Medicine and Health Sciences Commons^™

Quality Of Life And Related Factors Of Patients With Brugada Syndrome Type 1 At King Chulalongkorn Memorial Hospital, Boosamas Sutjaporn, Chavit Tunvirachaisakul, Apichai Khongphatthanayothin

Chulalongkorn Medical Journal

Background: Brugada syndrome (BrS) is a rare cardiac arrhythmic syndrome which can increase the risk of sudden cardiac death in patients without structural heart disease. BrS may affect patients’ quality of life due to long-term follow-up. Objective: To identify the quality of life and related factors in patients with BrS. Methods: Twenty-nine patients with BrS from King Chulalongkorn Memorial Hospital were recruited between August 2019 to April 2020. We collected demographic data, evaluated depression/anxiety with Thai-HADS test, and administered cognitive tests and the quality of life questionnaires (MacNew and SF-36). Descriptive and multiple linear regression were used to analyze the …

Nasal Obstruction And Positional Obstructive Sleep Apnea, Kornkla Panprapakorn, Prakobkiat Hirunwiwatkul, Busarakum Chaitusaney, Natamon Charakorn

Chulalongkorn Medical Journal

Background: Nasal obstruction is one of common risk factors of obstruction in obstructive sleep apnea (OSA) which can be caused by structural abnormalities. Positional obstructive sleep apnea (POSA) is defined that severity of OSA will be worsen in supine position. However, the correlation between nasal obstruction and POSA are unclear. Objectives: The aim of this study was to investigate the prevalence of nasal obstruction in OSA patients and find the correlation between nasal obstruction and respiratory disturbance index (RDI) in these subjects. We also aimed to determine find the correlations in OSA patients POSA and those without POSA. Methods: This …

Prevalence Of Depression And Anxiety Among The Patients With Multiple Sclerosis And Neuromyelitis Optica Spectrum Disorder At King Chulalongkorn Memorial Hospital, Thanawat Sakthanakul, Thanin Asawavichienjinda, Sookjaroen Tangwongchai

Chulalongkorn Medical Journal

Background: Demyelinating disease is an inflammatory disease of the white matter in the brain and of the sheath that covers the nerves, optic nerves, and spinal cord, and its progression is often found to be continuously recurring and eventually develops into disability, stress, depression and anxiety. Objectives: To study the prevalence and the related factors of depression and anxiety among patients with demyelinating disease. Methods: Data were collected from a group of patients diagnosed with demyelinating disease by neurologists at the Outpatient Department, Neurology Unit, King Chulalongkorn Memorial Hospital. Depression and anxiety were assessed with the Thai Hospital Anxiety and …

Age Estimation Using Ankle Radiographic Examination In A Contemporary Thai Population, Aekawit Triamkitsawat, Dittapong Songsaeng, Vijarn Vachirawongsakorn

Chulalongkorn Medical Journal

Background: Radiologic evaluation of skeletal maturity is one of the three practical methods to assess age in a living person. Objective: To assess the average age from the epiphyseal fusion of the distal tibia and fibula in Thai children and young adults. Methods: Ankle radiographs of 217 Thai patients aged 0 to 22 years who came to Siriraj Hospital from 1 January 2000 to 31 March 2020 were recruited for the study. The development of epiphyseal plate in the distal tibia and fibula was analyzed as a grading system. A composite score was also calculated. The relationship between age, the …

Incidence Of Delirium In Hip Fracture Surgery At King Chulalongkorn Memorial Hospital, Siree Sukhanonsawat, Yanin Thipakorn, Paul Thisayakorn

Chulalongkorn Medical Journal

Background: Postoperative delirium in hip fracture patients is a significant public health problem that affects the quality of patients’ lives and increases morbidity and mortality rate. Objective: To investigate the incidence of delirium and associated factors in elderly patients who underwent hip fracture surgery. Methods: This is a cross-sectional descriptive study. Data were collected from the patients aged  65 years who underwent hip fracture surgery at King Chulalongkorn Memorial Hospital. The Thai Mental State Examination (TMSE) was used to investigate cognitive function preoperatively and on the 4th postoperative day. Postoperative delirium was assessed for 4 consecutive days using the …

Detection Of Human Papillomavirus Type 16 L1 Gene Methylation In Leftover Dna Samples Obtained From Cobas 4800 Hpv Test, Rungtip Thumbovorn, Arkom Chaiwongkot

Chulalongkorn Medical Journal

Background: It has been known that persistent infections with the high-risk human papillomavirus (HR-HPVs) is the main risk factor for cervical cancer progression. However, a minor of HR-HPV infected women developed cancer. Therefore, it is necessary to look for additional test to particularly identify HR-HPV infected women who are at higher risk to progress to cervical cancer quickly. Objective: We aimed to detect HPV16 L1 gene methylation levels in the leftover DNA samples of HPV16 positive samples with cytology diagnosed as atypical squamous cells of undetermined significance (ASCUS) obtained from Roche Cobas 4800 HPV assay. Methods: Methylation analysis within HPV16 …

Effects Of Transcranial Direct-Current Stimulation Combined With Physical Therapy In Chronic Low Back Pain Treatments: A Randomized Controlled Pilot Study, Mai Loan Pham Thi, Wanida Donpunha, Saowanee Nakmareong, Paradee Auvichayapat, Kittisak Sawanyawisuth, Taweesak Janyacharoen

Chulalongkorn Medical Journal

Background: Chronic low back pain (CLBP) affects 80.0% of the population and reduces their quality of life (QOL). Searching for its most effective treatment has being a challenge in the health-care system. Although studies using transcranial direct current stimulation (tDCS) plus physical therapy (PT) that aim to relieve pain, an optimal intervention method and clinical effectiveness evaluations related to CLBP patient aspects have not been completely investigated. Objectives: The purpose of this study was to compare treatment effects between a combination of tDCS and PT (combined group) and PT alone (PT group) in pain intensity, gait speed, lumbar range of …

Dose-Dependent Effect Of Local Treatment Of Phyllanthus Emblica L. Cream On Diabetic Wound, Ting-Ting Liao, Supakanda Sukpat, Chaisak Chansriniyom, Suthiluk Patumraj

Chulalongkorn Medical Journal

Background: Non-healing diabetic ulcers are the most common cause of amputation. Several studies have reported for new, more effective treatments for chronic wounds in diabetic patients. Objective: This study aimed to evaluate the effect of local treatment of Phyllanthus emblica Linn. (PE) on a full-thickness wound model in streptozotocin-induced diabetic mice. Methods: Balb/c mice were divided into five groups: control group (CON), diabetic wounded group (DM, streptozotocin 45 mg/kg i.p. daily for 5 days), diabetic wounded group with daily treatment of different concentrations of PE cream (10%; 100%; and 200%, w/v). Seven days after the diabetic induction, all mice were …

Anxiety And Related Factors Among Mothers Of Postoperative Pediatric Patients At King Chulalongkorn Memorial Hospital, Yadaporn Yordsawat, Chutima Roomruangwong, Prapapan Rajatapiti

Chulalongkorn Medical Journal

Background: According to previous studies, mothers caring for children with various diseases had anxiety. However, few studies were conducted on anxiety and related factors among mothers of postoperative pediatric patients in Thailand. Objectives: To study the prevalence of anxiety and related factors among mothers of postoperative pediatric patients at King Chulalongkorn Memorial Hospital. Methods: Data were collected from 105 mothers of pediatric patients receiving corrective surgery as in-patients and out-patients by using questionnaires including: 1) The mothers’ demographic questionnaire; 2) The children’s background questionnaire; 3) The STAI Form-Y1, Y2 anxiety measuring form; and, 4) The Parental Stress Scale: Pediatric Intensive …

Safety And Efficacy Of The Novel Surgical Dye From Blue Butterfly Pea Flower: An Ex Vivo And In Vitro Study, Rossukon Khotcharrat, Wanachat Thongsuk, Pussadee Paensuwan

Chulalongkorn Medical Journal

Background: The chemical dyes were used for anterior capsule staining with caution. There is no natural dye available. The extract from traditional Thai herb may be an alternative dye. Objectives: To assess the in vitro cytotoxicity of the novel surgical dye on corneal endothelial cells and evaluate the proper concentration for staining on anterior lens capsule during cataract surgery in ex vivo. Methods: Safety of the dye in various concentrations on human corneal endothelial cell line was evaluated by resazurin technique. The efficacy of human anterior capsular staining at different concentrations of the dye and different time-points was also studied …

Prevalence And Associated Factors Of Anxiety And Depression In Liver Cirrhosis At Outpatient Clinic, Naphat Sirinimnualkul, Piyawat Komolmit, Teerayuth Rungnirundorn

Chulalongkorn Medical Journal

Background: Liver cirrhosis is one of the chronic medical conditions which frequently leads to psychiatric comorbidities including depression and anxiety disorder. Objective: The aim of this study was to evaluate the prevalence and associated factors of anxiety and depression in patients with liver cirrhosis in outpatient clinic. Methods: Patients with liver cirrhosis aged from 18 years and above, excluded active liver malignancy, were recruited from liver clinic at outpatient of department of medicine. Anxiety and depression were identified using Thai Hospital Anxiety and Depression Scale (THAI-HADS). Descriptive statistic was applied to estimate prevalence of anxiety and depression and factors associated …

Design And Evaluation Of An Artificial Positive Control Construct For Detection Of The Novel Coronavirus 2019 Using Triplex Pcr, Afshin Samiminemati, Mehdi Zeinoddini, Nasrin Xodadadi, Fatemeh Sheikhi

Chulalongkorn Medical Journal

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a novel-emerged strain with the person-to-person transmission that had never been found in humans. The main method for the identification of SARS-CoV2 is the genome-based reverse transcription polymerase chain reaction (RT-PCR) using expensive instrument (real time thermal cycler); therefore, viral RNA is required to perform PCR reaction. On the other hand, false-positive or negative results of RT-PCR detection of this virus are a challenge for all clinical laboratories. One smart and scientific strategy for solving this problem is designing an artificial positive control construct. Objectives: To design and evaluate this positive …

Intention To Have No Children And Its Relation To Mental Health: A Case Study Of Personality And Coping Traits Of Married Couples, Registering At Bangrak District Office, Pichaya Wattanavitukul, Chutima Roomruangwong

Chulalongkorn Medical Journal

Background: Modern families tend to have fewer children, planning to have no children has seen more and more. There are pieces of evidence that many families planned to have no children even the family’s economic status has improved. Objectives: To examine the prevalence of intention to have no children among those who come to get marriage registration at Bangrak District Office, Bangkok Metropolis, and association between intention to have no children and personality and coping. Methods: The cross-sectional descriptive study was conducted in males and females who come to get marriage registration at Bangrak District Office, Bangkok Metropolis. The data …

Effects Of Social Cognitive Enhancement With Family Involvement Program On Game Addictive Prevention In Male Junior High School Students, Pagagrong Laolam, Punyarat Lapvongwatana, Natkamol Chansatitporn

Chulalongkorn Medical Journal

Background: Gaming addiction is addressed in the 11th revision of the International Classification of Diseases (ICD-11) as its high negative effects to personal, family, social, educational, and occupational aspects of adolescents’ life. Objective: This quasi-experimental research aimed to examine positive effects of social cognitive enhancement with family involvement (SCEFI) program on game addictive prevention in male junior high school. Methods: Sixty-two of 8th Grade students were equally assigned into the experimental and comparison groups. The experimental group received the SCEFI program plus one activity of family involvement while the comparison group received routine activities. The study intervention was 7 weeks …

Analysis Of Breast Mri Performed On Patients With Axillary Nodal Metastasis And Negative Mammogram And Ultrasound, Palita Hansakul

Chulalongkorn Medical Journal

Background: Occult breast cancer is a rare type of breast cancer which magnetic resonance imaging (MRI) has an immense role to confirm diagnosis and disclose non-demonstrable finding on initial modality. Objectives: To analyge breast MRI findings in patients with axillary nodal metastasis and negative mammo gram and ultrasound and retrospectively review the initial mammography and second-look ultrasound. Methods: From January 2010 to January 2023, women who diagnosed occult breast cancer by presenting metastatic axillary lymph node on pathological report with negative mammography and ultrasonography, underwent breast MRI to identify occult breast carcinoma. Their breast MRI were retrospectively reviewed. The imaging …

Treatment Of Eyelid Divided Nevus Using Shave And Graft: An Alternative Technique, Suppapong Tirakunwichcha

Chulalongkorn Medical Journal

Divided nevus of the eyelid is an uncommon feature among congenital melanocytic nevi. To report the outcome after treatment of eyelid divided nevus using shave and graft technique. Two cases of small to moderate size divided nevus at the eyelids were demonstrated, one on medial part including upper and lower punctal area and the other on lateral part. Shave and graft were done to alleviate the nevus in one or two-staged of operation. Patients underwent the uneventful operation. Pathologic results found nevus, free surgical margin without malignant transformation. Cosmetic result was satisfactory. In patient with medial divided nevus, no epiphora …

Diagnostic Accuracy Of Dual-Energy Ct To Determine Urinary Tract Stone Composition: Differentiating Between Uric Acid And Non-Uric Acid Urinary Tract Stone, Pawanaporn Rojanavijitkul, Pattama Tantigate, Supoj Ratchanon, Manint Usawachintachit, Krit Pongpirul, Bundit Chaopathomkul

Chulalongkorn Medical Journal

Background: The urinary tract stone is a worldwide condition with various clinical significances. Optimal treatment requires multiple considerations including stone composition. Dual-energy computed tomography (DECT) has been used to determine uric acid and non-uric acid urinary tract stones. Objective: To evaluate the diagnostic accuracy of rapid-kilovoltage (kV) switching DECT in differentiating between uric acid and non-uric acid stones compared with reference standard infrared spectroscopy (IRS). Methods: A prospective study enrolled patients from February 2018 to March 2020 who underwent a DECT scan for urinary tract stone with 3-mm stone (s). Post-processed material-density (MD) images were used to differentiate between uric …

Political Economy Of Cannabis In Thailand, Mano Laohavanich

Chulalongkorn Medical Journal

Cannabis has been classified as category 5 addictive herb. However, the new tread of the world has found it useful resulting a change of policy by the Ministry of Public health in Thailand, i.e., to follow the California Model that allows cannabis to be grown no more than seven in a household. This review article aimed to explore the origin of policy on cannabis of the current government of Thailand, especially under the new Minister of Public Health, its applications, obstacles and plausible solutions and the policy suggestion for deregulation of cannabis. Literature reviews were conducted on history of cannabis, …

Validity And Reliability Of The Thai-Version Of Post Stroke Depression Scale (Psds-T), Kuankidnuttha Arunsri, Aurauma Chutinet, Sookjareon Tangwongchai

Chulalongkorn Medical Journal

Background: Currently, there has been limited effective and practical instruments for screening post-stroke depression (PSD) in Thailand. In 2014, Post-Stroke Depression Scale (PSDS) has been testified to be a valid and reliable self-rated questionnaire for evaluating Chinese patients with PSD. Objective: This study proposed to validate the Thai version of PSDS (PSDS-T) in Thai patients with acute ischemic stroke. Methods: The PSDS was translated into Thai language (PSDS-T). The validity and reliability were tested in 145 acute ischemic stroke patients. Subjects were consecutively recruited to complete PSDS-T; they were clinically evaluated for PSD using DSM-5 diagnosis of adjustment disorder with …

Cpap Acceptance And Adherence In Osa Patients In Lower Northern Region Part Of Thailand, Mantana Prakassajjatham

Chulalongkorn Medical Journal

Background: Continuous positive airway pressure (CPAP) is the mainstay in obstructive sleep apnea (OSA) treatment. Good CPAP adherence reduces many risks of diseases and improves the overall quality of life.

Objective: The purpose of this study was to determine the acceptance and adherence to CPAP therapy among Thai patients with OSA who attend an otorhinolaryngology sleep clinic.

Methods: This retrospective study was conducted at the otorhinolaryngology sleep clinic, Naresuan University Hospital, Thailand between January 2015 and October 2021. The study enrolled all patients over 18 years old with OSA diagnosis. The patients were scheduled for follow-up appointments at least two …

Rapid And Simple Detection Of Escherichia Coli O157: H7 Using Multiplex Pcr, Alaleh Valiallahi, Mehdi Zeinoddini, Alireza Saeedinia, Fatemeh Sheikhi

Chulalongkorn Medical Journal

Background: Escherichia coli O157:H7 is a major foodborne pathogen and can be found globally. Traditional microbiological methods to detect E.coli O157:H7 are expensive and time consuming. However, detection assay using polymerase chain reaction (PCR) can be very specific and may be a suitable alternative. Objective: The present study aimed to evaluate a simple and rapid diagnostic multiplex PCR assay for the selective identification of attaching and effacing genes of E.coli O157:H7. Methods: One-step multiplex PCR using specific primers for eae (Intimin) and rfbE (O157 antigen) genes was carried out. PCR products were analyzed by agarose gel electrophoresis. The specificity of …

Relationships Between Activities Of Daily Living Capabilities, Family Support, And Quality Of Life And Mental Health In The Elderly In Laplae District, Uttaradit Province, Tanyarat Jeenheng, Siriluck Suppapitiporn

Chulalongkorn Medical Journal

Background: Due to the sociocultural context of Laplae District, Uttaradit Province as the example district of long-term care services for dependent elderly project. To improve public health, quality of life and mental health of elderly in this district would be interesting and useful. Objective: To explore the abilities of activities of daily living (ADL), the family support, the quality of life, and the mental health of the elderly and relationships among them. Methods: This cross-sectional study with participation of 381 elderly used structured questionnaires included demographic questions, ADL assessment (Barthel of Activities of Daily Living: ADL), family support and quality …

Quality Of Sleep In Stroke Patients At Phramongkutklao Hospital, Jirat Lothaka, Chavit Tunvirachaisakul, Naratorn Soponprapakorn

Chulalongkorn Medical Journal

Background: Stroke is one of the leading causes of death and serious long-term disability worldwide. A common consequence of stroke is reduced quality of sleep. Objective: To study the quality of sleep in patients with stroke, related factors and the compatibility of wearable tracker device for collecting sleep data. Methods: This cross-sectional study included 66 subjects with stroke at Phramongkutklao Hospital using questionnaires including demographic questions, sleep quality assessment (PSQI), and the satisfaction of Wearable tracker tool assessments. Each subject received a wearable tracker to examine the sleep quality. Results: According to the PSQI assessment, the majority of subjects had …

Surgical Aspects Of Adrenal Tumors In Children, Sirima Liukitithara, Paisarn Vejchapipat, Katawaetee Decharun, Apirak Santingamkun

Chulalongkorn Medical Journal

Background: Adrenal tumors are uncommon in children. They can be divided into 2 categories, namely: adrenomedullary tumor and adrenocortical tumor. Surgical aspects of these conditions receive little attention. Objective: The objective of this study was to describe clinical data, operative findings, and operative complications in children with adrenal tumors. Methods: Patients, aged 0 - 15 years, undergoing adrenalectomy between January 2007 and December 2016 were retrospectively reviewed. Results: Thirty-seven patients underwent adrenalectomies. Male to female ratio was 1.31 to 1. Median age of the patients was 44 months (range, 2 months-14 years). Pathological examination revealed 27 adrenomedullary tumors (19 neuroblastomas, …

Game Addiction And Severity Of Adhd Symptoms Among Adolescent Adhd Patients, Nuttawut Suksamai, Napakkawat Buathong, Sasithorn Preechawuttidach

Chulalongkorn Medical Journal

Background: Children and adolescents who use the Internet and play games are at risk for the Internet and game addiction because they are still developing and learning new things. Problematic game players are more likely to have attention-deficit hyper activity disorder (ADHD) compared with the general population. The data about game addiction in Adolescents with ADHD in Thailand are still limited. Objectives: To examine the prevalence of game addiction and its association with the severity of ADHD symptoms and other factors in adolescent ADHD patients attending the Child and Adolescents Outpatient Psychiatric Clinic, King Chulalongkorn Memorial Hospital. Methods: This cross-sectional …

Stress And Associated Factors Of Caregivers Of Elderly Medical Inpatients At King Chulalongkorn Memorial Hospital, Rattanaporn Chumnisart, Chavit Tunvirachaisakul

Chulalongkorn Medical Journal

Background: Parallel with the increasing number for elderlies, the need of care when they were acutely ill has multiplied, with caregivers being tasked from the beginning to the end of the illness. A family member was often a primary person to take care of the elderly. This role might affect their mental health and quality of life. Objective: To explore the progression of stress and the associated factors among caregivers of the elderlies admitted with acute illness. Methods: This longitudinal descriptive study examined various factors associated with caregivers of the elderlies who were admitted to the medical wards of King …

Rate Of Drug-Resistant Streptococcus Pneumoniae In Children With Invasive Pneumococcal Disease: A Decade Review, Thritsawan Thanyapalit, Suvaporn Anugulruengkitt, Watsamon Jantarabenjakul, Tuangtip Theerawit, Nattapong Jitrungruengnij, Thanyawee Puthanakit

Chulalongkorn Medical Journal

Background: Streptococcus pneumoniae is a common causative organism of pneumonia, bacteremia and meningitis in children. Rate of drug-resistant Streptococcus pneumoniae (DRSP) is an important information to guide appropriate empirical antibiotics. Objectives: This study aimed to describe rates of DRSP and clinical outcomes of patients with invasive pneumococcal disease (IPD). Methods: A retrospective study was conducted among pediatric patients with IPD from 2008 -2017. DRSP was defined as National Committee for clinical laboratory standards guidelines 2013. Results: From January 2008 to December 2017, 71 patients with diagnosis of IPD were identified. Median (interquartile range) age was 2 years (2 months - …

Comparative Accuracy Of Unenhanced And Iv-Contrast Enhanced Mdct In Detection Of Acute Appendicitis In Adult Patients, Sirivipa Charuswattanakul, Thitinan Chulroek

Chulalongkorn Medical Journal

Background: Computed tomography (CT) is the preferred imaging modality for suspected acute appendicitis. However, optimal CT technique remains controversial. Objectives: To compare the diagnostic accuracy of unenhanced CT with standard IV-contrast enhanced CT in the diagnosis of acute appendicitis in adult patients and whether body mass index (BMI) affects the diagnosis. Methods: A total of 209 patients (70 males and 139 females) with clinically suspected acute appendicitis underwent both unenhanced and IV-contrast enhanced CT with rectal contrast administration. We retrospectively reviewed radiographic findings of appendicitis, appendiceal visualization, likelihood of appendicitis and alternative diagnoses. Receiver operating characteristic (ROC) analysis, unpaired t …

Spiritual Perspectives Of Thai Psychiatrists On Mental Health, Vasin Kosolsak, Buranee Kanchanatawan

Chulalongkorn Medical Journal

Background: Although the positive impact of spirituality on mental health has become more widely accepted in the past decade, it is a challenging subject due to its distinctive nature between beliefs and cultures. Objectives: This study aimed to define the term spirituality and its influence on mental health based on the viewpoint of Thai psychiatrists. Methods: This qualitative research was conducted in 20 Thai psychiatrists recruited from all regions across Thailand using a semi-structured in-depth interview, based on literature reviews. The collected data were analyzed via content analysis. Results: We found that Thai psychiatrists define spirituality as a belief, reliance, …

Prevalence And Type Of Kras Mutations In Endometrial Endometrioid Carcinoma, Supaporn Suwiwat, Papitchaya Watcharanuruk, Siriwong Lattakanjanang, Anupong Nitiruangjaras, Kobkul Tungsinmunkong

Chulalongkorn Medical Journal

Background: KRAS encodes a small G-protein that involves cell proliferation, differentiation, and survival. Objectives: To determine the prevalence and type of KRAS mutations in Southern Thai patients with endometrial endometrioid carcinoma as well as their correlation with clinicopathological variables. Methods: A total of 190 patients with endometrioid carcinoma were analyzed for KRAS exon 2 mutations using direct sequencing. The statistical correlation of KRAS mutations with clinicopathogical variables was also evaluated using the Chi-square or Fisher exact test. Results: KRAS mutations were detected in 17.4% (33/190) of cases. All of them were missense mutations and 72.7% (24/33) occurred in hotspot codons …