Medicine and Health Sciences Commons^™

Health Outcomes In Children With Prenatal Opioid Exposure With And Without Neonatal Abstinence Syndrome In The First Seven Years Of Life: An Observational Cohort Study, Joshua Lambert, Sara Arter, Henry Ofori Duah, Teenu Xavier, Jon E. Sprague

College of Nursing Faculty Research and Publications

Introduction Prenatal opioid exposure (POE) is a major public health consequence of the opioid epidemic. Long-term health outcomes associated with POE remain unclear, especially for children with POE without a diagnosis of neonatal abstinence syndrome (NAS). Here, we aimed to describe the health outcomes of children with POE and with POE and NAS compared to unexposed children during the first 7 years of life. Design In this retrospective observational cohort study, children born between 2015 and 2022 were identified from the Maternal and Infant Data Hub (MIDH), a data repository that continuously integrates maternal, neonatal, and pediatric records from two …

Fetal Sex Effects On Maternal Health Can Now Be Tested Via Randomization: A First-In-Class Illustration In Cows On Glucoregulatory Outcomes, Aridany Suarez-Trujillo, Colby J Vorland, Griffin T Nicholls, Daniella E Chusyd, Chelsie Parker, Lilian Golzarri-Arroyo, Sophia Swann, Bethany J Funnell, Kara R Stewart, David B Allison

Children’s Nutrition Research Center Staff Publications

Background: The maternal-offspring relationship, such as whether fetal sex influences maternal health, is essential to explore to advance prenatal and maternal health. While associations exist between fetal sex and maternal health outcomes, it is unclear whether these reflect a causal relationship.

Objective: To demonstrate that fetal sex can be randomly assigned to test the causal effect of fetal sex on maternal outcomes.

Methods: Holstein dairy cows were stratified and randomized using sealed opaque envelopes to be artificially inseminated with either X- or Y-sorted bull semen until 40 cows became pregnant. Monthly body weight measurements were recorded, and an intravenous glucose …

Avulsion Of The Flexor Digitorum Profundus Tendon During The Curettage Of A Recurrent Enchondroma: A Case Report, Shunpei Hama, Masataka Yasuda, Makoto Fukuda, Katsuaki Onishi, Takaaki Chikugo

Children’s Nutrition Research Center Staff Publications

Enchondroma rarely occurs in the distal phalanx, and avulsion of the flexor digitorum profundus (FDP) tendon in this area is also rare. We report a case of recurrent enchondroma in the distal phalanx, which required reconstruction for an accidental FDP avulsion during surgery. A 36-year-old right-handed woman visited our hospital with a suspected recurrence of enchondroma and a planned surgery. Radiographs and computed tomography revealed three translucent lesions in the distal phalanx of her left index finger. We performed curettage and calcium phosphate bone cement (CPC) grafting. During the procedure, an avulsion of the FDP tendon was found. We reattached …

Your Mda Team: Working For You, John Tramontana Ms, Cae

The Journal of the Michigan Dental Association

This month's cover feature introduces the Michigan Dental Association (MDA) team based in Okemos, highlighting their dedication to providing exceptional service and value to MDA members.

The team, many of whom have decades of experience, is always available to answer questions and offer support. With a focus on delivering top-notch service, the MDA staff strives to be the best dental association in the country. The article includes an overview of the team members, their roles, and a helpful "Who to Call" guide for members seeking assistance.

The executive director emphasizes the team's expertise and institutional knowledge, inviting members to reach …

Exophytic And Focally Ulcerated Mass On The Mandibular Gingiva, Abrar Shamim D.D.S., M.A., Scott Peters D.D.S., Shahid R. Aziz D.M.D., M.D., Facs, Frcsed, Gregg Jacob D.M.D., Facs

The New York State Dental Journal

The pyogenic granuloma is a benign vascular proliferation which may present either on the skin or intraorally. While the majority of oral pyogenic granulomas remain less than 1 cm in size, they can grow to large sizes if care is neglected. Herein, we report case of a large pyogenic granuloma on the mandibular alveolar ridge gingiva which grew to 10x10cm in size due to failure to seek treatment.

Guidelines For Interproximal Enamel Reduction (Ipr), Sewon Yang D.D.S., Min Seok Kim D.D.S., Eugene H. Bass D.M.D.

The New York State Dental Journal

The purpose of this review is to present current guidelines for Interproximal Enamel Reduction (IPR) safety and aims to provide clinical protocols for the practitioner to follow in order to conduct safe and effective IPR. This comprehensive step-by-step protocol for IPR, including the pre-, intra-, and post-operative safety measures, are proposed with further suggestions to assure the safety of the procedures and to minimize the potential iatrogenic side effects of IPR.

Diverse Pathways In Gpcr-Mediated Activation Of Ca2+ Mobilization In Hek293 Cells, Francesco De Pascali, Asuka Inoue, Jeffrey L. Benovic

Department of Biochemistry and Molecular Biology Faculty Papers

G protein-coupled receptors transduce extracellular stimuli into intracellular signaling. Ca²⁺ is a well-known second messenger that can be induced by G protein-coupled receptor activation through the primary canonical pathways involving Gα_q- and Gβγ-mediated activation of phospholipase C-β (PLCβ). While some G_s-coupled receptors are shown to trigger Ca²⁺ mobilization, underlying mechanisms remain elusive. Here, we evaluated whether G_s-coupled receptors including the β₂-adrenergic receptor (β₂AR) and the prostaglandin EP₂ and EP₄ receptors (EP₂R and EP₄R) that are endogenously expressed in human embryonic kidney 293 …

Inquire, Act, Empower: Resilience Strategies For Adolescent Mental Wellness, Brandy Carlisle Bsn, Rn

Nursing Publications, Posters, & Presentations

Presented at the 2024 Parkview Nursing Research Symposium.

Background/Problem: Adolescence is a pivotal period for mental health development, with many experiencing stressors that may contribute to the onset of mental health disorders. Research has identified key resilience factors that enhance mental well-being and mitigate the risk of these disorders. Translating this research into practical nursing interventions promotes mental wellness among adolescents.

Objectives/Aim/Purpose: This poster aims to explore evidence-based resilience factors in adolescents and present action-oriented nursing interventions that can be integrated into clinical practice to empower young individuals in maintaining mental wellness and preventing mental health disorders.

Methods: A systematic …

Prepping As An Inclusive Team For A Successful Tjc Site Visit, Erika Whetstone Msn, Rn, Cphq

Nursing Publications, Posters, & Presentations

Presented at the 2024 Parkview Nursing Research Symposium.

Background: Department rounds and leadership virtual meetings were being used to prep for an anticipated Joint Commission Re-accreditation survey. Preparation did not provide a robust frontline multifaceted approach for both non-clinical and clinical co-workers which posed communication and preparedness gaps. Purpose: To develop a multifaceted approach in coworker preparation for an upcoming Joint Commission Onsite Survey by increasing staff awareness, knowledge, and understanding of the survey process. Ultimately striving for decreased survey anxiety and citations received. Methods: Preparation was developed and implemented from a multifaceted approach to include both non-clinical and clinical …

When The Lights Go Out: Drill Your Way To Downtime Success, Krista Dreyer Msn, Rn, Cmsrn

Nursing Publications, Posters, & Presentations

Presented at the 2024 Parkview Nursing Research Symposium

Problem: The adoption of the electronic medical record (EMR) in healthcare facilities has significantly surged since the implementation of the Health Information Technology for Economic and Clinical Health Act in 2009. Despite advancements in electronic documentation, both planned and unplanned EMR downtimes pose substantial challenges. Such downtimes can disrupt clinical workflows, lead to delays in patient care and compromise the overall quality of services provided. Purpose: The aim of this project is to evaluate solutions for EMR downtime preparation that enhance staff confidence and minimize disruption of workflow during downtime events. Methods: …

Evaluation Of Shared Governance Perceptions At Parkview Health, Erin Lacross Dnp, Rn, Nea-Bc, Cenp, Jan Powers Phd, Rn, Ccns, Ccrn, Ne-Bc, Ebp-C, Fccm, Fcns, Faan, Mindy Flanagan Phd

Nursing Publications, Posters, & Presentations

Presented at the 2024 Parkview Nursing Research Symposium.

Background: Shared governance is a structure for clinical nurses to have a voice in decisions regarding practice and the practice environment. It is imperative to have a model that is inclusive of all nurses and allows for decision-making and accountability related to nursing practice. It is essential that nurses are empowered to make decisions at the point of care related to patient care decisions. Objective: The purpose of this study was to assess current state of shared governance councils at Parkview Health. Method: Data was collected using the Index of Professional Nursing …

Slay The Antibiotic Delay, Angela Shuch Asn, Rn, Lauren Meyer Bsn, Rn, Kristina Pavey Bsn, Rn, Gero-Bc

Nursing Publications, Posters, & Presentations

Presented at the 2024 Parkview Nursing Research Symposium.

Background: Rapid Response nurses are educated to respond to emergent situations and provides support to the patient care team, often intervening to prevent patient complications. These specialty nurses are repeatedly called to place an intravenous (IV) for scheduled medications when the bedside nurses is unsuccessful or hesitant to place one. Prioritizing IV starts compete with emergent patient situations which frequently cause retiming of IV antibiotics. Objectives/Aim/Purpose: The purpose of this quality improvement project was to prevent IV medication delays including re-timing. Methods: Nurses were surveyed and identified reasons for delays and re-timing …

Temporal Trends In The Management Practices Of Clinically Important Perioperative Atrial Fibrillation After Noncardiac Surgery, Michael Ke Wang, P J Devereaux, Maura Marcucci, Vladimir Lomivorotov, Daniel I Sessler, Matthew T V Chan, Flavia K Borges, Sandra N Ofori, Pilar Paniagua, James D Douketis, Alben Sigamani, Joel L Parlow, Chew Y Wang, Juan Carlos Villar, Sadeesh K Srinathan, Wojciech Szczeklik, María José Martínez-Zapata, German Malaga, Soori Sivakumaran, William F Mcintyre, María-Virginia Rodríguez Funes, Patricia Cruz, Jesús Alvarez-Garcia, Isabelle Greiss, Ekaterine Popova, Martin E Hemels, Axel Brandes, Clara K Chow, Satish Prasad Barnawal, Jeff S Healey, David Conen

Faculty, Staff and Student Publications

Background: Clinically important perioperative atrial fibrillation (POAF) is a common cardiac complication after noncardiac surgery. Little is known about how patients with POAF are managed acutely and whether practices have changed over time.

Methods: We conducted an observational substudy of patients who had POAF, were at elevated cardiovascular risk, and were enrolled in the PeriOperative Ischemic Evaluation (POISE)-1, 2 and 3 trials between 2002 and 2021. POAF was defined as new, clinically important atrial fibrillation occurring within 30 days after surgery. We assessed the use of rhythm-control and anticoagulation treatment in response to POAF, at hospital discharge and at 30 …

Protein Biomarkers Of Ultra-Processed Food Consumption And Risk Of Coronary Heart Disease, Chronic Kidney Disease, And All-Cause Mortality, Shutong Du, Jingsha Chen, Hyunju Kim, Alice H Lichtenstein, Bing Yu, Lawrence J Appel, Josef Coresh, Casey M Rebholz

Faculty, Staff and Student Publications

Background: There is a need to understand the underlying biological mechanisms through which ultra-processed foods negatively affect health. Proteomics offers a valuable tool with which to examine different aspects of ultra-processed foods and their impact on health.

Objectives: The aim of this study was to identify protein biomarkers of usual ultra-processed food consumption and assess their relation to the incidence of coronary heart disease (CHD), chronic kidney disease (CKD), and all-cause mortality risk.

Methods: A total of 9361 participants from the Atherosclerosis Risk in Communities visit 3 (1993-1995) were included. Dietary intake was assessed using a 66-item food-frequency questionnaire and …

Trends In The Use Of Biologic Disease-Modifying Antirheumatic Drugs In Patients With Rheumatoid Arthritis And Recently Diagnosed Colorectal, Lung, Or Prostate Cancer, Maria E Suarez-Almazor, Juan I Ruiz, Xiudong Lei, Chi-Fang Wu, Hui Zhao, Suja S Rajan, Sharon H Giordano

Faculty, Staff and Student Publications

INTRODUCTION: Biologic disease-modifying antirheumatic drugs (bDMARD) are often discontinued when a patient with rheumatoid arthritis (RA) is diagnosed with cancer. Our aim was to determine trends in bDMARD utilization in patients with RA and recently diagnosed cancer.

METHOD: We examined two national claims databases to identify adults with RA and recently diagnosed colorectal, lung, or prostate cancer (Optum's de-identified Clinformatics® Data Mart Database 2008-2022, and Surveillance, Epidemiology, and End Results Program (SEER) Medicare-linked 2008-2017). We determined time trends in bDMARD and tumor necrosis factor inhibitor (TNFi) prescriptions during the first 3 years after cancer with Cochram-Armitage tests and multivariable logistic …

Association Between Risk Of Alzheimer’S Disease And Related Dementias And Angiotensin Receptor Ⅱ Blockers Treatment For Individuals With Hypertension In High-Volume Claims Data, Sori Kim Lundin, Xinyue Hu, Jingna Feng, Karl Kristian Lundin, Lu Li, Yong Chen, Paul Ernest Schulz, Cui Tao

Faculty, Staff and Student Publications

Background: Findings regarding the protective effect of Angiotensin II receptor blockers (ARBs) against Alzheimer's disease and related dementias (AD/ADRD) and cognitive decline have been inconclusive.

Methods: Individuals with hypertension who do not have any prior ADRD diagnosis were included in this retrospective cohort study from Optum's de-identified Clinformatics® Data Mart. We identified antihypertensive medication (AHM) drug classes and subclassified ARBs by blood-brain barrier (BBB) permeability. We compared baseline characteristics and used the Kaplan-Meier (KM) survival curve and adjusted Cox proportional hazards (PH) model for survival analyses.

Findings: From 6,390,826 individuals with hypertension, there were 1,839,176 ARB users, 3,366,841 non-ARB AHM …

History Of Incarceration And Dental Care Use Among Older Adults In The United States, Alexander Testa, Dylan B Jackson, Carmen Gutierrez, Chantal Fahmy, Vahed Maroufy, Rafael Samper-Ternent, Ana C Neumann

Faculty, Staff and Student Publications

INTRODUCTION: Dental care is a critical component of healthy aging; however, emerging evidence suggests that having been previously incarcerated is a risk factor for not using dental care services. This study investigates the relationship between prior incarceration and dental care among older adults and assesses whether wealth and dental insurance explain this relationship.

METHODS: Data are from the Health and Retirement Study, a nationally representative sample of community-dwelling older adults in the United States, collected in 2012 and 2014. Multivariable logistic regression is used to assess the relationship between a history of incarceration and dental care. Mediation analyses were conducted …

Incorporating External Controls In The Design Of Randomized Clinical Trials: A Case Study In Solid Tumors, Emily M Damone, Jiawen Zhu, Herbert Pang, Xiao Li, Yinqi Zhao, Evan Kwiatkowski, Lisa A Carey, Joseph G Ibrahim

Faculty, Staff and Student Publications

BACKGROUND: The use of historical external control data in clinical trials has grown in interest and needs when considering the design of future trials. Hybrid control designs can be more efficient to achieve the same power with fewer patients and limited resources. The literature is sparse on appropriate statistical methods which can account for the differences between historical external controls and the control patients in a study. In this article, we illustrate the analysis framework of a clinical trial if a hybrid control design was used after determining an RCT may not be feasible.

METHODS: We utilize two previously completed …

A Novel Statistical Framework For Meta-Analysis Of Total Mediation Effect With High-Dimensional Omics Mediators In Large-Scale Genomic Consortia, Zhichao Xu, Peng Wei

Faculty, Staff and Student Publications

Meta-analysis is used to aggregate the effects of interest across multiple studies, while its methodology is largely underexplored in mediation analysis, particularly in estimating the total mediation effect of high-dimensional omics mediators. Large-scale genomic consortia, such as the Trans-Omics for Precision Medicine (TOPMed) program, comprise multiple cohorts with diverse technologies to elucidate the genetic architecture and biological mechanisms underlying complex human traits and diseases. Leveraging the recent established asymptotic standard error of the R-squared (R2)-based mediation effect estimation for high-dimensional omics mediators, we have developed a novel meta-analysis framework requiring only summary statistics and allowing inter-study heterogeneity. Whereas the proposed …

Persistent Post-Dural Puncture Headaches One Year After Lumbar Puncture: A Case Report, Zamanali Khakhar, Maeheq Mir, Soraiya Manji, Sheila Waa, Sayed Karar

Internal Medicine, East Africa

Post-dural puncture headaches usually occur when the cerebrospinal fluid (CSF) leaks due to trauma to the dura mater. This often results in spontaneous intracranial hypotension characterized by orthostatic headaches, neck stiffness, and nausea. In this case report, we discuss a 20-year-old male patient who developed symptoms of intracranial hypotension one year following a lumbar puncture. A spinal magnetic resonance imaging (MRI) revealed a CSF collection in the epidural space. This was treated successfully by an epidural blood patch (EBP) which resolved the patient's symptoms. This case highlights the necessity of recognizing delayed lumbar puncture complications and the need for a …

Postnatal Growth Of Etiologically Characterized Preterm Newborns According To Gestational Age At Birth, Paola Roggero, Irina Ryumina, Robert Gunier, Adele Winsey, Stephen Rauch, Irma Alejandra Coronado Zarco, Shabina Ariff, Maria Albertina Rego, Constanza Soto Conti, R. Ochieng

Obstetrics and Gynaecology, East Africa

Objective: To examine the relationship between etiologically-based preterm birth sub-groups and early postnatal growth according to gestational age at birth.

Methods: Prospective, multinational, cohort study involving 15 hospitals that monitored preterm newborns to hospital discharge. Measures/exposures: maternal demographics; etiologically-based preterm birth sub-groups; very, moderate and late preterm categories, and feeding. Primary outcomes: serial anthropometric measures expressed as z-scores of the INTERGROWTH-21st preterm postnatal growth standards.

Results: We included 2320 singletons and 1180 twins: very=24.4% (n = 856, including 178 < 28 weeks’ gestation); moderate=16.9% (n = 592) and late preterm=58.6% (n = 2052). The median (interquartile range) postmenstrual age at the last measure was 37 (36–38) weeks. The ‘no main condition’ sub-group percentage increased from early to late preterm; the ‘perinatal sepsis’ sub-group percentage decreased. ‘Perinatal sepsis’, ‘suspected IUGR’ and ‘fetal distress’ very and late preterm infants had lower postnatal growth patterns than the ‘no main condition’ reference sub-group. This pattern persisted in late but not very preterm infants when postnatal growth was corrected for weight z-score at birth.

Conclusion: The proportional contribution of etiologically-based preterm sub-groups and their postnatal growth trajectories vary by preterm category. Postnatal growth is partially …

The Association Of Migration-Related Stress With Poor Mental Health Among Recently Resettled Afghan Refugees, Munjireen Sifat, Sarah Kenney, Venera Bekteshi, Shawn Chiang, Motolani Ogunsanya, Laili Boozary, Adam Alexander, Darla Kendzor

Department of Medical Oncology Faculty Papers

BACKGROUND: The resettlement of Afghan refugees in Oklahoma City, OK, provides a critical context for examining the mental health challenges faced by this population due to post-migration stressors.

METHODS: This study utilized online surveys to recently resettled Afghan refugees in Oklahoma City, with support provided by bilingual research assistants to accommodate low literacy rates. Surveys, initially in English, were professionally translated into Dari and Pashto and validated through back-translation.

RESULTS: Participants (N = 348) were majority of Pashtun ethnicity. High rates of mental health issues were evident, with 62.1 % of participants screening positive for depression and 20.1 % …

A Phase I Dose Escalation Study Of The Lrp5 Antagonist Bi 905681 In Patients With Advanced And Metastatic Solid Tumors, D. R. Spigel, J. S. Wang, L. Pronk, B. Muskens, M. Teufel, Babar Bashir, H. Burris

Department of Medical Oncology Faculty Papers

BACKGROUND: The Wnt pathway is involved in proliferation and tissue homeostasis. Aberrant activation promotes cancer cell proliferation and survival. Inhibition of the low-density lipoprotein receptor-related protein 5/6 (LRP5/6) coreceptors that regulate Wnt signaling could prevent cancer cell proliferation. BI 905681 is a novel LRP5 antagonist that has demonstrated potent in vivo antitumor activity.

PATIENTS AND METHODS: This was a phase I, dose escalation study (NCT04147247) evaluating BI 905681 in patients with advanced solid tumors over two dosing schedules (schedule A: every 3 weeks, 3-week cycles and schedule B: every 2 weeks, 4-week cycles). The primary endpoint was the maximum tolerated …

Ancds Diversity Writing Group Discussion: The Evidence Base For Neuro-Rehabilitation Of Acquired And Degenerative Communication Disorders In Diverse Populations: What Is Available, What Is Needed, And Reasons Why, Gloriajean Wallace, Ivan Portillo, Latoya Roberts, Whitney Postman, Gerald Imaezue, Anthony Pak-Hin Kong, Taryn Malcolm

Library Presentations, Posters, and Audiovisual Materials

This presentation will discuss evidence-based practice (EBP), with a focus on available research that supports the neurorehabilitation care of people with neurogenic disorders, including the increasingly large number of people from culturally and linguistically diverse communities.  Presenters will provide the audience with preliminary findings of the ANCDS Diversity Writing group.  Presenters will then provide the audience with thoughts about topics related to neurorehabilitation care of people from diverse communities, including topics relating to academic and clinical training, professional training, current practices, and conversation focused on cultural and linguistic considerations including the use of interpreters and translators.  The presentation will pinnacle …

Participation Of Behavioral Health Facilities In Medicare Accountable Care Organizations, Yucheng Hou, Susan H Busch, Helen Newton

Faculty, Staff and Student Publications

This cross-sectional study examines temporal trends in behavioral health facility inclusion in accountable care organizations (ACOs) and beneficiary characteristics of such ACOs.

Genomic Analysis Of Intracranial And Subcortical Brain Volumes Yields Polygenic Scores Accounting For Variation Across Ancestries, Luis M García-Marín, Adrian I Campos, Santiago Diaz-Torres, Jill A Rabinowitz, Zuriel Ceja, Brittany L Mitchell, Katrina L Grasby, Jackson G Thorp, Ingrid Agartz, Saud Alhusaini, David Ames, Philippe Amouyel, Ole A Andreassen, Konstantinos Arfanakis, Alejandro Arias-Vasquez, Nicola J Armstrong, Lavinia Athanasiu, Mark E Bastin, Alexa S Beiser, David A Bennett, Joshua C Bis, Marco P M Boks, Dorret I Boomsma, Henry Brodaty, Rachel M Brouwer, Jan K Buitelaar, Ralph Burkhardt, Wiepke Cahn, Vince D Calhoun, Owen T Carmichael, Mallar Chakravarty, Qiang Chen, Christopher R K Ching, Sven Cichon, Benedicto Crespo-Facorro, Fabrice Crivello, Anders M Dale, George Davey Smith, Eco J C De Geus, Philip L De Jager, Greig I De Zubicaray, Stéphanie Debette, Charles Decarli, Chantal Depondt, Sylvane Desrivières, Srdjan Djurovic, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Guillén Fernández, Irina Filippi, Simon E Fisher, Debra A Fleischman, Evan Fletcher, Myriam Fornage, Andreas J Forstner, Clyde Francks, Barbara Franke, Tian Ge, Aaron L Goldman, Hans J Grabe, Robert C Green, Oliver Grimm, Nynke A Groenewold, Oliver Gruber, Vilmundur Gudnason, Asta K Håberg, Unn K Haukvik, Andreas Heinz, Derrek P Hibar, Saima Hilal, Jayandra J Himali, Beng-Choon Ho, David F Hoehn, Pieter J Hoekstra, Edith Hofer, Wolfgang Hoffmann, Avram J Holmes, Georg Homuth, Norbert Hosten, M Kamran Ikram, Jonathan C Ipser, Clifford R Jack, Neda Jahanshad, Erik G Jönsson, Rene S Kahn, Ryota Kanai, Marieke Klein, Maria J Knol, Lenore J Launer, Stephen M Lawrie, Stephanie Le Hellard, Phil H Lee, Hervé Lemaître, Shuo Li, David C M Liewald, Honghuang Lin, W T Longstreth, Oscar L Lopez, Michelle Luciano, Pauline Maillard, Andre F Marquand, Nicholas G Martin, Jean-Luc Martinot, Karen A Mather, Venkata S Mattay, Katie L Mcmahon, Patrizia Mecocci, Ingrid Melle, Andreas Meyer-Lindenberg, Nazanin Mirza-Schreiber, Yuri Milaneschi, Thomas H Mosley, Thomas W Mühleisen, Bertram Müller-Myhsok, Susana Muñoz Maniega, Matthias Nauck, Kwangsik Nho, Wiro J Niessen, Markus M Nöthen, Paul A Nyquist, Jaap Oosterlaan, Massimo Pandolfo, Tomas Paus, Zdenka Pausova, Brenda W J H Penninx, G Bruce Pike, Bruce M Psaty, Benno Pütz, Simone Reppermund, Marcella D Rietschel, Shannon L Risacher, Nina Romanczuk-Seiferth, Rafael Romero-Garcia, Gennady V Roshchupkin, Jerome I Rotter, Perminder S Sachdev, Philipp G Sämann, Arvin Saremi, Muralidharan Sargurupremraj, Andrew J Saykin, Lianne Schmaal, Helena Schmidt, Reinhold Schmidt, Peter R Schofield, Markus Scholz, Gunter Schumann, Emanuel Schwarz, Li Shen, Jean Shin, Sanjay M Sisodiya, Albert V Smith, Jordan W Smoller, Hilkka S Soininen, Vidar M Steen, Dan J Stein, Jason L Stein, Sophia I Thomopoulos, Arthur W Toga, Diana Tordesillas-Gutiérrez, Julian N Trollor, Maria C Valdes-Hernandez, Dennis Van T Ent, Hans Van Bokhoven, Dennis Van Der Meer, Nic J A Van Der Wee, Javier Vázquez-Bourgon, Dick J Veltman, Meike W Vernooij, Arno Villringer, Louis N Vinke, Henry Völzke, Henrik Walter, Joanna M Wardlaw, Daniel R Weinberger, Michael W Weiner, Wei Wen, Lars T Westlye, Eric Westman, Tonya White, A Veronica Witte, Christiane Wolf, Jingyun Yang, Marcel P Zwiers, M Arfan Ikram, Sudha Seshadri, Paul M Thompson, Claudia L Satizabal, Sarah E Medland, Miguel E Rentería

Faculty, Staff and Student Publications

Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. Here we performed genome-wide association studies meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and the ventral diencephalon) in 74,898 participants of European ancestry. We identified 254 independent loci associated with these brain volumes, explaining up to 35% of phenotypic variance. We observed gene expression in specific neural cell types across differentiation time points, including genes involved in intracellular signaling and brain aging-related processes. Polygenic scores for brain volumes showed predictive ability when applied to individuals of diverse …

Feasibility, Acceptability, And Initial Efficacy Of A Wheelchair Exercise Training Program In Persons With Multiple Sclerosis: Study Protocol For A Parallel Group Randomized Controlled Trial, Stephanie L Silveira, Robert W Motl, Katherine Froehlich-Grobe, Mitch Kay

Faculty, Staff and Student Publications

Purpose: This study is a randomized controlled trial (RCT) that examines the feasibility, acceptability, and initial efficacy of a home-based, remotely supported and supervised exercise training program that was developed using a three-step community engaged research process for persons with multiple sclerosis (MS) who are wheelchair users.

Materials and methods: The study design is a parallel group RCT (NCT05888727). We aim to enroll 24 wheelchair users with MS who will be randomly assigned using REDCap randomization module into exercise training or attention/contact wellness control conditions. The conditions will be delivered remotely over 16 weeks and supported using online, …

Sex Differences In Hypertension And Its Management Throughout Life, Wan-Jin Yeo, Rahul Abraham, Aditya L Surapaneni, Pascal Schlosser, Shoshana H Ballew, Bige Ozkan, Carina M Flaherty, Bing Yu, Joseph V Bonventre, Chirag R Parikh, Paul L Kimmel, Ramachandran S Vasan, Josef Coresh, Morgan E Grams

Faculty, Staff and Student Publications

Background: The prevalence of hypertension and uncontrolled hypertension may differ by age and sex.

Methods: We included participants in the Atherosclerosis Risk in Communities study at seven study visits over 33 years (visit 1: 15 636 participants; mean age, 54 years; 55% women), estimating sex differences in prevalence of hypertension (systolic blood pressure ≥130 mm Hg; diastolic blood pressure ≥80 mm Hg; or self-reported antihypertension medication use) and uncontrolled hypertension (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg) using unadjusted and comorbidity-adjusted models.

Results: The prevalence of hypertension increased with age from 40% (ages, 43-46 …

Serum Metabolomic Markers Of Artificially Sweetened Beverage Consumption, Hejingzi Jia, Lauren Bernard, Jingsha Chen, Shutong Du, Lyn M Steffen, Kari E Wong, Bing Yu, Valerie K Sullivan, Casey M Rebholz

Faculty, Staff and Student Publications

BACKGROUND: The consumption of artificially sweetened beverages is on the rise. Use of artificial sweeteners has been associated with adverse health outcomes. There is a need to identify novel objective biomarkers of artificially sweetened beverages in order to improve dietary assessment and to provide insight into their metabolic impact.

OBJECTIVES: We aimed to identify serum metabolites that are associated with artificially sweetened beverage consumption.

METHODS: In the Atherosclerosis Risk in Communities (ARIC) study, consumption of artificially sweetened beverages was assessed using a food frequency questionnaire and fasting serum samples were collected during the first study visit (1987-1989). Participants were categorized …

Loss Of Sc5d Results In Micrognathia Due To A Failure In Osteoblast Differentiation, Chihiro Iwaya, Akiko Suzuki, Junichi Iwata

Faculty, Staff and Student Publications

INTRODUCTION: Mutations in genes related to cholesterol metabolism, or maternal diet and health status, affect craniofacial bone formation. However, the precise role of intracellular cholesterol metabolism in craniofacial bone development remains unclear.

OBJECTIVE: The aim of this study is to determine how cholesterol metabolism aberrations affect craniofacial bone development.

METHODS: Mice with a deficiency in Sc5d, which encodes an enzyme involved in cholesterol synthesis, were analyzed with histology, micro computed tomography (microCT), and cellular and molecular biological methods.

RESULTS: Sc5d null mice exhibited mandible hypoplasia resulting from defects in osteoblast differentiation. The activation of the hedgehog and WNT/β-catenin signaling pathways, …