Medicine and Health Sciences Commons^™

Addition Of Gabapentin To Opioids Does Not Improve Pain In Patients With Chronic Neck And Low Back Pain, Nebojsa Nick Knezevic, Tabish Aijaz, Alvaro Camacho-Ortega, Kenneth Candido

Scientific Day

No abstract provided.

Time To Positivity And Antibiotic Duration In Febrile Neonates At Advocate Children's Hospital, Tabitha Tate, Tejaswi Dittakavi, Yusuf Askaroglu, Ronda Oram, Emily Keller

Scientific Day

No abstract provided.

List Of Events For 47th Annual Scientific Day, Advocate Aurora Health

Scientific Day

No abstract provided.

Diagnostic Accuracy Of Magnetic Resonance Imaging (Mri) And Dynamic Ultrasound For The Diagnosis Of Plantar Plate Injuries: A Systematic Review And Meta-Analysis, Manali Chingre, Rachel Albright, Brandon Brooks, Erin E. Klein, Lowell S. Weil Jr, Adam Fleischer

Scientific Day

No abstract provided.

Does Digital Information Alter Decision Making In Bariatric Surgery?, Diana Kantarovich, Eric Veilleux, Shadi Aboudi, Molly O'Brien, Emma Wood, Francisco Quinteros, Rami Lutfi

Scientific Day

No abstract provided.

In-Hospital Mortality And Outcomes In Hospitalized Patients With Myocardial Injury And Covid-19 Infection, Khalil Odeh, Ana Cristina Perez, Viviana Zlochiver, Fekadesilassie Moges, Michael Peterson, Ashley Mainville, Katie Busniewski, Jon Wrobel, Hlu Vang, Sara Walczak, Suhail Allaqaband, A. Jamil Tajik, Bijoy Khandheria, Muhammad Fuad Jan

Scientific Day

No abstract provided.

Cardiac, Renal And Liver Functionin Neonates With Hypoxic Ischemic Encephalopathy Treated With Therapeutic Hypothermia, Gospodin Stefanov, Timothy Colombo, Lorene Schweig, Preetha Prazad, Ramona Donovan

Scientific Day

No abstract provided.

Serum Micronutrient Status, Sleep Quality And Neurobehavioral Function Among Early Adolescents, Xiaopeng Ji, Charlene W. Compher, Sharon Y. Irving, Jinyoung Kim, David F. Dinges, Jianghong Liu

Nursing Faculty Research

Objective: To examine associations between serum micronutrients and neurobehavioral function and the mediating role of sleep quality in early adolescents. Design: In this cross-sectional study, peripheral blood samples were analyzed for iron and zinc levels. The Pittsburgh Sleep Quality Index and Penn Computerized Neurocognitive Battery were used to assess sleep quality and neurobehavioral function, respectively. The generalized linear regressions (bootstrap) were performed to estimate the associations. Setting: Jintan, China Participants: 226 adolescents (106 females) from the Jintan Child Cohort study. Results: Adolescents with low iron (< 75 ug/dl) (OR=1.29, p=0.04) and low zinc (< 70 ug/dl) (OR=1.58, p0.05). Conclusion: Iron and zinc deficiencies may possibly be associated with poor sleep and neurobehavioral function among early adolescents. Poor sleep may partially mediate the relationship between micronutrients and neurobehavioral function.

How Will The Future Of Work Shape Osh Research And Practice? A Workshop Summary, Sarah A Felknor, Jessica M K Streit, Michelle Mcdaniel, Paul A Schulte, L Casey Chosewood, George L Delclos

Faculty, Staff and Student Publications

Growth of the information economy and globalization of labor markets will be marked by exponential growth in emerging technologies that will cause considerable disruption of the social and economic sectors that drive the global job market. These disruptions will alter the way we work, where we work, and will be further affected by the changing demographic characteristics and level of training of the available workforce. These changes will likely result in scenarios where existing workplace hazards are exacerbated and new hazards with unknown health effects are created. The pace of these changes heralds an urgent need for a proactive approach …

The Epidemiology, Evaluation, And Assessment Of Lateral Ankle Sprains In Athletes, G. Javier Cavazos Jr., Lawrence B. Harkless

School of Medicine Publications

Approximately 30,000 ankle injuries occur every day in the United States. With the incidence estimated at more than 3 million a year and at a rate of 2.15/1,000 in the U.S. alone, medical specialists and other healthcare providers caring for the foot and ankle must take notice. Despite the millions of ankle injuries sustained annually, the true incidence may be underestimated, as fewer than half of individuals with ankle sprains seek medical attention from healthcare professionals. The economic burden associated with the evaluation, diagnosis, and treatment is close to $4 billion annually. Ankle sprains account for half of all sports …

Female With Intermittently Bleeding Abdominal Wall Mass., Evan Osterman, Rebecca Lisowski, Arthur Au

Department of Emergency Medicine Faculty Papers

No abstract provided.

Development Of Improved Diagnostic Tests For Lyme Disease, Ezdehar Ghazal

NYMC Student Theses and Dissertations

Laboratory diagnosis is very critical for early treatment of Lyme disease, as Lyme disease could be difficult to diagnose because of vague symptoms or the confusion with symptoms from other illnesses. Previously, the standard two tiered-testing (STTT) was the traditional testing for Lyme disease with two different lab testing methods, Enzyme Immunoassay (EIA) as the first-tier test and immunoblot as the second-tier test to confirm the diagnosis. However, western immunoblotting had a poor sensitivity of <50% for early Lyme disease and high costs. Recently, the Centers for Disease Control and Prevention (CDC) recommended the use of a modified two tiered-testing (MTTT) which was cleared by The US Food and Drug Administration (FDA) in which EIA can be used instead of western immunoblotting.

In this study we followed a recent multiplexed paper-based immunoassay study for early Lyme disease serodiagnostic testing by using an Enzyme Linked Immunosorbent Assay (ELISA) …

Effect Of Yoga On Perceived Stress And Pulmonary Function In High Stressed Postmenopausal Women, Vinodini Na

Kasturba Medical College, Mangalore Theses and Dissertations

No abstract provided.

2021-05-25_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-05-25_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

Investigating The Effects Of Zero Balancing On The Physical, Mental, Emotional, And Spiritual Dimensions Of Wellness: A Phenomenological Mixed Methods Pilot Study, Misty L. Rhoads, Mary Murphy, Michele Doucette, Tom Gentile, Dylan Rhoads, Jacob Watson

Journal of Transformative Touch

Background: Today, the necessity for relieving undue stress on the physical, mental, emotional, and spiritual levels is evident at this time of concomitant global crises from the pandemic, societal inequity, and climatic challenges. Methods to restore and enhance human well-being are critically needed.The study of overall wellness has not yet included the role that skilled, conscious touch may play in supporting the dimensions of wellness, an awareness of which this study seeks to elevate by exploring the effects of receiving positive touch on the physical, mental, emotional, and spiritual dimensions of wellness.

Methods: The researchers chose to utilize a concurrent …

2021-05-25_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

2021-05-25_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-05-25_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

The Antibiogram: Key Considerations For Its Development And Utilization, William R. Truong, Levita Hidayat, Michael A. Bolaris, Lee Nguyen, Jason Yamaki

Pharmacy Faculty Articles and Research

The antibiogram is an essential resource for institutions to track changes in antimicrobial resistance and to guide empirical antimicrobial therapy. In this Viewpoint, data and examples from literature are presented that suggest institutions have not completely adopted the standardized approach in developing antibiograms, as variations in the development methodologies of antibiograms exist despite consensus guidelines (M39) published by CLSI. We emphasize developing antibiograms in line with the M39 recommendations will help ensure that they are accurate, reliable and valid, and highlight that understanding the limitations of antibiogram data is critical to ensuring appropriate interpretation and application to clinical decision-making. We …

Component Causes Of Infectious Bovine Keratoconjunctivitis—Non-Moraxella Organisms In The Epidemiology Of Infectious Bovine Keratoconjunctivitis, John Dustin Loy, Kristin A. Clothier, Gabriele Maier

School of Veterinary and Biomedical Sciences: Faculty Publications

• Non-Moraxella organisms are associated with infectious bovine keratoconjunctivitis (IBK).

• Mycoplasma bovoculi can cause conjunctivitis and has a potential role in IBK pathogenesis.

• Other Non-Mycoplasma agents can cause disease that resembles IBK but is clinically different.

• Genomics and molecular technology are advancing research in this area.

• Classification and determination of pathogenesis potential of these organisms may be better understood through metagenomics and whole genome sequencing.

Evaluation Of Liver Kinase B1 Downstream Signaling Expression In Various Breast Cancers And Relapse Free Survival After Systemic Chemotherapy Treatment, Khoa Nguyen, Andrew Rivera, Madlin Alzoubi, Henri Wathieu, Shengli Dong, Hassan Yousefi, Margarite Matossian, Suresh Alahari, David Drewry, Matthew Burow, Bridgette Collins-Burow

School of Medicine Faculty Publications

LKB1-signaling has prominent roles in cancer development and metastasis. This report evaluates LKB1-signaling pathway gene expression associations with patient survival in overall breast cancer, specific subtypes, as well as pre- and post-chemotherapy. Subtypes analyzed were based on intrinsic molecular subtyping and traditional biomarker classifications. Intrinsic molecular subtypes included were Luminal-A, Luminal-B, HER2-enriched, and Basal-like. The biomarker subtypes assessed were Estrogen-Receptor Positive (ER+) and Negative (ER-), Wild-Type TP53 (WT-TP53) & Mutant-TP53, and Triple-Negative Breast Cancer (TNBC). Additionally, comparisons were made between these subtypes and breast cancer overall, and analyses between LKB1 signaling to patient survival before and after chemotherapy were made. …

Alzheimer’S Disease Drug Development Pipeline: 2021, Jeffrey Cummings, Garam Lee, Kate Zhong, Jorge Fonseca, Kazem Taghva

Brain Health Faculty Research

Introduction The number of individuals worldwide with Alzheimer's disease (AD) is growing at a rapid rate. New treatments are urgently needed. We review the current pipeline of drugs in clinical trials for the treatment of AD. Methods We interrogated ClinicalTrials.gov, the federal registry of clinical trials to identify drugs in trials. Results There are 126 agents in 152 trials assessing new therapies for AD: 28 treatments in Phase 3 trials, 74 in Phase 2, and 24 in Phase 1. The majority of drugs in trials (82.5%) target the underlying biology of AD with the intent of disease modification; 10.3% are …

Improved First Trimester Maternal Iodine Status With Preconception Supplementation: The Women First Trial, Amy E. Young, Jennifer F. Kemp, Charis Uhlson, Jamie L. Westcott, Sumera Aziz Ali, Sarah Saleem, Ana Garcès, Lester Figueroa, Manjunath S. Somannavar, Shivaprasad S. Goudar

Community Health Sciences

Maternal iodine (I) status is critical in embryonic and foetal development. We examined the effect of preconception iodine supplementation on maternal iodine status and on birth outcomes. Non-pregnant women in Guatemala, India and Pakistan (n ~ 100 per arm per site) were randomized ≥ 3 months prior to conception to one of three intervention arms: a multimicronutrient-fortified lipid-based nutrient supplement containing 250-μg I per day started immediately after randomization (Arm 1), the same supplement started at ~12 weeks gestation (Arm 2) and no intervention supplement (Arm 3). Urinary I (μg/L) to creatinine (mg/dl) ratios (I/Cr) were determined at 12 weeks …

Metabolites Profiling Of Coffee Seeds In Context To Their Origin, Processing And Gut Microbiota Interaction, Amr Abdelwareth

Theses and Dissertations

Coffee is among the most consumed beverages worldwide, with the present study to focus on the aroma and non-volatiles composition associated with coffee seeds processing, brewing methods and gut microbiota interaction. The study uncovered a large number of primary and secondary metabolites in diverse coffee products consumed in the Middle East in the context of its origin, roasting, and blends and microbiota mediated biotransformation products. First, aroma of authentic coffee specimens of Coffea arabica and Coffea robusta alongside with commercial products consumed in the Middle East were analyzed using HS-SPME coupled to GC-MS and modelled using multivariate data analyses (MVA). …

Gaming Disorder And Well-Being Among Emirati College Women, Marina Verlinden, Justin Thomas, Mahra Hasan Abdulla Ahamed Almansoori, Shamil Wanigaratne

All Works

Background: The present study examined Internet Gaming Disorder (IGD) and depressive symptom levels among a predominantly female sample of college students from the United Arab Emirates (UAE). Methods: IGD was assessed among two successive cohorts of students at the beginning of the academic year in 2016 and 2019, respectively. All participants (n = 412) completed the Internet Gaming Disorder Scale – Short-Form (IGDS9-SF) and the WHO-5 Well-being Index (WHO-5), a tool widely used for the screening and assessment of depressive symptomatology. Results: Mean IGDS9-SF scores (15.85, SD = 6.40) were fairly similar to those observed in other nations. The prevalence …

Analysis Of Single Cell Rna-Seq Data Revealed Interferon Gamma Signaling Alteration In Severe Covid Patients, Ahmed Elbaz

Theses and Dissertations

Background: SARS-COV2 virus detected in December 2019, and was considered a pandemic in March 2020 by the WHO. Symptoms range from asymptomatic to life threatening ones. Studying cell-cell interactions in patients' blood samples may lead to novel diagnosis and treatment approaches.

Aim: This study aims to analyze single-cell RNA sequencing data to identify differences in cell-cell communications between healthy and COVID patients and differentially expressed T-cells genes that contributed to immune system antiviral activity.

Materials and methods: Single-Cell RNA sequencing data from seven COVID patients and five healthy individuals were collected from (GEO accession GSE155673). Cell types were identified and …

Cell Lineage Tracing Links Erα Loss In Erbb2-Positive Breast Cancers To The Arising Of A Highly Aggressive Breast Cancer Subtype, Yunfeng Ding, Yonghong Liu, Dong-Kee Lee, Zhangwei Tong, Xiaobin Yu, Yi Li, Yong Xu, Rainer B Lanz, Bert W O'Malley, Jianming Xu

Children’s Nutrition Research Center Staff Publications

HER2-positive (HER2+) breast cancers (BrCs) contain approximately equal numbers of ERα+HER2+ and ERα−HER2+ cases. An enduring obstacle is the unclear cell lineage-related characteristics of these BrCs. Although ERα+HER2+ BrCs could lose ERα to become ERα−HER2+ BrCs, direct evidence is missing. To investigate ERα dependencies and their implications during BrC growth and metastasis, we generated ERαCreRFP-T mice that produce an RFP-marked ERα+ mammary gland epithelial cell (MGEC) lineage. RCAS virus-mediated expression of Erbb2, a rodent Her2 homolog, first produced comparable numbers of ERα+RFP+Erbb2+ and ERα−RFP−Erbb2+ MGECs. Early hyperplasia developed mostly from ERα+RFP+Erbb2+ cells and ERα−RFP−Erbb2+ cells in these lesions were rare. …

Scaling Up Information Sharing On Hiv-Associated Neurocognitive Disorder: Raising Awareness And Knowledge Among Key Stakeholders, Renato M. Liboro, Paul A. Shuper, Lori E. Ross

Psychology Faculty Research

Although the majority of specialists and researchers in the field of HIV/AIDS are aware and knowledgeable about HIV-associated neurocognitive disorder (HAND) as a condition that affects as much as 50% of people living with HIV/AIDS (PLWH), research has documented that many health care and service providers who work directly with PLWH are either unaware of HAND or believe they do not know enough information about HAND to effectively support their clients experiencing neurocognitive challenges. Based on the findings of a qualitative study that interviewed 33 health care and service providers in HIV/AIDS services to identify and examine their awareness and …

Timing Of Home Health Care Initiation And 30-Day Rehospitalizations Among Medicare Beneficiaries With Diabetes By Race And Ethnicity., Jamie M Smith, Haiqun Lin, Charlotte Thomas-Hawkins, Jennifer Tsui, Olga F Jarrín

College of Nursing Faculty Papers & Presentations

Older adults with diabetes are at elevated risk of complications following hospitalization. Home health care services mitigate the risk of adverse events and facilitate a safe transition home. In the United States, when home health care services are prescribed, federal guidelines require they begin within two days of hospital discharge. This study examined the association between timing of home health care initiation and 30-day rehospitalization outcomes in a cohort of 786,734 Medicare beneficiaries following a diabetes-related index hospitalization admission during 2015. Of these patients, 26.6% were discharged to home health care. To evaluate the association between timing of home health …