Medicine and Health Sciences Commons^™

Telehealth: A Rising Intervention For Latina Mothers Experiencing Prenatal And Postpartum Depression, Britney Gutierrez

Nursing | Senior Theses

Background: Postpartum depression (PPD) is high among Latina women but often goes unrecognized and untreated. Recognition and management of PPD in this population is crucial as PPD contributes to negative health effects on the mother and infant. Purpose: This research aims to look into telehealth to improve screening methods and treatment for Latina mothers through a Spanish mobile health application that will provide screening and education on PPD. Method: This mixed-method quality improvement study will include 300 participants from an OB-GYN and Pediatrics community clinic, > 18 years old, of Hispanic/Latino ethnicity, Spanish speaking, currently pregnant, or had a child within …

Optimizing Ventilator-Associated Pneumonia Prevention And Education: In Adult Icu Settings, Danielle Gonzalez

Nursing | Senior Theses

Background: Ventilator associated pneumonia (VAP) in adult intensive care patient units (ICU) is one of the most common and deadly nosocomial infections today. Studies have identified a gap in intensive care nurse ventilator education and compliance with hospital protocols. Overall increasing the rates of VAP and morbidity. Hospitals worldwide have shown a decrease in VAP rates after inheriting "VAP-bundles''. This includes nurse specific interventions and assessments as a preventative measure. However, studies failed to demonstrate which bundle interventions directly correspond to the prevention of VAP. Purpose: Address all components of education, a nurse’s ability to properly identify and understand the …

Developmental Effects Of Child Abuse: The Relevance Of Timing, Laura Luz Alvarez Pineda, Karla Susana Saldaña

Nursing | Senior Theses

Background: Early physical, sexual, and emotional child abuse has been associated with long-life cognitive, emotional, and physical health repercussions. Purpose: The current paper, in addition to a literature review, proposes a research design to examine the emotional outcomes of physical, emotional, and sexual child abuse on Hispanics when a psychosocial therapy program is implemented. Methods: Participants will be recruited from children’s hospitals, daycares, and preschools around the Bay Area. Parental-informed consent will be obtained prior to participation. This longitudinal quantitative quasi-experimental study will be comprised of three phases to measure posttraumatic stress and depression symptoms, and suicidal ideation. Results: Multivariate …

Enhancing Mental Health Support And Reducing Burnout In Nursing: A Holistic Approach, Alexa Miller, Andrea Quintela

Nursing | Senior Theses

Urgent action is needed to strengthen mental health support for nurses experiencing burnout. This thesis examines the stigma surrounding burnout in the nursing community and implements holistic approaches to alleviate burnout of those affected. Integrating mental health awareness, mindfulness-based interventions, personal self-care, and supportive hospital practice can decrease nurse burnout. By first coming to terms with nurse turnover and further prioritizing nurses' physiological, emotional, and social welfare, leadership and organization can implement holistic strategies to address these diverse challenges nurses face. Through a deep dive into existing literature, relevant studies, and a blend of critical findings, this thesis emphasizes the …

Advancing School Nursing Practice: A Novel Approach To Screening For Gastrointestinal Disorders In Children, Ashley Bunting, Isabella Cavlan

Nursing | Senior Theses

Background: Currently, mandated health screenings in California schools are limited to vision, hearing, and scoliosis; this leaves several other body systems unmonitored during the crucial years of childhood development. One such system is the gastrointestinal (GI) system, which plays a vital role in the normal growth, nutrition status, development, and overall health of children. Objective: By developing and implementing a GI-specific screening tool in the outpatient school setting, this research aims to increase the detection of GI disorders in children. Not only that, but school nurses can use this novel screening tool to promote early diagnosis, intervention, and …

Public Health Implications Of Social Media On Adolescent Health Behaviors: Upstream Approaches To Prevention Strategies, Joseph Donnelly, Elena Saldutti

Department of Public Health Scholarship and Creative Works

This commentary provides a comprehensive overview of the influence of social media on the health and well-being of adolescents, focusing on emotional/mental health, self-esteem, alcohol and drug use, peer pressure, and both negative and positive influences. It highlights concerns about the potential negative impact of social media, including increased levels of anxiety, depression, and loneliness, as well as the impact on self- esteem through seeking validation and unrealistic comparisons. Furthermore, it discusses how social media exposes adolescents to content promoting alcohol and drug use and amplifies peer pressure, leading to potential substance abuse and negative decision-making. Despite these drawbacks, the …

Enhancing Reproducibility In Single Cell Research With Biocytometry: An Inter-Laboratory Study, Pavel Fikar, Laura Alvarez, Laura Berne, Martin Cienciala, Christopher Kan, Hynek Kasl, Mona Luo, Zuzana Novackova, Sheyla Ordonez, Zuzana Sramkova, Monika Holubova, Daniel Lysak, Lyndsay Avery, Andres A. Caro, Roslyn N. Crowder, Laura A. Diaz-Martinez, David W. Donley, Rebecca R. Giorno, Irene K. Guttilla Reed, Lori Hensley

Research, Publications & Creative Work

Biomedicine today is experiencing a shift towards decentralized data collection, which promises enhanced reproducibility and collaboration across diverse laboratory environments. This inter-laboratory study evaluates the performance of biocytometry, a method utilizing engineered bioparticles for enumerating cells based on their surface antigen patterns. In centralized and aggregated inter-lab studies, biocytometry demonstrated significant statistical power in discriminating numbers of target cells at varying concentrations as low as 1 cell per 100,000 background cells. User skill levels varied from expert to beginner capturing a range of proficiencies. Measurement was performed in a decentralized environment without any instrument cross-calibration or advanced user training outside …

The Effect Of Creatine Nitrate And Caffeine Individually Or Combined On Exercise Performance And Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial, Gina Mabrey, Majid S. Koozehchian, Andrew T. Newton, Alireza Naderi, Scott C. Forbes, Monoem Haddad

Research, Publications & Creative Work

This study examined the effect of creatine nitrate and caffeine alone and combined on exercise performance and cognitive function in resistance-trained athletes. In a double-blind, randomized crossover trial, twelve resistance-trained male athletes were supplemented with 7 days of creatine nitrate (5 g/day), caffeine (400 mg/day), and a combination of creatine nitrate and caffeine. The study involved twelve resistance-trained male athletes who initially provided a blood sample for comprehensive safety analysis, including tests for key enzymes and a lipid profile, and then performed standardized resistance exercises—bench and leg press at 70% 1RM—and a Wingate anaerobic power test. Cognitive function and cardiovascular …

Active Transfer Learning For Audiogram Estimation, Hossana Twinomurinzi, Herman Myburgh, Dennis L Barbour

2020-Current year OA Pubs

Computational audiology (CA) has grown over the last few years with the improvement of computing power and the growth of machine learning (ML) models. There are today several audiogram databases which have been used to improve the accuracy of CA models as well as reduce testing time and diagnostic complexity. However, these CA models have mainly been trained on single populations. This study integrated contextual and prior knowledge from audiogram databases of multiple populations as informative priors to estimate audiograms more precisely using two mechanisms: (1) a mapping function drawn from feature-based homogeneous Transfer Learning (TL) also known as Domain …

Plasma Mirna Expression Profile In Pediatric Pineal Pure Germinomas, Mona Fakhry, Moatasem Elayadi, Mariam G Elzayat, Omar Samir, Eslam Maher, Hala Taha, Mohamed El-Beltagy, Amal Refaat, Manal Zamzam, Mohamed S Abdelbaki, Ahmed A Sayed, Mark Kieran, Alaa Elhaddad

2020-Current year OA Pubs

BACKGROUND: Pure germinomas account for 40% of pineal tumors and are characterized by the lack of appreciable tumor markers, thus requiring a tumor biopsy for diagnosis. MicroRNAs (miRNA) have emerged as potential non-invasive biomarkers for germ cell tumors and may facilitate the non-invasive diagnosis of pure pineal germinomas.

MATERIAL AND METHODS: A retrospective chart review was performed on all patients treated at the Children's Cancer Hospital Egypt diagnosed with a pineal region tumor between June 2013 and March 2021 for whom a research blood sample was available. Plasma samples were profiled for miRNA expression, and DESeq2 was used to compare …

Successful Management Of Spontaneous Unilateral Twin Ectopic Pregnancy With Two-Step Dose Of Methotrexate, Lauren A. Forbes, Navya Nuthivana, Renee Morales

Department of Obstetrics & Gynecology Faculty Publications

The incidence of unilateral tubal twin pregnancy is 1/20,000–1/250,000 with about 100 reported cases. Four of the six cases that were medically managed were successful. A 24-year-old female presented to the emergency department (ED) with vaginal bleeding and abdominal cramping. She was hemodynamically stable without signs of an acute abdomen. Laboratory evaluation revealed she was pregnant with a serum beta-human chorionic gonadotropin (b-hCG) of 798 mIU/mL. Transvaginal ultrasound (TVUS) revealed a single left tubal pregnancy with a yolk sac. The patient elected medical management with body surface area (BSA)–based intramuscular (IM) methotrexate (MTX). On Day 4, the patient returned to …

Gene Expression Of Tight Junctions In Foreskin Is Not Affected By Hiv Pre-Exposure Prophylaxis, Emily L. Webb, Stefan Petkov, Heejin Yun, Laura Else, Limakatso Lebina, Jennifer Serwanga, Azure-Dee A.P. Pillay, Thabiso B. Seiphetlo, Susan Mugaba, Patricia Namubiru, Geoffrey Odoch, Daniel Opoka, Andrew S. Ssemata, Pontiano Kaleebu, Saye Khoo, Neil Martinson, Julie Fox, Clive M. Gray, Carolina Herrera, Francesca Chiodi

Department of Obstetrics & Gynecology Faculty Publications

Introduction: Tight junctions (TJs) serve as permeability filters between the internal and external cellular environment. A large number of proteins have been identified to be localized at the TJs. Due to limitations in tissue collection, TJs in the male genital tract have been understudied.

Methods: We analysed the transcriptomics of 132 TJ genes in foreskin tissue of men requesting voluntary medical male circumcision (VMMC) and enrolled in the Combined HIV Adolescent Prevention Study (CHAPS) trial conducted in South Africa and Uganda (NCT03986970). The trial evaluated the dose requirements for event-driven HIV pre-exposure prophylaxis (PrEP) with emtricitabine-tenofovir (FTC-TDF) or emtricitabine-tenofovir alafenamide …

Lifelong Safe Optimal Adaptive Tracking Control Of Nonlinear Strict-Feedback Discrete-Time Systems, Behzad Farzanegan, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents a comprehensive approach for achieving multi-task safe optimal adaptive tracking (MSOAT) for a class of nonlinear discrete-time systems, particularly those in strict-feedback form, utilizing a multi-layer neural network (MNN)-based framework. To begin, a cost function with a novel Barrier function (BF) term is introduced for each subsystem to address the weak safely reachable problem, serving as a crucial tool for guiding the system's trajectory toward the safe set while avoiding unwanted sets. To deal with the tracking problem, the Hamilton-Jacobi-Bellman (HJB) framework is used through the actor-critic MNN-based backstepping technique to estimate the solution of the value …

Relative Altitude Estimation Of Infrared Thermal Uav Images Using Sift Features, Shirin Nasr Esfahani, Jagannathan Sarangapani

Electrical and Computer Engineering Faculty Research & Creative Works

Unmanned Aerial Vehicles (UAVs) have become indispensable in various applications, including surveillance, urban scene analysis, and agricultural monitoring. Accurate altitude estimation is critical for UAV operations, especially in environments where traditional sensors like GPS, pressure altimeters, and radar may fail. This paper explores the use of infrared and thermal imaging for relative altitude estimation of UAVs, highlighting their significant advantages over traditional RGB images. Infrared and thermal imaging offer superior performance in low-light and adverse weather conditions, providing clearer visibility and more reliable feature detection. By leveraging the Scale-Invariant Feature Transform (SIFT) features, this approach utilizes the inherent benefits of …

Vaginal And Rectal Microbiome Changes Following Administration Of A Multi-Species Antenatal Probiotic: A Randomized Control Trial, Emily Malloy, Ashley Kates, Jonah Dixon, Colleen Riley, Nasia Safdar, Lisa Hanson

College of Nursing Faculty Research and Publications

The gut and vaginal microbiome undergo changes during pregnancy which may be protective or harmful to the birthing person. Probiotics have been found to cause protective changes to the gut and vaginal microbiomes, with the potential to improve perinatal outcomes. This randomized control trial compares the vaginal and rectal microbiomes before and after an antenatal probiotic or placebo intervention, with a diverse group of pregnant people and a special focus on racial disparities. The vaginal and rectal microbiomes reveal non-significant increased Lactobacillus in the probiotics group, with a greater increase in participants who identified as Black. Potential implications and future …

Feasibility And Acceptability Of Studying Full-Time Nurse Faculty Salaries, Kathryn J. Malin, Jessica L. Zemlak, Jacqueline Christianson, Jessica Leiberg, Lisa M. Grabert

College of Nursing Faculty Research and Publications

Background

The nursing shortage is driven, in part, by the critical shortage of nursing faculty. Consequently, qualified potential nursing students are being turned away from nursing schools each year. The preeminent issue influencing the United States nurse faculty workforce shortage is salary; financial compensation is higher in clinical and private-sector settings than educational settings. The purpose of this study is to describe current full-time nurse faculty salary, sources of income, and perceived need for more income, as well as the feasibility and acceptability of research focused on full-time nurse faculty salaries, so to guide future nursing faculty workforce research.

Methods …

The Cousa Objective: A Long-Working Distance Air Objective For Multiphoton Imaging In Vivo, Che-Hang Yu, Jinkyung Kim, Et Al.

2020-Current year OA Pubs

Multiphoton microscopy can resolve fluorescent structures and dynamics deep in scattering tissue and has transformed neural imaging, but applying this technique in vivo can be limited by the mechanical and optical constraints of conventional objectives. Short working distance objectives can collide with compact surgical windows or other instrumentation and preclude imaging. Here we present an ultra-long working distance (20 mm) air objective called the Cousa objective. It is optimized for performance across multiphoton imaging wavelengths, offers a more than 4 mm

Association Between Papillary Thyroid Cancer And Xrcc6 Gene Polymorphisms In The Turkish Population, Egemen Akgün, Fadi̇me Mutlu İçduygu, Demet Şengül, Ebru Alp, Mehmet Alkanat, Aysegül Cebi̇, Tuncer Ozturk

Turkish Journal of Medical Sciences

Background/aim: This study aims to investigate the association between rs2267437, rs5751129 and rs132770 polymorphisms of the XRCC6 gene, which plays a role in repairing DNA double strand breaks, and the risk of Papillary Thyroid Cancer (PTC).Methods: The study included 150 patients who had been diagnosed with PTC and 204 healthy control subjects. Genotyping of SNPs was performed by Polymerase Chain Reaction - Restriction Fragment Length Polymorphism method (PCR - RFLP).Results: In rs2267437 polymorphism, individuals with GG genotype had lower risk of PTC than wild-type CC genotype (p=0.037, 95% CI=0.19-0.96, OR=0.67). The combined genotypes CG+GG were found to be related to …

Clinicopathological Features For The Prediction Of Immunosuppressive Treatment Responses In Sarcoidosis-Related Kidney Involvement: A Single-Center Retrospective Study, Ahmet Burak Di̇ri̇m, Vafa Suleymanova, Ozge Hurdogan, Özgür Oto, Ayşe Artan, Savas Ozturk, Yasemi̇n Ozluk, Isi̇n Ki̇li̇caslan, Hali̇l Yazi̇ci̇

Turkish Journal of Medical Sciences

Background/aim: Sarcoidosis is a multisystem disorder that affects many organs, including the kidneys. This single-center retrospective study investigated the clinical, pathological, and laboratory findings of patients with kidney sarcoidosis who were treated with immunosuppressives.Materials and Methods: Twenty-three patients with biopsy-confirmed kidney sarcoidosis were included. Demographics, clinical, pathological, and laboratory findings, in addition to treatments, and outcomes of twenty patients with at least one month of follow-up were evaluated.Results: Median age at the time of biopsy was 47 years(60.9 % female). Median baseline eGFR and proteinuria were 21.5 ml/min and 1 g/g or g/day, respectively. Nineteen of the 23 patients were …

Evaluation Of The Association Of Mucosa-Associated Invariant T (Mait) Cells With Childhood Asthma, Meral Ekşi̇, Huri̇ Bulut, Erdem Akalin, Feyza Ustabaş Kahraman, Hakan Yazan, Mebrure Yazici, Mustafa Nursoy, Emi̇n Özkaya, Abdürrahi̇m Koçyi̇ği̇t, Erkan Çakir

Turkish Journal of Medical Sciences

Background/aim: Innate-like T lymphocytes are a recently defined group of T cells comprising mainly mucosa-associated invariant T (MAIT) cells. The relationship between MAIT cells and childhood asthma is controversial. In this study, we aimed to determine the role of MAIT cells in patients with allergic asthma (AA) and nonallergic asthma (NAA). This is the first study to compare the ratios of these cells in patients with AA and NAA.Materials and methods: The study included children aged 6–18 years with AA (n = 41) or NAA (n = 30) and healthy control subjects (n = 36). The control group consisted of …

Evaluating The Performance Of The Mskcc Gastric Cancer Survıval Calculator In The Turkısh Population, İlknur Deli̇ktaş Onur, Tuğba Başoğlu Tüylü, Nazim Demi̇rcan, Tuğba Akin Telli̇, Ruki̇ye Arikan, Özlem Ercelep, Serdar Turhal, Mehmet Öztürk, Perran Yumuk, Faysal Dane

Turkish Journal of Medical Sciences

Bacground/Aim: The MSKCC(Memorial Sloan Kettering Cancer Center) nomogram was developed to predict survivorship in gastric cancer patients undergoing R0 resection. This study aimed to evaluate the predictive power of this nomogram in the Turkish patient population. Materials and Methods: Gastric cancer patients over 18 years of age who were admitted to our clinic between 2000 and 2019 and underwent primary curative surgery and R0 resection were included in the study. The 5-year and 9-year overall survival rates of 489 patients were analyzed. Real-life survival rates and those calculated with the MSKCC tool were compared in all patients and subgroups. The …

Minimally Invasive Sacroiliac Fusion; Current Insights And A Comprehensive Literature Review, Aydin Apaydin, Mehmet Yurtluk, Khoi̇ Than

Turkish Journal of Medical Sciences

The sacroiliac joint (SIJ) is an easily dismissable cause of lower back pain (LBP). Recently has gained attention as the source of pain and surgeries addressing this issue have gained attention among surgeons. Classically open fusion surgery was used for the pelvic and sacral fractures to stabilize the structure and then open SIJ fusion surgery started to be used for pain management until the discovery of minimally invasive surgery (MIS). MIS offered fast and effective pain relief with significantly less risk of adverse events following the surgery. Therefore gaining more and more attention each day among surgeons. Our literature review …

Elevating Voices, Addressing Depression, Toxic Stress, And Equity Through Group Prenatal Care: A Pilot Study, Shannon N Lenze, Kelly Mckay-Gist, Rachel Paul, Melissa Tepe, Katherine Mathews, Sara Kornfield, Cheron Phillips, Richelle Smith, Amanda Stoermer, Ebony B Carter

2020-Current year OA Pubs

INTRODUCTION: Elevating Voices, Addressing Depression, Toxic Stress and Equity (EleVATE) is a group prenatal care (GC) model designed to improve pregnancy outcomes and promote health equity for Black birthing people. This article outlines the foundational community-engaged process to develop EleVATE GC and pilot study results.

METHODS: We used community-based participatory research principles and the Ferguson Commission Report to guide creation of EleVATE GC. The intervention, designed by and for Black birthing people, centers trauma-informed care, antiracism, and integrates behavioral health strategies into group prenatal care to address unmet mental health needs. Using a convenience sample of patients seeking care at …

Leveraging Murine Models Of The Neurofibromatosis Type 1 Cancer Predisposition Syndrome To Elucidate The Cellular Circuits That Drive Pediatric Low-Grade Glioma Formation And Progression, David H Gutmann

2020-Current year OA Pubs

Brain tumors are the leading cause of cancer-related death in children, where low-grade gliomas (LGGs) predominate. One common hereditary cause for LGGs involves neurofibromatosis-1 (NF1) gene mutation, as seen in individuals with the NF1 cancer predisposition syndrome. As such, children with NF1 are at increased risk of developing LGGs of the optic pathway, brainstem, cerebellum, and midline brain structures. Using genetically engineered mouse models, studies have revealed both cell-intrinsic (MEK signaling) and stromal dependencies that underlie their formation and growth. Importantly, these dependencies represent vulnerabilities against which targeted agents can be used for preclinical investigation prior to clinical translation.

Intermuscular Coherence As An Early Biomarker For Amyotrophic Lateral Sclerosis: The Protocol For A Prospective, Multicenter Study, Naoum P Issa, Serdar Aydin, Eric Polley, Nathan Carberry, Mark A. Garret, Sean Smith, Ali A. Habib, Nicholas W. Baumgartner, Betty Soliven, Kourosh Rezania

2020-Current year OA Pubs

OBJECTIVE: To describe the protocol of a prospective study to test the validity of intermuscular coherence (IMC) as a diagnostic tool and biomarker of upper motor neuron degeneration in amyotrophic lateral sclerosis (ALS).

METHODS: This is a multicenter, prospective study. IMC of muscle pairs in the upper and lower limbs is gathered in ∼650 subjects across three groups using surface electrodes and conventional electromyography (EMG) machines. The following subjects will be tested: 1) neurotypical controls; 2) patients with symptomatology suggestive for early ALS but not meeting probable or definite ALS by Awaji Criteria; 3) patients with a known ALS mimic. …

Iuphar Review- Preclinical Models Of Neuropathic Pain: Evaluating Multifunctional Properties Of Natural Cannabinoid Receptors Ligands, Khalid Benamar

School of Medicine Publications

Neuropathic pain remains prevalent and challenging to manage and is often comorbid with depression and anxiety. The new approach that simultaneously targets neuropathic pain and the associated comorbidities, such as depression and anxiety, is timely and critical, given the high prevalence and severity of neuropathic pain and the lack of effective analgesics. In this review, we focus on the animal models of neuropathic pain that researchers have used to investigate the analgesic effects of cannabidiol (CBD) and Beta-Caryophyllene (BCP) individually and in combination while addressing the impact of these compounds on the major comorbidity (e.g., depression, anxiety) associated with neuropathic …

Attitudes Toward And Readiness For Medical Artificial Intelligence Among Medical And Health Science Students, Jonas Preposi Cruz, Anara Sembekova, Dinara Omirzakova, Srinivasa Rao Bolla, Ejercito Mangawa Balay-Odao

Health Professions Education

Purpose: This study assessed general attitudes toward artificial intelligence and medical artificial intelligence readiness among medical and health sciences students and examined the factors that influence the medical artificial intelligence readiness of the students.

Methods: A descriptive cross-sectional quantitative online survey was conducted among medical and health sciences students. We employed the 'General Attitudes Toward Artificial Intelligence Scale' (GAAIS) to assess students' artificial intelligence attitudes and the 'Medical Artificial Intelligence Readiness of Students Scale for Medical Students' (MAIRS-MS) to measure student readiness for medical artificial intelligence.

Results: Nearly all students did not receive/ attend any experience of …

Empathy Development Among Undergraduate Health Professions’ Students Serving As Caregivers To Hospice Patients, Kelly Melekis, Carol S. Weisse, Emma Phillips, Claire Slattery

Health Professions Education

Although empathy is considered a core competency for healthcare providers and has been shown to play an important role in improving patient outcomes, empathy development while working with dying patients is not well understood and may present challenges during clinical training. This qualitative study explored empathy development among 24 undergraduate health professions students participating in an experiential training program where they served as caregivers providing bedside care to hospice patients. An exploratory case study design was used to assess empathy development as expressed via responses to a series of questions and vignettes prior to and upon completion of the training …

Case Report: Deep Sequencing And Long-Read Genome Sequencing Refine Prior Genetic Analyses In Families With Apparent Gonadal Mosaicism In Pik3cd-Related Activated Pi3k Delta Syndrome, Halyn Orellana, Alex Paul, Nermina Saucier, Megan Cooper, Et Al.

2020-Current year OA Pubs

Gonadal and gonosomal mosaicism describe phenomena in which a seemingly healthy individual carries a genetic variant in a subset of their gonadal tissue or gonadal and somatic tissue(s), respectively, with risk of transmitting the variant to their offspring. In families with one or more affected offspring, occurrence of the same apparently

Changing Hearts And Minds: Theorizing How, When, And Under What Conditions Three Social Influence Implementation Strategies Work, Bryan J Weiner, Rosemary D Meza, Predrag Klasnja, Rebecca Lengnick-Hall, Gretchen J Buchanan, Aaron R Lyon, Kayne D Mettert, Marcella H Boynton, Byron J Powell, Cara C Lewis

2020-Current year OA Pubs

BACKGROUND: Opinion leadership, educational outreach visiting, and innovation championing are commonly used strategies to address barriers to implementing innovations and evidence-based practices in healthcare settings. Despite voluminous research, ambiguities persist in how these strategies work and under what conditions they work well, work poorly, or work at all. The current paper develops middle-range theories to address this gap.

METHODS: Conceptual articles, systematic reviews, and empirical studies informed the development of causal pathway diagrams (CPDs). CPDs are visualization tools for depicting and theorizing about the causal process through which strategies operate, including the mechanisms they activate, the barriers they address, and …