Medicine and Health Sciences Commons^™

Preparedness For Practice Of Health Professionals In Papua New Guinea: A Cross-Sectional Survey Of Nurses And Community Health Workers., Mary Kililo, Julie Dopsie, Sulpain Passingan, Julie Kep, Nina Joseph, Russel Kitau, Mary Roroi, Chris Rossiter, Jenny Sim, Di Brown, Caroline Havery, Ali Moloney, Michele Rumsey

Pacific Journal of Health

Introduction

Papua New Guinea (PNG) experiences widespread health inequity and shortage of health professionals, exacerbated by poverty, isolation, gender-based violence and limited infrastructure, transport and accessible services. Nurses and community health workers (CHW) represent 72% of health workforce. However, health professional education programs are outdated and not aligned with national health priorities. We aimed to explore the adequacy of current curricula for nurses and CHWs by examining graduate competencies and preparedness for practice.

Methods

Cross-sectional study with four cohorts: 1) 130 new nurse graduates, 2) 75 nurses who supervised them, 3) 105 new CHW graduates and 4) 65 CHW supervisors. …

Social Determinants Of Health And How They Affect A Small Rural Community (Case Study) Eastern Shore Of Maryland, Kristopher S. Durham, Lindsay Gietzen

Pacific Journal of Health

The Eastern Shore of Maryland is rural and is characterized by prevalent poverty, housing instability, lack of access to healthcare, chronic diseases, substance abuse, and issues with transportation to access healthcare services. The same problems exist for the population in Maryland and the United States. Understanding the challenges experienced by rural communities in Maryland is critical to addressing the vulnerable population. This study is an explanatory case study that examines the social determinants of health and how those affect small rural communities on the Eastern Shore of Maryland by examining literature published between 2016 and 2024. The literature reviewed resulted …

Staff Education Project For Adult Icu Nurses, Hani Ayyad

Walden Dissertations and Doctoral Studies

This staff education project is a crucial initiative designed to enhance nursing knowledge and skills in the care of central lines. Its overarching goal is to reduce the incidence of central line-associated bloodstream infections (CLABSI) in a teaching hospital. Given that CLABSIs are a major concern in Intensive Care Units (ICUs), due to higher morbidity, mortality, and healthcare expenditures, this project is very important. My goal was to fill these gaps by providing a comprehensive staff education program addressing this critical issue. The evidence-based practice question (EBP) guiding this Doctor of Nursing Project (DNP) project was: Does the Staff Education …

Lived Experiences Of Low-Income African American Burn Survivors In Greater Washington, Dc, Angela White

Walden Dissertations and Doctoral Studies

Burn injuries are wounds that affect the skin and other organic tissue, categorized according to the mechanism of injury and brought on by heat, electricity, chemicals, fire, or flames. In the United States, researchers have shown that race and other healthcare inequalities lead to increased burn injuries among African Americans but have yet to explore their lived experiences after sustaining these injuries. This phenomenological study explored perceptions and understanding of the manifestation of burn injuries of seven African American burn survivors. Participants were recruited in health services public waiting areas, community storefronts, mailers, and on Facebook. Data were collected via …

The Contribution Of Neutrophil Extracellular Traps To Coagulopathy In Patients With Covid-19-Related Thrombosis, Carolyn Enochs, Gabriela Delevati Colpo, Lucy Couture, Lynae Baskin, Ana E Cahuiche, Eunyoung Angela Lee, Shahid Nimjee, Louise D Mccullough

Faculty, Staff and Student Publications

COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with hypercoagulability and increased incidence of thrombotic events. In this study, we investigated the levels of neutrophil extracellular trap biomarkers and von Willebrand factor to assess if these could predict the occurrence of a thrombotic event in COVID-19 patients. We enrolled 202 patients hospitalized with symptomatic COVID-19 infection. Of those, 104 patients did not experience any type of thrombotic events before or during their hospitalization. These patients were compared to the other cohort of 98, who experienced thrombotic events before or during their hospitalization. In total, …

A Genome-Wide Association Study Identifies Genetic Determinants Of Hemoglobin Glycation Index With Implications Across Sex And Ethnicity, John S. House, Joseph H. Breeyear, Farida S. Akhtari, Violet Evans, John B. Buse, James Hempe, Alessandro Doria, Josyf C. Mychaleckyi, Vivian Fonseca, Mengyao Shi, Changwei Li, Shuqian Liu, Tanika N. Kelly, Daniel Rotroff, Alison A. Motsinger-Reif

School of Medicine Faculty Publications

Introduction: We investigated the genetic determinants of variation in the hemoglobin glycation index (HGI), an emerging biomarker for the risk of diabetes complications. Methods: We conducted a genome-wide association study (GWAS) for HGI in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial (N = 7,913) using linear regression and additive genotype encoding on variants with minor allele frequency greater than 3%. We conducted replication analyses of top findings in the Atherosclerosis Risk in Communities (ARIC) study with inverse variance-weighted meta-analysis. We followed up with stratified GWAS analyses by sex and self-reported race. Results: In ACCORD, we identified single …

Assessing The Impact Of Dietary Supplements On Diabetic Quality Of Life: Insights From The Eq-5d Model, Inas Rifaat Ibrahim

Maaen Journal for Medical Sciences

The use of dietary supplements (DS) has been observed to be increasing among patients with diabetes. However, the effect of DS on health-related quality of life (HRQoL) is still an understudied area. This study aims to evaluate the prevalence of DS use among diabetic patients, their attitudes toward these supplements, and their effect on HRQoL. A cross-sectional study was conducted among diabetic patients attending an outpatient facility in Iraq. A validated survey instrument was used to collect data on DS use, attitudes, and HRQoL using EQ-5D measures. The study found that 73.8% of patients used DS, including omega-3 fatty acids, …

Evaluation Of One Stage Bilateral Total Knee Arthroplasty Versus Staged Bilateral Total Knee Arthroplasty, Ahmed Sarhan Mazyon

Maaen Journal for Medical Sciences

Background: Complete knee replacement is a resolving method for treatment for severe osteoarthritis and rheumatoid arthritis that relieves pain and restores function. Individuals in necessary condition to do bilateral surgery total knee arthroplasty underwent two different surgical procedures, or one stage of surgery with one anesthesia session. Aim of the study: To compare the knee and functional outcome, safety, and possible complications between one stage and staged bilateral total knee arthroplasty. Patients and methods: An interventional study conducted in the Orthopedic Department in Al-Yarmouk Teaching Hospital and private hospital, Baghdad, Iraq during a time of three years from (June 2020 …

Right Heart Failure After Tricvalve Implantation For Symptomatic Torrential Tricuspid Regurgitation: A Case Report, King Sum Luk, Chun Kit Wong

Journal of the Hong Kong College of Cardiology

Patients with symptomatic torrential tricuspid regurgitation (TR) presenting with right heart failure are associated with significant morbidity and mortality. While medical therapy is often ineffective, the perioperitive risks of surgical correction are high. Transcatheter TricValve implantation is one of the evolving therapeutic options for this condition with many unanswered questions. We reported a case of life-threatening right heart failure after transcatheter TricValve implantation despite initial improvement. Important considerations of TricValve implantation are discussed. In particular, careful patient selection and evaluation with perioperative echocardiogram are of paramount importance.

From Books To The Bedside: Post-Graduation Impact Of 'Week On The Wards' On Medical Education., Ashley Russell, Kimberly Eberenz, Meena Khandelwal

Cooper Medical School of Rowan University Departmental Research

BACKGROUND: The transition between preclinical and clinical years during medical school has been shown to be challenging. Cooper Medical School of Rowan University (CMSRU) implements one required two-week-long shadowing program for first and one one-week-long shadowing program for second-year medical students called Week On the Wards (WOW). The goal of this study is to ascertain whether students who completed the WOW curriculum found it beneficial over the long-term. Specifically, we want to evaluate alumni's impression of the program's influence on career, specialty choice, professional development, personal development, and confidence.

METHODS: To evaluate our program, we developed, validated, and distributed a …

Y-27632 Targeting Rock1&2 Modulates Cell Growth, Fibrosis And Epithelial-Mesenchymal Transition In Hyperplastic Prostate By Inhibiting Β-Catenin Pathway., Shidong Shan, Min Su, Hejin Wang, Feng Guo, Yan Li, Yongying Zhou, Huan Liu, Lu Du, Junchao Zhang, Jizhang Qiu, Michael E. Disanto, Yuming Guo, Xinhua Zhang

Cooper Medical School of Rowan University Departmental Research

Benign prostatic hyperplasia (BPH) is a prevalent condition affecting the male urinary system, with its molecular mechanisms of pathogenesis remaining unclear. Y-27632, a non-isoform-selective Rho kinase inhibitor, has shown therapeutic potential in various diseases but its effects on static factors and fibrosis in BPH remain unexplored. This study investigated human prostate tissues, human prostate cell lines, and BPH rat model using immunofluorescence, flow cytometry, quantitative reverse transcription polymerase chain reaction, western blotting, and cell counting kit-8. ROCK1 and ROCK2 were significantly up-regulated in BPH tissues, correlating with clinical parameters. Y-27632 targeted the inhibition of ROCK1 & ROCK2 expression and inhibited …

There Is "Thorn" Than Meets The Eye, Zaid Alnabulsi

Conference Presentation Abstracts

No abstract provided.

Radiomics-Based Machine Learning With Natural Gradient Boosting For Continuous Survival Prediction In Glioblastoma, Mert Karabacak, Shiv Patil, Zachary C. Gersey, Ricardo J. Komotar, Konstantinos Margetis

SKMC Student Presentations and Publications

(1) Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with an aggressive disease course that requires accurate prognosis for individualized treatment planning. This study aims to develop and evaluate a radiomics-based machine learning (ML) model to estimate overall survival (OS) for patients with GBM using pre-treatment multi-parametric magnetic resonance imaging (MRI). (2) Methods: The MRI data of 865 patients with GBM were assessed, comprising 499 patients from the UPENN-GBM dataset and 366 patients from the UCSF-PDGM dataset. A total of 14,598 radiomic features were extracted from T1, T1 with contrast, T2, and FLAIR MRI sequences …

Chronic Intestinal Pseudo-Obstruction: A Debilitating Complication Of Scleroderma, Pawan Gyawali

Conference Presentation Abstracts

No abstract provided.

Myxedema Coma Due To Interrupted Levothyroxine Therapy, Tajuldeen Al Hasani

Conference Presentation Abstracts

No abstract provided.

A Rare Case Of An Immune Checkpoint Inhibitor-Induced Myopericarditis, Morgan Korn

Conference Presentation Abstracts

No abstract provided.

The Kitchen Sink Approach: A Case Of Idiopathic Non-Histaminergic Angioedema, Vickie Xin

Conference Presentation Abstracts

No abstract provided.

Rheumatoid Arthritis And Anca Vasculitis Overlap: A Rare Case With Renal And Respiratory Involvement, Ayed Shahatit

Conference Presentation Abstracts

No abstract provided.

Cardiac Tamponade As An Initial Manifestation Of Lung Adenocarcinoma, Lark Steafo

Conference Presentation Abstracts

No abstract provided.

Disseminated Lyme Leading To Complete Heart Block, Lara Hakim

Conference Presentation Abstracts

No abstract provided.

Specialized Contact Sites Regulate The Fusion Of Chlamydial Inclusion Membranes, Christine Linton, Jordan Wesolowski, Anna Lobley, Toshiyuki Yamaji, Kentaro Hanada, Fabienne Paumet

Department of Microbiology and Immunology Faculty Papers

The intracellular bacterial pathogen Chlamydia trachomatis replicates within a membrane-bound compartment called the inclusion. Upon infection with several chlamydiae, each bacterium creates its own inclusion, resulting in multiple inclusions within each host cell. Ultimately, these inclusions fuse together in a process that requires the chlamydial protein IncA. Here, we show that inclusions form unique contact sites (inclusion contact sites, ICSs) prior to fusion, that serve as fusogenic platforms in which specific lipids and chlamydial proteins concentrate. Fusion depends on IncA clustering within ICSs and is regulated by PI(3,4)P₂ and sphingolipids. As IncA concentrates within ICSs, its C-terminus likely interacts …

Fevers, Lung Nodules, And A Colon Polyp: A Case Of Fusobacterium Nucleatum Endocarditis, Elizabeth Jakubowski

Conference Presentation Abstracts

No abstract provided.

Disseminated Mac In A Patient With Aids, Emma Glover

Conference Presentation Abstracts

No abstract provided.

Ten Challenges And Opportunities In Computational Immuno-Oncology, Riyue Bao, Alan Hutson, Anant Madabhushi, Vanessa D Jonsson, Spencer R Rosario, Jill S Barnholtz-Sloan, Elana J Fertig, Himangi Marathe, Lyndsay Harris, Jennifer Altreuter, Qingrong Chen, James Dignam, Andrew J Gentles, Edgar Gonzalez-Kozlova, Sacha Gnjatic, Erika Kim, Mark Long, Martin Morgan, Eytan Ruppin, David Van Valen, Hong Zhang, Natalie Vokes, Daoud Meerzaman, Song Liu, Eliezer M Van Allen, Yi Xing

Faculty, Staff and Student Publications

Immuno-oncology has transformed the treatment of cancer, with several immunotherapies becoming the standard treatment across histologies. Despite these advancements, the majority of patients do not experience durable clinical benefits, highlighting the imperative for ongoing advancement in immuno-oncology. Computational immuno-oncology emerges as a forefront discipline that draws on biomedical data science and intersects with oncology, immunology, and clinical research, with the overarching goal to accelerate the development of effective and safe immuno-oncology treatments from the laboratory to the clinic. In this review, we outline 10 critical challenges and opportunities in computational immuno-oncology, emphasizing the importance of robust computational strategies and interdisciplinary …

Dead For 22 Minutes: Case Of Pea Arrest In 31-Year-Old Woman With Hemorrhagic Pheochromocytoma, Vera Nattler

Conference Presentation Abstracts

No abstract provided.

A Case Of Acute Hypotension Following Initiation Of Ripe Therapy, Nathanial Bartosek

Conference Presentation Abstracts

No abstract provided.

Streptococcus Dysgalactiae: Identifying A Usual Presentation Of An Unusual Organism, Julia Meireles

Conference Presentation Abstracts

No abstract provided.

Unexpected Turn: Abdominal Cramping To Cardiac Tamponade Postheart Cath, Ayesha Sharif

Conference Presentation Abstracts

No abstract provided.

From Books To The Bedside: Post-Graduation Impact Of ‘Week On The Wards’ On Medical Education, Ashley Russell, Kimberly Eberenz, Meena Khandelwal

Abington Jefferson Health Papers

BACKGROUND: The transition between preclinical and clinical years during medical school has been shown to be challenging. Cooper Medical School of Rowan University (CMSRU) implements one required two-week-long shadowing program for first and one one-week-long shadowing program for second-year medical students called Week On the Wards (WOW). The goal of this study is to ascertain whether students who completed the WOW curriculum found it beneficial over the long-term. Specifically, we want to evaluate alumni's impression of the program's influence on career, specialty choice, professional development, personal development, and confidence.

METHODS: To evaluate our program, we developed, validated, and distributed a …

Iron Deficiency And Internalizing Symptoms Among Adolescents In The National Health And Nutrition Examination Survey, Dimitri Fiani, Solangia Engler, Yang Ni, Sherecce Fields, Chadi Calarge

Faculty, Staff and Students Publications

Background: Iron Deficiency (ID) affects two billion people worldwide, predominantly adolescent girls, and may be associated with increased psychopathology. The associations between ID and symptoms of depression and anxiety in adolescents were examined using data from the National Health and Nutrition Examination Survey (NHANES), a cross-sectional survey of a nationally representative sample of non-institutionalized Americans.

Methods: The current analysis included survey cycles where both iron-related markers and mental health-related outcomes were collected in adolescents 12 to 17 years old. Acute and serious medical conditions, acute inflammation, and abnormal birth weight led to exclusion. Linear multivariable regression analyses examined the association …