Medicine and Health Sciences Commons^™

Geranylgeraniol (Ggoh), Incorporated Into A Bone Cement Pellet Promotes Osteoclast Function And Healing In A Model Of Medication-Related Osteonecrosis Of The Jaw, George J Feldman, David Young, Theresa Freeman, Lauren Israel, Daniel Taub, Robert Diecidue

Department of Oral and Maxillofacial Surgery Faculty Papers

INTRODUCTION: There is no cause -based treatment for Medication-Related Osteonecrosis of the Jaw (MRONJ). MRONJ is a morbid condition including exposed, infected bone and mandibular fractures in osteoporotic individuals and metastatic cancers patients treated with nitrogen containing bisphosphonates (NBP). NBPs inhibit farnesyl diphosphate synthase (FDPS) in the mevalonate pathway, depriving osteoclasts and other bone cells of small GTPases necessary for their function and survival. We test the hypothesis that geranylgeraniol (GGOH),a metabolite downstream of FDPS, when incorporated into a bone cement pellet, enhances osteoclast function and promotes local bone healing in

METHODS:

RESULTS: The release of GGOH from bone cement …

Combining Static And Dynamic Myofascial Dry Cupping Therapy To Improve Local And Regional Symptoms In Individuals With Low Back Pain: A Case Series, Brent Harper, Alana Dudek, Julianne Williamson, Alex Siyufy, Jo Armour Smith

Physical Therapy Faculty Articles and Research

Introduction

Chronic low back pain is a common musculoskeletal healthcare presentation with an expense of over $100 billion annually. The clinical effect of myofascial cupping on pain and function is not clear, especially when different cupping techniques are combined. The purpose of this case series was to explore changes in pain and function following local static and distal dynamic myofascial dry cupping treatments in patients with chronic low back pain.

Case Descriptions

Three adults from the general population received three ten-minute treatment sessions, 48 hours between each session, of static dry cupping to the low back followed by dynamic myofascial …

The Impact Of Implementation Of A Trauma Care Protocol On The Mortality Of Polytrauma Patients At A Tertiary Centre In Kenya: Case Control Study, Charbel Ngigi Kamau

Master of Medicine in General Surgery

Introduction: This study set out to evaluate how adopting a standardized trauma care protocol, based on the Advanced Trauma Life Support (ATLS) program by the American College of Surgeons, impacts the 30-day outcomes of severe trauma patients with Injury Severity Scores (ISS) higher than 15.

Objectives: To determine the association between Advanced Trauma Life Support (ATLS) trauma care protocol use (Introduction) and mortality within 30 days among polytrauma patients at AKUH, N between 2010 and 2022.

Methods: A total of 184 patients, evenly distributed into two groups, were included in the study, all diagnosed with polytrauma with an ISS score …

Cerebral Oxygenation Monitoring For Early Detection Of Subarachnoid Haemorrhage In Infratentorial Arteriovenous Malformation Undergoing Embolisation: A Case Study, Kunal K Sharma, Prachi Sharma, Rohini M Surve

Faculty, Staff and Student Publications

No abstract provided.

Impact Of Neighborhood Disadvantage On Tumor Biology And Breast Cancer Survival, Neha Goel, Alexandra Hernandez, Deukwoo Kwon, Michael H Antoni, Steve Cole

Faculty, Staff and Student Publications

Objective: The aim of this study was to evaluate the association between neighborhood disadvantage and Oncotype DX score, a surrogate for tumor biology, among a national cohort.

Background: Women living in disadvantaged neighborhoods have shorter breast cancer (BC) survival, even after accounting for individual-level, tumor, and treatment characteristics. This suggests unaccounted social and biological mechanisms by which neighborhood disadvantage may impact BC survival.

Methods: This cross-sectional study included stage I and II, ER + /HER2 - BC patients with Oncotype DX score data from the National Cancer Database (NCDB) from 2004 to 2019. Multivariate regression models tested the association of …

Exploring Lived Experiences Of Gunshot Wound Survivors: A Key To Ethnographically Informed Public Health Interventions For Curbing Firearm Violence, Paul Webb, Jack Jimenez, Andre Elder, Alfredo Ortega Cotte, Apoorva Ravichandran, Emily Holbrook, Roberta Baer, Jason Wilson

College of Medicine & TGH Faculty Publications

Intro: The high rates of gun violence in the United States are a recognized public health concern with increased attention since the 1990′s. The predominant studies used in gun violence research have been epidemiological approaches and quantitative analyses. This study, instead, examines lived experiences of gunshot wound survivors to better understand their situations. This study also compared the different census categories and their types of gunshot wound injuries. Ethnographic informed analyses may inform public health interventions to decrease firearm injuries. Methods: Data was collected through a series of semi-structured interviews at the emergency department of an urban, Level-1, academic trauma …

Prevalence Of Dengue Virus Among Healthy Blood Donors In Mombasa County, Kenya, Festus Mulakoli, George Gachara, Eric Ndombi, Samoel Khamadi

School of Nursing & Midwifery, East Africa

Introduction: Dengue fever (DF) is a viral infection caused by a flavivirus called Dengue virus. The virus has four known serotypes (named DENV 1-4) that circulate between humans and Aedes mosquitoes throughout the tropical region of the world. The virus is transmitted primarily by the bite of an infected Aedes aegypti or, to a lesser extent, Aedes albopictus. Current evidence from published case studies shows that blood transfusions can transmit Dengue infection in hyperendemic regions in the tropics. It is important to note that 75% of people infected with DENV show no symptoms. Therefore, an infected individual could …

Comparing Ait And Eft In The Reduction Of Negative Emotions Associated With A Past Memory: A Randomized Controlled Trial, Gregory Brown, Kavita Batra, Raveena Bakhru, Andrew Han, Arianna Palermini, Robert Sottile, Sherine Khanbijian

Psychiatry & Behavioral Health Faculty Research

The field of Energy Psychology [EP] has amassed several hundred published research studies over its thirty year history which includes systematic reviews and meta-analyses. These have consistently demonstrated significant effect sizes equivalent to EMDR and trauma based CBT (Church et al., 2022, and Feinstein, 2021). Energy Psychology Techniques typically include an energetic component, an emotional component, a somatic component, focus upon a specific memory, and secondary cognitive shifts. Memory Reconsolidation may be primary for effect. Emotional Freedom Technique [EFT] is the most studied EP technique to date, and considered an evidenced based treatment for a number of conditions. Advanced Integrative …

Let Your Nicu Nurses Put Your Mind At Ease, Victoria Carter Rn, Charity Mokaya Bsn, Rn, Caroline Spugnardi Bsn, Rn, Kiauna Graham Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Newborn Fall Prevention, Ashlynn Ashmore Rn, Omotola Oduwole Bsn, Rn, Victoria Wieruszewski Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Activities Of Daily Living Sheet For Behavioral Health Hold Patients In The Emergency Room Setting, Emma Rokosky Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Increasing Confidence In New Graduate Nurses On Giving Report To Icu/Llm, Kyra Bruns Bsn, Rn, Melissa Crenko Bsn, Rn, Catie Kittle Bsn, Rn, Courtney Roberson Bsn, Rn, Tyra Santos Bsn, Rn, Kelsea Snyder Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Time To Time Out In The Operating Room, Nicole West Bsn, Rn, Brett Swire Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Use Of Qr Codes To Access Frequently Used Protocols, Vannesa Bunsee Rn, Olivia Frawley Adn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

90-90 Gulp: Stop Aspiration, Allison Davis Bsn. Rn, Kristine Griffith Adn, Rn, Charlotte Cherry Adn, Rn, Jacquelin Tankersley Bsn, Rn, Debra Rose Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Nonpharmacological Pain Interventions For Labor, Brielle Artis Bsn, Rn, Kaylee Conrad Adn, Rn, Nicole Krepps Bsn, Rn, Macie Mcgaughran Adn, Rn, Mariah Moorehouse Adn, Rn, Kristine Ulshafer Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Making Cities Mental Health Friendly For Adolescents And Young Adults, Pamela Y. Collins, Moitreyee Sinha, Tessa Concepcion, George Patton, Thaisa Way, Layla Mccay, Augustina Mensa-Kwao, Helen Herrman, Evelyne De Leeuw, Lukoye Atwoli

Brain and Mind Institute

Urban life shapes the mental health of city dwellers, and although cities provide access to health, education and economic gain, urban environments are often detrimental to mental health1,2. Increasing urbanization over the next three decades will be accompanied by a growing population of children and adolescents living in cities3. Shaping the aspects of urban life that influence youth mental health could have an enormous impact on adolescent well-being and adult trajectories4. We invited a multidisciplinary, global group of researchers, practitioners, advocates and young people to complete sequential surveys to identify and prioritize the characteristics of a mental health-friendly city for …

Correction: Prevalence Of Lifestyle Cardiovascular Risk Factors And Estimated Framingham 10-Year Risk Scores Of Adults With Psychotic Disorders Compared To Controls At A Referral Hospital In Eldoret, Kenya., Edith Kwobah, Nastassja Koen, Ann Mwangi, Lukoye Atwoli, Dan Stein

Brain and Mind Institute

No abstract provided.

02.26.2024 Orsp Connect, Liz Williamson

ORED Newsletter

No abstract provided.

02.12.2024 Orsp Connect, Liz Williamson

ORED Newsletter

I-RED Program, Training on Python and R available, Christy White spotlight, UM Researchers Find Turmeric, Thyme Oils Repel Fire Ants

02.05.2024 Orsp Connect, Liz Williamson

ORED Newsletter

NSF Revises PAPPG, Mickey McLaurin spotlight, ORSP Training Available: NSF Project Summary, Inclusive Entrepreneurship Event

Himmelfarb Library Liaison Letter - February 2024, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Firearm-Related Traumatic Brain Injuries In Adults: A Scoping Review, Gabriel Reyes, Ron Gadot, Lara Ouellette, Shervin H Nouri, Shankar P Gopinath, Akash J Patel

Library Staff Publications

BACKGROUND AND OBJECTIVES: Firearm-related traumatic brain injury (TBI) has emerged as a significant public health issue in the United States, coinciding with a rapid increase in gun-related deaths. This scoping review aims to update our understanding of firearm-related TBI in adult populations.

METHODS: A comprehensive search of 6 online databases yielded 22 studies that met the inclusion criteria. The reviewed studies predominantly focused on young adult men who were victims of assault, although other vulnerable populations were also affected.

RESULTS: Key factors in evaluating patients with firearm-related TBI included low Glasgow Coma Scale scores, central nervous system involvement, hypotension, and …

The Interrai Ed Tool For Screening Older Patients In The Emergency Department: “What Am I Supposed To Do With This?”, Michael L. Malone

Journal of Geriatric Emergency Medicine

not applicable for Collective Wisdom/ Editorial per JGEM author guidelines.

Predictive Algorithm For Surgery Recommendation In Thoracolumbar Burst Fractures Without Neurological Deficits, Charlotte Dandurand, Nader Fallah, Cumhur F. Öner, Richard J. Bransford, Klaus Schnake, Alex R. Vaccaro, Lorin M. Benneker, Emiliano Vialle, Gregory D. Schroeder, Shanmuganathan Rajasekaran, Mohammad El-Skarkawi, Rishi M. Kanna, Mohamed Aly, Martin Holas, Jose A. Canseco, Sander Muijs, Eugen Cezar Popescu, Jin Wee Tee, Gaston Camino-Willhuber, Andrei Fernandes Joaquim, Ory Keynan, Harvinder Singh Chhabra, Sebastian Bigdon, Ulrich Spiegel, Marcel F. Dvorak

Department of Orthopaedic Surgery Faculty Papers

STUDY DESIGN: Predictive algorithm via decision tree.

OBJECTIVES: Artificial intelligence (AI) remain an emerging field and have not previously been used to guide therapeutic decision making in thoracolumbar burst fractures. Building such models may reduce the variability in treatment recommendations. The goal of this study was to build a mathematical prediction rule based upon radiographic variables to guide treatment decisions.

METHODS: Twenty-two surgeons from the AO Knowledge Forum Trauma reviewed 183 cases from the Spine TL A3/A4 prospective study (classification, degree of certainty of posterior ligamentous complex (PLC) injury, use of M1 modifier, degree of comminution, treatment recommendation). Reviewers' regions …

Metabolic Syndrome And Obesity Among Marginalised School-Going Adolescents In Karachi, Pakistan: A Cross-Sectional Study, Hina Sharif, Sana Sharif Sheikh, Tooba Seemi, Hira Naeem, Unab Khan, Shah Sumaya Jan

Department of Family Medicine

Background: Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors which increase the likelihood of developing type 2 diabetes and cardiovascular disease. This study aimed to determine the prevalence of MetS among adolescents living in slums aged 11-18 years in Karachi, Pakistan.
Methods: Data were collected from 689 adolescents attending five schools in two slum areas of Karachi, Korangi and Baldia, from February 2023 to March 2023. Measurements of weight, height, waist circumference, and blood pressure were obtained from the study participants. Blood samples were collected to assess fasting plasma glucose, High density lipoprotein HDL-cholesterol, and triglyceride levels as …

Diagnostic Accuracy Of Intraoperative Frozen Section For Margin Evaluation Of Oral Cavity Squamous Cell Carcinoma, Javaria P. Ali, Bakhtawar Allauddin Mallick, Khushbakht Rashid, Umair Arshad Malik, Atif Ali Hashmi, Shamail Zia, Muhammad Irfan, Amir Khan, Naveen Faridi

Section of Internal Medicine

Objectives: Intraoperative frozen-section evaluation is a valuable technique for detecting positive margins intraoperatively for oral squamous cell carcinoma. We conducted this study to determine the diagnostic accuracy of frozen section in detecting margin status and the effect of tumor grade and stage on diagnostic accuracy.
Results: A total of 251 biopsy-proven cases of oral squamous cell carcinoma were included in this study. The tissue specimen resected during surgery was sent to the laboratory for frozen section evaluation. The frozen section results were then compared with the permanent section results to determine the sensitivity, specificity, positive predictive value, negative predictive value, …

Quantifying Turning Tasks With Wearable Sensors: A Reliability Assessment, Angela R. Weston, Prokopios Antonellis, Peter C. Fino, Carrie W. Hoppes, Mark E. Lester, Margaret M. Weightman, Leland E. Dibble, Laurie A. King

Physical Therapy Faculty Publications

Objective

The aim of this study was to establish the test–retest reliability of metrics obtained from wearable inertial sensors that reflect turning performance during tasks designed to imitate various turns in daily activity.

Methods

Seventy-one adults who were healthy completed 3 turning tasks: a 1-minute walk along a 6-m walkway, a modified Illinois Agility Test (mIAT), and a complex turning course (CTC). Peak axial turning and rotational velocity (yaw angular velocity) were extracted from wearable inertial sensors on the head, trunk, and lumbar spine. ICCs were established to assess the test–retest reliability of average peak turning speed for each task. …

Deep Learning-Based H-Score Quantification Of Immunohistochemistry-Stained Images, Zhuoyu Wen, Danni Luo, Shidan Wang, Ruichen Rong, Bret M Evers, Liwei Jia, Yisheng Fang, Elena V Daoud, Shengjie Yang, Zifan Gu, Emily N Arner, Cheryl M Lewis, Luisa M Solis Soto, Junya Fujimoto, Carmen Behrens, Ignacio I Wistuba, Donghan M Yang, Rolf A Brekken, Kathryn A O'Donnell, Yang Xie, Guanghua Xiao

Faculty, Staff and Student Publications

Immunohistochemistry (IHC) is a well-established and commonly used staining method for clinical diagnosis and biomedical research. In most IHC images, the target protein is conjugated with a specific antibody and stained using diaminobenzidine (DAB), resulting in a brown coloration, whereas hematoxylin serves as a blue counterstain for cell nuclei. The protein expression level is quantified through the H-score, calculated from DAB staining intensity within the target cell region. Traditionally, this process requires evaluation by 2 expert pathologists, which is both time consuming and subjective. To enhance the efficiency and accuracy of this process, we have developed an automatic algorithm for …

Immune Evasion, Infectivity, And Fusogenicity Of Sars-Cov-2 Ba286 And Flip Variants, Panke Qu, Kai Xu, Julia N Faraone, Negin Goodarzi, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Jeffrey C Horowitz, Rama K Mallampalli, Linda J Saif, Eugene M Oltz, Daniel Jones, Richard J Gumina, Shan-Lu Liu

Faculty, Staff and Student Publications

Evolution of SARS-CoV-2 requires the reassessment of current vaccine measures. Here, we characterized BA.2.86 and XBB-derived variant FLip by investigating their neutralization alongside D614G, BA.1, BA.2, BA.4/5, XBB.1.5, and EG.5.1 by sera from 3-dose-vaccinated and bivalent-vaccinated healthcare workers, XBB.1.5-wave-infected first responders, and monoclonal antibody (mAb) S309. We assessed the biology of the variant spikes by measuring viral infectivity and membrane fusogenicity. BA.2.86 is less immune evasive compared to FLip and other XBB variants, consistent with antigenic distances. Importantly, distinct from XBB variants, mAb S309 was unable to neutralize BA.2.86, likely due to a D339H mutation based on modeling. BA.2.86 had …