Medicine and Health Sciences Commons^™

Detecting Receptivity For Mhealth Interventions In The Natural Environment, Varun Mishra, Florian Künzler, Jan-Niklas Kramer, Elgar Fleisch, Tobias Kowatsch, David Kotz

Dartmouth Scholarship

Just-In-Time Adaptive Intervention (JITAI) is an emerging technique with great potential to support health behavior by providing the right type and amount of support at the right time. A crucial aspect of JITAIs is properly timing the delivery of interventions, to ensure that a user is receptive and ready to process and use the support provided. Some prior works have explored the association of context and some user-specific traits on receptivity, and have built post-study machine-learning models to detect receptivity. For effective intervention delivery, however, a JITAI system needs to make in-the-moment decisions about a user's receptivity. To this end, …

Encephalitis Associated With Hemophagocytic Lymphohistiocytosis Secondary To Immune Checkpoint Inhibitors: An Unfamiliar Spin-Off., Ghulam Ghous, Hafiz Muhammad Hassan Shoukat, Muhammad Usman Zafar, Joseph W Mcgreevy, Zahid Ijaz Tara

Department of Emergency Medicine

Checkpoint inhibitors (CPI) have become mainstream in standard therapy in various tumors, especially in malignant melanoma. Despite their widespread beneficial effects, these inhibitors are also notorious for immune-related adverse events (irAEs). Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation. We report a case of a 33-year-old male having a history of metastatic melanoma on immunotherapy (status post two cycles of ipilimumab/nivolumab) admitted for persistent fever and elevated liver enzymes. Additional work showed anemia, thrombocytopenia, hypertriglyceridemia, and hyperferritinemia which meet the diagnostic criteria of histiocyte society HLH-2004. The patient was effectively treated with oral prednisone. Moreover, …

Medicate And Segregate: How Due Process Fails To Protect Mentally Ill Inmates From Medically Inappropriate Confinement And Restraint, Peter J. Teravskis

Minnesota Journal of Law, Science & Technology

No abstract provided.

B Cells In Idiopathic Pulmonary Fibrosis: Targeting Immune Cells With Antifibrotic Agents., Jesse Roman, Hirofumi Chiba

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

No abstract provided.

Association Between Dialysate Sodium Concentration And Interdialytic Weight Gain In Patients Undergoing Twice Weekly Haemodialysis, Soraiya Manji, Jasmit Shah, Ahmed Twahir, Ahmed Sokwala

Internal Medicine, East Africa

A Rapid Fecal Immunochemical Test For Gastrointestinal Bleeding Detection In Cynomolgus Macaques (Macaca Fascicularis), Taratorn Kemthong, Krittiga Sapkanarak, Piyachada Rounmakok, Thipchompoo Sing-Ayudthaya, Lalitta Suriya-Arunroj, Florian Föger, Martin Werle, Suchinda Malaivijitnond

The Thai Journal of Veterinary Medicine

We used the Fecal Immunochemical Occult Blood Test (FIT) kit, a lateral flow immunochromatographic assay specific for human hemoglobin, on cynomolgus monkeys (Macaca fascicularis). We aimed to employ this test to detect gastrointestinal injury in captive animals at the National Primate Research Center of Thailand-Chulalongkorn University (NPRCT-CU). The cross-reactivity and sensitivity of the test for monkey blood were determined and compared with the human blood. The anti-human hemoglobin antibody of the FIT kit reacted with the monkey blood in a similar way as it did with humans and the intensity (T/C ratio) values between the two data sets closely correlated …

Multiple Sclerosis In Kenya: Demographic And Clinical Characteristics Of A Registry Cohort, Imran Jamal, Jasmit Shah, Peter Mativo, Juzar Hooker, Mitchell Wallin, Dilraj Sokhi

Internal Medicine, East Africa

Background: Multiple Sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults. There is limited literature regarding the burden of MS in sub-Saharan Africa (SSA).

Objective: To describe the demographic and clinical characteristics of patients with MS (PwMS) presenting to a tertiary referral hospital in Nairobi.

Methods: We conducted a retrospective descriptive study for PwMS presenting to Aga Khan University Hospital, Nairobi from 2008–2018.

Results: 99 cases met the diagnostic criteria for MS with a male to female ratio of 1:4. Majority (68.7%) of PwMS were indigenous Africans with a mean age of onset …

Whole-Exome Sequencing Identifies Somatic Mutations And Intratumor Heterogeneity In Inflammatory Breast Cancer., Rui Luo, Weelic Chong, Qiang Wei, Zhenchao Zhang, Chun Wang, Zhong Ye, Maysa Abu-Khalaf, Daniel P. Silver, Robert T. Stapp, Wei Jiang, Ronald E. Myers, Bingshan Li, Massimo Cristofanilli, Hushan Yang

Department of Medical Oncology Faculty Papers

Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer. Although it is a rare subtype, IBC is responsible for roughly 10% of breast cancer deaths. In order to obtain a better understanding of the genomic landscape and intratumor heterogeneity (ITH) in IBC, we conducted whole-exome sequencing of 16 tissue samples (12 tumor and four normal samples) from six hormone-receptor-positive IBC patients, analyzed somatic mutations and copy number aberrations, and inferred subclonal structures to demonstrate ITH. Our results showed that KMT2C was the most frequently mutated gene (42%, 5/12 samples), followed by HECTD1, LAMA3, FLG2, UGT2B4, STK33, BRCA2, …

Unsupervised Machine Learning For Identifying Challenging Behavior Profiles To Explore Cluster-Based Treatment Efficacy In Children With Autism Spectrum Disorder: Retrospective Data Analysis Study, Julie Gardner-Hoag, Marlena N. Novack, Chelsea Parlett-Pelleriti, Elizabeth Stevens, Dennis Dixon, Erik Linstead

Engineering Faculty Articles and Research

Background: Challenging behaviors are prevalent among individuals with autism spectrum disorder; however, research exploring the impact of challenging behaviors on treatment response is lacking.

Objective: The purpose of this study was to identify types of autism spectrum disorder based on engagement in different challenging behaviors and evaluate differences in treatment response between groups.

Methods: Retrospective data on challenging behaviors and treatment progress for 854 children with autism spectrum disorder were analyzed. Participants were clustered based on 8 observed challenging behaviors using k means, and multiple linear regression was performed to test interactions between skill mastery and treatment …

June 2021, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

Men's Health Week: June 14-20, 2021

The purpose of Men’s Health Week is to heighten the awareness of preventable health problems and encourage early detection and treatment of disease among men and boys.

Navigator Role For Promoting Adaptive Sports And Recreation Participation In Individuals With Disabilities, Moriah Iverson, Alexander V. Ng, Alice F. Yan, Kimberley Zvara, Michael Bonk, Deb Falk-Palec, Cherri Sylla, Maurine Strickland, Rachel Preston, Diane W. Braza

Exercise Science Faculty Research and Publications

Objective

The aims of the study were to gain a better understanding of the resources, barriers, and facilitators of participation in adaptive sport and recreational activities as a means of achieving physical activity recommendations in individuals with disability and to understand preferences for a patient navigator service to help mitigate the barriers.

Design

Clinical, academic, and community stakeholders applied a community-engaged research approach to develop online surveys and focus group questions for adults with a disability or parents of a child with a disability to meet study objectives.

Results

One hundred ninety-eight adults and 146 parents completed the online surveys. …

Influence Of The Bar Position On Joint-Level Biomechanics During Isometric Pulling Exercises, Nayun Ahn, Hoon Kim, John Krzyszkowski, Stuart Roche, Kristof Kipp

Exercise Science Faculty Research and Publications

The purpose of this study was to investigate the influence of the bar position on ankle, knee, and hip net joint moments (NJMs), relative muscular effort (RME), and vertical ground reaction forces (GRFs) during isometric pulling exercises, such as the isometric midthigh pull. Eight female lacrosse athletes performed maximal effort isometric pulls at 3 different bar positions (low: above patella, mid: midthigh, and high: crease of hip) while motion capture and GRF data were recorded. Net joint moments were calculated with inverse dynamics. Relative muscle effort was defined as the ratio between the inverse dynamics NJMs and the maximum theoretical …

Modeling The Spread Of Covid-19 Over Varied Contact Networks, Ryan L. Solorzano

Master's Theses

When attempting to mitigate the spread of an epidemic without the use of a vaccine, many measures may be made to dampen the spread of the disease such as physically distancing and wearing masks. The implementation of an effective test and quarantine strategy on a population has the potential to make a large impact on the spread of the disease as well. Testing and quarantining strategies become difficult when a portion of the population are asymptomatic spreaders of the disease. Additionally, a study has shown that randomly testing a portion of a population for asymptomatic individuals makes a small impact …

Emotion And Cognition Analysis Of Intro And Senior Cs Students In Software Engineering, Justin Evans

Master's Theses

he software engineering community has advanced the field in the past few decades towards making the software development life cycle more efficient, robust, and streamlined. Advances such as better integrated development environments and agile workflows have made the process more efficient as well as more flexible. Despite these many achievements software engineers still spend a great deal of time writing, reading and reviewing code. These tasks require a lot of attention from the engineer with many different variables affecting the performance of the tasks. In recent years many researchers have come to investigate how emotion and the way we think …

Resuscitation Of Severe Accidental Hypothermia To Normal Neurologic Outcome With Use Of Extracorporeal Membrane Oxygenation., Jamie Allen, Megan D Wardak, Rovinder S. Sandhu Md, Ahmed Nassar, Marna R. Greenberg Do, Mph, Facep

Department of Emergency Medicine

Accidental hypothermia is a condition associated with significant morbidity and mortality. A 48-year-old male with a history of alcohol use disorder and optic neuropathy presented to the emergency department after being found unresponsive with an unknown downtime. One hundred four minutes passed from resuscitation, to pre-hospital discovery, until cannulation with extracorporeal membrane oxygenation. Here, a rare case of successful resuscitation of a profoundly hypothermic patient to normal neurologic outcome is presented.

Prevalence Of Allergic Fungal Sinusitis Among Patients With Nasal Polyposis, Rahim Dhanani, Shayan Khalid, Basit Salam, Hamdan Ahmed Pasha, Farah Hafiz Yousuf, Mubasher Ikram

Section of Otolaryngology, Head & Neck Surgery

Objective: To determine the frequency of allergic fungal sinusitis among patients with nasal polyps, and to compare Lund-Mackay scores of patients with and without allergic fungal sinusitis.
Methods: The cross-sectional longitudinal study was conducted at a tertiary healthcare centre in Karachi, Pakistan, from December 2016 to November 2018, and comprised patients with sinonasal polyposis undergoing surgery. The patients were categorised as having allergic fungal sinusitis when histopathology showed allergic mucin with fungal hyphae and culture was positive for fungal growth. Lund-Mackay scoring of each patient was noted and mean scores of allergic fungal sinusitis and non-allergic fungal sinusitis patients were …

The Acquisition Of Dental Competencies And Clinical Skills: Perceptions From Students, Faculty, Practicing Dentists And Industry Professionals In The Dominican Republic, Laura Virginia Reyes Alardo

Dissertations

The Dominican healthcare system faces many challenges, and dental education is not an exception. The lack of competencies established for dentistry is one of the most critical challenges that dentistry faces. There is no way to guarantee that all dentists receive the same quality education with no standards and lack of competencies. Previous research has revealed that the competencies achieved by dental students determine the way such students develop their professional practice in the future as dental graduates (Alcota, De Gauna, & González, 2016). However, there is a lack of shared language observed in dental education around the world. Not …

Computational Analysis Of Protein Stability And Allosteric Interaction Networks In Distinct Conformational Forms Of The Sars Cov 2 Spike D614g Mutant: Reconciling Functional Mechanisms Through Allosteric Model Of Spike Regulation, Gennady M. Verkhivker, Steve Agajanian, Deniz Oztas, Grace Gupta

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this study, we used an integrative computational approach to examine molecular mechanisms underlying functional effects of the D614G mutation by exploring atomistic modeling of the SARS-CoV-2 spike proteins as allosteric regulatory machines. We combined coarse-grained simulations, protein stability and dynamic fluctuation communication analysis with network-based community analysis to examine structures of the native and mutant SARS-CoV-2 spike proteins in different functional states. Through distance fluctuations communication analysis, we probed stability and allosteric communication propensities of protein residues in the native and mutant SARS-CoV-2 spike proteins, providing evidence that the D614G mutation can enhance long-range signaling of the allosteric spike …

A Quantitative Assessment Of Marital Quality Among Couples In Kerala, India, Grace Kochuparambil

Dissertations

The increasing number of divorces and domestic violence in Kerala, India points out the need to assess marital quality among couples in Kerala. The lack of assessment tools in the native language prevents evaluating Malayali couples' marital relationships. The purpose of the proposed study was to examine couples' marital quality in Kerala and validate the translated Marital Adjustment Questionnaire (MAQ) and Marital Quality Scale (MQS), the M-MAQ and the M-MQS, respectively. The instruments were translated into Malayalam through a forward and backward translation. A quantitative survey research design collected data from a criterion[1]based sample of 260 couples in Kerala using …

How Effective Is Psychotherapy In Reducing Opioid Usage Among Patients With Chronic Pain?, Charity Harold Whorley

Doctoral Dissertations and Projects

The purpose of this integrative review is to evaluate the effectiveness of psychotherapy in the management of chronic pain thorough a comprehensive review and synthesis of current literature on the topic. Chronic pain is a prevalent condition throughout America with an estimated 30% of the population affected. As such, it is a common condition encountered in primary care. At one point the mainstay of treatment was opioid therapy. Unfortunately, this along with other issues has contributed to an overprescribing of narcotics and ultimately the opioid crisis in America. Healthcare providers are in a unique position to assist in reversing this …

Pediatric Concussion Management In The School Setting: An Integrative Literature Review, Renee Mann

Doctoral Dissertations and Projects

Concussions in the pediatric population are a growing concern due to the impact concussions could have on the child’s health and well-being. Appropriate management of concussions in the pediatric population promotes recovery and the return of the student who has sustained a concussion to school and to normal physical activities. The purpose of this integrative review project is to evaluate the current practices, evidence-based recommendations, and guidelines to ascertain the optimum recovery times in children who have sustained a concussion within the school setting, grades K-12. An integrative review was conducted utilizing the Whitmore and Knafl framework. The four main …

Promoting Health Literacy To Aging Christians To Combat The Scourge Of Euthanasia Through The Church, Willie Mae Corley

Doctoral Dissertations and Projects

The many dilemmas that occur in the medical care of chronically ill seniors raise the question of whether senior populations have become the new black. The research seeks to provide an evidence-based review of limited health literacy among elderly African American Christians regarding diagnoses and medical treatments, which has resulted in unethical Christian practices becoming a norm. The researcher adapted the health literacy framework of Paasche Orlow and Wolf’s view of three distinct causes that influence health literacy: the access and utilization of health care, the patient-provider relationship, and self-care. The problem is that Victory Church members may not understand …

Factors Hindering Human Papillomavirus(Hpv) Vaccination Uptake Among Children And Young Adults Between Ages Nine To Twenty-Six In America, Foluke Olufunbi Ajuwon

Doctoral Dissertations and Projects

This Integrative Review Project searched relevant literature and conducted research to discover factors hindering HPV vaccination among children and young adults in America and interventions to increase HPV vaccination among individuals in this group. The importance of the HPV vaccination cannot be understated; the HPV vaccine is the most effective approach for preventing infections and decreasing risk of HPV-associated conditions such as cervical, oral pharyngeal, and rectal cancer. In the United States, HPV inoculation uptake is reported to be less than 80% for the initial dosage, and less than 40% of young males and females complete all the series dosage …

Mitigating The Risk Of Opioid Overdose And Death Of The Veteran: An Integrative Review, Cheryl Anne Landry

Doctoral Dissertations and Projects

Pain is a complicated phenomenon; it is an individual’s subjective experience and is often characterized by its duration. Chronic pain lasts longer than 90 days and can continue after the injury or illness that caused it has healed or gone away; chronic pain was identified as a national public health problem in a 2017 study by the National Academy of Medicine. Not only is chronic pain a national problem, but there is an opioid epidemic in the United States that is perpetuated by prescription pain medications. The opioid epidemic continues to consume veterans daily, but not much is said about …

J Mich Dent Assoc June 2021

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

• A cover story “Team-Based Treatment of Oral Cancer: The U-M Experience”.
• A feature article, “Dental Management of the Head and Neck Cancer Patient Treated with Radiation Therapy: Update 2021”.
• A feature article on “Understanding Cyber Threats and the Risk they Pose to Your Practice”.
• "A Train-the-Trainer Education Model and Rural Dental Opioid Prescribing Outcomes”, a …

A Direct Machine-Specific Parameters Incorporated Spot-Scanning Proton Arc (Sparc) Algorithm, Gang Liu, Lewei Zhao, Di Yan, Xiaoqiang Li, Xuanfeng Ding

Conference Presentation Abstracts

No abstract provided.

Neurosurgical Shunts, Trouble Shooting For Malfunction, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Neurosurgical Shunts, Trouble Shooting For Infection, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Boar Sperm Production In A Tropical Environment, Janyaporn Rungruangsak, Somchai Sangkaphet, Kakanang Buranaamnuay, Panupan Pongpeng, Padet Tummaruk

The Thai Journal of Veterinary Medicine

In a tropical environment, sow productivity is strongly associated with boar sperm production. Regular monitoring of semen quality in boars that produce semen for artificial insemination is important. The objective of the present study was to investigate the boar sperm production in an evaporative cooling system in a tropical environment in association with breed and season. A total of 2878 ejaculates from 68 boars were collected from a boar stud in the western region of Thailand. The breeds consisted of 22 Duroc, 22 Yorkshire, 18 Landrace and six hybrid boars. Seasons were classified as cool, hot or rainy. Semen volume, …

Investigation Of Avian Polyomavirus And Psittacine Beak And Feather Disease Virus In Parrots In Taiwan, Sheng-Chang Chung, Ching-Dong Chang, Perng-Chih Shen, Wei Lin, Chiu-Huang Ting, Hung-Yi Wu

The Thai Journal of Veterinary Medicine

This study aimed to understand the related statistics of APV and PBFDV in parrots, such as the positive percentage and the distributions of various ages, seasons, breeds and areas, in order to obtain more information on the health care of captive parrots in Taiwan today. Blood samples were collected from parrots that were household pets and from commercial aviaries in the northern (e.g. Taipei), central (e.g. Taichung) and southern (e.g. Kaohsiung) Taiwan regions randomly. Collection targets were mainly small and medium species such as Psittacula krameri and others such as Psittacus erithacus. Sixty samples were collected every month and a …