Medicine and Health Sciences Commons^™

Effects Of Biodensity Training On Lipid Profile In Young Women: A Pilot Study, Tristan R. Issa, Rosalinda Escobar-Prado, Auguste Torres, Maurice Cruz, Carolina Garcia, Braulio Cazarez, Nathaniel Bodell, Zhaojing Chen

International Journal of Exercise Science: Conference Proceedings

bioDensity training is a novel type of resistance exercise, which includes four basic isometric exercises in a subsequent fashion: chest press, leg press, core pull, and vertical lift. Although it’s primarily targeted on bone strength, a previous study showed that it improved HbA1C, fasting glucose, HDL, LDL and total cholesterol in elderly patients with Type 2 diabetes (Zheng et al. 2019). To date, the research on bioDensity training is limited, and its effects on a healthy population are unknown. PURPOSE: We are looking to examine the effects of 12-week bioDensity training on lipid profiles in young women. METHODS: …

Vascular Alteration With Postural Change As Observed Using The Anterior Tibial Artery: A Pilot Study, Camille L. Nguyen, Kassity D. Clay, Pat R. Vehrs Facsm, Aaron W. Johnson

International Journal of Exercise Science: Conference Proceedings

Plantar fasciopathy and plantar fasciosis are common lower extremity conditions. Vascular health is an important aspect of plantar fascia health. Footwear choices are thought to influence lower extremity vascular flow, but how the anterior tibial artery is affected by purely postural changes over time is unknown. PURPOSE: To observe the anterior tibial artery vascular alterations over a ten-minute period after transitioning from a sitting to a standing position while barefoot. METHODS: Nine participants (age= 23.8yrs ±2.5, height= 176.0cm ±8.0, weight= 69.8kg ±10.2) were recruited from Brigham Young University for a single 30-minute visit. The participants had no previous …

Examining Stroke Volume Changes During Exercise In Healthy Young Adults, Thomas Clark, Anthony Ciccone, Zane Evans, Keslee Stephenson, Chandler Rose, Carlos Goff, Shane Draper, Nicolas Clark

International Journal of Exercise Science: Conference Proceedings

Cardiac output is determined by the combination of heart rate and stroke volume. While heart rate is primarily influenced by cardiac autonomic input, stroke volume's behavior is more intricate due to the interplay between myocardial response to stretch (Frank-Starling law) and adrenergic changes in contractility. No consensus exist on its behavior during exercise despite extensive data. PURPOSE: The aim of this study was to assess how normalized stroke volume scores (SV) change in young, healthy adult males during a graded exercise test to exhaustion (GXT). METHODS: Participants (n=20; age=22.9±2.4; BMI=23.7±2.4) were instructed to abstain from engaging in vigorous …

Validation Of The Work Capacity Test For Wildland Firefighters, Cassandra Mcfarland, Zachary Hofheins, Janna Thompson, Lexi Sorensen, Andrew Creer, Shane Draper

International Journal of Exercise Science: Conference Proceedings

Much of the reported Wildland Firefighter (WLFF) data use prediction equations which tend to underestimate oxygen consumption (VO2) during load carriage. As a result, the reported metabolic and oxygen consumption data values may actually be higher creating a larger gap between the US Forest Service arduous pack test (APT) and true occupational demand. The reported data regarding the energy cost upon which the APT has been based (22.5 mL/kg/min of oxygen) has overwhelmingly been tested in current WLFF with few participants. However, no studies have recently examined the current energy expenditure of men and women who want to qualify to …

Health & Wellness Team- Esports At Csudh, Dr. Monique Turner, Alyse Freeman

International Journal of Exercise Science: Conference Proceedings

The goal of the Health and Wellness Team within Esports at California State University, Dominguez Hills (CSUDH) is to share the skill sets we have learned in our professional careers and apply them to our student eAthletes, so they are equipped with the mental, physical, nutritional, and socio-emotional resources, education, and support they need to thrive. PURPOSE: The Health and Wellness Team (HWT) within Esports at CSUDH and the student club organization aligns with the five pillars of the academy: Academics & Research, Career Development, Community, Competition, and Entertainment. The HWT can reach our student population through mental, …

The Effects Of Initiating A Fast With A High Fat Or A High Carbohydrate Shake On Mcp-1, Tnf-Alpha, And Il-6 Levels, Gage Jensen, Bruce Bailey

International Journal of Exercise Science: Conference Proceedings

Alzheimer’s disease, stroke, heart disease, and diabetes all rank among the leading causes of death in the United States, particularly among the elderly. While many behavioral and pharmacological strategies have been employed to reduce the incidence of these conditions, increasing evidence indicates that entering a mild to moderate state of ketosis through fasting or a very low carbohydrate diet can improve the prognosis for these conditions. PURPOSE: The purpose of this study was to evaluate the extent to which a high carbohydrate low fat (HC/LF) pre-fast meal altered MCP-1, TNF-alpha and IL-6 compared to a low carbohydrate high-fat pre-fast …

Testing The Reliability Of A Modified Spider Test For Pickleball, Margaret Falknor, Matt Ritchey, George Beckham, Eric Martin

International Journal of Exercise Science: Conference Proceedings

The spider test has been used to assess change of direction performance in tennis players. Though similar in some aspects to tennis, pickleball is not as well studied. Therefore, we have modified the spider test from tennis for the pickleball court. PURPOSE: Our objective is to determine the reliability of the modified test and the number of trials needed to obtain consistent performance accounting for learning and fatigue effects. METHODS: Participants included 16 adults between the ages of 19 and 78. Sex of participants included 5 females and 11 males. Participants were asked to perform a standardized dynamic …

Effects Of High Heeled Gait On Knee Joint Mechanics, James Baldonado, Errin Abosolo, Harry Montoya, Zander Sadorra, Christie R. O'Hara

International Journal of Exercise Science: Conference Proceedings

Numerous women wear high heeled shoes, whether it be a professional attire, part of an outfit for a ballroom gala, or just casual day to day wear. Often, the high heel of choice in these situations is the stiletto. These shoes adversely affect natural gait and have the potential to alter joint mechanics in the knee during gait. PURPOSE: This study is designed to analyze the impacts of wearing high heels, and if it puts the user at a higher risk of a degenerative condition with repeated use. We hypothesized that all of our dependent variables would see a …

Risk Factors For Eating Disorders Among Uae University Students: The Role Of Family Dysfunction And Attachment Styles, Aya Jaber Dandachi

Thesis/ Dissertation Defenses

A topic that is highly researched nowadays in the UAE is eating disorders (EDs). They are characterized by a persistent disturbance of eating-related behaviors that can result in altered consumption of food. Literature has suggested that there are several factors that can make an individual vulnerable to EDs, including family dynamics and attachment styles. This thesis is an attempt to examine the impact of family dynamics and early attachment on mental health wellbeing. The main objective is to examine how family dysfunctional concepts (rigid, chaotic, enmeshed, and disengaged) and attachment styles (close, dependent, and anxious) can be potential risk factors …

The Association Between Attachment And Binge Eating Behaviours: Examination Of The Mediational Role Of Emotional Dysregulation In The Arab Region, Diala Kassab

Thesis/ Dissertation Defenses

Many factors are said to affect binge eating behaviours, one of these factors is the individual’s attachment style. Attachment styles is the early relationship that shape a child's ideas and expectations about themselves and the availability of other people. This can be mediated by the ability to effectively respond and manage emotional experiences. This thesis aimed to examine the role of emotional dysregulation on attachments styles and binge eating behaviours in the Arab region. A sample of 326 Arab university students, predominantly Emirati and Lebanese, were recruited using convenience sampling and snowball sampling technique. Participants were asked to complete a …

No “Jitters” But No Energy From A Commercially Available Energy Drink., Jose Antonio, Jason M. Curtis

Journal for Sports Neuroscience

Abstract

Introduction: The purpose of this study was to determine the effects of an energy drink (JOCKO GO) on mood, sustained attention/reaction time, and hand steadiness.

Methods: A total of 29 active men (n = 9) and women (n=20) (mean ± SD: age 22 ± 5 yr.; height 168±8 cm; body mass 68.2 ± 12.8 kg; lean body mass 51.9 ± 15.0 kg; fat mass 15.4 ± 6.8 kg; percent body fat 22.6 ± 8.9%; total body water 38.6 ± 8.6 liters) completed this randomized, crossover, counterbalanced trial. Each subject consumed either one can (355 ml) of the energy …

Knowledge, Attitude, And Perception Of The General Public Towards The Impact Of Hemoglobinopathies On Pregnancy Outcomes: A Questionnaire-Based Study, Kumud Dhankhar, Kiran Dahiya, Shobha Chikkavaddaragudi Ramachandra, Akila Prashant

International Journal of Health and Allied Sciences

Background: Knowledge about hemoglobinopathies in the general public is unsatisfactory. Many couples are unaware of their carrier status and a child can be born with unexpected, serious hemoglobinopathies. Willingness to participate in screening programs can substantially help in bringing down the birth of children affected with hemoglobinopathies. To understand the knowledge, attitude, and perception of the general public on various hemoglobinopathies and their pregnancy outcomes we performed a questionnaire-based descriptive survey. Methods: After obtaining approval from the institutional ethics committee and validation by an expert panel we circulated a Google form consisting of 21 questions via WhatsApp which was made …

Nutritional And Health Benefits Of Singhara – A Review Article., Soma Basu, A.J. Hemamalini

International Journal of Health and Allied Sciences

Trapa Natans commonly known as Singhara or Paniphal in India. It grows throughout the East of India. Dried water chestnuts can be ground into flour to make a kind of porridge. Young nuts can be eaten raw with its greenish skin removed. The Singhara shell and core are rich in starch, dietary fiber, essential amino acids, certain types of phenols and minerals and have demonstrated various biological activities, including anticancer and antioxidant properties. Singhara contains several antioxidants that can reduce the risk of multiple chronic diseases and conditions.

The Therapeutic Potential Of Nelumbo Nucifera: A Comprehensive Review Of Its Phytochemistry And Medicinal Properties, Sparsh Bhat, Suresh Joghee, Meenakshi S. Iyer

International Journal of Health and Allied Sciences

Nelumbo nucifera generally known as ‘sacred lotus’ is a plant with high medicinal value in traditional medicine system especially in Chinese medicine system which is having a wide distribution worldwide in Asian, Western European, American and Australian continent. All the parts of the plant have different medicinal value, as their extract contains various valuable chemical constituents which yield desired remedial effects against many diseases. The plant is used traditionally more compared to its commercial usage. It has also been used for dental and skin care products in many herbal formulations. In this review, data about its general description, its distribution, …

“Cost-Effective Markers To Identify Metabolically Healthy/Unhealthy Individuals And Their Future Risk For Cardiovascular Disorders”, Shobha C Ramachandra, Akila Prashant, Akshitha Shivanna, Ananth Koushik Bhujanga, Syeda Meherunnisa, Prashant Vishwanath

International Journal of Health and Allied Sciences

Background: With the rising prevalence of metabolically healthy obese, it becomes essential to identify markers to differentiate them from metabolically unhealthy obese and their future risk for cardiovascular disorders (CVD). The study aims to identify suitable markers for risk stratification of metabolically healthy/unhealthy individuals and their risk for CVD. Method: Total 84 individuals aged 18-60 years of age without any comorbidities were enrolled. Their demographic details along with anthropometric measurements were noted. The biochemical parameters like fasting glucose, insulin, lipid profile, and serum adipokines were estimated. Insulin resistance (IR) markers and atherogenic indices were calculated. The data were analyzed on …

Risk Assessment In Discharge Process Using Pfmea Tool In A Multi-Specialty Hospital, Shalini ., Kanakavalli K. Kundury, H. Basavana Gowdappa

International Journal of Health and Allied Sciences

Introduction: ‘Quality’ is an inseparable component of healthcare. It focuses not only on care parameters but also in identifying the potential failures/ risks associated with the care process; thereby addressing them pro-actively before the occurrence of the loss. There are several quality tools available such as Process Failure Mode Effect Analysis (PFMEA) that helps in analyzing a process for identification of possible failures. This helps to find ways to avoid the occurrence of the failure or have a strategy to eliminate or minimize the risk. Thus, the current study was undertaken on identifying the risks involved in the discharge process …

The Increasing Vulnerability Of African Youths To Mental Health Disorders: Risk Factors, Advocacy And Recommendations, Fidelis Ikechukwu Edeh, Abdullateef Ridwanullah Olamide

International Journal of Health and Allied Sciences

There is no abstract for this article type.

Impacts Of Hydrophobic Mismatch On Antimicrobial Peptide Efficacy And Bilayer Permeabilization., Steven Meier, Zachary M Ridgway, Angela L Picciano, Gregory A. Caputo

College of Science & Mathematics Departmental Research

Antimicrobial resistance continues to be a major threat to world health, with the continued emergence of resistant bacterial strains. Antimicrobial peptides have emerged as an attractive option for the development of novel antimicrobial compounds in part due to their ubiquity in nature and the general lack of resistance development to this class of molecules. In this work, we analyzed the antimicrobial peptide C18G and several truncated forms for efficacy and the underlying mechanistic effects of the sequence truncation. The peptides were screened for antimicrobial efficacy against several standard laboratory strains, and further analyzed using fluorescence spectroscopy to evaluate binding to …

Binding Interactions Of Biologically Relevant Molecules Studied Using Surface-Modified And Nanostructured Surfaces, Palak Sondhi

Dissertations

This research focuses on the field of surface nanobioscience, wherein different nanosurfaces that will be used as working electrodes in the electrochemical cell are manufactured and surface modified to understand the critical binding interactions between biologically significant molecules like proteins, carbohydrates, small drug molecules, and glycoproteins. This research is essential if we are to determine whether a synthetic molecule can serve as a therapeutic candidate or diagnose a disease in its early stages. In order to fully understand the binding interactions, the study begins with defining some of the fundamental concepts, principles, and analytical tools for biosensing.

Afterwards, we addressed …

Circulating Tumor Dna Monitoring On Chemo-Immunotherapy For Risk Stratification In Advanced Non-Small Cell Lung Cancer, Bruna Pellini, Russell W Madison, Merrida A Childress, Shoshana T Miller, Ole Gjoerup, Jason Cheng, Richard S P Huang, Michael Krainock, Pratyush Gupta, Wei Zou, David S Shames, Solomon Moshkevich, Marcus Ballinger, Minetta C Liu, Amanda Young, Minu K Srivastava, Geoffrey R Oxnard, Mark A Socinski

Faculty, Staff and Student Publications

PURPOSE: Chemoimmunotherapy (chemoIO) is a prevalent first-line treatment for advanced driver-negative non-small cell lung cancer (NSCLC), with maintenance therapy given after induction. However, there is significant clinical variability in the duration, dosing, and timing of maintenance therapy after induction chemoIO. We used circulating tumor DNA (ctDNA) monitoring to inform outcomes in patients with advanced NSCLC receiving chemoIO.

EXPERIMENTAL DESIGN: This retrospective study included 221 patients from a phase III trial of atezolizumab+carboplatin+nab-paclitaxel versus carboplatin+nab-paclitaxel in squamous NSCLC (IMpower131). ctDNA monitoring used the FoundationOne Tracker involving comprehensive genomic profiling of pretreatment tumor tissue, variant selection using an algorithm to exclude nontumor …

Mirna As Systemic Mediators For Environmentally Persistent Free Radical-Induced Cardiovascular Dysfunction, Ankit Aryal

LSU Doctoral Dissertations

Air pollution is consistently linked with elevations in cardiovascular disease (CVD) and its mortality. Particulate matter (PM) is a pivotal factor in air pollution-associated CVD. PM containing environmentally persistent free radicals (EPFR) forms from the incomplete combustion of organic wastes. These products adhere to particulate matter carrying redox-active transition metals on its surface. To enable systematic research of the health impacts of EPFR, our colleagues developed a combustion method to produce EPFR-containing PM that closely resemble urban PM and validated their use for typical laboratory settings. We exposed mice to laboratory generated EPFR through whole-body inhalation and investigated their dose-dependent …

Sexual Minorities Are More Depressed And Anxious Than Heterosexuals In The U.S., Especially Among Women, Joshua Grove

Population Health Research Brief Series

Depression and anxiety are harmful to health. People who suffer from depression or anxiety are more likely to engage in risky health behaviors and have higher risk of various chronic diseases and premature death. This data slice uses data from the 2022 National Wellbeing Survey to explore the prevalence of depression and anxiety among U.S. adults ages 18-64. The results show that sexual minority adults are significantly more likely than those who identify as heterosexual to suffer from depression and anxiety, and differences in prevalence rates between sexual minority and heterosexual women are larger than the differences between men.

Impact Of Climate Change On Surgery: A Scoping Review To Define Existing Knowledge And Identify Gaps, Tina Bharani, Rebecca Achey, Harris Jamal, Alexis Cherry, Malcolm K. Robinson, Guy J. Maddern, Deirdre K. Tobias, Divyansh Agarwal

Department of Surgery Faculty Papers

With climate change accelerated at a worrisome rate, global warming also will have implications for surgery and surgical practice. The goal of this current study was to systematically survey the literature and better understand how climate change has affected surgical disease burden, surgical care delivery, and surgical outcomes. We performed a comprehensive scoping review, screening 3334 unique citations from three databases – 1766 from Embase, 1329 from Pubmed and 239 from Scopus – to identify studies that had associated climate change with surgery. After systematic searching, quality appraisal, and data extraction, we synthesized findings from qualitative and quantitative studies. Twenty-six …

Novel Clinical Trial Designs With Dose Optimization To Improve Long-Term Outcomes, Peter F Thall, Yong Zang, Andrew G Chapple, Ying Yuan, Ruitao Lin, David Marin, Pavlos Msaouel

Faculty, Staff and Student Publications

Conventional designs for choosing a dose for a new therapy may select doses that are unsafe or ineffective and fail to optimize progression-free survival time, overall survival time, or response/remission duration. We explain and illustrate limitations of conventional dose-finding designs and make four recommendations to address these problems. When feasible, a dose-finding design should account for long-term outcomes, include screening rules that drop unsafe or ineffective doses, enroll an adequate sample size, and randomize patients among doses. As illustrations, we review three designs that include one or more of these features. The first illustration is a trial that randomized patients …

Mechanisms And Treatment Options For Hyperthyroid-Induced Osteoporosis: A Narrative Review, Robert M. Branstetter 4th, Rahib K. Islam, Collin A. Toups, Amanda N. Parra, Zachary Lee, Shahab Ahmadzadeh, Giustino Varrassi, Sahar Shekoohi, Alan D. Kaye

School of Medicine Faculty Publications

Normal thyroid hormone levels are crucial for the homeostasis of many metabolic cycles and processes throughout the human body. Thyroid dysfunction, such as thyrotoxicosis, can result from many different etiologies, including Graves' disease (GD), toxic multinodular goiter (MNG), and toxic adenoma. These hyperthyroid disease states can cause devastating complications and disease, including the disruption of the bone remodeling cycle and skeletal development, which can result in osteoporosis. Osteoporosis is characterized by a decrease in bone mineral density and a propensity for fragility fractures. In addition to patients with overt hyperthyroidism, studies have provided evidence of other high-risk patient demographics, such …

Effectiveness Of A Bivalent Mrna Vaccine Dose Against Symptomatic Sars-Cov-2 Infection Among U.S. Healthcare Personnel, September 2022–May 2023, Ian D. Plumb, Melissa Briggs Hagen, Ryan Wiegand, Ghinwa Dumyati, Christopher Myers, Karisa K. Harland, Anusha Krishnadasan, Jade James Gist, Glen Abedi, Katherine E. Fleming-Dutra, Nora Chea, Jane E. Lee, Melissa Kellogg, Alexandra Edmundson, Amber Britton, Lucy E. Wilson, Sara A. Lovett, Valerie Ocampo, Tiffanie M. Markus, Howard A. Smithline, Peter C. Hou, Lilly C. Lee, William Mower, Fernand Rwamwejo, Mark T. Steele, Stephen C. Lim, Walter A. Schrading, Brian Chinnock

School of Medicine Faculty Publications

Background: Bivalent mRNA vaccines were recommended since September 2022. However, coverage with a recent vaccine dose has been limited, and there are few robust estimates of bivalent VE against symptomatic SARS-CoV-2 infection (COVID-19). We estimated VE of a bivalent mRNA vaccine dose against COVID-19 among eligible U.S. healthcare personnel who had previously received monovalent mRNA vaccine doses. Methods: We conducted a case-control study in 22 U.S. states, and enrolled healthcare personnel with COVID-19 (case-participants) or without COVID-19 (control-participants) during September 2022–May 2023. Participants were considered eligible for a bivalent mRNA dose if they had received 2–4 monovalent (ancestral-strain) mRNA vaccine …

Impact Of Audio-Visually Enhanced Pedagogy On Student Performance And Satisfaction In The Blended Anatomy And Physiology Classroom, Pradeepa Poudyal

Graduate Theses, Dissertations, and Capstones

Demand for Anatomy and Physiology (AP) courses is increasing with the popularity of health care professions in the United States. Institutions are adopting blended mode of delivery in AP classes for its practicality. This mode allows implementation of multimodal pedagogy in the curriculum. Hence, students get to choose the resource that matches their learning preferences; understanding student needs is instrumental in enhancing learning experiences in any course. This study aimed to assess the impact of audio-visual interactive media (AVIM) on performance and satisfaction in the virtual lectures of blended AP courses. This study was conducted in two blended AP courses …

Post-Acute Sequelae Of Covid-19 (Pasc) In Pediatrics: Factors That Impact Symptom Severity And Referral To Treatment., Catherine Soprano, Ryan Ngo, Casey A Konys, Ashley Bazier, Katherine Salamon

Department of Medicine Faculty Papers

The post-acute sequelae of COVID-19 (PASC) is a complex condition. While there are emerging studies on its effects in adults, there is scarce research regarding the long-term effects of COVID-19 infection among youth. Several researchers have likened long-haul COVID-19 to chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and postural orthostatic tachycardia syndrome (POTS). In adults, the prognosis for these diagnoses is less promising than that in youth; however, there is currently very little information available on the presentation of youth with PASC. A better understanding of the specific symptom presentation for youth diagnosed with PASC is necessary. Retrospective chart reviews were conducted …

Dhodh: A Promising Target In The Treatment Of T-Cell Acute Lymphoblastic Leukemia, Amy N Sexauer, Gabriela Alexe, Karin Gustafsson, Elizabeth Zanetakos, Jelena Milosevic, Mary Ayres, Varsha Gandhi, Yana Pikman, Kimberly Stegmaier, David B Sykes

Faculty, Staff and Student Publications

Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) have a poor prognosis with few therapeutic options. With the goal of identifying novel therapeutic targets, we used data from the Dependency Map project to identify dihydroorotate dehydrogenase (DHODH) as one of the top metabolic dependencies in T-ALL. DHODH catalyzes the fourth step of de novo pyrimidine nucleotide synthesis. Small molecule inhibition of DHODH rapidly leads to the depletion of intracellular pyrimidine pools and forces cells to rely on extracellular salvage. In the absence of sufficient salvage, this intracellular nucleotide starvation results in the inhibition of DNA and RNA synthesis, …

Pharyngeal Oxygen Delivery Device Sustains Manikin Lung Oxygenation Longer Than High-Flow Nasal Cannula, Jeramie B Hanson, John R Williams, Emily H Garmon, Phillip M Morris, Russell K Mcallister, Courtney N Shaver, William C Culp

Faculty, Staff and Student Publications

PURPOSE: Hypoxemia during a failed airway scenario is life threatening. A dual-lumen pharyngeal oxygen delivery device (PODD) was developed to fit inside a traditional oropharyngeal airway for undisrupted supraglottic oxygenation and gas analysis during laryngoscopy and intubation. We hypothesized that the PODD would provide oxygen as effectively as high-flow nasal cannula (HFNC) while using lower oxygen flow rates.

METHODS: We compared oxygen delivery of the PODD to HFNC in a preoxygenated, apneic manikin lung that approximated an adult functional residual capacity. Four arms were studied: HFNC at 20 and 60 liters per minute (LPM) oxygen, PODD at 10 LPM oxygen, …