Medicine and Health Sciences Commons^™

The Determinants Of Stunting For Children Aged 24-59 Months In Kulon Progo District 2019, Chatrine Aprilia Hendraswari, Yuliasti Eka Purnamaningrum, Tri Maryani, Yani Widyastuti, Sakinah Harith

Kesmas

This study pertains to stunting in children in Indonesian with z-scores of less than -2 Standard Deviation (SD) and less than -3 SD. The preliminary study results showed the highest prevalence of stunting to be 22.6%, at the Temon II Primary Health Care in Kulon Progo District. The study aimed to assess the determinants of stunting children aged 24–59 months. This study was conducted from September 2018–May 2019. The design of this study was analytical observational with study design case-control. The sample was 60 children aged 24–59 months. The method utilized proportional sampling, whereas the data analysis applied chi-square and …

A Path Analysis Model For Explaining The Factors Influencing Wearing A Mask Among Commuting Workers Using Commuter Line Bogor-Jakarta, David Kusmawan, Shofi Andari, Ira Gustina, Indri Hapsari Susilowati, Mufti Wirawan

Kesmas

Jakarta is one of the most air-polluted cities in the world, which can increase the health risk of commuting workers exposed to pollutants. This study aimed to determine the factors that directly and indirectly affect healthy behavior (wearing a mask) for commuters using the Bogor-Jakarta Commuter Line. Furthermore, a total of 155 respondents participated and the data collected were analyzed using descriptive and path analysis. The commuters aware of the hazard potential related to air pollution during commuting were 137 people (88.4%). While 104 people (67.1%) were aware of the good perception of pollution and 125 uses masks during commuting …

Empowering Health Cadres To Support Drug-Resistant Tuberculosis (Dr-Tb) Patient To Enroll In Treatment, Esty Febriani, Adik Wibowo, Neeraj Kak, Hala Jassim Al Mossawi

Kesmas

Tuberculosis (TB) remains a big challenge globally, while the involvement of health cadres’ constitutes one of the key strategies for the TB program in Indonesia. These roles were further expanded to providing support to DR-TB patients. This study was a qualitative study, conducted in 2015 to explore the various factors which influence the performance of health cadres’ in supporting DR-TB patients to enroll in treatment. A total of 39 informants consisting of 24 health cadres, three nurses, four DR-TB patients, and three family members, two peer support, a head of primary health care, and two TB staffs from the District …

National Health Insurance Scheme: Internal And External Barriers In The Use Of Reproductive Health Services Among Women, Evi Martha, Herna Lestari, Resvi Siti Zulfa, Yoslien Sopamena

Kesmas

Lack of familiarity among the community, medical workers, and administrative staff regarding reproductive health services covered by Badan Penyelenggara Jaminan Sosial (BPJS) or the National Health Insurance (NHI) in Indonesia remained a problem. Therefore, this resulted in sub-optimal use of the medical services, as shown by surveys from the Women's Health Foundation for three consecutive years (2015-2017). This qualitative study was conducted with a Rapid Assessment Procedure design in three cities within Indonesia: Padang Pariaman, Manado, and Kupang. Data were collected through IDIs (n = 47informants) and 6 FGDs (7 persons/group). Participants also consisted of NHI RHS users (mothers and …

Prevalence And Determinants Of Pre-Lacteal Feeding: Insights From The 2017 Indonesia Demographic And Health Survey, Siti Nurokhmah, Siti Masitoh, Kusuma Estu Werdani

Kesmas

Pre-lacteal feeding is widely known as a distraction to exclusive breastfeeding, and the malpractice continues to be prevalent in Indonesia. Therefore, this study aimed to explore the potential determinants of pre-lacteal feeding among mothers of infants below 24 months. A sample of 6,455 mother-infant pairs from the 2017 Indonesia Demographic and Health Survey (IDHS) was used. Also, multivariate logistic regression was employed to identify factors associated with pre-lacteal feeding practice. In Indonesia, 44% of infants were introduced to solid/liquid feeds in their first three days of life. Infant formula was the most common pre-lacteal feed given, followed by any other …

Inter-Related Factors Influencing Sexual Quality Of Life Among Women Living With Hiv In Banten Province, Indonesia: A Mixed Methods Study, Dyah Juliastuti, Judith Dean, Yati Afiyanti, Lisa Fitzgerald

Kesmas

Socio-cultural concerns often restrict women's sexual rights and well-being living with HIV (WLHIV) in developing countries. These convergent parallel mixed methods study combined quantitative and qualitative approaches to explore factors influencing WLHIV sexual quality of life in Banten Province, Indonesia. A 2017 cross-sectional survey of 207 reproductive-aged WLHIV was analyzed using univariate and multivariate logistic regression statistics. Furthermore, in-depth interviews with a sub-sample of survey participants (n = 30) were thematically analyzed. Most of the women (60%) involved reported loss of sexual pleasure and depressed sexual life. Meanwhile, 48% affirmed low sexual quality of life which was associated with unemployment …

Attitudes Concerning Sexual Behavior Towards Risky Sexual Behavior Of Sexual Transmitted Infections Among Male Adolescents In Indonesia, Helda Helda, Nurul Muchlisa

Kesmas

There has been an increase of sexually transmitted infections (STIs) such as HIV/AIDS worldwide, especially in Indonesia. Several studies on adolescent behavior, especially the male as the main predictor, reported increased in STIs’ cases due to risky sexual behavior. This study aimed to show the relationship between attitudes, sexual behavior, and the risks of STIs among male adolescents in Indonesia based on the Indonesia Demographic and Health Survey (IDHS) data in 2017. This cross-sectional study involved 10,547 male adolescents using the total sampling method according to the inclusion and exclusion criteria. Data were analyzed using a complex sample logistic regression …

Extracellular Superoxide Dismutase (Ec-Sod) Regulates Gene Methylation And Cardiac Fibrosis During Chronic Hypoxic Stress., Ayan Rajgarhia, Kameshwar R. Ayasolla, Nahla Zaghloul, Jorge M. Lopez Da Re, Edmund J. Miller, Mohamed Ahmed

Manuscripts, Articles, Book Chapters and Other Papers

Chronic hypoxic stress induces epigenetic modifications mainly DNA methylation in cardiac fibroblasts, inactivating tumor suppressor genes (RASSF1A) and activating kinases (ERK1/2) leading to fibroblast proliferation and cardiac fibrosis. The Ras/ERK signaling pathway is an intracellular signal transduction critically involved in fibroblast proliferation. RASSF1A functions through its effect on downstream ERK1/2. The antioxidant enzyme, extracellular superoxide dismutase (EC-SOD), decreases oxidative stress from chronic hypoxia, but its effects on these epigenetic changes have not been fully explored. To test our hypothesis, we used an in-vitro model: wild-type C57B6 male mice (WT) and transgenic males with an extra copy of human hEC-SOD (TG). …

Brown Treesnake Mortality After Aerial Application Of Toxic Baits, Scott M. Goetz, Eric T. Hileman, Melia G. Nafus, Amy A. Yackel Adams, Amanda R. Bryant, Robert N. Reed, Shane R. Siers

United States Department of Agriculture Wildlife Services: Staff Publications

Quantitative evaluation of control tools for managing invasive species is necessary to assess overall effectiveness and individual variation in treatment susceptibility. Invasive brown treesnakes (Boiga irregularis) on Guam have caused severe ecological and economic effects, pose a risk of accidental introduction to other islands, and are the greatest impediment to the reestablishment of extirpated native fauna. An aerial delivery system for rodent‐based toxic baits can reduce brown treesnake abundance and heterogeneity among individuals may influence bait attraction or toxicant susceptibility. Previous baiting trials have either been simulated aerial treatments or relied on slightly different bait capsule compositions and the results …

Ferumoxytol For The Treatment Of Iron Deficiency And Iron-Deficiency Anemia Of Pregnancy., Jesse Gerb, William Strauss, Richard Derman, Vanessa Short, Phd, Mph, Ben Mendelson, Huzefa Bahrain, Michael Auerbach

Department of Obstetrics and Gynecology Faculty Papers

Introduction: A litany of recent evidence supports the morbidity of intra-natal iron-deficiency anemia and its prodrome, iron deficiency. Oral iron administered during second and third trimesters does not get to the developing fetus if the mother is iron deficient. This is especially concerning as the rapidly developing fetal brain is in particular need of iron sufficiency. Intra-natal iron deficiency is associated with autism, schizophrenia and abnormal brain structure. The obstetrical literature reports an unacceptably high incidence of gastrointestinal adverse events with oral iron. The time iron honored standard in the United States for intravenous iron replenishment in gravidas is iron …

Patient-Reported Outcomes Through 1 Year Of An Hiv-1 Clinical Trial Evaluating Long-Acting Cabotegravir And Rilpivirine Administered Every 4 Or 8 Weeks (Atlas-2m), Vasiliki Chounta, Edgar T. Overton, Anthony Mills, Susan Swindells, Paul D. Benn, Simon Vanveggel, Rodica Van Solingen-Ristea, Yuanyuan Wang, Krischan J. Hudson, Mark S. Shaefer, David A. Margolis, Kimberly Y. Smith, William R. Spreen

Journal Articles: Infectious Diseases

BACKGROUND: Advances in HIV-1 therapeutics have led to the development of a range of daily oral treatment regimens, which share similar high efficacy rates. Consequently, more emphasis is being placed upon the individual's experience of treatment and impact on quality of life. The first long-acting injectable antiretroviral therapy for HIV-1 (long-acting cabotegravir + rilpivirine [CAB + RPV LA]) may address challenges associated with oral treatment for HIV-1, such as stigma, pill burden/fatigue, drug-food interactions, and adherence. Patient-reported outcomes (PROs) collected in an HIV-1 clinical trial (ATLAS-2M; NCT03299049) comparing participants' experience with two dosing regimens (every 4 weeks [Q4W] vs. every …

Insights From An Inaugural Eight-Month Interprofessional Collaborative Co-Design Educational Experience Between Occupational Therapy And Industrial Design, Rebecca Brown, Kimberly S. Mollo, Madalyn Peterson, Mikael Avery, Eric Schneider, Tod Corlett

Department of Occupational Therapy Faculty Papers

The design of the built environment greatly impacts how all types of individuals and populations actively participate in their daily lives. Lack of access in the built environment for disabled populations remains a daily reality, negatively impacting engagement and life satisfaction, leading to isolation, loneliness, and depression. A university in the Northeastern United States sought to expand current constructs of the end-user and environment within a universal design (UD) perspective. On an eight-month inaugural interprofessional collaborative co-design experience, third-year occupational therapy doctoral (OTD) students were embedded in a first-year masters of industrial design (MSID) curriculum, which ran the course of …

Lactoferrin-Bearing Gold Nanocages For Gene Delivery In Prostate Cancer Cells In Vitro, Jamal Almowalad, Sukrut Somani, Partha Laskar, Jitkasem Meewan, Rothwelle J. Tate, Margaret Mullin, Christine Dufès

School of Medicine Publications

Background: Gold nanocages have been widely used as multifunctional platforms for drug and gene delivery, as well as photothermal agents for cancer therapy. However, their potential as gene delivery systems for cancer treatment has been reported in combination with chemotherapeutics and photothermal therapy, but not in isolation so far. The purpose of this work was to investigate whether the conjugation of gold nanocages with the cancer targeting ligand lactoferrin, polyethylene glycol and polyethylenimine could lead to enhanced transfection efficiency on prostate cancer cells in vitro, without assistance of external stimulation.

Methods: Novel lactoferrin-bearing gold nanocages conjugated to polyethylenimine and …

End Of Life Decision-Making Challenges In A Latino Patient With Covid-19: Facing Barriers, Irma Huayanay, Celia Pantoja, Chelsea Chang

School of Medicine Publications

COVID-19 pandemic brought difficult scenarios that patients and families are facing about end- of-life decisions. This exposed some weak areas in the healthcare system where we can continue improve in reducing disparities and emphasizing advance care planning from a primary level of care. We present a case of challenges in end-of-life decision-making in a Latino patient.

Implementing A Program Of Lifestyle Modification In Pregnancy To Reduce The Risk Of Recurrent Gestational Diabetes Mellitus (Gdm), Connie Van Baah

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

The occurrence of Gestational Diabetes Mellitus (GDM) has significantly increased globally, as has the threat of GDM recurrence in subsequent pregnancies. GDM recurrence rate can range from 40% to 73% in some populations. GDM is associated with acute maternal health problems and long-term diseases, such as type II diabetes and recurrent GDM. Fetuses and infants of mothers with GDM can experience primary health complications early and late in life. Although lifestyle changes such as healthy eating and physical activity in high-risk patients are effective in reducing diabetes risk factors, limited attention has been paid to the possible benefits of translating …

Characterization Of Time-Variant And Time-Invariant Assessment Of Suicidality On Reddit Using C-Ssrs, Manas Gaur, Vamsi Aribandi, Amanuel Alambo, Ugur Kursuncu, Krishnaprasad Thirunarayan, Jonathan Beich, Jyotishman Pathak, Amit Sheth

Publications

Suicide is the 10th leading cause of death in the U.S (1999-2019). However, predicting when someone will attempt suicide has been nearly impossible. In the modern world, many individuals suffering from mental illness seek emotional support and advice on well-known and easily-accessible social media platforms such as Reddit. While prior artificial intelligence research has demonstrated the ability to extract valuable information from social media on suicidal thoughts and behaviors, these efforts have not considered both severity and temporality of risk. The insights made possible by access to such data have enormous clinical potential - most dramatically envisioned as a trigger …

Amending Traditional Substrate Rice Straw With Agroforestry Tree Foliage Increases Production Cycle And Nutritional Value Of Pleurotus Floridanus, Samora M Andrew, John R Mbwambo

Tanzania Journal of Science

The recent heightened attention on mushrooms has not considered shortening the production time and increasing nutritional value using substrates from agroforestry trees in addition to traditionally used agro-industrial residues. This study therefore, examined harvesting time, protein and essential minerals of Pleurotus floridanus grown on rice straw amended with Gliricidia sepium foliage in Morogoro, Tanzania. Mushrooms were cultivated in 30 x 40 cm 4 kg dry weight polythene bags in randomized complete block design (RCBD) experiment. Results showed that the addition of 5% G. sepium into rice straw reduced total time between spawning and first harvest of P. floridanus. Gliricidia sepium …

Application Of Optimal Control To Tuberculosis Model With Parameter Estimations: Bayesian Approach, Goodluck M Mlay, Alfred K Hugo

Tanzania Journal of Science

In this paper, one-strain tuberculosis (TB) model with two control mechanisms, education campaigns and chemoprophylaxis of TB-infected patients, was studied to determine their effects on the reduction of latent and active TB cases. In the case of analysis, boundedness and positivity of the model solutions were carried out to determine the biological feasibility of the study. Besides, the calibration of the parameters by utilizing the identifiability technique through the Markov chain Monte Carlo (MCMC) was thoroughly analysed. The optimum conditions for controlling TB were derived from the Pontryagin Maximum Principle. The numerical simulations were carried out using the forward-back sweep …

Atypical Structural Neuroconnectivity Associated With Emotional Face Processing And Clinical Affect In Children With Chromosome 22q11.2 Deletion Syndrome, David Dodd Stephenson Jr

LSU New Orleans Theses and Dissertations

Schizophrenia spectrum disorder (SCZ) is a debilitating psychiatric disorder that affects approximately 1% of the general population. The etiopathology of this disorder is not fully understood with genetic and environmental factors underpinning vulnerability and disease progression. Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) are at ultra-high risk for developing SCZ with 30% developing the disorder in adolescence or young adulthood. To investigate associations with psychosis vulnerability, much work has been performed looking at neurological underpinnings between schizophrenia and 22q11.2DS to assess similarities between both genetic and idiopathic forms of schizophrenia in adults. However, many past studies have assessed this using …

Do People With Unilateral Mid-Portion Achilles Tendinopathy Who Participate In Running-Related Physical Activity Exhibit A Meaningful Conditioned Pain Modulation (Cpm) Effect: A Pilot Study, Myles C. Murphy, Ebonie K. Rio, Paola Chivers, James Debenham, Sean I. Docking, Mervyn Travers, William Gibson

Research outputs 2014 to 2021

Objectives: Our primary objective was to report the presence of a conditioned pain modulation (CPM) effect in people with localised mid-portion Achilles tendinopathy and whether changes occur over a 12-week period. Our secondary objectives were to quantify the proportion of participants who present for tendinopathy research with previous interventions or co-morbidities, which may impact the CPM-effect and investigate modulating factors.

Design: Prospective, observational cohort pilot study. Method: 215 participants presented for this Achilles tendinopathy research and were screened for inclusion with nine being included. Included participants had the CPM-effect (cold-pressor test) assessed using pressure pain thresholds at the Achilles tendon …

Intraoperative Hypothermia In Patients Undergoing Total Knee Arthroplasty: A Cross-Sectional Study From A Developing Country, Ronika Devi Ukrani, Aiman Arif, Anum Sadruddin Pidani, Obada Hussein Hasan, Shahryar Noordin

Medical College Documents

Background: Intraoperative hypothermia is associated with various risk factors, morbidity, and mortality in patients undergoing total knee arthroplasty (TKA), increasing the emotional and financial burden on patients. This study aimed to identify risk factors of intraoperative hypothermia in patients undergoing TKA.
Materials and methods: All adult patients (⩾18 years) who underwent TKA from January 2016 to December 2017 at a tertiary-care hospital in Pakistan were included in this retrospective, cross-sectional study. Temperature < 36 °C was defined as hypothermia.
Results: The study included 286 patients (77.6% female) with a mean age of 61.4 ± 10.4 years. The overall proportion of intraoperative hypothermia was 26.6%. Of the total …

Fruit And Vegetable Intake Is Inversely Associated With Perceived Stress Across The Adult Lifespan, Simone Radavelli-Bagatini, Lauren C. Blekkenhorst, Marc Sim, Richard L. Prince, Nicola P. Bondonno, Catherine P. Bondonno, Richard Woodman, Reindolf Anokye, James Dimmock, Ben Jackson, Leesa Costello, Amanda Devine, Mandy J. Stanley, Joanne M. Dickson, Dianna J. Magliano, Jonathan E. Shaw, Robin M. Daly, Jonathan M. Hodgson, Joshua R. Lewis

Research outputs 2014 to 2021

Background & aims: Poor nutritional habits are linked to higher perceived stress, but the relationship between fruit and vegetable (FV) intake and stress is uncertain. The primary aim of this cross-sectional study was to explore the relationship between FV intake and perceived stress in a population-based cohort of men and women aged ≥ 25 years from the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study. A secondary aim was to investigate the relationship between serum carotenoids, biomarkers of FV intake, and perceived stress.

Methods: In Australian men and women, dietary intake was assessed using a Food Frequency Questionnaire in 1999–2000 (n …

Learning Objectives Of Cultural Immersion Programs: A Scoping Review, Kate Buchanan, Marrianne Velandia, Marina Weckend, Sara Bayes

Research outputs 2014 to 2021

Background: Cultural immersion as a learning activity provides students with the opportunity to experience diversity and develop cultural safety. Both, ‘Study Abroad Programs’ and ‘Internationalisation at Home’ (IaH) aim to provide a cultural immersion experience for students. However, explicit learning objectives are essential for quality pedagogy and for students to develop cultural safety from their learning experience.

Objective: To identify the learning objectives of study abroad and Internationalisation at Home (IaH) programs in higher education health profession programs.

Design: A scoping review was undertaken according to recommendations by the Joanna Briggs Institute (Peters et al., 2020) and PRISMA guidelines.

Data …

Racial And Ethnic Disparities In Opioid Use For Adolescents At Us Emergency Departments, Michael T. Phan, Daniel M. Tomaszewski, Cody Arbuckle, Sun Yang, Candice D. Donaldson, Michelle A. Fortier, Brooke Jenkins, Erik Linstead, Zeev N. Kain

Pharmacy Faculty Articles and Research

Background

Racial/ethnic disparities in the use of opioids to treat pain disorders have been previously reported in the emergency department (ED). Further research is needed to better evaluate the impact race/ethnicity may have on the use of opioids in adolescents for the management of pain disorders in the ED.

Methods

This was a cross-sectional study using data from the National Hospital Ambulatory Medical Care Survey from 2006 to 2016. Multivariate models were used to evaluate the role of race/ethnicity in the receipt of opioid agonists while in the ED. All ED visits with patients aged 11–21 years old were analyzed. …

Safety And Efficacy Of Umbilical Cord-Derived Wharton's Jelly Compared To Hyaluronic Acid And Saline For Knee Osteoarthritis: Study Protocol For A Randomized, Controlled, Single-Blind, Multi-Center Trial, Ashim Gupta, Nicola Maffulli, Hugo C Rodriguez, Eric W Carson, Randa A Bascharon, Kristin Delfino, Howard J Levy, Saadiq F El-Amin

2020-Current year OA Pubs

BACKGROUND: Osteoarthritis (OA) is the most common joint disorder in the United States of America (USA) with a fast-rising prevalence. Current treatment modalities are limited, and total knee replacement surgeries have shown disadvantages, especially for grade II/III OA. The interest in the use of biologics, including umbilical cord (UC)-derived Wharton's jelly (WJ), has grown in recent years. The results from a preliminary study demonstrated the presence of essential components of regenerative medicine, namely growth factors, cytokines, hyaluronic acid (HA), and extracellular vesicles, including exosomes, in WJ. The proposed study aims to evaluate the safety and efficacy of intra-articular injection of …

Investigation Of Some Factors Associated With Utilization Of Maternal Health Care Services By Adolescent Mothers In Tanzania, Elia Magwaja, Jacqueline Minja, Majige Selemani Budeba, Rocky R.J. Akarro

Tanzania Journal of Science

This study examined some factors associated with the utilization of maternal health care servicesby adolescent mothers (15-19 years) in Tanzania in order to provide advice accordingly. The studyused cross-sectional study of adolescent mothers aged 15-19 years using Demographic HealthSurvey and Malaria indicator Survey 2015/16 data. The dependent variables were number ofantenatal care visits, the place where an adolescent mother delivered and post-natal checkup(adolescent mother’s health checking after being discharged or after a home delivery). Theindependent variables were birth order, education level of a mother, marital status of a mother,media exposure, wealth index, distance to health facility. Multiple binary logistic regression …

Removing The Noise From X-Ray Image Using Image Processing Technology: A Bibliometric Survey And Future Research Directions, Ayushi Kamboj, Mrinal Bachute

Library Philosophy and Practice (e-journal)

The retrieval of superior-quality photographs with a minimal exposure is an interesting subject in radiography. Pre-processing is a key phase in signal and image processing such as healthcare, telecommunications, and satellite, and it focuses on reducing or eliminating the extent of noise in the image. Denoising aids in the recovery of finer data and relevant material. Medical images including ECG, Ultrasound, CT-scan, and X-ray provide incredibly fine data that has to be precise and noise-free in order for the knowledge and aspects of interest to be retained during diagnosis. Various noise reduction technologies for medical images, such as wavelet transform, …

Mesenchymal Chondrosarcoma Simulating A Periodontal Disease: A Case Report, Adham Fahmy, Abanoub Selim, Yara Youssef, Iman Mostafa, Hala El-Kammar

Future Dental Journal

Mesenchymal chondrosarcoma (MCS) is a rare high-grade variant of chondrosarcoma. MSC`s represent about 1% to 9% of chondrosarcomas. Less than 500 cases of MCS have been reported in literature, so far. As opposed to other variants, MSC develops outside of the bone in almost third of the cases. Pain and swelling are the most common symptoms at presentation. The overall prognosis of MSC is poor, with frequent distant metastases. Histopathologically, MCS typically exhibits a biphasic pattern consisting of both small cells, and islands of atypical cartilage. The immunohistochemical profile of this lesion overlaps with several other entities. Resection with wide …

Evaluation Of Mucograft® In Increasing The Peri-Implant Soft Tissue Thickness In The Esthetic Zone., Sarah Gamal Moussa, Nivine Ibrahim Ragy, Khaled Abdel Ghaffar

Future Dental Journal

Objective: To study the effect of Collagen matrix Mucograft (CM) in enhancing the soft tissue thickness around immediate implants (II) in comparison to palatal connective tissue grafts (SCTG).

Subjects & methods: This randomized, controlled clinical trial included 16 patients, who were randomly divided into test (IIP +CM) and control (IIP+SCTG) groups. Clinical parameters evaluated at baseline, 3-months, and 6-months were papillary bleeding index (PBI), gingival index (GI), facial probing depth (FPD), palatal probing depth (PPD). Direct measurements of gingival thickness were evaluated at baseline and 6-months follow up. Pink esthetic score (PES) and white esthetic score (WES) were evaluated at …

Influence Of Leucocyte Platelet Rich Fibrin (L-Prf) On Guided Tissue Regeneration Using Perforated Membrane (Randomized Clinical Trial), Mariam Samir Nabih, Nivine Ibrahim Ragy, Waleed Abbas Nada, Ahmed Youssef Gamal

Future Dental Journal

Background: Passage of gingival fibroblasts/gingival mesenchymal stem cells through macro-perforated barrier membranes may allow them to contribute positively in periodontal regeneration. The present study was designed to evaluate the effect of use of Leucocyte Platelet Rich Fibrin (L-PRF) on periosteum-derived stem/ progenitor cells (PDPCs) and gingival mesenchymal stem cells (GMSCs) encouraging their passage through membrane perforations. Methods: twenty patients were randomly allocated into two equal groups; Group I perforated membrane (PM): included intrabony defects treated by perforated membranes. Group II Leucocyte-platelet rich fibrin + perforated membrane (L-PRF + PM): included intrabony defects treated by Leucocyte platelet rich fibrin & perforated …