Medicine and Health Sciences Commons^™

From Primary Myelofibrosis To Chronic Myeloid Leukemia, Bcr::Abl1+ B-Lymphoblastic Leukemia, And Back To Primary Myelofibrosis: An Illustration Of Dynamic Clonal Evolution, Devin Wang, Wataru Kamata, Fengxi Ye, M James You

Faculty, Staff and Student Publications

The simultaneous detection of BCR::ABL1 and JAK2 V617F was rarely reported and their clonal relationship and dynamic clonal shift were not characterized. Here, we described a unique case with the initial presentation as JAK2 V617F+ primary myelofibrosis, followed by the emergence of BCR::ABL1+ chronic myeloid leukemia. The patient then developed BCR::ABL1+ B-lymphoblastic leukemia. Treatment for B-lymphoblastic leukemia prompted a regression to the state of primary myelofibrosis. In light of these observations, we proposed a clonal evolution model for this case.

Sionx Coating Regulates Mesenchymal Stem Cell Antioxidant Capacity Via Nuclear Erythroid Factor 2 Activity Under Toxic Oxidative Stress Conditions, Neelam Ahuja, Kamal Awad, Su Yang, He Dong, Antonios Mikos, Pranesh Aswath, Simon Young, Marco Brotto, Venu Varanasi

Faculty, Staff and Student Publications

Healing in compromised and complicated bone defects is often prolonged and delayed due to the lack of bioactivity of the fixation device, secondary infections, and associated oxidative stress. Here, we propose amorphous silicon oxynitride (SiONx) as a coating for the fixation devices to improve both bioactivity and bacteriostatic activity and reduce oxidative stress. We aimed to study the effect of increasing the N/O ratio in the SiONx to fine-tune the cellular activity and the antioxidant effect via the NRF2 pathway under oxidative stress conditions. The in vitro studies involved using human mesenchymal stem cells (MSCs) to examine the effect of …

Metabolism, Fibrosis, And Apoptosis: The Effect Of Lipids And Their Derivatives On Keloid Formation, Chen-Yu Li, Ru-Xin Xie, Shi-Wei Zhang, Jiao Yun, Ai Zhong, Ying Cen, Jun-Jie Chen

Faculty, Staff and Student Publications

Keloids, pathological scars resulting from skin trauma, have traditionally posed significant clinical management challenges due to their persistence and high recurrence rates. Our research elucidates the pivotal roles of lipids and their derivatives in keloid development, driven by underlying mechanisms of abnormal cell proliferation, apoptosis, and extracellular matrix deposition. Key findings suggest that abnormalities in arachidonic acid (AA) synthesis and non-essential fatty acid synthesis are integral to keloid formation. Further, a complex interplay exists between lipid derivatives, notably butyric acid (BA), prostaglandin E2 (PGE2), prostaglandin D2 (PGD2), and the regulation of hyperfibrosis. Additionally, combinations of docosahexaenoic acid (DHA) with BA …

Epigenetic Regulation In Cancer, Minzhi Gu, Bo Ren, Yuan Fang, Jie Ren, Xiaohong Liu, Xing Wang, Feihan Zhou, Ruiling Xiao, Xiyuan Luo, Lei You, Yupei Zhao

Faculty, Staff and Student Publications

Epigenetic modifications are defined as heritable changes in gene activity that do not involve changes in the underlying DNA sequence. The oncogenic process is driven by the accumulation of alterations that impact genome's structure and function. Genetic mutations, which directly disrupt the DNA sequence, are complemented by epigenetic modifications that modulate gene expression, thereby facilitating the acquisition of malignant characteristics. Principals among these epigenetic changes are shifts in DNA methylation and histone mark patterns, which promote tumor development and metastasis. Notably, the reversible nature of epigenetic alterations, as opposed to the permanence of genetic changes, positions the epigenetic machinery as …

Identification Of A Novel Cg307 Sub-Clade In Third-Generation-Cephalosporin-Resistant, Selvalakshmi Selvaraj Anand, Chin-Ting Wu, Jordan Bremer, Micah Bhatti, Todd J Treangen, Awdhesh Kalia, Samuel A Shelburne, William C Shropshire

Faculty, Staff and Student Publications

Despite the notable clinical impact, recent molecular epidemiology regarding third-generation-cephalosporin-resistant (3GC-R) Klebsiella pneumoniae in the USA remains limited. We performed whole-genome sequencing of 3GC-R K. pneumoniae bacteraemia isolates collected from March 2016 to May 2022 at a tertiary care cancer centre in Houston, TX, USA, using Illumina and Oxford Nanopore Technologies platforms. A comprehensive comparative genomic analysis was performed to dissect population structure, transmission dynamics and pan-genomic signatures of our 3GC-R K. pneumoniae population. Of the 178 3GC-R K. pneumoniae bacteraemias that occurred during our study time frame, we were able to analyse 153 (86 %) bacteraemia isolates, 126 …

Neurologic Morbidity And Functional Independence In Adult Survivors Of Childhood Cancer, Stefanie C Vuotto, Mingjuan Wang, M Fatih Okcu, Daniel C Bowers, Nicole J Ullrich, Kirsten K Ness, Chenghong Li, Deo Kumar Srivastava, Rebecca M Howell, Todd M Gibson, Wendy M Leisenring, Kevin C Oeffinger, Leslie L Robison, Gregory T Armstrong, Kevin R Krull, Tara M Brinkman

Faculty, Staff and Student Publications

OBJECTIVE: To examine associations between neurologic late effects and attainment of independence in adult survivors of childhood cancer treated with central nervous system (CNS)-directed therapies.

METHODS: A total of 7881 survivors treated with cranial radiation therapy (n = 4051; CRT) and/or intrathecal methotrexate (n = 4193; IT MTX) ([CNS-treated]; median age [range] = 25.5 years [18-48]; time since diagnosis = 17.7 years [6.8-30.2]) and 8039 without CNS-directed therapy reported neurologic conditions including stroke, seizure, neurosensory deficits, focal neurologic dysfunction, and migraines/severe headaches. Functional independence was assessed using latent class analysis with multiple indicators (independent living, assistance with routine and personal …

Aneuploidy And Complex Genomic Rearrangements In Cancer Evolution, Toby M Baker, Sara Waise, Maxime Tarabichi, Peter Van Loo

Faculty, Staff and Student Publications

Mutational processes that alter large genomic regions occur frequently in developing tumors. They range from simple copy number gains and losses to the shattering and reassembly of entire chromosomes. These catastrophic events, such as chromothripsis, chromoplexy and the formation of extrachromosomal DNA, affect the expression of many genes and therefore have a substantial effect on the fitness of the cells in which they arise. In this review, we cover large genomic alterations, the mechanisms that cause them and their effect on tumor development and evolution.

Transcription-Replication Interactions Reveal Bacterial Genome Regulation, Andrew W Pountain, Peien Jiang, Tianyou Yao, Ehsan Homaee, Yichao Guan, Kevin J C Mcdonald, Magdalena Podkowik, Bo Shopsin, Victor J Torres, Ido Golding, Itai Yanai

Faculty, Staff and Student Publications

Organisms determine the transcription rates of thousands of genes through a few modes of regulation that recur across the genome1. In bacteria, the relationship between the regulatory architecture of a gene and its expression is well understood for individual model gene circuits2,3. However, a broader perspective of these dynamics at the genome scale is lacking, in part because bacterial transcriptomics has hitherto captured only a static snapshot of expression averaged across millions of cells4. As a result, the full diversity of gene expression dynamics and their relation to regulatory architecture remains unknown. Here we present a novel genome-wide classification of …

Phase I Study Of Sapanisertib (Cb-228/Tak-228/Mln0128) In Combination With Ziv-Aflibercept In Patients With Advanced Solid Tumors, Niamh Coleman, Bettzy Stephen, Siqing Fu, Daniel Karp, Vivek Subbiah, Jordi Rodon Ahnert, Sarina A Piha-Paul, John Wright, Senait N Fessahaye, Fengying Ouyang, Bulent Yilmaz, Funda Meric-Bernstam, Aung Naing

Faculty, Staff and Student Publications

BACKGROUND: Sapanisertib is a potent ATP-competitive, dual inhibitor of mTORC1/2. Ziv-aflibercept is a recombinant fusion protein comprising human VEGF receptor extracellular domains fused to human immunoglobulin G1. HIF-1α inhibition in combination with anti-angiogenic therapy is a promising anti-tumor strategy. This Phase 1 dose-escalation/expansion study assessed safety/ tolerability of sapanisertib in combination with ziv-aflibercept in advanced solid tumors.

METHODS: Fifty-five patients with heavily pre-treated advanced metastatic solid tumors resistant or refractory to standard treatment received treatment on a range of dose levels.

RESULTS: Fifty-five patients were enrolled and treated across a range of dose levels. Forty were female (73%), median age …

A04: A Pilot Study On The Persistence Of Children's Online Sports Games, Haoye Shen, Xiaozan Wan, Meiyuan Chen, Mengke Kang, Hao Li, Yiang Yuan

International Journal of Physical Activity and Health

Purpose: In the post-epidemic era, children's physical activity has decreased sharply, and smart sports at home have gradually emerged, making online sports games an important path for children's sports participation. This pilot study was to explore the persistence of children's online sports game participation through exercise frequency recording and provided guidance for online sports game intervention programs. Methods: A total of 29 primary school children were enrolled, including 24 boys and 5 girls. Participants exercise autonomously through motion software. In this study, the movement of each participant was recorded through the background of the software system and exported to Excel. …

A01: A Pilot Study Of Student Cadres Mental Health At A Sport University During Covid-19, Yuan Yuan, Haijun Han, Hongwei Guan

International Journal of Physical Activity and Health

Purpose: Over 90% of college students have experienced negative mental health symptoms due to the pandemic, according to a survey from BestColleges.com. More than half (54%) of college students believe COVID-19 circumstances have impacted their mental health. Although the pandemic's influence on mental health expanded, not all students have felt its effects to the same degree. Physical activity has been reported to have many physical and mental health benefits. Students at sport universities tend to participate in more sport and physical activity. During the pandemic, student cadres are expected to take more responsibilities such as coordinating COVID-19 tests and interacting …

A10: Analyzing Perceptual Differences Toward Esports Among Students Across Various Educational Levels Of America, Xianhua Luo, Li Chen, Yong Yang, Hui Deng

International Journal of Physical Activity and Health

Purpose: Electronic sports (Esports) draw increasing attention in the world and become popular across institutions of American higher education. Scholars in Esports research have explored various findings and discussions related to education, marketing and promotion, organization and management, and sociology and psychology of sport. However, the perceptual differences of Esports participants remain unknown across educational levels across American institutions. The purposes of this study were to examine the perceptual differences toward Esports across educational levels in the United States. Methods: A total of 397 voluntary participates with various education levels took part in a reginal survey in the east coast …

A52: Practice Research On Orientation Movement Teaching In Primary School, Ziying Zeng, Haicheng Wen, Liyan Lao, Shunzhou Du, Yuntao Zeng

International Journal of Physical Activity and Health

Purpose: Sports shoulder the important task of improving the physical health of teenagers, is an indispensable part of the school quality education, more importantly, is to undertake the fundamental mission of moral cultivation. Orienteering is a new sports project integrating intelligence and physical strength. It not only strengthens the body, but also improves the students' self-control ability such as thinking and judging ability and solving difficulties by themselves, so as to truly realize the ideal effect of "sports people". Methods: From the perspective of the implementation of school-based orienteering curriculum in our school, this paper adopts experimental methods, mathematical statistics …

A56: Mediation Analysis Of Association Between Fundamental Motor Skills And Physical Activity In Elementary School Students, Jun Chen, Xiaozan Wang, Ouyi Chen, Haizhu Long

International Journal of Physical Activity and Health

Purpose: This study aimed to investigate the association of fundamental motor skills (FMS), perceived motor competence (PMC), physical activity (PA) in elementary school students, as well as to examine whether PMC mediated the relationship between FMS and PA. Methods: Participants were 470 3-6th grade students (210 boys vs. 242 girls; Mean age = 10.11 years old; SD = 1.19) at five elementary schools from the province of Hunan in China. The students’ FMS were assessed with The Test of Gross Motor Development-3, PMC was assessed using the perceived athletic competence sub-scale of Harter’s Self-perception profile for children and PA were …

A57: A Study On The Correlation Between Basic Motor Skills And Attention, Parent-Child Relationship And Behavior, Mengke Kang, Xiaozan Wang, Meiyuan Chen, Haoye Shen

International Journal of Physical Activity and Health

Purpose: In the Curriculum Standards of Physical Education and Health for Compulsory Education (2022 Edition) newly issued by China in 2022, basic motor skills are included in the curriculum, requiring students to learn, practice and experience mobility skills, control skills, manipulative skills, and other basic motor skills. The purpose of this study is to explore the correlation between basic motor skills and pupils' attention, parent-child relationship, and behavior, and to provide a theoretical basis for its further implementation. Methods: In this study, 45 primary school students from Malu Primary School, Jiading District, Shanghai, with an average age of 9.76 years …

A60: Gait Kinematics Characteristics Of The Overweight And Obese Elderly At Different Walking Speeds, Liu Min

International Journal of Physical Activity and Health

Purpose: Gait is associated with falls. Overweight, obesity and falls are prominent problems affecting the healthy life of the elderly in China. The purpose of this study is to measure the gait kinematic parameters of the overweight and obese elderly using BTS SMART DX Motion Capture System, and to analyze the gait characteristics of the overweight and obese elderly when walking with different speeds, so as to provide reference for the prevention of falls in the overweight and obese elderly. Methods: A total of 42 healthy old women (overweight or obese group: N = 20, age = 67.36±6.11 yrs.; normal …

A70: An Experimental Study Of Sports Vr Equipment On Cultivating High School Students' Interest In Sports, Zhang Rui

International Journal of Physical Activity and Health

Purpose: The incorporation of VR virtual teaching has garnered significant attention, with its applications spanning various disciplines and fields. Notably, in the realm of physical education, VR integration has not only contributed to the enhancement of instructional effectiveness but has also played a pivotal role in fostering the holistic development and personality growth of students. The primary objective of this study is to investigate whether VR virtual teaching can elevate the interest of high school students in the learning of physical education. Methods: Eighty students in high school were recruited and randomly divided into experimental and control groups (40 students …

A67: The Influence Of Physical Exercise On College Students' Psychological Pressure: A Chain Intermediary Effect, Zhenqi Zhou, Zhen Li

International Journal of Physical Activity and Health

Purpose: At this stage, the increasingly fierce social competition makes college students face significant challenges while striving for development opportunities. They will encounter various setbacks and challenges, causing excessive psychological pressure on college students, which will affect their mental health. As an effective means to promote people's physical and mental development, physical exercise plays an important role in the development of college students, It plays a very important role in relieving college students' psychological pressure. Therefore, it is particularly important to study how physical exercise affects college students' psychological pressure and the role of other factors. The purpose of this …

A111: Relationship Between Physical Activity And Mental Toughness: A Cross-Sectional Study Among Chinese College Students, Ke Wang, Jiaju Hu

International Journal of Physical Activity and Health

Purpose: Physical activity has favorable impacts on exercisers' stress levels, psychological distress and anxiety, emotional regulation, and mental wellness. In recent years, the global outbreak of COVID-19 has subtly altered college students' lifestyles. Studies have shown that the physical and mental health of students has deteriorated dramatically, which is alarming. Mental toughness refers to the ability to adapt well in the face of major pressures, setbacks, and adversity in life. The purpose of the present study was to examine variations in mental toughness depending on the intensity, length, and frequency of physical activity. Methods: A total of 3,120 Chinese college …

A127: Difficulties Facing And Coping Strategies Of Physical Education And Health Interdisciplinary Teaching In China, Jie Yang, Liping Xu, Zhihua Yin

International Journal of Physical Activity and Health

Purpose: In response to the national demand for compound talents, “Physical Education (PE) and Health Curriculum (2022 version) for Compulsory Education” proposes to include interdisciplinary teaching in five major courses in China. Due to the lack of course cases for reference, there’s a certain gap between interdisciplinary theory and practice. Therefore, it’s urgent to analyze the difficulties faced by interdisciplinary teaching and find out the coping strategies. Methods: By using keywords such as "interdisciplinary teaching," "PE and health curriculum," and "interdisciplinary," this study collected and studied 39 articles from CNKI, Web of Science, Scopus, and other databases, and analyzed the …

A123: Research Progress And Review Of Key Competencies Of Physical Education Curriculum In China, Liping Xue, Zhihua Yin

International Journal of Physical Activity and Health

Purpose: The introduction of the "Opinions on Comprehensively Deepening Curriculum Reform and Implementing the Fundamental Task of Establishing Virtues and Cultivating People" marked the initiation of comprehensive curriculum reform across all disciplines in our country, with a particular emphasis on key competencies. Among these competencies, those integral to the Physical Education (PE) curriculum have garnered increasing attention from scholars. Building upon this foundation, this paper systematically reviews and analyzes pertinent research on the key competencies within the PE curriculum. The exploration covers the development process, current research hotspots, and future prospects in this field, aiming to serve as a reference …

A143: Influence Of Sports Participation On Females’ Health In The Cold Cities Of Northeast China, Chenxu Zuo

International Journal of Physical Activity and Health

Purpose: People living in the northeastern, cold region of China have been enduring a severe climate. It’s well known that sports participation can promote health. However, there is a lack of research on sports participation among urban females in cold areas of China. Therefore, this study aims to analyze the influence of sports participation on urban females’ health in northeastern China. Methods: A total of 305 urban females (aged 39 years) from Harbin completed an online survey, which asks about demographic information, health status, and sports participation. Health status was assessed by measuring three dimensions of health-related indicators (BMI, chronic …

A153: The Relationships Between Physical Activity And Health-Related Quality Of Life In Parent-Child Dyads With Asd, Yu Song, Bo Shen

International Journal of Physical Activity and Health

Purpose: Researchers have found that the core and combined symptoms of autism spectrum disorder (ASD) negatively influence the health-related quality of life (HRQoL) of autistic children and their parents. Although it is supported that participation in physical activity (PA) can enhance the HRQoL and well-being in general, few studies have addressed the relationship between HRQoL with PA in the population with ASD. This study examines how much leisure-time physical activity participation is correlated to HRQoL in parent-child dyads with ASD. Method: Participants were recruited from two Rehabilitation Centers for neurodevelopmental disability children. Eighty-five ASD children and their parents participated in …

A155: Research On The Influence Of Kinesthetic Intelligence Courses With Industrialized Education On Children's Physical Fitness, Yanli Luo, Xiaoming Gong, Yanqing Chen, Lianglei Xiana, Jie Luo, Kaidi Wu

International Journal of Physical Activity and Health

Purpose: Nowadays, the industrialization of education has led to the shortage of teachers and consequently hindered resource allocation and curriculum optimization. These problems are profound for educators when applying Kinesthetic Intelligence (KI) curriculum for children in early childhood. This paper examines the impact of the current KI course delivery on children’s physical fitness to provide reference for researchers and educators. Methods: Forty-six kids were randomly selected from two intermediate Kindergarten classes and were divided into an experimental group (EG) and a control group (CG). A pre-test of physical fitness was done on eight indices such as stature, weight, throwing, and …

Temporal Patterns Of Cancer Burden In Asia, 1990–2019: A Systematic Examination For The Global Burden Of Disease 2019 Study, Gbd 2019 Asia And All Cancers Collaborators, Ali Artaman

All Works

Background: Cancers represent a challenging public health threat in Asia. This study examines the temporal patterns of incidence, mortality, disability and risk factors of 29 cancers in Asia in the last three decades. Methods: The age, sex and year-wise estimates of incidence, mortality, and disability-adjusted life years (DALYs) of 29 cancers for 49 Asian countries from 1990 through 2019 were generated as a part of the Global Burden of Disease, Injuries and Risk Factors 2019 study. Besides incidence, mortality and DALYs, we also examined the cancer burden measured in terms of DALYs and deaths attributable to risk factors, which had …

Etiology Of Drug-Induced Edema: A Review Of Dihydropyridine, Thiazolidinedione, And Other Medications Causing Edema, Evan S. Sinnathamby, Bretton T. Urban, Robert A. Clark, Logan T. Roberts, Audrey J. De Witt, Danielle M. Wenger, Aya Mouhaffel, Olga Willett, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye, Giustino Varrassi

School of Medicine Faculty Publications

Edema is an accumulation of fluid in the body's tissues that affects millions of Americans yearly. It can affect multiple body parts, for example, the brain or eyes, but often occurs in the periphery, including the feet and legs. Medications, such as dihydropyridine and thiazolidinediones (TZDs), can be the etiology of edema. Edema can develop in association with problems in the vasculature or lymphatic flow. In recent years, a better understanding of these drug-induced mechanisms has been appreciated. Specifically, dihydropyridines can increase hydrostatic pressure and cause selective pre-capillary vessel vasodilation. TZDs can cause edema through increased vascular permeability and increased …

Erratum

Saudi Medical Journal

No abstract provided.

A08: Effects Of Participation In Sports Clubs Activity On College Students’ Perceived Stress And Well-Being, Zhonghui He, Hui Xie, Xiaoyuan Zhang

International Journal of Physical Activity and Health

Purpose: Mandated social distancing to prevent the spread of COVID-19 pandemic has brought more anxiety and stress to college students. The primary purpose of this study was to examine whether college students' participation in sports club activities can reduce anxiety and stress. The secondary purpose was to compare the effects of different types of sport clubs. Methods: The sample consisted of 242 college students (143 males; mean age=22.63 years old) in an academically prestigious university. They were voluntarily enrolled in either team sports clubs, such as volleyball, football, baseball, and softball, etc. (n=96), or individual sports clubs, such as squash, …

A22: Investigation On The Status Quo Of Extracurricular Sports Activities In Primary And Secondary Schools Of Yan 'An City Before And After Covid-19, Zhigang Xue, Hujiie Ran, Xiaoyan Yang

International Journal of Physical Activity and Health

Purpose: Since the outbreak of the Novel coronavirus pneumonia (COVID-19) in December 2019, the General Office of the National Health Commission has put forward the epidemic prevention requirements, such as minimizing unnecessary travel. In December 2022, The State Council issued the latest epidemic prevention policy, marking the country's three-year epidemic control policy. In this case, this paper conducted a comparative study on the number of participants, cognition, attitude, motivation, frequency, time and organization of extracurricular sports activities in primary and secondary schools of Yan 'an City before and after the COVID-19 outbreak, and analyzed and studied the data obtained. Methods: …

A37: An Experimental Study On The Effect Of Traditional Old Games On Fundamental Motor Skills Of Children Aged 7-8, Qian Mao, Xiaozan Wang, Qinping Xu

International Journal of Physical Activity and Health

Purpose: Fundamental Motor Skills as the "cornerstone" of children's healthy growth, its firmness determines children's future development. However, with the progress of science and technology and the convenience of modern life, the physical activity level of children has decreased significantly, and the development of basic motor skills has increased rapidly. Therefore, in October 2020, it was clearly proposed to gradually improve the school physical education teaching model of "health knowledge + basic sports skills + special sports skills". At the same time, as the wisdom crystallization of human development, traditional old games are increasingly replaced by the ever-changing electronic games …