Medicine and Health Sciences Commons^™

A Phase 1 Study Of Prophylactic Anakinra To Mitigate Icans In Patients With Large B-Cell Lymphoma, Paolo Strati, Andrew Jallouk, Qing Deng, Xubin Li, Lei Feng, Ryan Sun, Sherry Adkins, Swapna Johncy, Taylor Cain, Raphael E Steiner, Sairah Ahmed, Dai Chihara, Luis E Fayad, Swaminathan P Iyer, Sandra Horowitz, Loretta J Nastoupil, Ranjit Nair, Ahmed Hassan, Taher E Daoud, Misha Hawkins, Maria A Rodriguez, Elizabeth J Shpall, Jeremy L Ramdial, Partow Kebriaei, David S Hong, Jason R Westin, Sattva S Neelapu, Michael R Green

Faculty, Staff and Student Publications

No abstract provided.

Gasdermin D Permeabilization Of Mitochondrial Inner And Outer Membranes Accelerates And Enhances Pyroptosis, Rui Miao, Cong Jiang, Winston Y Chang, Haiwei Zhang, Jinsu An, Felicia Ho, Pengcheng Chen, Han Zhang, Caroline Junqueira, Dulguun Amgalan, Felix G Liang, Junbing Zhang, Charles L Evavold, Iva Hafner-Bratkovič, Zhibin Zhang, Pietro Fontana, Shiyu Xia, Markus Waldeck-Weiermair, Youdong Pan, Thomas Michel, Liron Bar-Peled, Hao Wu, Jonathan C Kagan, Richard N Kitsis, Peng Zhang, Xing Liu, Judy Lieberman

Faculty, Staff and Student Publications

Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial damage, but its underlying mechanism and functional consequences are largely unknown. Here, we show that the N-terminal pore-forming GSDMD fragment (GSDMD-NT) rapidly damaged both inner and outer mitochondrial membranes (OMMs) leading to reduced mitochondrial numbers, mitophagy, ROS, loss of transmembrane potential, attenuated oxidative phosphorylation (OXPHOS), and release of mitochondrial proteins and DNA from the matrix and intermembrane space. Mitochondrial damage occurred as soon as GSDMD was cleaved prior to plasma membrane damage. Mitochondrial damage was independent of the B-cell lymphoma 2 family and depended on GSDMD-NT binding to cardiolipin. Canonical and …

Cigarette Smoke Exposure Accelerates Aml Progression In Flt3-Itd Models, Mary Figueroa, Huaxian Ma, Mansour Alfayez, Daniel Enrique Morales-Mantilla, Fei Wang, Yue Lu, Marcos R Estecio, Katherine Y King, Eugenie Kleinerman, Seyed Javad Moghaddam, Naval Daver, Michael Andreeff, Marina Konopleva, Courtney Dinardo, Joya Chandra

Faculty, Staff and Student Publications

No abstract provided.

Emergency Department Presentations Of Diabetic Ketoacidosis In A Large Cohort Of Children, Lisa E. Nigrovic, Nathan Kuppermann, Simona Ghetti, Jeff E. Schunk, Michael J. Stoner, Arleta Rewers, Julie K. Mcmanemy, Kimberly S. Quayle, Jennifer L. Trainor, Leah Tzimenatos, Jonathan E. Bennett, Maria Y. Kwok, Sage R. Myers, Kathleen M. Brown, T. Charles Casper, Cody S. Olsen, Nicole S. Glaser

Department of Emergency Medicine Faculty Papers

Background.

Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of childhood diabetes. However, the influence of demographic factors on presentation are not well-defined.

Methods.

We included children from 12 centers who were <18 years with DKA (glucose > 300 mg/dL, serum pH < 7.25, or serum bicarbonate <15 mEq/L) enrolled in the Pediatric Emergency Care Applied Research Network (PECARN) Fluid Therapies Under Investigation in DKA (FLUID) Trial. Data were also collected for children who presented to the centers during the enrollment period but were not enrolled due to disease or treatment-related reasons. We compared demographic, clinical, and biochemical findings among children with newly and previously diagnosed diabetes and children in different age groups.

Results.

Of the 1,679 DKA episodes in 1,553 children, 799 (47.5%) episodes occurred in children with newly diagnosed diabetes and 396 (23.6%) were severe (pH < 7.1). Newly diagnosed children <6 years of age were not more likely to have severe DKA in terms of pH, but had more severe hypocarbia and higher blood urea nitrogen levels, factors previously associated with the risk of cerebral injury. Lower socioeconomic status (SES) (based on family income and maternal education level) were associated with more severe DKA in new onset children, and recurrent DKA in the previously diagnosed children.

Conclusions.

Greater efforts are needed to identify the children with diabetes early and to prevent recurrent DKA, particularly among children in low-SES groups. Young children with DKA may need more intensive monitoring due to higher …

Phase 1 Study Of Vibecotamab Identifies An Optimized Dose For Treatment Of Relapsed/Refractory Acute Myeloid Leukemia, Farhad Ravandi, Asad Bashey, James Foran, Wendy Stock, Raya Mawad, Nicholas Short, Musa Yilmaz, Hagop Kantarjian, Olatoyosi Odenike, Anand Patel, Raman Garcha, William Barrett Ainsworth, Raphael Clynes, Jitendra Kanodia, Ying Ding, Huajiang Li, Steve Kye, Alice Mims

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML), an aggressive malignancy with unmet medical need, lacks immunotherapeutic options. CD123, the cellular receptor for interleukin-3, expressed in AML is an attractive target for tumor-specific therapy. Vibecotamab (XmAb14045), a humanized bispecific antibody, monovalently binds both CD3 and CD123 to recruit cytotoxic T cells to kill CD123+ tumor cells. This phase 1 study's primary objectives were safety and tolerability and identification of a maximum tolerated dose/recommended dose for use as monotherapy in patients with relapsed/refractory AML. Identification of a recommended phase 2 vibecotamab dose comprised 3 step-up doses (Week 1), which were noted to reduce cytokine response …

Prefrontal Cortex Glutamatergic Adaptations In A Mouse Model Of Alcohol Use Disorder, Mahum T. Siddiqi, Dhruba Podder, Amanda R. Pahng, Alexandria C. Athanason, Tali Nadav, Chelsea Cates-Gatto, Max Kreifeldt, Candice Contet, Amanda J. Roberts, Scott Edwards, Marisa Roberto, Florence P. Varodayan

School of Graduate Studies Faculty Publications

Alcohol use disorder (AUD) produces cognitive deficits, indicating a shift in prefrontal cortex (PFC) function. PFC glutamate neurotransmission is mostly mediated by α-amino-3‑hydroxy-5-methyl-4-isoxazolepropionic acid-type ionotropic receptors (AMPARs); however preclinical studies have mostly focused on other receptor subtypes. Here we examined the impact of early withdrawal from chronic ethanol on AMPAR function in the mouse medial PFC (mPFC). Dependent male C57BL/6J mice were generated using the chronic intermittent ethanol vapor-two bottle choice (CIE-2BC) paradigm. Non-dependent mice had access to water and ethanol bottles but did not receive ethanol vapor. Naïve mice had no ethanol exposure. We used patch-clamp electrophysiology to measure …

Tlr7 Promotes Smoke-Induced Experimental Lung Damage Through The Activity Of Mast Cell Tryptase, Gang Liu, Tatt Jhong Haw, Malcolm R Starkey, Ashleigh M Philp, Stelios Pavlidis, Christina Nalkurthi, Prema M Nair, Henry M Gomez, Irwan Hanish, Alan Cy Hsu, Elinor Hortle, Sophie Pickles, Joselyn Rojas-Quintero, Raul San Jose Estepar, Jacqueline E Marshall, Richard Y Kim, Adam M Collison, Joerg Mattes, Sobia Idrees, Alen Faiz, Nicole G Hansbro, Ryutaro Fukui, Yusuke Murakami, Hong Sheng Cheng, Nguan Soon Tan, Sanjay H Chotirmall, Jay C Horvat, Paul S Foster, Brian Gg Oliver, Francesca Polverino, Antonio Ieni, Francesco Monaco, Gaetano Caramori, Sukhwinder S Sohal, Ken R Bracke, Peter A Wark, Ian M Adcock, Kensuke Miyake, Don D Sin, Philip M Hansbro

Faculty, Staff and Students Publications

Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that the severity of CS-induced emphysema and COPD is reduced in TLR7-deficient mice, while inhalation of imiquimod, a TLR7-agonist, induces emphysema without CS exposure. This imiquimod-induced emphysema is reduced in mice deficient in mast cell protease-6, or when wild-type mice are treated with the mast cell stabilizer, cromolyn. Furthermore, therapeutic treatment with anti-TLR7 monoclonal antibody suppresses CS-induced emphysema, experimental COPD and accumulation of pulmonary mast cells in mice. …

An Automatic Pipeline For Pet/Mri Attenuation Correction Validation In The Brain, Mahdjoub Hamdi, Chunwei Ying, Hongyu An, Richard Laforest

2020-Current year OA Pubs

PURPOSE: Challenges in PET/MRI quantitative accuracy for neurological uses arise from PET attenuation correction accuracy. We proposed and evaluated an automatic pipeline to assess the quantitative accuracy of four MRI-derived PET AC methods using analytically simulated PET brain lesions and ROIs as ground truth for PET activity.

METHODS: Our proposed pipeline, integrating a synthetic lesion insertion tool and the FreeSurfer neuroimaging framework, inserts simulated spherical and brain ROIs into PET projection space, reconstructing them via four PET MRAC techniques. Utilizing an 11-patient brain PET dataset, we compared the quantitative accuracy of four MRACs (DIXON, DIXONbone, UTE AC, and DL-DIXON) against …

Research Data Management Readiness At Uganda Cancer Institute, Edward Mukiibi, Joyce Bukirwa

Library Philosophy and Practice (e-journal)

The study explored research data management readiness at the Uganda Cancer Institute. Its objectives were to; establish the state of research data and the institutional readiness for research data management practices. The case study applied a survey method using a questionnaire modified from the Data Asset Framework and the Community Capability Model Framework. The respondents were 60 staff members at different professional levels purposively selected. The findings show massive data generated from clinical trials, and routine cancer clinics at the institute. The business processes are mainly manual except for the funded research projects which are hybrid. The existing data sets …

Targeted Suppression Of Mtorc2 Reduces Seizures Across Models Of Epilepsy, James Okoh, Jacqunae Mays, Alexandre Bacq, Juan A Oses-Prieto, Stefka Tyanova, Chien-Ju Chen, Khalel Imanbeyev, Marion Doladilhe, Hongyi Zhou, Paymaan Jafar-Nejad, Alma Burlingame, Jeffrey Noebels, Stephanie Baulac, Mauro Costa-Mattioli

Faculty, Staff and Students Publications

Epilepsy is a neurological disorder that poses a major threat to public health. Hyperactivation of mTOR complex 1 (mTORC1) is believed to lead to abnormal network rhythmicity associated with epilepsy, and its inhibition is proposed to provide some therapeutic benefit. However, mTOR complex 2 (mTORC2) is also activated in the epileptic brain, and little is known about its role in seizures. Here we discover that genetic deletion of mTORC2 from forebrain neurons is protective against kainic acid-induced behavioral and EEG seizures. Furthermore, inhibition of mTORC2 with a specific antisense oligonucleotide robustly suppresses seizures in several pharmacological and genetic mouse models …

Reducing Prescribing Of Antibiotics For Acute Respiratory Infections Using A Frontline Nurse-Led Ehr-Integrated Clinical Decision Support Tool: Protocol For A Stepped Wedge Randomized Control Trial, Elizabeth R Stevens, Ruth Agbakoba, Devin M Mann, Rachel Hess, Safiya I Richardson, Thomas Mcginn, Paul D Smith, Wendy Halm, Marlon P Mundt, Katherine L Dauber-Decker, Simon A Jones, Dawn M Feldthouse, Eun Ji Kim, David A Feldstein

Faculty, Staff and Students Publications

Background: Overprescribing of antibiotics for acute respiratory infections (ARIs) remains a major issue in outpatient settings. Use of clinical prediction rules (CPRs) can reduce inappropriate antibiotic prescribing but they remain underutilized by physicians and advanced practice providers. A registered nurse (RN)-led model of an electronic health record-integrated CPR (iCPR) for low-acuity ARIs may be an effective alternative to address the barriers to a physician-driven model.

Methods: Following qualitative usability testing, we will conduct a stepped-wedge practice-level cluster randomized controlled trial (RCT) examining the effect of iCPR-guided RN care for low acuity patients with ARI. The primary hypothesis to be tested …

Mirna As Systemic Mediators For Environmentally Persistent Free Radical-Induced Cardiovascular Dysfunction, Ankit Aryal

LSU Doctoral Dissertations

Air pollution is consistently linked with elevations in cardiovascular disease (CVD) and its mortality. Particulate matter (PM) is a pivotal factor in air pollution-associated CVD. PM containing environmentally persistent free radicals (EPFR) forms from the incomplete combustion of organic wastes. These products adhere to particulate matter carrying redox-active transition metals on its surface. To enable systematic research of the health impacts of EPFR, our colleagues developed a combustion method to produce EPFR-containing PM that closely resemble urban PM and validated their use for typical laboratory settings. We exposed mice to laboratory generated EPFR through whole-body inhalation and investigated their dose-dependent …

Missense Mutations In Crx Homeodomain Cause Dominant Retinopathies Through Two Distinct Mechanisms, Yiqiao Zheng, Chi Sun, Xiaodong Zhang, Philip A Ruzycki, Shiming Chen

2020-Current year OA Pubs

Homeodomain transcription factors (HD TFs) are instrumental to vertebrate development. Mutations in HD TFs have been linked to human diseases, but their pathogenic mechanisms remain elusive. Here, we use

Mechanical Loading And Hyperosmolarity As A Daily Resetting Cue For Skeletal Circadian Clocks, Michal Dudek, Dharshika R J Pathiranage, Beatriz Bano-Otalora, Anna Paszek, Natalie Rogers, Cátia F Gonçalves, Craig Lawless, Dong Wang, Zhuojing Luo, Liu Yang, Farshid Guilak, Judith A Hoyland, Qing-Jun Meng

2020-Current year OA Pubs

Daily rhythms in mammalian behaviour and physiology are generated by a multi-oscillator circadian system entrained through environmental cues (e.g. light and feeding). The presence of tissue niche-dependent physiological time cues has been proposed, allowing tissues the ability of circadian phase adjustment based on local signals. However, to date, such stimuli have remained elusive. Here we show that daily patterns of mechanical loading and associated osmotic challenge within physiological ranges reset circadian clock phase and amplitude in cartilage and intervertebral disc tissues in vivo and in tissue explant cultures. Hyperosmolarity (but not hypo-osmolarity) resets clocks in young and ageing skeletal tissues …

Comparing Muscle Oxygenation And Maximal Blood Lactate Concentration In Middle-Distance Athletes: A Speed Reserve Ratio Analysis, Braeden Kraft, Ayla Kraft, Kurt A. Escobar, Evan E. Schick, Joshua A. Cotter

International Journal of Exercise Science: Conference Proceedings

Middle-distance running is a unique discipline that utilizes both aerobic and anaerobic abilities, resulting in a physiologically diverse athlete population. This diversity in athlete makeup underscores the necessity for precise physiological profiling methods to improve individualized training and race strategy approaches. While the Speed Reserve Ratio (SRR) has garnered attention as an accurate and effective tool in athlete profiling, skeletal muscle oxygenation (SmO2) and blood lactate also have shown potential in this field. However, the effectiveness of these biomarkers in middle-distance populations, especially in conjunction with SRR, is less understood. PURPOSE: This research aims to understand the relationships between …

Impacts Of Creatine Supplementation On Running Anaerobic Sprint Performance Test (Rast) Power And Velocity In Youth Soccer Players, Nia Howard, Citlaly Jauregui, Heitor P N Amorim, Sullen B. Sant'ana, Juan Mielgo Ayuso, Dailson Paulucio, Marco Machado, Steven B. Machek

International Journal of Exercise Science: Conference Proceedings

Creatine supplementation commonly enhances short-term, high-intensity effort performance such the soccer-specific ability to perform repeated sprints. Research in this regard is both generally sparse but specifically more so in youth athletes. PURPOSE: to determine the effect of 28 days of creatine monohydrate supplementation on running anaerobic sprint performance (RAST) power and velocity in youth soccer players. METHODS: Sixteen male youth soccer players were randomized in double-blinded, parallel-group fashion to either 28 days of creatine supplementation (CRE; 15.9±0.35y) or an equivalently-dosed dextrose (PLA; 15.5±0.54y; 0.3g/kg/d loading dose for the first seven days, followed by 0.03g/kg/d for the remaining period), whereby they …

Effects Of Nitrate Supplementation On In Vivo Muscle Torque Recovery From Bacl2-Induced Injury, Dylan M. Kasper, Lloyd Marshall, Leonardo Nogueira

International Journal of Exercise Science: Conference Proceedings

During repair from muscle injury, muscle satellite cells depend on nitric oxide production by immune cells to proliferate and differentiate. Nitrate supplementation has been shown to improve muscle endurance and oxygen consumption, but little is known about the ability of nitrate supplementation to interfere with muscle regeneration following injury. PURPOSE: To investigate whether nitrate supplementation affects muscle recovery of force after muscle injury produced by intramuscular injection of barium chloride. METHODS: Transgenic male mice (12 weeks old) that express Td-Tomato fluorescent protein in Pax7+ cells (i.e., satellite cells; Pax7CreER-Ai9 mice) were treated with tamoxifen (2 mg in corn …

Diaphragm Force And Mitochondrial Function Ex Vivo Following Gsnor Inhibition In Vivo Preceding Mechanical Ventilation, Simon P. Pierce, Daniel T. Cannon, Leonardo Nogueira

International Journal of Exercise Science: Conference Proceedings

During mechanical ventilation (MV), force developed by the diaphragm is decreased over time much faster than locomotor muscles. This is known as ventilator-induced diaphragm dysfunction (VIDD), and VIDD may be accelerated by intramyofiber oxidative stress. An important free radical used for the treatment of acute respiratory distress syndrome (ARDS) is nitric oxide (NO) which can diffuse to diaphragm myofibers during treatment. However, little is known whether NO or NO by-products such as S-nitrosothiols (RSNO), can accelerate or prevent VIDD. PURPOSE: To investigate whether inhibiting S-nitrosoglutathione reductase (GSNORi) during MV could affect ex vivo diaphragm force and mitochondrial respiration. METHODS …

A Case Study Examining Health And Fitness Effects Of Thru Hiking The Pacific Crest Trail, Holland Gaston, Dante Argento, Anna Grexton, Cory Greever

International Journal of Exercise Science: Conference Proceedings

The Pacific Crest Trail (PCT), a long-distance hiking route spanning from the U.S.-Mexico Border to the U.S.-Canada border, is a compelling research topic for studying human performance. Thru hiking involves enduring high volumes of moderate-vigorous exercise, load carriage of survival gear, environmental conditions, hydration, nutrition, sleep, and psychological well-being, alongside addressing challenges like navigation, limited resupply, encounters with wild animals and injury/illness. PURPOSE: This case study investigated the impact of thru hiking the PCT on physical fitness and health in a cohort of three non-elite male hikers. METHODS: The participants had two visits to the lab, following an 8-12 hour …

Intra And Inter-Rater Reliability Of The Exercise Thresholds App In Identifying Ventilatory Thresholds Using Undergraduate Raters, Anna Grexton, Dante Argento, Holland Gaston, Cory Greever

International Journal of Exercise Science: Conference Proceedings

Identifying the gas exchange threshold (GET) and the respiratory compensation point (RCP) are the least invasive methods for determining aerobic training zones from maximal graded exercise tests. This process requires a thorough examination of several respiratory gas exchange parameters from breath-by-breath or time binned averages. Given the nature of processing data in this fashion, standardized tools could be useful in improving exercise physiology student’s accuracy in identifying these thresholds. The Exercise Thresholds App is a computer application developed to simultaneously visualize eight different respiratory gas exchange parameters (VE, VO_2, VCO2, VE/VCO2, VE/VO2, PETO2, PETCO2, RER) from maximal exercise tests …

Rare Case Of Traction Sural Neuropathy Due To Acute Achilles Tendon Rupture, Heather Lystad, Kenneth Vitale

International Journal of Exercise Science: Conference Proceedings

Sural nerve injury (SNI) is a reported complication of acute Achilles tendon rupture (ATR), primarily iatrogenic in operatively managed cases. The sural nerve typically runs along the lateral border of the Achilles tendon. Its branches provide sensory information from the lateral foot and ankle. Given its proximity to the Achilles tendon, sural nerve-related complications in operatively managed cases are a known adverse outcome. However, the incidence of SNI in conservatively managed cases is thought to be much less common. Most patients recover to normal sensation by one year of injury to the sural nerve. CASE DESCRIPTION: A previously healthy 30 …

Abdominal Adiposity Indexed By The Sagittal Abdominal Diameter And Risk Of Mortality In 14,119 U.S. Adults, Joshua A. Brockbank, Larry A. Tucker

International Journal of Exercise Science: Conference Proceedings

The body mass index (BMI) is frequently used as a general measure of overweight and obesity. It is a good predictor of disease and premature death. However, research shows that indices of abdominal adiposity tend to be better predictors of disease risk and mortality than BMI. To date, the sagittal abdominal diameter (SAD), an index of abdominal adiposity, has never been evaluated as a predictor of mortality. PURPOSE: The present study was conducted to determine the extent that adults with different levels of SAD vary in their risk of all-cause mortality over an average follow-up of 6 years. METHODS: A …

Effects Of Dance Footwear On Kinetics And Lower Limb Joint Kinematics During Sauté Jumps, Eloisa Hernandez, Erin Onat, Kevin Phan, Jenny Camacho, Ricardo Tolentino, Danielle N. Jarvis

International Journal of Exercise Science: Conference Proceedings

While some efforts have been made to design footwear that would be beneficial for dancers in terms of performance and injury prevention, most footwear commonly used by dancers offers very little support to the foot and ankle region. Footwear has the potential to modify the interaction between the foot and the floor, but there is minimal research examining the effects of footwear on dance performance. PURPOSE: The purpose of this study was to investigate the effects of footwear on ground reaction forces and lower extremity joint motion during a sauté (dance specific bipedal vertical jump) landing. METHODS: Eighteen …

Portability Vs. Precedent: Imus Vs. 3d Motion Capture For Collecting Kinematic Data In Dancers, Ricardo Tolentino, Gwendolyn R. Retzinger, Stephana Powell, Luis F. Gonzalez, Danielle N. Jarvis

International Journal of Exercise Science: Conference Proceedings

The emergence of portable kinematic data collection systems (Inertial Measurement Units - IMUs) have become a potential alternative to 3D video motion capture systems for real-world application. However, there remains little research on the application of IMU technology for the evaluation of dancers’ biomechanical movement. PURPOSE: To assess the validity of the Noraxon IMU system compared with the Cortex 3D video motion capture system for kinematic data collection during a sauté. METHODS: 10 healthy, advanced female dancers were equipped with both a Noraxon IMU (200Hz) system and reflective markers used with a 12-camera Motion Analysis system (Cortex, 250 …

Time Since Injury Influences Eccentric Hamstring Force Imbalance In Collegiate American Football Players, Lee J. Hinkle, Gilbert W. Fellingham, Malorie Wilwand, Aaron W. Johnson

International Journal of Exercise Science: Conference Proceedings

Hamstring injuries (HSI) are among the most common non-contact injuries in American football. Understanding effects of duration since injury may inform how coaches, trainers, and athletes approach rehabilitation and return to play decisions. PURPOSE: To compare hamstring imbalance in athletes injured more than 12 months ago to hamstring imbalance in athletes with no HSI and compare hamstring imbalance in athletes injured within the last 12 months to imbalance in those with no HSI. METHODS: Sixty-one collegiate football players (age: 22.5 ± 1.8, height: 187.6 ± 6.2 cm, weight: 105 ± 21.6 kg) rostered in 2022 self-identified as having …

Single-Leg Resistance Exercise Training In Mice Leads To A Fast Increase In In Vivo Torque Of Anterior Crural Muscles, Lloyd K.T. Marshall, Dylan M. Kasper, Leonardo Nogueira Phd

International Journal of Exercise Science: Conference Proceedings

Resistance exercise is known to produce muscle hypertrophy. However, little is known about the role of muscle satellite cells in generating new myofibers or in incorporating satellite cells to live myofibers during exercise training. PURPOSE: To investigate whether single-leg resistance exercise training can activate the incorporation of muscle satellite cells in mice. METHODS: Transgenic male mice (12 weeks old) that express Td-Tomato fluorescent protein in Pax7+ (i.e., satellite cells) cells (Pax7CreER-Ai9) were treated with tamoxifen (2 mg in corn oil, i.p.) once a day for 5 days. Three days later, mice were single-leg exercise trained (i.e stimulation of …

Effect Of Lead Leg And Fatigue On Ground Reaction Forces In Front Lunges, Jasmyne Holliday, Michele Leblanc

International Journal of Exercise Science: Conference Proceedings

Front lunges are a beneficial exercise that are frequently used for rehabilitation and strength training. In the studies previously conducted, only vertical ground reaction force (GRF) data for the preferred lead leg was analyzed and only male subjects were included (Gao et al., 2022, Park et al., 2021). PURPOSE: The aim of this study was to determine the effect of lead leg and fatigue on lead leg anterior/posterior (Fy) and vertical (Fz) GRFs during the eccentric and concentric phases of the front lunge. METHODS: Ten recreationally active women were recruited and performed front lunges with an assigned step …

Trends In Weightlifting Injuries In Pediatric And Adult Populations: 2013 – 2022, Tolulope Popoola, Daniel Novak

International Journal of Exercise Science: Conference Proceedings

Weightlifting can serve as a valuable exercise method for managing obesity and preparing young individuals for sports, provided it is carried out under the guidance of qualified experts and with proper safety measures in mind. Nevertheless, the persistent worry about the potential for injuries remains a significant factor behind the hesitancy of medical professionals in endorsing weightlifting for pediatric populations. PURPOSE: To determine whether there are differences in rates and types of injury associated to weightlifting across different age groups. METHODS: Information regarding weight training injuries was collected from the National Electronic Injury Surveillance System of the US …

The Effects Of A High-Carbohydrate Versus A High-Fat Shake On Biomarkers Of Metabolism And Glycemic Control When Used To Interrupt A 38-Hour Fast: A Randomized Crossover Study, Cameron Jacobsen, Landon Deru, Bruce W. Bailey

International Journal of Exercise Science: Conference Proceedings

As the link between metabolic health and chronic diseases have come into focus, it has highlighted the need to establish methods for improving metabolic flexibility. The ability to efficiently switch metabolic fuels from glucose to fatty acid-derived ketones is an indication of good metabolic health. Regular fasting allows the body to make the metabolic switch to ketones more often, which is commonly identified through the measurement of the ketone beta-hydroxybutyrate (BHB). Measuring both BHB and glucose levels can provide information about the body’s response to various foods, fasting regimens, or other metabolic stressors, and give valuable insights to measuring a …

Effects Of Acute Late Sleep Restriction On Strength, Power, And Running Speed In Recreationally Active Females, Karolina Iznerowicz, Jared W. Coburn, Sydney Leisz, Trevor Gillum, Michael Robinson, William Boyer

International Journal of Exercise Science: Conference Proceedings

Previous research suggests that late sleep restriction (SR) paired with exercise in the morning does not have a significant impact on sport performance measures. However, this evidence is based on research conducted primarily in males. PURPOSE: To examine the effects of late sleep restriction on measures of strength, speed, and power among recreationally active females. METHODS: Twenty-three (23) recreationally active (aerobic physical activity and resistance exercise at least three times a week for six months) females participated in this study (mean age 21.5 years, BMI 23 kg/m²). A randomized, cross-over design was used under two conditions, recommended sleep …