Role Of The Ormdls In Keratinocytes, Souad Hatmi

Theses and Dissertations

The epidermis, the outermost layer of the skin, serves as a vital barrier protecting the body from environmental stressors, pathogens, and dehydration. Keratinocytes, the predominant cell type in the epidermis, play a central role in maintaining skin integrity and barrier function. In normal human skin, keratinocytes move from the basal layer to the stratum corneum, the top layer of the epidermis. In their travel, keratinocytes undergo a process of terminal differentiation, loss their ability to proliferate, secrete sphingolipids into the extracellular space, and gradually loss their nucleus and organelles. Sphingolipids, particularly ceramides, are key components of the intercellular lipid lamellae …

Quantitative And Molecular Genetic Analyses Of Brain Structure, Substance Use, And Posttraumatic Stress Phenotypes: Data From Children, Adolescents And Adults, Daniel Bustamante

Theses and Dissertations

Abstract

QUANTITATIVE AND MOLECULAR GENETIC ANALYSES OF BRAIN-IMAGING, SUBSTANCE USE, AND POSTTRAUMATIC STRESS PHENOTYPES: DATA FROM CHILDREN, ADOLESCENTS AND ADULTS

By Daniel Bustamante, B.S., B.A.

Doctoral dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Integrative Life Sciences – Behavioral and Statistical Genetics at Virginia Commonwealth University.

Virginia Commonwealth University, 2023.

Dissertation directors: Michael C. Neale, Ph.D., Banks Distinguished Professor of Psychiatry & Human and Molecular Genetics; and, Ananda B. Amstadter, Ph.D., Professor of Psychiatry, Psychology, & Human and Molecular Genetics.

Substance use (SU) and posttraumatic stress disorder (PTSD) phenotypes are comorbid, share …

An Epidemiological Synthesis Of Emerging And Re-Emerging Zoonotic Disease Threats In Cameroon, 2000-2022: A Systematic Review, Nancy B. Tahmo, Frankline Sevidzem Wirsiy, Dum-Buo Nnamdi, Marcel Tongo, James V. Lawler, M. Jana Broadhurst, Charles S. Wondji, David Brett-Major

Journal Articles: Epidemiology

INTRODUCTION: Population factors such as urbanization, socio-economic, and environmental factors are driving forces for emerging/re-emerging zoonotic diseases in Cameroon. To inform preparedness and prioritization efforts, this study mapped out epidemiological data (including prevalence) of zoonotic diseases occurring in Cameroon between 2000 and 2022 by demographic factors.

METHODS: Following the PRISMA guidelines, a protocol was registered in the PROSPERO database (CRD42022333059). Independent reviewers searched the PubMed, Embase, CINAHL, Cochrane, and Scopus databases on May 30, 2022 for relevant articles; duplicates were removed, and the titles, abstracts, and full texts were screened to identify eligible articles.

RESULTS: Out of 4142 articles identified, …

The Association Between Mediated Deprivation And Ovarian Cancer Survival Among African American Women, Andrew B. Lawson, Joanne Kim, Courtney Johnson, Kendra Ratnapradipa, Anthony J. Alberg, Maxwell Akonde, Theresa Hastert, Elisa V. Bandera, Paul Terry, Hannah Mandle, Michele L. Cote, Melissa Bondy, Jeffrey Marks, Lauren C. Peres, Joellen Schildkraut, Edward S. Peters

Journal Articles: Epidemiology

BACKGROUND: Deprivation indices are often used to adjust for socio-economic disparities in health studies. Their role has been partially evaluated for certain population-level cancer outcomes, but examination of their role in ovarian cancer is limited. In this study, we evaluated a range of well-recognized deprivation indices in relation to cancer survival in a cohort of self-identified Black women diagnosed with ovarian cancer. This study aimed to determine if clinical or diagnostic characteristics lie on a mediating pathway between socioeconomic status (SES) and deprivation and ovarian cancer survival in a minority population that experiences worse survival from ovarian cancer.

METHODS: We …

Roles Of Specialized Pro-Resolving Mediators And Omega-3 Polyunsaturated Fatty Acids In Periodontal Inflammation And Impact On Oral Microbiota, Chun-Teh Lee, Gena D Tribble

Faculty, Staff and Student Publications

Periodontitis is a chronic inflammatory disease induced by dysbiotic dental biofilms. Management of periodontitis is primarily anti-bacterial via mechanical removal of bacterial biofilm. The successful resolution requires wound healing and tissue regeneration, which are not always achieved with these traditional methods. The discovery of specialized pro-resolving mediators (SPMs), a class of lipid mediators that induce the resolution of inflammation and promote local tissue homeostasis, creates another option for the treatment of periodontitis and other diseases of chronic inflammation. In this mini-review, we discuss the host-modulatory effects of SPMs on periodontal tissues and changes in the taxonomic composition of the gut …

Identification Of Preceptor Best Practices, Reese Daley, Kenedy Darland, Ashley Harper, Carlie Hunter, Kayla Lee, Alex Marshall, Sara Myers, Savan Nguyen, Erin Shaffer, Ariel Winchester

2022

No abstract provided.

Reduction Of Hemolyzed Lab Specimens: Does Venipuncture Or Heel/Finger Stick Result In More Hemolyzed Labs?, Peyton Hasse, Megan O’Sullivan

2022

No abstract provided.

Chg Foam Vs. Chg Wipes, Holley Caldwell, Caitlyn Gilbert, Shayla Mitchell, Edith Rojas

2022

No abstract provided.

Protecting Low-Income Consumers In The Era Of Digital Grocery Shopping: Implications For Wic Online Ordering, Qi Zhang, Priyanka Patel, Caitlin M. Lowery

Community & Environmental Health Faculty Publications

The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is now expected to allow participants to redeem their food benefits online, i.e., via online ordering, rather than only in-store. However, it is unclear how this new benefit redemption model may impact participants’ welfare since vendors may have an asymmetric information advantage compared with WIC customers. The WIC online ordering environment may also change the landscape for WIC vendors, which will eventually affect WIC participants. To protect WIC consumers’ rights in the new online ordering model, policymakers need an appropriate legal and regulatory framework. This narrative review provides that …

Psychometric Properties Of The Persian Version Of Consideration Of Future Safety Consequence (Cfsc) Scale, Fazel Rajabi, Hamidreza Mokarami, Payam Farhadi, Sean Banaee, Mehdi Jahangiri

Community & Environmental Health Faculty Publications

Background: Personality traits, due to having a relative stability, are important factors for predicting employees’ safety behavior. Consideration of Future Safety Consequence (CFSC) is a personality trait that was recently introduced to predict the safety behaviors. The purpose of this study was to translate and assess the psychometric properties of the Persian version of the CFSC scale.

Methods: In the first stage of this cross-sectional study, the instrument was prepared by the forward-backward forward translation technique and evaluated by 487 employees of a gas refinery. The validity of the scale was evaluated through face, concurrent, validity, and construct validity. The …

Virtual Home Visits During Covid-19 Pandemic: Mothers' And Home Visitors' Perspectives, Abdullah Al-Taiar, Michele A. Kekeh, Stephanie Ewers, Amy L. Prusinski, Kimberly J. Alombro, Nancy Welch

Community & Environmental Health Faculty Publications

Background

The experiences of mothers enrolled in Maternal, Infant and Early Childhood Home Visiting (MIECHV) program with virtual home visiting (VHV) during the pandemic remain mostly unknown. This study aimed to describe in detail the experience of home visitors and mothers with VHV during COVID-19 pandemic. This is a prerequisite for guiding future efforts to optimize MIECHV services that are provided through virtual operation.

Methods

Focus groups discussion were conducted with home visitors (n = 13) and mothers (n = 30) who were enrolled in BabyCare program in Virginia from January 2019 to June 2022. This included mothers who received …

Unveiling Similarities And Differences Between Cutaneous And Ocular Melanomas, Abdallah Badou, Nour El Imane Issam Salah, Mohamed Elbelhadji

Health Sciences

Melanomas are outstandingly aggressive cancers, still their incidence is increasing. They can occur in the skin as cutaneous melanoma or in the eye as ocular melanoma. Their pathogenesis is generally similar; however, the prognosis of ocular melanoma patients is still poor, due to its special genetic profile and tumor microenvironment. Here we review the similarities and differences between cutaneous and ocular melanoma, with a focus on their prognostic significance, their molecular signature, and their tumor microenvironment, in order to understand the strategies adopted to escape immune response. Gathering and understanding available knowledge of melanomas and their specificities may help to …

2023 Hsc Committee Executive Meetings Calendar, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Improving Screen Time Review And Adherence To Age-Based Limits In A Fqhc, Erin K. Milner

DNP Projects

Background: Children in the US spend an average of 7.5 hours a day in front of a screen, well above the recommended 2 hours per day for entertainment. Screen time of greater than 3 hours per day is associated with higher body mass indices and insulin resistance that can lead to type 2 diabetes. Providers should review and reinforce age-appropriate screen time guidelines at well-child visits. Screen time education and behavior contracts can be used to facilitate age-appropriate screen time.

Project Goals:

1. To implement screen time education and behavior contracts in a pediatric population in a federally qualified health center …

Conspiracy Theories And Ebola: Lessons Learned Important For Future Pandemics, Shawn C. Smallman

International & Global Studies Faculty Publications and Presentations

The public health campaign against Ebola in the Democratic Republic of the Congo faced serious challenges, some due to conspiracy theories and denial. These beliefs were so powerful that they even caused repeated attacks upon health care providers and medical centers. These conspiracy theories were nothing new, as they are a common feature of all frightening epidemics, such as HIV and COVID-19. These narratives also circulated during the 2015 West African Ebola outbreak. Addressing conspiracy theories during an epidemic requires a coordinated campaign involving not only local leaders but also the cooperation of social media organizations

Effects Of Plasma Sample Handling On Equine Insulin Assays, Lauren Willett

Murray State Theses and Dissertations

Often, the assumption is made that the results of the various laboratory tests being run are accurate, and that abnormal results reflect a physiologic change occurring in the patient. Unfortunately, this assumption is not always true. Inaccurate results, for various reasons, are an inherent part of diagnostic testing. Having inaccurate results is often worse than having no results at all, because they can lead to an incorrect diagnosis or result in unnecessary testing, wasting the client’s financial resources, or potentially expose the patient to unnecessary risks in pursuit of the cause of an abnormality that does not exist. With appropriate …

The Effects Of Inspiratory Muscle Training On Exercise-Induced Laryngeal Obstruction In Young Adults, Allison Lyman

Murray State Theses and Dissertations

Exercise-induced laryngeal obstruction (EILO) is a condition that results from abnormal vocal fold adduction upon inspiration (Abdel-Hamid, 2018). Symptoms of this ailment include dyspnea, choking sensations, an audible stridor, and/or coughing during physical exertion (Marcinow et al., 2014). These symptoms affect an individual’s ability to breathe adequately during exercise. A review of current literature suggests that there are a variety of interventions that can be used to reduce perceived dyspnea in individuals who suffer from EILO. One such intervention is known as inspiratory muscle training (IMT), which works to reduce dyspnea by strengthening the primary muscle of inspiration: the posterior …

Implications Of Lgbtq Identity On Help-Seeking In College Students, Matthew T. Allen

Murray State Theses and Dissertations

LGBTQ individuals find themselves experiencing both mental and physical health concerns at disproportionate rates than cisgender and heterosexual individuals. However, LGBTQ individuals have been shown to seek help for these concerns. Studies examining this phenomenon on college campuses have focused predominantly on mental health concerns. This study hoped to look at both physical and mental health concerns and determine the implications of an LGBTQ identity on help-seeking behavior in college students. The study utilized quantitative research methods through targeted snowball sampling on social media and email. At the conclusion of the collection period, 61 participants completed a survey that included …

Reducing Catheter-Associated Urinary Tract Infection Rates By Educating Staff On Bundle Interventions, Tirath Kaur

Master's Projects

PURPOSE: Catheter associated urinary tract infection is an undesired burden to the patients and healthcare system. This systematic review explores the published literature and determines the impact of educating nursing staff on the indication of urinary catheter, insertion of foley catheters, maintenance of urinary catheters, and periodical communication between nurses and physicians for changing foley catheters can reduce the CAUTI rates in adult patients in the acute care hospital setting. METHOD: A systemic review was conducted using CINHAL, Science Direct, PubMed, and MEDLINE within the time period of ten years from 2012 to 2022. Eight published articles are reviewed and …

A Roadmap To Safer Hyaluronic Acid Injections, Mandi Lonergan

Master's Projects

Non surgical aesthetic treatments have become increasingly more popular in the United States (2020 Plastic Surgery Statistics Report 2021). Hyaluronic acid (HA) fillers are the second most popular non-surgical aesthetic treatment behind Botulinum toxin injections (The Aesthetic Society, 2021). The increased use of these fillers has led to increased rates of complications With the release of new long lasting fillers in 2014, providers began to see an increase in delayed onset nodules (DON). A DON is considered in the aesthetic field to be a nodule that occurs 30 days to years after filler injection (Convery et al., 2021). A …

The Impact Of Utilizing The Eat, Sleep, Console Model On Pharmacologic Interventions And Length Of Stay, Kareena Parks

Master's Projects

Purpose: This systematic review seeks to explore whether utilizing Eat, Sleep, Console (ESC) over the Finnegan Neonatal Abstinence Scale (FNASS) in the neonatal abstinence syndrome (NAS) population decreases length of stay or pharmacological interventions.
Method: Systematic literature review utilizing CINAHL, PubMed and Google Scholar databases.
Results: Utilizing Eat Sleep Console, over FNASS decreased length of stay and pharmacologic intervention.
Conclusions: There is compelling research suggesting a change in NAS treatment from FNASS to ESC with a decrease in length of stay and pharmacologic intervention. However, there is an opportunity for further studies providing higher levels of evidence as the current …

Genotype-Phenotype Correlation In Patients With 21-Hydroxylase Deficiency., Peng Tang, Jun Zhang, Song Peng, Yapeng Wang, Haoyang Li, Ze Wang, Yao Zhang, Yiqiang Huang, Jing Xu, Dianzheng Zhang, Qiuli Liu, Luofu Wang, Weihua Lan, Jun Jiang

PCOM Scholarly Works

INTRODUCTION: 21-hydroxylase deficiency (21OHD) is the most common cause of congenital adrenal hyperplasia (CAH). However, patients with 21OHD manifest various phenotypes due to a wide-spectrum residual enzyme activity of different CYP21A2 mutations.

METHODS: A total of 15 individuals from three unrelated families were included in this study. Target Capture-Based Deep Sequencing and Restriction Fragment Length Polymorphism was conducted on peripheral blood DNA of the three probands to identify potential mutations/deletions in CYP21A2; Sanger sequencing was conducted with the DNA from the family members of the probands.

RESULTS: Dramatically different phenotypes were seen in the three probands of CAH with different …

Virtual Teaching Kitchen Classes And Cardiovascular Disease Prevention Counselling Among Medical Trainees, Alexander C. Razavi, Anna Latoff, Amber Dyer, Jaclyn Lewis Albin, Kristi Artz, Alexandra Babcock, Francesca Cimino, Farzaneh Daghigh, Beth Dollinger, Maya Fiellin, Emily A. Johnston, Grace Marie Jones, Robert D. Karch, Emily T. Keller, Heather Nace, Nimisha K. Parekh, Stephanie Nelson Petrosky, Amy Robinson, Jessica Rosen, Eva M. Sheridan, Susan W. Warner, Jada L. Willis, Timothy S. Harlan

PCOM Scholarly Works

Background: Hands-on culinary medicine education for medical trainees has emerged as a promising tool for cardiovascular health promotion. Purpose: To determine whether virtual culinary medicine programming associates with Mediterranean diet (MedDiet) adherence and lifestyle medicine competencies among medical trainees across the USA. Method: A total of 1433 medical trainees across 19 sites over a 12-month period were included. The Cooking for Health Optimisation with Patients-Medical Trainees survey composed of 61 questions regarding demographics, nutritional attitudes, dietary habits including MedDiet score and lifestyle medicine counselling competencies. Multivariable logistic regression assessed the association of virtual culinary medicine education with MedDiet intake and …

Social Determinants Of Health In People Living With Psychiatric Disorders: The Role Of Pharmacists., Carla D Cobb, Shari N. Allen, Joseph M Cusimano, Michelle Ding, Amanda S Eloma, Carol A Ott, Kimberly B Tallian

PCOM Scholarly Works

INTRODUCTION: Social determinants of health (SDOH) affect outcomes of people living with psychiatric disorders, including substance use disorders. As experts in medication optimization, pharmacists play a vital role in identifying and addressing medication-related problems associated with SDOH. However, there is a paucity of literature on how pharmacists can be part of the solution.

OBJECTIVE: The purpose of this article is to provide a narrative review and commentary on the intersection between SDOH, medication-related outcomes in people living with psychiatric disorders, and the role of pharmacists in addressing them.

METHOD: The American Association of Psychiatric Pharmacists appointed an expert panel to …

Dissociation Of Pulse Wave Velocity And Aortic Wall Stiffness In Diabetic Db/Db Mice: The Influence Of Blood Pressure., Patricia E Mccallinhart, Yong Ung Lee, Avione Lee, Mircea Anghelescu, Jeffrey R Tonniges, Ed Calomeni, Gunjan Agarwal, Joy Lincoln, Aaron J Trask

PCOM Scholarly Works

Introduction: Vascular stiffness is a predictor of cardiovascular disease and pulse wave velocity (PWV) is the current standard for measuring in vivo vascular stiffness. Mean arterial pressure is the largest confounding variable to PWV; therefore, in this study we aimed to test the hypothesis that increased aortic PWV in type 2 diabetic mice is driven by increased blood pressure rather than vascular biomechanics. Methods and Results: Using a combination of in vivo PWV and ex vivo pressure myography, our data demonstrate no difference in ex vivo passive mechanics, including outer diameter, inner diameter, compliance (Db/db: 0.0094 ± 0.0018 mm2/mmHg vs. …

Regulation, Targets And Functions Of Csk., Shudong Zhu, Hui Wang, Kamakshi Ranjan, Dianzheng Zhang

PCOM Scholarly Works

The Src family kinases (SFK) plays an important role in multiple signal transduction pathways. Aberrant activation of SFKs leads to diseases such as cancer, blood disorders, and bone pathologies. By phosphorylating and inactivating SFKs, the C-terminal Src kinase (CSK) serves as the key negative regulator of SFKs. Similar to Src, CSK is composed of SH3, SH2, and a catalytic kinase domain. However, while the Src kinase domain is intrinsically active, the CSK kinase domain is intrinsically inactive. Multiple lines of evidence indicate that CSK is involved in various physiological processes including DNA repair, permeability of intestinal epithelial cells (IECs), synaptic …

Incidence Of Lung Cancer Among Healthcare Workers In Hunan Province And Analysis Of Related Risk Factors., Jinzhang Xiao, Sishi Li, Shudong Zhu, Kamakshi Ranjan, Dianzheng Zhang

PCOM Scholarly Works

BACKGROUND: The prevalence of lung cancer, a major type of malignant tumor, has been increasing over the years greatly impacting the health of Chinese residents. This study investigates the epidemiological characteristics of lung cancer among healthcare workers in the Hunan Province, as well as the occupational risk factors.

METHODS: The data analyzed in this study was collected from the largest tumor hospital in the province: the Hunan Provincial Tumor Hospital affiliated with Central South University, School of Medicine. The data collected encompasses input collected between the years of 2004 to 2013 of the population of healthcare workers who were hospitalized …

In-Between Space: Latinas Sharing Their Stories Of Cultural Integration, Maria Elena Fuster

Art Therapy | Doctoral Dissertations

This study explores how an art-based narrative allows Latinas to explore their own experiences of cultural integration in a way that honors their lived experience. The women used art materials to help them explore their identities and, through this process, discovered new truths about themselves through their stories of living between, within, and outside of both cultures. The art acted as a catalyst to express feelings the women had never before questioned or recognized in themselves and, in doing so, allowed them to create meaning and discover parts of their identities they had never explored before. This further allowed the …

Impact Of Insurance Payer On Stage At Diagnosis Of Prostate Cancer, Hunter M. Stiff

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objectives: Prostate cancer (CaP) is the most common site of cancer in men in the United States and is very treatable when diagnosed in localized and regional stages. While there are widely available forms of screening that can detect CaP in its early stages, factors that can affect healthcare access such as health insurance, race, and Appalachian residency have been linked with differences in rates of distant-stage CaP diagnosis. This study aimed to explore the relationships between health insurance, race, Appalachian residency, and late-stage CaP diagnosis in the state of Kentucky.

Methods: A sample of 26,622 men from the state …

ผลของการประคบเย็นโดยใช้หมอนข้าวไรซ์เบอรี่ต่อความปวดหลังผ่าตัดเปิดช่องท้องในผู้ป่วยโรคระบบทางเดินอาหาร, โชติกา ทองหล่อ, รัตน์ศิริ ทาโต, ปิ่นหทัย ศุภเมธาพร

Journal of Nursing Research, Innovation, and Health

วัตถุประสงค์: เพื่อเปรียบเทียบคะแนนเฉลี่ยความปวดของผู้ป่วยโรคระบบทางเดินอาหารหลังผ่าตัดเปิดช่องท้อง ระหว่างกลุ่มทดลองที่ได้รับการใช้หมอนข้าวไรซ์เบอรี่ประคบเย็นและกลุ่มควบคุมที่ได้รับการพยาบาลปกติในวันที่ 1, 2 และ 3 หลังผ่าตัด

รูปแบบการวิจัย: การวิจัยเชิงทดลองรูปแบบสุ่มที่มีกลุ่มควบคุมและมีการวัดซ้ำ

วิธีดำเนินการวิจัย: กลุ่มตัวอย่าง คือ ผู้ป่วยที่ได้รับการวินิจฉัยว่าเป็นโรคระบบทางเดินอาหารเกี่ยวกับส่วนของกระเพาะอาหาร ลำไส้เล็ก ไส้ติ่ง ถุงน้ำดี ลำไส้ใหญ่และทวารหนัก และรอรับการผ่าตัดเปิดช่องท้อง ที่รับไว้เป็นผู้ป่วยในหอผู้ป่วยศัลยกรรม โรงพยาบาลระยอง จำนวน 40 คน จับฉลากเข้ากลุ่มควบคุมและกลุ่มทดลอง กลุ่มละ 20 คน เครื่องมือที่ใช้ในการวิจัย คือ โปรแกรมการประคบเย็นด้วยหมอนข้าวไรซ์เบอรี่ แบบประเมินความปวดมาตรวัดตัวเลข มีค่าสัมประสิทธิ์สหสัมพันธ์ของเพียร์สัน r = .80 และแบบบันทึกการใช้นวัตกรรมหมอนข้าวไรซ์เบอรี่ประคบเย็น วิเคราะห์ข้อมูลโดยใช้สถิติ Independent t-test และ Repeated Measured ANOVA

ผลการศึกษา:  ผู้ป่วยหลังผ่าตัดเปิดช่องท้องที่ได้รับการประคบเย็นด้วยหมอนข้าวไรซ์เบอรี่ ในวันที่ 1, 2 และ 3 หลังผ่าตัด มีคะแนนเฉลี่ยความปวดต่ำกว่าผู้ป่วยหลังผ่าตัดเปิดช่องท้องที่ได้รับการพยาบาลตามปกติ อย่างมีนัยสำคัญทางสถิติที่ระดับ .05 (p <.05)