career Faculty, Daniel A Gorelick, Jason Gertz, Kaitlin J Basham, Lindsey S Treviño

Faculty, Staff and Students Publications

Nuclear receptors are important in normal physiology and disease. Physicians and scientists who study nuclear receptors organize and attend conferences and symposia devoted to foundational and translational nuclear receptor research, but the field lacks a platform for early-stage investigators and aspiring leaders. In 2019, Zeynep Madak-Erdogan, Rebecca Riggins, and Matthew Sikora founded Nuclear Receptor (NR) Interdisciplinary Meeting for Progress And Collaboration Together (IMPACT, https://nrimpact.com), a collaborative group designed for early- and mid-career faculty who study nuclear receptors in any context or organism [1]. NR IMPACT addresses challenges for early- and mid-career faculty. Here, we review the progress of NR IMPACT …

Mutational Scanning Of Crx Classifies Clinical Variants And Reveals Biochemical Properties Of The Transcriptional Effector Domain, James L Shepherdson, David M Granas, Jie Li, Zara Shariff, Stephen P Plassmeyer, Alex S Holehouse, Michael A White, Barak A Cohen

2020-Current year OA Pubs

The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human

State Of The Art Of Mobile Health Technologies Use In Clinical Arrhythmia Care, Arun R Sridhar, Jennifer N A Silva, Et Al.

2020-Current year OA Pubs

The rapid growth in consumer-facing mobile and sensor technologies has created tremendous opportunities for patient-driven personalized health management. The diagnosis and management of cardiac arrhythmias are particularly well suited to benefit from these easily accessible consumer health technologies. In particular, smartphone-based and wrist-worn wearable electrocardiogram (ECG) and photoplethysmography (PPG) technology can facilitate relatively inexpensive, long-term rhythm monitoring. Here we review the practical utility of the currently available and emerging mobile health technologies relevant to cardiac arrhythmia care. We discuss the applications of these tools, which vary with respect to diagnostic performance, target populations, and indications. We also highlight that requirements …

Addressing Weight Bias Among Pediatric Healthcare Clinical Staff., Kathyrn Kyler, Codi Cutburth, Gayla Goleman, Sarah Hampl, Amy R. Beck

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Children with obesity may experience weight-based discrimination as a result of weight bias and stigma, which can have deleterious effects on their health and wellbeing, including increased risk of dysregulated, maladaptive, and disordered eating such as restriction, purging, and binging. Prior work has shown that weight bias occurs from healthcare workers caring for adults, but less is known about the prevalence of weight bias in the pediatric healthcare setting.

METHODS: We aimed to determine what proportion of pediatric healthcare professionals had attitudes of weight bias at our own institution by constructing a survey with questions from validated weight bias …

Healthy Community Healthy Mind: An Evidence-Based Culturally Sensitive Aboriginal Child And Adolescent Mental Health Program, Shane Murphy, Kirra Roberts

Journal of the Australian Indigenous HealthInfoNet

This brief report describes an area of promising practice and a model of care that encapsulates the intersection of non-Indigenous methods and Aboriginal and Torres Strait Islander ways of knowing, being, and doing. The Ballarat and District Aboriginal Cooperative (BADAC) Aboriginal Child and Adolescent Mental Health Program provides evidence-based mental health practice integrating the cultural knowledge and lived experience of Aboriginal staff, clients, and families. The program focus is on building trust with community and clients. This paper presents the outcomes from the first year of the program. Data from referral and assessment processes and outcomes for the young people …

Building Cultural Safety And Capabilities In The Burn Services Of The Children’S Hospital At Westmead: A Pilot Study, Camila A. Kairuz Santos, Kate Hunter, Courtney Ryder, Madeleine Jacques, Keziah Bennett-Brook, Andrew J A Holland, Bianca Barnier, Karl Briscoe, Summer M. Finlay, Kerry Bolwell, Julieann Coombes

Journal of the Australian Indigenous HealthInfoNet

Health systems built on Western philosophies of health are not culturally safe for First Nations people. Cultural competency courses developed for Australian health services tend to be a single event and fail to achieve real reflexivity and shift to culturally safe service provision. This study aimed to implement and evaluate a pilot training program on Cultural Safety and Capabilities, delivered to health professionals in the burn services at a tertiary paediatric hospital. An interactive program using Indigenous learning processes was developed by Aboriginal and Torres Strait Islander researchers in partnership with line-managers from the burns services. Evaluation included a validated …

Practical Strategies For Establishing A Physical Activity Program For Older Aboriginal People - Reflections About Decolonising Practice, Margaret Gidgup, Josephine Umbella, Anne-Marie Hill

Journal of the Australian Indigenous HealthInfoNet

Background
Physical activity (PA) is a vital component of healthy ageing. However, there are few culturally appropriate PA programs available for older Aboriginal and Torres Strait Islander people. The objectives of this review were to i) assist health professionals to gain understanding about working with older Aboriginal people, ii) provide practical strategies that guide a decolonising approach when delivering PA programs.

Methods
A review of PA program delivery was undertaken by two researchers, one of whom was a Noongar Wadjak woman. The researchers conducted a weekly PA program for older Aboriginal people on Noongar Boodja (Country). The researchers took a …

Evaluating Uv-Protective Low-Emissivity Window Films: Implications For Thermal And Visual Comfort In Luminous Office Buildings, Lina M. Shaker

AUIQ Complementary Biological System

This review article explores the integration of thin window films and solar energy systems to enhance thermal comfort in luminous office buildings. Luminous office buildings, which prioritize natural lighting, often face challenges in maintaining thermal comfort for occupants. By integrating solar energy systems, such as photovoltaic (PV) and solar thermal systems, with thin window films, it is possible to optimize thermal comfort while harnessing sustainable energy sources. Thin window films act as a barrier against solar radiation, reducing heat gain while allowing therapeutic blue light (400-520nm) transmission. The advantages of thin window films include improved thermal insulation, glare reduction, and …

Lower Urinary Tract Symptoms, Depression And Sleep Problems; A Triple Whammy For Patients’ Health-Related Quality Of Life, Muhammad Salman, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Jeffery David Hughes, Junaid Habib Khan, Yusra Habib Khan, Tauqeer Hussain Mallhi

Bulletin of Faculty of Pharmacy Cairo University

Introduction: Lower urinary tract symptoms (LUTS) are characterized by voiding, storage and post-micturition symptoms. LUTS can have detrimental effects on various facets of patients’ quality of life. Therefore, this study was aimed to evaluate the association of LUTS with depression and sleep disturbances, and their impact on patients’ health-related quality of life (HRQOL).

Methods: A cross-sectional survey was conducted among a clinical sample of calcium channel blocker-users (n = 410), recruited via convenient sampling. Outcomes were assessed using validated Urdu translated instruments [LUTS: International Prostate Symptom Score; sleep problems: Jenkins sleep evaluation questionnaire (JSEQ); depression: Center for Epidemiologic Studies Short …

The Recent History And Near Future Of Digital Health In The Field Of Behavioral Medicine: An Update On Progress From 2019 To 2024, Danielle Arigo, Danielle E Jake-Schoffman, Sherry L Pagoto

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The field of behavioral medicine has a long and successful history of leveraging digital health tools to promote health behavior change. Our 2019 summary of the history and future of digital health in behavioral medicine (Arigo in J Behav Med 8: 67-83, 2019) was one of the most highly cited articles in the Journal of Behavioral Medicine from 2010 to 2020; here, we provide an update on the opportunities and challenges we identified in 2019. We address the impact of the COVID-19 pandemic on behavioral medicine research and practice and highlight some of the digital health advances it prompted. We …

Sustaining Life On Earth: An Arts-Based Research Exploration Of Collective Lived Experiences Of Covid-19, Nancy Gerber, Karin Hannes, Marco Gemignani, Jacelyn Biondo, Richard Siegesmund, Lucia Carriera, Elisabetta Biff, Madeline Centracchio, Mandy Archibald, Gioia Chilton, Janet L. Kuhnke, Angela Dawson, Jorge Lucero, Nicky Haire, Sara Scott Shields

College of Health Professions Faculty Papers

This article presents the philosophy, innovative methods, and final aesthetic synthesis of a collaborative arts-based research project about the lived experience of COVID-19. The project was initiated in 2020 and completed in 2022. Nineteen international arts-based research scholars participated as co-researchers, submitting their arts-based and narrative responses to the project. The six-member core research team guiding the project collected and organized the submissions while simultaneously entering into immersive, iterative, dynamic, arts-based data generation, dialogic analytic and syntheses processes with co-researchers, and each other. Materials-discursive analytic processes, arts-based responses, sensorial coding, intersubjective dialogues, and arts-based assemblages conducted iteratively throughout the project. …

Intouch Week Of October 28, 2024, New York Medical College

InTouch

• Medical Students Run for Charity at the 2024 TCS New York City Marathon
• NYMC Goes Pink for Breast Cancer Awareness Month
• Furry Friends Bring Comfort to the College
• Faculty Spotlight: From Pupil to Professor: Alumni Lighting the Way at NYMC
• Student Spotlight: AMA Foundation Physicians of Tomorrow Scholarship Recipient

Rezafungin Versus Caspofungin For Patients With Candidaemia Or Invasive Candidiasis In The Intensive Care Unit: Pooled Analyses Of The Restore And Strive Randomised Trials, Patrick M Honoré, Massimo Girardis, Marin Kollef, Oliver A Cornely, George R Thompson Iii, Matteo Bassetti, Alex Soriano, Haihui Huang, Jose Vazquez, Bart Jan Kullberg, Peter G Pappas, Nick Manamley, Taylor Sandison, John Pullman, Saad Nseir

2020-Current year OA Pubs

BACKGROUND: Rezafungin is an echinocandin approved in the US and EU to treat candidaemia and/or invasive candidiasis. This post-hoc, pooled analysis of the Phase 2 STRIVE and Phase 3 ReSTORE trials assessed rezafungin versus caspofungin in patients with candidaemia and/or invasive candidiasis (IC) in the intensive care unit (ICU) at randomisation.

METHODS: STRIVE and ReSTORE were randomised double-blind trials in adults with systemic signs and mycological confirmation of candidaemia and/or IC in blood or a normally sterile site ≤ 96 h before randomisation. Data were pooled for patients in the ICU at randomisation who received intravenous rezafungin (400 mg loading …

Insights And Opportunities Of Serving Academic Partners And Communities With Institutional Repositories, Alice Sherwood, Jose Javier Franco Garza

Library Staff Publications

Looking forward to seeing if other institutions with institutional repositories would have interest in this subject sharing ideas with one another and others that may not have an institutional repository yet. Some questions for discussion for the roundtable attendees, hopefully we get one or two other products other than Digital Commons users: ­

1. What kind of product does your institutional repository use? (eg, Digital Commons, Omeka, DSpace) ­ What kind of collections do you offer? (eg. Journals, exhibits, dissertations/thesis, journal articles, archival materials) ­
2. How long has your institution been using this product? What made your institution decide to use …

Targeting Trem2 Signaling Shows Limited Impact On Cerebrovascular Calcification, Sucheta Sridhar, Yingyue Zhou, Adiljan Ibrahim, Sergio Bertazzo, Tania Wyss, Amanda Swain, Upasana Maheshwari, Sheng-Fu Huang, Marco Colonna, Annika Keller

2020-Current year OA Pubs

Brain calcification, the ectopic mineral deposits of calcium phosphate, is a frequent radiological finding and a diagnostic criterion for primary familial brain calcification. We previously showed that microglia curtail the growth of small vessel calcification via the triggering receptor expressed in myeloid 2 (TREM2) in the

Partial Wrapping Of Single-Stranded Dna By Replication Protein A And Modulation Through Phosphorylation, Rahul Chadda, Vikas Kaushik, Iram Munir Ahmad, Jaigeeth Deveryshetty, Alex S Holehouse, Snorri Th Sigurdsson, Gargi Biswas, Yaakov Levy, Brian Bothner, Richard B Cooley, Ryan A Mehl, Reza Dastvan, Sofia Origanti, Edwin Antony

2020-Current year OA Pubs

Single-stranded DNA (ssDNA) intermediates which emerge during DNA metabolic processes are shielded by replication protein A (RPA). RPA binds to ssDNA and acts as a gatekeeper to direct the ssDNA towards downstream DNA metabolic pathways with exceptional specificity. Understanding the mechanistic basis for such RPA-dependent functional specificity requires knowledge of the structural conformation of ssDNA when RPA-bound. Previous studies suggested a stretching of ssDNA by RPA. However, structural investigations uncovered a partial wrapping of ssDNA around RPA. Therefore, to reconcile the models, in this study, we measured the end-to-end distances of free ssDNA and RPA-ssDNA complexes using single-molecule FRET and …

10.28.2024 Orsp Connect, Liz Williamson

ORED Newsletter

ORSP Name Change

RED Talk

Businesses Invited to a Day With NASA

LINC Door Prize Winners

Characteristics Of Interventions That Address Racism In The United States And Opportunities To Integrate Equity Principles: A Scoping Review, Brooke Dipetrillo, Paris B. Adkins-Jackson, Ruqaiijah Yearby, Crystal Dixon, Terri D. Pigott, Ryan J. Petteway, Ana Laboy, Aliza Petiwala, Margaret Leonard

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background:

As a driver of racial and health inequities, racism is deeply ingrained in the interconnected systems that affect health and well-being. Currently, no common frame is employed across researchers, interventionists, and funders to design, implement, and evaluate comprehensive interventions to address racism. Consequently, there is a need to examine the characteristics of interventions implemented in the United States that address racism across social and structural determinants of health and socio-ecological levels. Additionally, we utilized a Health Equity Action Research (HEART) framework to assess how interventions integrate equity principles.

Methods:

This scoping review examined the characteristics of multi-level interventions that …

Factors Influencing Abortion Care-Seeking Outside Of Formal Healthcare Settings: Lived Experiences From Rwandan Young Women, Jean Pierre Ndayisenga, Assumpta Yamuragiye, Abe Oudshoorn, Godfrey Katende, Aimable Nkurunziza, Olive Tengera, Jean Bosco Henri Hitayezu, Justine Bagirisano, Jeanne D’ Arc Ayinkamiye, Gilbert Uwitonze

School of Nursing & Midwifery, East Africa

Background: Informal abortions, commonly known as unsafe abortions, refer to all induced abortions that occur outside of formal healthcare settings conducted without the assistance of a licensed, trained healthcare provider. Despite the legalization of safe induced abortion care services, informal abortions continue to be among the major causes of maternal mortality and morbidity among young women in Rwanda living in rural areas with limited or no access to safe abortion care services. The purpose of this qualitative study was to gain an in-depth understanding of the lived experience of seeking informal abortions from the perspective of young women in …

Exploring Pharmacists' Perceptions Of Text-Based Artificial Intelligence In Resident And Student Education., Keaton S Smetana, Scott Postema, Megan E Smetana

Medical Education Articles

No abstract provided.

Challenges Of Conceptualizing, Creating, And Researching The History Of South Louisiana Hospitals, Chandler D. Smith, Jennifer K. Lloyd

Library Faculty Publications

Objective: To create a resource guide on closed and relocated historical hospitals in the southern region of Louisiana, documenting rural and urban hospitals with their address, years open, interesting facts, and photographs if available.

Methods: A reference question about a historical hospital in the area prompted the idea, as when doing research for information about the hospital, it was more challenging than initially thought it would be to find photos and other information. Information was collected from a wide range of sources such as directories, newspaper and magazine articles, government reports, etc. Using this information, we have built a public …

Inclusiveness Of English As A Second Language Nursing Students In The Academic Setting, Bahgat Youwakeem

Walden Dissertations and Doctoral Studies

This study explored the perceptions of English as a Second Language (ESL) nursing students regarding inclusiveness in nursing programs in the southern United States. The problem addressed is the limited research on how ESL nursing students perceive inclusiveness in academic environments, particularly in the Southern States, where diversity is increasing. Previous studies have focused on the general challenges faced by ESL students, but few have examined their specific perceptions of inclusivity in nursing programs. The purpose of this qualitative phenomenological study, guided by Whannell and Whannell’s identity theory, was to gain insights into ESL nursing students' lived experiences of inclusiveness. …

Dna-Binding Proteins From Mbd Through Zf To Ben: Recognition Of Cytosine Methylation Status By One Arginine With Two Conformations, Xing Zhang, Robert M Blumenthal, Xiaodong Cheng

Faculty, Staff and Student Publications

Maintenance methylation, of palindromic CpG dinucleotides at DNA replication forks, is crucial for the faithful mitotic inheritance of genomic 5-methylcytosine (5mC) methylation patterns. MBD proteins use two arginine residues to recognize symmetrically-positioned methyl groups in fully-methylated 5mCpG/5mCpG and 5mCpA/TpG dinucleotides. In contrast, C2H2 zinc finger (ZF) proteins recognize CpG and CpA, whether methylated or not, within longer specific sequences in a site- and strand-specific manner. Unmethylated CpG sites, often within CpG island (CGI) promoters, need protection by protein factors to maintain their hypomethylated status. Members of the BEN domain proteins bind CGCG or CACG elements within CGIs to regulate gene …

Developmental-Status-Aware Transcriptional Decomposition Establishes A Cell State Panorama Of Human Cancers, Yikai Luo, Han Liang

Faculty, Staff and Student Publications

Background: Cancer cells evolve under unique functional adaptations that unlock transcriptional programs embedded in adult stem and progenitor-like cells for progression, metastasis, and therapeutic resistance. However, it remains challenging to quantify the stemness-aware cell state of a tumor based on its gene expression profile.

Methods: We develop a developmental-status-aware transcriptional decomposition strategy using single-cell RNA-sequencing-derived tissue-specific fetal and adult cell signatures as anchors. We apply our method to various biological contexts, including developing human organs, adult human tissues, experimentally induced differentiation cultures, and bulk human tumors, to benchmark its performance and to reveal novel biology of entangled developmental signaling in …

Prenatal Opioid And Alcohol Exposures: Association With Altered Placental Serotonin Transporter Structure And/Or Expression, Nune Darbinian, Nana Merabova, Gabriel Tatevosian, Sandra Adele, Armine Darbinyan, Mary F Morrison, C Lindsay Devane, Sammanda Ramamoorthy, Laura Goetzl, Michael E Selzer

Faculty, Staff and Student Publications

Fetal exposures to many drugs of abuse, e.g., opioids and alcohol (EtOH), are associated with adverse neurodevelopmental problems in early childhood, including abnormalities in activity of the serotonin (5HT) transporter (SERT), which transports 5HT across the placenta. Little is known about the effects of these drugs on SERT expression. Pregnant women who used EtOH or opioids were compared to gestational age-matched controls using a structured questionnaire to determine prenatal substance exposure. Following elective pregnancy termination, placental membranous vesicles and exosomes were prepared from first and second trimester human placentas. Changes in EtOH- or opioid-exposed placental SERT expression and modifications were …

Using Geographic Momentary Assessment To Explore Spatial Environment Influences On Wellbeing In People With Hiv, Rayna E. Gasik, Ethan A. Smith, Simone J. Skeen, Stephanie Tokarz, Gretchen Clum, Erica Felker-Kantor, Katherine P. Theall

School of Public Health Faculty Publications

Place-based socio-economic and racial inequities contribute to health disparities among people with HIV (PWH). We used geographic ecological momentary assessment (GEMA) methodologies to explore the interplay between psychosocial outcomes in daily diaries and community spatial measures among PWH in New Orleans. PWH (N = 69) were recruited from a clinic-based cohort study. Micro-longitudinal data were collected via smartphone-based daily diaries and geospatial tracking over 14 days. First, correlations were run between diary derived outcomes (e.g., feeling safe in current location, stress), and spatial measures (e.g., violent crime, alcohol outlets, and vacant lots) within a half-mile buffer around each diary point …

Effect Of Build Orientation On The Fabrication Trueness Of Additively Manufactured Implant-Supported Complete Arch Interim Fixed Prostheses, Amir H. Nejat, Mehmet Esad Güven, Gülce Çakmak, Burak Yilmaz, Mustafa Borga Donmez

School of Dentistry Faculty Publications

PURPOSE: To evaluate how build orientation affects the fabrication trueness of additively manufactured implant-supported complete arch prostheses by comparing them to subtractively manufactured high-impact polymer-based prostheses. MATERIALS AND METHODS: An edentulous maxillary model with four implants at canine and first molar regions bilaterally was digitized (ATOS Core 80 5MP) to design a reference implant-supported complete arch prosthesis standard tessellation language file (RF-STL). The STL file was used to manufacture prostheses additively in five different orientations according to the build platform (AM-0, 0-degree; AM-15, 15-degree; AM-30, 30-degree; AM-45, 45-degree; AM-90, 90-degree) or subtractively (SM-HIP, control) (n = 10). The prostheses were …

Effective Deep Brain Stimulation For Obsessive-Compulsive Disorder After Failed Anterior Capsulotomy: Illustrative Cases, Anthony K Allam, Nisha Giridharan, Mohammed Hasen, Garrett P Banks, Gabriel Reyes, Huy Dang, Katherine E Kabotyanski, Alyssa G Hertz, Sarah R Heilbronner, Nicole Provenza, Eric A Storch, Wayne K Goodman, Sameer A Sheth

Faculty, Staff and Students Publications

BACKGROUND: Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions) performed to relieve distress related to the obsessions. For patients with severe illness refractory to first-line pharmacotherapy and psychotherapy, neurosurgical treatments such as deep brain stimulation (DBS) and stereotactic lesioning are an option. The choice between DBS and lesioning is often driven by patient preference, but these options are not mutually exclusive. Here, the authors highlight the success of one surgical therapy (DBS) after the failure of another (lesioning).

OBSERVATIONS: Two patients with severe, treatment-refractory OCD underwent DBS lead implantation targeting the …

Engineered Cas9 Variants Bypass Keap1-Mediated Degradation In Human Cells And Enhance Epigenome Editing Efficiency, Jianfeng Chen, Siyuan Su, Adrian Pickar-Oliver, Anna M Chiarella, Quentin Hahn, Dennis Goldfarb, Erica W Cloer, George W Small, Smaran Sivashankar, Dale A Ramsden, Michael B Major, Nathaniel A Hathaway, Charles A Gersbach, Pengda Liu

2020-Current year OA Pubs

As a potent and convenient genome-editing tool, Cas9 has been widely used in biomedical research and evaluated in treating human diseases. Numerous engineered variants of Cas9, dCas9 and other related prokaryotic endonucleases have been identified. However, as these bacterial enzymes are not naturally present in mammalian cells, whether and how bacterial Cas9 proteins are recognized and regulated by mammalian hosts remain poorly understood. Here, we identify Keap1 as a mammalian endogenous E3 ligase that targets Cas9/dCas9/Fanzor for ubiquitination and degradation in an 'ETGE'-like degron-dependent manner. Cas9-'ETGE'-like degron mutants evading Keap1 recognition display enhanced gene editing ability in cells. dCas9-'ETGE'-like degron …

A Veteran Mental Health Approach Sustaining Identity Post-Military Life: A Comprehensive Overview, Darren Sosa, Lindsay Gietzen

Pacific Journal of Health

Veterans and their mental health face readjustment challenges based on veteran identity, intersectionality, and experiences from their time serving in the military. This comprehensive overview and PRISMA analysis investigate the current evidence-based practices of veterans' identity and intersectionality. Specifically, psychoeducation and evidence-based practices for veterans readjusting back into their communities. A gap identified in this research’s findings calls for suggestions for future research on the veteran population and intersectionality. No specific psychoeducation or evidence-based practices tailored for identity readjustment or veteran intersectionality were found. This research constructs a tailored framework of suggestions for current and future evidence-based practices for the …