Medicine and Health Sciences Commons^™

2021-05-19_Michiganoverview_Covidtestingtimes, Michigan Department Of Health & Human Services

Michigan COVID-19 Testing Turnaround Data

The COVID Testing Turnaround Time page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-545615--,00.html.

This report was created by the Michigan Department of Health & Human Services, providing data for the past 14 days on the average time it takes for a diagnostic COVID-19 laboratory test to be reported to the state health department. Testing turnaround time data will be updated weekly on Friday mornings.

MDHHS receives results from commercial labs, hospitals, and public health labs. However, public health laboratories perform limited diagnostic testing and disease surveillance for infectious diseases. Total turnaround time is calculated from the difference of …

Development Of A Binge-Like Eating Animal Model Using Foods Of Varying Palatability: Effects Of The Catecholamine Uptake Blocker Lisdexamfetamine, Ariba Memon

Honors Scholar Theses

Binge Eating Disorder (BED) is a psychiatric disorder that is characterized by the consumption of an excessive amount of food in a short period of time despite not being hungry. Numerous animal models have been developed that can induce binge-like eating behavior through limited access to a highly palatable food. One such model utilizes Cadbury’s milk chocolate that is very successful in inducing binge-like eating behavior in both male and female rats. Lisdexamfetamine (LDX), a d-amphetamine prodrug and the only FDA approved pharmaceutical treatment for BED, has been shown to significantly reduce chocolate consumption in the chocolate binge-like animal model. …

Development Of A Multilevel Intervention To Increase Colorectal Cancer Screening In Appalachia, Aaron J. Kruse-Diehr, Jill M. Oliveri, Robin C. Vanderpool, Mira L. Katz, Paul L. Reiter, Darrell M. Gray Ii, Michael L. Pennell, Gregory S. Young, Bin Huang, Darla Fickle, Mark Cromo, Melinda Rogers, David Gross, Ashley Gibson, Jeanne Jellison, Michael D. Sarap, Tonia A. Bivens, Tracy D. Mcguire, Ann Scheck Mcalearney, Timothy R. Huerta, Saurabh Rahurkar, Electra D. Paskett, Mark B. Dignan

Health, Behavior & Society Faculty Publications

Background

Colorectal cancer (CRC) screening rates are lower in Appalachian regions of the United States than in non-Appalachian regions. Given the availability of various screening modalities, there is critical need for culturally relevant interventions addressing multiple socioecological levels to reduce the regional CRC burden. In this report, we describe the development and baseline findings from year 1 of “Accelerating Colorectal Cancer Screening through Implementation Science (ACCSIS) in Appalachia,” a 5-year, National Cancer Institute Cancer Moonshot^SM-funded multilevel intervention (MLI) project to increase screening in Appalachian Kentucky and Ohio primary care clinics.

Methods

Project development was theory-driven and included the …

International Journal Of Dentistry, Ahmed Hamdy, Dalia Ghalwash, Waleed M. Abbas, Hala K. Abd El Gaber

Dentistry

Objectives. This study aimed to clinically assess and compare the width of peri-implant keratinized mucosa following the use of a readymade plastic stent with apically repositioned flap versus conventional apically repositioned flap with papillary sparing incisions during single-stage implant placement protocol. Materials and Methods. A total of 20 patients were enrolled in this study. In the test group, a prefabricated implant-retained stent was clipped on the healing abutment after implant surgery to reposition the keratinized tissue buccoapically. In the control group, simple interrupted sutures were applied instead of using a stent. After the surgical procedure, the width of …

Nurses' Perspectives On Pain Management In The Emergency Department, Elizabeth Fitzgerald

Seton Hall University Dissertations and Theses (ETDs)

Over 130 million people seek care in emergency departments (ED) in the United States annually. Most patients who seek treatment in emergency departments are experiencing a painful condition, and as such, ED nurses should have a deep understanding of pain management in the ED. There is limited qualitative research which explores pain management from the nurses’ perspective. The purpose of this study is to describe pain management from the nurse’s perspective. Thorne’s (2005) method of Interpretive Description guided this qualitative inquiry. New knowledge describing the nature of pain management in the ED provides insight into elements which support and impede …

The Effects Of The Mckenzie Method And Strengthening/Stabilization Exercises In Patients With Chronic Nonspecific Low Back Pain., Lufei Harder

Honors College Theses

Background & objective: Low back pain is a frequent problem that the majority of people will face at some point in their lifetime. Exercise has been advocated as an effective treatment for chronic nonspecific low back pain; however, there is a lack of consensus on the best form of exercise treatment. This review was designed to compare the effectiveness of the McKenzie Method against stabilization/strengthening exercises in patients with chronic nonspecific low back pain.

Methods: A literature review examining McKenzie and stabilization exercises for chronic nonspecific low back pain were identified from three databases.

Results: A total of nine articles …

Conceptualization Of College Students' Covid-19 Related Mask-Wearing Behaviors Using The Multi-Theory Model Of Health Behavior Change, Robert E. Davis, Manoj Sharma, Kayla E. Simon, Amanda H. Wilkerson

Environmental & Occupational Health Faculty Presentations

Background: Recommendations and policies, regarding the use of face coverings, have been instituted to control transmission of coronavirus disease 2019 (COVID-19). Understanding of psychosocial factors related to the use of face coverings within the context of COVID-19 is needed. This study aimed to conceptualize mask-wearing behavior among students using the Multi-theory Model (MTM) of behavior change. Methods: In October 2020, students (n = 595) enrolled in a large public southeastern US university were recruited to participate in a cross-sectional survey, using a valid and reliable instrument. Univariate, bivariate, and multivariate techniques described mask-wearing behavior and differentiated theoretical drivers of mask-wearing …

Transcription Factor Β-Catenin Plays A Key Role In Fluid Flow Shear Stress-Mediated Glomerular Injury In Solitary Kidney., Tarak Srivastava, Daniel P. Heruth, R Scott Duncan, Mohammad H. Rezaiekhaligh, Robert E. Garola, Lakshmi Priya, Jianping Zhou, Varun C. Boinpelly, Jan Novak, Mohammed Farhan Ali, Trupti Joshi, Uri S. Alon, Yuexu Jiang, Ellen T. Mccarthy, Virginia J. Savin, Ram Sharma, Mark L. Johnson, Mukut Sharma

Manuscripts, Articles, Book Chapters and Other Papers

Increased fluid flow shear stress (FFSS) in solitary kidney alters podocyte function in vivo. FFSS-treated cultured podocytes show upregulated AKT-GSK3β-β-catenin signaling. The present study was undertaken to confirm (i) the activation of β-catenin signaling in podocytes in vivo using unilaterally nephrectomized (UNX) TOPGAL mice with the β-galactosidase reporter gene for β-catenin activation, (ii) β-catenin translocation in FFSS-treated mouse podocytes, and (iii) β-catenin signaling using publicly available data from UNX mice. The UNX of TOPGAL mice resulted in glomerular hypertrophy and increased the mesangial matrix consistent with hemodynamic adaptation. Uninephrectomized TOPGAL mice showed an increased β-galactosidase expression at 4 weeks …

Normal Versus Half-Normal Saline In The Treatment Of Children With Diabetic Ketoacidosis, Amal G. Mohamed, Nada M. F. Elsayed, Raya A. M. Saleh, Sally R. Eid

Journal of Medicine in Scientific Research

Objective This study aims to determine the effect of 0.9% saline (NS) versus 0.45% saline (half NS) on blood pressure and serum electrolytes in children with diabetic ketoacidosis. Patients and methods This is a cross-sectional prospective comparative study carried out on 105 patients (1–18 years) from those admitted to the pediatric ICU of Al-Zahraa University Hospital from March 2017 to August 2019. Cases were divided into three groups (35 in each group). Group I patients received a shock, deficit, and maintenance therapy with NS. Group II patients received a shock therapy NS along with deficit and maintenance therapy with half …

Postoperative Astigmatism After Small-Incision Cataract Surgery With Sclera Tunnel Suturing And Without Scleral Tunnel Suturing: A Comparative Study, Mohammed S. Ahmed

Journal of Medicine in Scientific Research

Background and aim Cataract represents a significant socioeconomic burden and a public health concern, as it is the leading cause of blindness worldwide. Small-incision cataract surgery (SICS) is one of the cataract surgical techniques commonly used in developing countries. There have been many improvements and changes in SICS's technique since its development, including changes in the site and size of the incision. Patients and methods This study was conducted aiming to study postoperative astigmatism after SICS with or without scleral tunnel suturing. This study was performed on 100 eligible eyes in 59 consecutive patients. Identical surgical methods were used in …

A Case Of Positive Covid-19-Infected Patient With Retinal Detachment And A Large Macular Hole: A Case Report, Mohammed S. Ahmed

Journal of Medicine in Scientific Research

Retinal detachment (RD) associated with macular hole accounts for 0.5% of RD. Here, we describe a rare case of RD and a large macular hole in a patient tested positive for COVID-19 in Sohag Teaching Hospital, Sohag, Egypt.

Using Methylene Blue Spray Intraoperatively To Perform Safe Thyroidectomy, Abdelrahman K. Abdelrahman, Esayed Elmokadem, Ihab Matar

Journal of Medicine in Scientific Research

Background Recurrent laryngeal nerve (RLN) injury and hypoparathyroidism are serious complications following thyroidectomy. Minimizing these complications is important to avoid a destructive life-long handicap. Aim Our goal was to decrease the incidence of intraoperative mishaps by spraying methylene blue dye on thyroid tissue and the tissues nearby. Patients and methods This is a prospective study that included 90 patients who underwent primary thyroid surgery for various thyroid diseases, with total thyroidectomy done in all. The patients were divided into two groups: methylene blue group included 45 patients who underwent surgery using methylene blue technique, and conventional group included 45 patients …

The Efficacy And Safety Of Ombitasvir/Paritaprevir/Ritonavir Plus Ribavirin In Hepatitis C Virus-Infected Patients With End-Stage Renal Disease On Regular Hemodialysis, Dalia Omran, Enass El Sayed, Muhammad M. A. Ghaffar

Journal of Medicine in Scientific Research

Background and aim Infection with hepatitis C virus (HCV) is an important cause of mortality and morbidity in patients with end-stage renal disease. Direct-acting antiviral drugs allow for the treatment of this group of patients. The current research aims to assess the efficacy and safety of ombitasvir/paritaprevir/ritonavir (OBV/PTV/RTV) combination therapy plus ribavirin in the treatment of HCV-infected Egyptian patients with chronic kidney disease stage V on regular hemodialysis. Patients and methods A total of 70 patients with chronic kidney disease stage V on regular hemodialysis with HCV infection were enrolled in this prospective cohort study, where 37 patients (group A) …

Evaluation Of Tissue Doppler Echocardiography In The Assessment Of Ventricular Function In Asthmatic Children, Amal G. Mohamed, Nada M. F. Elsayed, Safaa A. Mohammed, Sally R. Eid

Journal of Medicine in Scientific Research

Background Bronchial asthma is one of the commonest diseases in children. It not only affects the lung but also other organs, including the heart. Our study aims to assess the effect of bronchial asthma with varying degrees of severity on the ventricular function of the heart using tissue Doppler imaging. Patients and methods This is a case–control study that was performed at the Pediatric Department of Al-Azhar University Hospital and included 50 patients with bronchial asthma, who were compared with 50 age-matched and sex-matched healthy children as a control group. All children were subjected to full history taking, complete physical …

Selective Laser Trabeculoplasty In Silicone Oil-Induced Glaucoma, Hussam O. Elrashidy

Journal of Medicine in Scientific Research

Introduction One of the complications of using silicone oil is glaucoma. Selective laser trabeculoplasty (SLT) became an increasingly focused laser procedure for glaucoma because of its efficacy and minimal destructive effects on the surrounding tissues. The aim of our study is to analyze the efficacy of SLT on silicone oil-induced secondary glaucoma in terms of intraocular pressure (IOP). Patients and methods This is prospective study on 30 eyes of 30 patients with silicone oil-induced secondary glaucoma. The patients should have had no history of glaucoma or ocular hypertension before silicone oil injection. The patients were treated with laser at 360° …

Omentoplasty For Pelvic Defect Closure Following Abdominoperineal Resection In Lower Rectum Cancer, Amr A. Ella, Esayed Elmokadem, Ihab Matar

Journal of Medicine in Scientific Research

Background The perineal wound is considered an important source of postoperative morbidity and mortality following abdominoperineal resection (APR). Complications include wound dehiscence, infection, abscess, perineal herniation, radiation enteritis, persistent sinus, more nursing effort, prolonged hospital stay, and increase readmission with cost increase. Aim The aim of this study is to compare the result of conventional closure of pelvic defect following APR versus closure with omentoplasty. Patients and methods This study included 30 patients who underwent APR. The patients were divided into two groups: omentoplasty group included 15 patients who underwent pelvic defect closure using pedicle omental flap, and conventional group …

Functional Improvements Of Diabetic Macular Edema After Treatment With Ranibizumab, Hussam O. Elrashidy

Journal of Medicine in Scientific Research

Background Diabetic retinopathy and clinically significant macular edema are largely responsible for the irreversible, debilitating visual impairment. There is evidence suggesting that some of the diabetes-related visual abnormalities are due to neurodegeneration. Use of objective tests for early detection of retinal dysfunction of sight-threatening diabetic retinopathy would be of great value. Aim The aim was to study the functional improvements of macular functions after treatments with intravitreal injection of ranibizumab as detected with central visual field and multifocal electroretinogram (mfERG). Settings and design A prospective cohort interventional study that included 30 eyes of 30 patients. Materials and methods Prospective cohort …

Minimal Invasive Cardiac Surgery Coronary Artery Bypass Grafting And Hybrid Revascularization: Early Experience And Potential Indications, Ahmed Zaye, Mohamed M. Mohamed, Tamer El Banna, Yasser A. Sadek

Journal of Medicine in Scientific Research

Background There is increasing interest and patient demand for minimally invasive cardiac surgery. Aim We aimed to assess the safety and potential indications of minimally invasive coronary artery bypass grafting (CABG) and possibilities of such techniques and debating it will become the standard procedure. Patients and methods From February 2015 till February 2020, 83 cases underwent CABG via right submammary incision, and of them, 18 cases underwent hybrid technique. Results The procedure was successfully performed in all. Conversion rate to full sternotomy was 0%. Hospital mortality was seen in two (2.4%) patients. Re-exploration for bleeding was done in 0 (0%) …

The Significance Of Interferon-Inducible Protein-16 And Anti-Interferon-Inducible Protein-16 Antibodies In Rheumatoid Arthritis: Relation To Pulmonary Disease And Serological Markers, Eman R. Amer, Hala Abd-Elhameed Tabl, Sherry K. Abdelrahman, Suzan M. Farouk, Taghreed F. M. Mostafa

Journal of Medicine in Scientific Research

Aim The aim of the study was to detect the presence of interferon-inducible protein-16 (IFI16) as well as anti-IFI16 antibodies in the serum and synovial fluid of patients with rheumatoid arthritis (RA) and to evaluate the relation to pulmonary interstitial lung disease (ILD) patterns, disease activity, joints erosions, and serological markers. Patients and methods This study involved two groups: 82 adult patients with established RA participated as a study group, whereas 30 patients with knee osteoarthritis also joined as a control group. IFI16 and anti-IFI16 immunoglobulin G were assessed by enzyme-linked immunosorbent assay in serum of all patients and controls, …

Conceptualization Of College Students' Covid-19 Related Mask-Wearing Behaviors Using The Multi-Theory Model Of Health Behavior Change, Robert E. Davis, Manoj Sharma, Kayla E. Simon, Amanda H. Wilkerson

Environmental & Global Health Faculty Research

Background: Recommendations and policies, regarding the use of face coverings, have been instituted to control transmission of coronavirus disease 2019 (COVID-19). Understanding of psychosocial factors related to the use of face coverings within the context of COVID-19 is needed. This study aimed to conceptualize mask-wearing behavior among students using the Multi-theory Model (MTM) of behavior change. Methods: In October 2020, students (n = 595) enrolled in a large public southeastern US university were recruited to participate in a cross-sectional survey, using a valid and reliable instrument. Univariate, bivariate, and multivariate techniques described mask-wearing behavior and differentiated theoretical drivers of mask-wearing …

Infectious Disease Transmission By Arline Travel, Daniele Provenzano, Sofy Barocio

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Improvements in aviation technology have led to considerable growth of domestic and international flights worldwide especially during the past four decades. Commercial flights have increased the movement of and have connected people from virtually all corners of the globe since the end of World War II to exceed 3 billion passengers a year since 2013: a sizable proportion of the global human population. Flight times have decreased considerably from the onset of commercial aviation and the range of airliners has extended substantially. A passenger harboring an infectious agent embarking a flight on one continent can be deplaning on another continent …

Development Of A Multilevel Intervention To Increase Colorectal Cancer Screening In Appalachia, Aaron J Kruse-Diehr, Jill M Oliveri, Robin C Vanderpool, Mira L Katz, Paul L Reiter, Darrell M Gray, Michael L Pennell, Gregory S Young, Bin Huang, Darla Fickle, Mark Cromo, Melinda Rogers, David Gross, Ashley Gibson, Jeanne Jellison, Michael D Sarap, Tonia A Bivens, Tracy D Mcguire, Ann Scheck Mcalearney, Timothy R Huerta, Saurabh Rahurkar, Electra D Paskett, Mark Dignan

Faculty, Staff and Student Publications

BACKGROUND: Colorectal cancer (CRC) screening rates are lower in Appalachian regions of the United States than in non-Appalachian regions. Given the availability of various screening modalities, there is critical need for culturally relevant interventions addressing multiple socioecological levels to reduce the regional CRC burden. In this report, we describe the development and baseline findings from year 1 of "Accelerating Colorectal Cancer Screening through Implementation Science (ACCSIS) in Appalachia," a 5-year, National Cancer Institute Cancer Moonshot

METHODS: Project development was theory-driven and included the establishment of both an external Scientific Advisory Board and a Community Advisory Board to provide guidance in …

Electronic Clinical Decision Support For Children With Minor Head Trauma And Intracranial Injuries: A Sociotechnical Analysis, Jacob K Greenberg, Ayodamola Otun, Azzah Nasraddin, Ross C Brownson, Nathan Kuppermann, David D Limbrick, Po-Yin Yen, Randi E Foraker

2020-Current year OA Pubs

BACKGROUND: Current management of children with minor head trauma (MHT) and intracranial injuries is not evidence-based and may place some children at risk of harm. Evidence-based electronic clinical decision support (CDS) for management of these children may improve patient safety and decrease resource use. To guide these efforts, we evaluated the sociotechnical environment impacting the implementation of electronic CDS, including workflow and communication, institutional culture, and hardware and software infrastructure, among other factors.

METHODS: Between March and May, 2020 semi-structured qualitative focus group interviews were conducted to identify sociotechnical influences on CDS implementation. Physicians from neurosurgery, emergency medicine, critical care, …

Covid-19 Newsletter (Vol. 72), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

A Method To Delineate De Novo Missense Variants Across Pathways Prioritizes Genes Linked To Autism, Amanda Koire, Panagiotis Katsonis, Young Won Kim, Christie Buchovecky, Stephen J Wilson, Olivier Lichtarge

Faculty, Staff and Students Publications

Genotype-phenotype relationships shape health and population fitness but remain difficult to predict and interpret. Here, we apply an evolutionary action method in mutational landscapes to unravel genes and pathways connected to autism spectrum disorder (ASD). Evolutionary action predicts the impact of missense variants on protein function by measuring motions in fitness landscapes, based on phylogenetic distances and substitution odds in homologous sequences. By examining 368 pathways across 2,384 individuals with ASD (probands), we found that 23 pathways, a total of 398 genes, had de novo missense variants biased to higher evolutionary action scores than expected by random chance, including axonogenesis, …

Esomeprazole Attenuates Inflammatory And Fibrotic Response In Lung Cells Through The Mapk/Nrf2/Ho1 Pathway, Afshin Ebrahimpour, Min Wang, Li Li, Anil G Jegga, Mark D Bonnen, N Tony Eissa, Ganesh Raghu, Soma Jyothula, Farrah Kheradmand, Nicola A Hanania, Ivan O Rosas, Yohannes T Ghebre

Faculty, Staff and Students Publications

INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is an orphan disease characterized by progressive loss of lung function resulting in shortness of breath and often death within 3-4 years of diagnosis. Repetitive lung injury in susceptible individuals is believed to promote chronic oxidative stress, inflammation, and uncontrolled collagen deposition. Several preclinical and retrospective clinical studies in IPF have reported beneficial outcomes associated with the use of proton pump inhibitors (PPIs) such as esomeprazole. Accordingly, we sought to investigate molecular mechanism(s) by which PPIs favorably regulate the disease process.

METHODS: We stimulated oxidative stress, pro-inflammatory and profibrotic phenotypes in primary human lung epithelial …

Bibliometric Survey On Effect Of Socio-Economic Factors On Spread Of Corona Virus (Covid-19), Seema Patil Prof., Aayushi Verma Ms, Isha Patil Ms, Ravneesh Singh Mr, Raghav Gaur Mr

Library Philosophy and Practice (e-journal)

The Novel Coronavirus disease has been rapidly spreading all around the globe, from the time when it was first reported in the Wuhan city of China. The primary focus of this bibliometric survey is to distinguish the documents which have hypothesized and expanded on the effects of various socio-economic factors when it comes to the spread of the Coronavirus.

This survey does the evaluation on the 480 documents found. The United Kingdom of the Great Britain and United States have contributed the largest number of publications in this field of research followed closely by India and Italy.

The survey includes …

Calculation Of The Correct Angle Of Bifurcation Predicts The Atherosclerotic Lesion Severity More Accurately, Mehmet Ozgeyik, Onur Kaypakli, Mufide Okay Ozgeyik

Journal of the Saudi Heart Association

No abstract provided.

Rota Burr-Induced Aortic Cusp Laceration Necessitating Valve Replacement, Vinayak Vadgaonkar, Nooraldaem Yousif, Husam A. Noor, Sadananda Shivappa

Journal of the Saudi Heart Association

No abstract provided.

Opioid And/Or Psychotropic Use Increases Intraprocedural Sedation Drug Requirements, Sreeja Sanampudi, Ravi Jayavarapu, Trae C. Brooks, Driss Raissi

Radiology Faculty Publications

Objectives Acute pain management in opioid users can be challenging in the perioperative period. This study focuses on whether use of opioids increases sedation medication requirements in patients undergoing port placement under moderate sedation.

Materials and Methods A retrospective review was performed on all patients undergoing port placement between June 1, 2017, and June 30, 2019. Exclusion criteria included receiving general anesthesia, no sedation, and errors in data entry. Data collection included demographics, use of opioids, benzodiazepines, antidepressants, tobacco, alcohol, and sedation data.

Results Opioid, benzodiazepine, and selective serotonin reuptake inhibitors (SSRIs)/serotonin-norepinephrine reuptake inhibitors (SNRIs) use was significantly associated with …