Medicine and Health Sciences Commons^™

Implementation Of Childhood Obesity Prevention And Control Policies In The United States And Latin America: Lessons For Cross-Border Research And Practice, Rafael Perez-Escamilla, Mireya Vilar-Compte, Elizabeth Rhodes, Olga L. Sarmiento, Camila Corvalan, Rachel Sturke, Susan Vorkoper

Department of Public Health Scholarship and Creative Works

Progress has been made in the development and widespread implementation of effective interventions to address childhood obesity, yet important challenges remain. To understand how the United States and Latin American countries achieved success in implementing obesity policies and programs (PAPs) and identify improvement opportunities using implementation science principles. We identified three comparative case studies: (1) front-of-food package labeling (Mexico and Chile); (2) Open Streets/play streets (Colombia and the United States); and (3) the Baby-Friendly Hospital Initiative (Brazil and the United States). Information from multiple sources (e.g., scientific and gray literature and key informant interviews) was synthesized to describe barriers, facilitators, …

Design, Synthesis And Evaluation Of Molecules With Selective And Poly-Pharmacological Actions At D1r, D3r And Sigma Receptors, Pierpaolo Cordone

Dissertations, Theses, and Capstone Projects

The dopamine D3 receptor (D3R) is one of the most studied receptors involved in drug addiction. One of the most common strategies to treat substance use disorders is via D3R antagonism. The majority of the D3R antagonists synthesized so far have poor pharmacokinetic properties and/or lack selectivity toward D3R. In this thesis, the design, synthesis and biological evaluation of novel molecules that target the dopamine D1 receptor (D1R), D3R and the serendipitous discovery of molecules that target s receptors will be described.

Chapter 1 presents a survey of the fundamental pharmacology of D1R, D3R and s receptors and the therapeutic …

Alcohol And Its Long-Term Effects On Hearing Loss: A Systematic Review, Talia Sowalsky

Dissertations, Theses, and Capstone Projects

Objective: To review the literature on potential permanent effects of long-term alcohol consumption on hearing status in adults 40 years of age and older.

Study Design: Systematic review of prospective and retrospective studies; meta-analysis of case-controlled studies.

Methods: One researcher independently reviewed MEDLINE (January 1, 2000-May 1, 2019), CINAHL (January 1, 2000-May 1, 2019), PubMed (January 1, 2000-May 1, 2019), and Web of Science (January 1, 2000-May 1, 2019). A manual reference search was additionally conducted. Randomized controlled trials, prospective cohort studies, consecutive/non-consecutive case series, and retrospective reviews in which a clear definition of hearing loss was stated were included …

Machine Learning Classification Of Traumatic Brain Injury Patients Versus Healthy Controls Using Arterial Spin Labeled Perfusion Mri, Vanessa I. Grass

Dissertations, Theses, and Capstone Projects

Traumatic brain injury (TBI) is one of the most common causes of death and disability worldwide, yet accurate in vivo detection of TBI neuropathology remains challenging due to complexities in the structural and functional changes observed post-injury as well as limitations in conventional neuroimaging modalities. Although advanced neuroimaging techniques such as arterial spin labeling (ASL) can noninvasively assess cerebral blood flow (CBF) changes observed post-injury, this technique is underutilized in TBI research partly due to the low signal-to-noise-ratio (SNR) inherent in ASL imaging. The aim of the current study is to examine the use of machine learning, specifically a Support …

Systematic Review: The Effect Of Hearing Aids On Balance And Falls, Natalia Beatriz Pagan-Guadalupe

Dissertations, Theses, and Capstone Projects

Background: The population of individuals 65 years old is increasing and falls are one of the most prevalent causes of disabilities among this population. Recent studies have found association between neural hearing losses and increased risk of falls, suggesting that hearing is an important input that assist visual, proprioceptive and vestibular inputs in maintaining balance. Hearing aids are known to be beneficial to improve access to sound; however, it is very limited the research regarding the effects of amplification on balance and risk of falls.

Objectives: This systematic review intends to gather and analyze all the research available regarding the …

Infant Behavioral Speech Discrimination Procedures: A Systematic Review, Allison L. Mazzella

Dissertations, Theses, and Capstone Projects

Objective: The purpose of this capstone project was to conduct a systematic review of literature relating to two behavioral infant speech discrimination procedures to evaluate their potential clinical utility. The two procedures examined were the Observer-based Psychoacoustic Procedure (OPP) and the Visual Reinforcement of Infant Speech Discrimination (VRISD) method. The methodology utilized and the results obtained are examined for normal hearing infants and infants with hearing loss. The procedures are compared and contrasted in terms of potential clinical feasibility and modifications for potential clinical use are considered.

Methods: A comprehensive search was performed using Pubmed and EBSCO Academic Search Complete …

Daily Benefits Of Leader Dogs In Addition To Medical Treatment For Individuals With Usher Syndrome: A Case Study, Samantha H. Zwolan

Dissertations, Theses, and Capstone Projects

Background: Adults with Usher syndrome seeking audiologic rehabilitation and treatment often experience everyday difficulties that are not fully resolved using typical medical treatments. This case study examines the difficulties faced by individuals diagnosed with Usher syndrome in their everyday life, including quality of life, safety, and social issues. Additionally, the non-medical benefits that leader dogs can provide such individuals is also presented.

Method: A thorough literature review was performed to provide background information regarding Usher syndrome and the impact it has on the hearing and vision of affected individuals. A related literature review was performed to examine the role …

Experience And Satisfaction With Hearing Aid Services Delivered Via Teleaudiology In Adult Populations: A Systematic Review, Shelby Platia

Dissertations, Theses, and Capstone Projects

Objective: The goal of this systematic review is to examine the current literature to look at patient experience and satisfaction with teleaudiology services. Specifically, teleaudiology services that occur at the fitting and/or post-fitting stage of the adult hearing aid patient journey.

Methods: A comprehensive search utilizing PubMed, MEDLINE and EBSCOhost databases were conducted to identify pertinent, peer-reviewed, articles related to the clinical usage or clinical applications of teleaudiology for hearing aid fittings and/or follow-up for adult individuals. Inclusion criteria were studies that are empirical, included quantitative results, articles published in English, peer-reviewed articles; and persons who are 18 …

Neuroplasticity Of The Corticospinal System: Applications Of Neuromodulation-Based Therapies, Alzahraa M. Amer

Dissertations, Theses, and Capstone Projects

The motor cortex and corticospinal tract are necessary for producing skilled movements. I use intermittent theta burst stimulation (iTBS), a high-frequency stimulation protocol known to promote neural plasticity, as a tool to characterize short- and long-term plasticity of the CS system.

Although it is well known that activity-dependent motor cortex (MCX) plasticity produces long-term potentiation (LTP) of local cortical circuits, leading to enhanced motor evoked potentials (MEPs), the effects produced by the corticospinal (CS) projection on spinal cord neurons have not yet been thoroughly studied. In Chapter 2, I determined if the CS tract (CST) is capable of producing LTP …

Everyone Is Watching: Mastering The Challenge Of Caring For Infants At The End Of Life While Being Constantly Observed, Deborah A. Lawrence

Dissertations, Theses, and Capstone Projects

Nurses with specialized training care for the approximately 7% of newly born infants who are admitted annually to neonatal intensive care units in the United States. Although they receive care at advanced levels, some infants will not survive. Nurses maintain a constant presence at the bedsides of these neonates to provide end of life care in units and institutions where the gold standard is cure and rescue. The purpose of this grounded theory research study was to understand how nurses managed the challenges and demands of caring for dying infants in the context of Level III neonatal intensive care units. …

Delayed Modulation Of Glutamate Receptors By Anti-Epileptic Drugs After Traumatic Brain Injury In Rats, Edgar Rodriguez

Dissertations, Theses, and Capstone Projects

Traumatic brain injury (TBI) is a significant health concern. Around 74 million people sustain a traumatic brain injury worldwide. The damage caused by TBI produces two types of injury; primary and secondary injuries. Primary injury is caused within milliseconds and is irreversible. Secondary brain injury is delayed and produced by molecular, cellular, and structural disruption after the initial injury. One of the most devastating dysfunction after TBI is glutamate neurotransmitter overactivation that could lead to neurotoxic levels of glutamate in the brain (i.e., excitotoxicity). Excitotoxicity has been linked with the development of epilepsy after TBI, also known as post-traumatic epilepsy …

The Power Of A Sound Mind: Exploring Meditation And Sound Therapies For Treating The Emotional Impact Of Tinnitus, Sabeena A. Ramnanan

Dissertations, Theses, and Capstone Projects

Tinnitus is described as a sound perceived by an individual that has no external source. Some individuals with tinnitus can habituate to this phantom sound, while others become emotionally disturbed by it. There are several theories which attempt to rationalize the cause of tinnitus, and various treatments which aim to eliminate, mask, or facilitate habituation to one’s tinnitus. Current common treatments include sound therapies and cognitive-behavioral therapy (CBT), either in isolation or in combination with one another. However, not all these treatments aim to address the emotional impact of tinnitus. Novel treatments are emerging, with some attempting to reduce the …

A Novel Custom-Made External Fixator For Treating Femur Fractures In Goats, Hsu-Hsun Lee, Ting-Sheng Lin, Lee-Shuan Lin, Cheng-Shu Chung, Shyh-Shyan Liu, Huan-Yu Hsu, Ching-Hou Ma, Jai-Wei Lee

The Thai Journal of Veterinary Medicine

External fixation is commonly used to treat long bone fractures in goats. It provides good enough stabilization on fractures to improve healing, minimizes soft tissue injury and only causes mild obstruction of the blood supply around the wounds. However, the large size and heavy weight of traditional external fixators (TEFs) cause them leave something to be desired. In this study, the feasibility of a novel custom-made external fixator (CMEF) for treating femoral fractures in goats was evaluated. Three one-year-old Anglo-Nubian female goats were subjected to experimental femoral fractures to their left femur with a CMEF installed for fixation. To evaluate …

Radiographic And Ultrasonographic Appearances Of Chronic Tenosynovitis Of The Lateral Extensor Tendon At The Right Tarsus In An Argentinian Polo Pony, Metha Chanda, Ananya Pongpradit, Wutthiwong Theerapan, Attapon Kamlangdee, Chanikarn Puangthong, Thapana Jarutummasiri

The Thai Journal of Veterinary Medicine

A 19-year-old polo pony presented with mild lameness alongside a lateral protuberance of the right tarsus. Radiographic findings revealed various defects, including an osteochondral lesion of the medial trochlear ridge of the talus, a sclerotic lesion of the tarsometatarsal joint, a radiolucent area on the distal border of the fourth tarsal bone and an enthesophyte at the proximolateral aspect of the metatarsal bone. Ultrasonography demonstrated the interesting finding of synovial sheath thickening of the lateral extensor tendon with synovial fluid accumulation. In addition, the presence of neutrophils and a granular mucinous background, according to cytological analysis of the fluid, indicated …

Left Lateral Liver Lobe Torsion In A Siamese Cat, Dongwook Kim, Ki-Jeong Na, Dongwoo Chang, Gonhyung Kim

The Thai Journal of Veterinary Medicine

A 6-year-old neutered male Siamese cat was presented with an acute onset of vomiting, anorexia and lethargy lasting for four days. An abdominal mass was palpated on physical examination. The cat showed severe anemia, elevated liver enzymes and hypoalbuminemia. Abdominal ultrasonography revealed a suspected hepatic mass without blood flow within the affected region. Computed tomography was performed to better visualize the abdominal cavity and blood flow. Prompt diagnosis of torsion of the left lateral liver lobe was made and immediate surgery for liver lobectomy was performed. Histopathological examination revealed no evidence of neoplasia. The cat remained clinically normal during the …

The Use Of Human Suprapubic Bladder Catheter To Manage Obstructive Urolithiasis In A Saanen Buck, Nurul Hayah Khairuddin, Mark Wen Han Hiew, Syahirah Ahmad Affandi, Azim Salahudin Muhamad, Nur Asyikin Haron, Rozanaliza Radzi, Chen Hui Cheng, Ganesh Vythilingam

The Thai Journal of Veterinary Medicine

A three-year-old Saanen buck presented with a complaint of stranguria for 24 hours. A physical examination revealed that the perineal urethra was turgid, swollen, and tender, and the urinary bladder was distended. The goat was diagnosed with obstructive urolithiasis. A percutaneous tube cystotomy technique was performed to relieve progressive urinary bladder distension. Using a human suprapubic urinary bladder catheter system, the technique was performed twice due to the recurrence of the blocked urethra. Following drainage of the urine, all vital parameters returned to normal. After surgical cystotomy, an intraoperative observation revealed the urinary bladder was filled with white sandy urolith, …

Generalized Enamel Hypoplasia In A Dog: A Case Report, Issarin Sittijarusub, Panithi Sukho, Patchamon Supannawapat, Namphung Suemanotham

The Thai Journal of Veterinary Medicine

A one-year-old, spayed female Welsh Corgi dog referred to the dental and oral clinic with chief complaint of apparent pitted, rough teeth surfaces, stained a tan to dark brown color. The dog was diagnosed with diffused enamel hypoplasia with no evidence of endodontic disease or malformation of tooth root. A restorative procedure with nanohybrid composite resin was performed. After treatment, the dog showed a good outcome with a smooth tooth surface, restorative material replaced to cover the previous defect and no evidence of pain or discomfort. Even though enamel hypoplasia is a rare, this condition remains an important problem that …

Prevalence, Risk Factors And Antimicrobial Resistance Of Salmonella Infection In Turtles In Khon Kaen Province, Patchanee Sringam, Peerapol Sukon, Sarawut Sringam, Sunpetch Angkititrakul

The Thai Journal of Veterinary Medicine

Considering the impact of Salmonella in turtles and the role of turtles as a source of Salmonella outbreaks in humans, knowledge of Salmonella status in turtles is important. A cross-sectional study was conducted to investigate the prevalence, risk factors and antimicrobial resistance of Salmonella infections in turtles. Cloacal swabs were collected from 378 turtles in Turtle Villages located in Khon Kaen province of northeastern Thailand between January 2018 and April 2019. All samples were examined for Salmonella spp. isolation and identification by ISO 6597:2002. The overall prevalence of Salmonella in the turtles was 37.57% (142/378). Habitat, season and sex were …

Effect Of Daily Environment And Season In A Tropical Environment On The Expression Of Heat Shock Protein, And Steroidogenic And Apoptotic Genes In Bovine Cumulus-Oocyte Complex, S. Kanwichai, S. Panasophonkul, J. K. Bernard, W. Suriyasathaporn

The Thai Journal of Veterinary Medicine

The objectives of this study were to determine the differences in the expression of heat shock protein, and steroidogenic and apoptosis genes by cumulus-oocyte complex (COC) of beef cattle in a tropical environment as affected by seasonal and day effect of temperature and relative humidity. Real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to measure gene expression in COC in different seasons including cool (Jan to Feb), summer (Mar to Apr) and rainy (May to Jul) seasons. Ambient temperature and relative humidity recorded on the day before oocyte collection were used to classify environment groups as: low temperature and low …

Expression Of Recombinant S2 Domain Of Spike Protein Of Porcine Epidemic Diarrhea Virus, Jiraporn Sritun, Natnaree Inthong, Siriluk Jala, Sakuna Phatthanakunanan, Kaitkanoke Sirinarumitr, Preeda Lertwatcharasarakul, Theerapol Sirinarumitr

The Thai Journal of Veterinary Medicine

Porcine epidemic diarrhea virus (PEDV) is the causative agent of severe watery diarrhea in suckling piglets. PEDV outbreaks have been consistently reported in Europe, Asian countries and Thailand. The recombinant protein, especially the spike (S) protein, from field strain PEDV could be used to develop a sensitive diagnostic test or an effective vaccine. In this study, the recombinant S2 domain protein from the PEDV Thai isolate was expressed using the E. coli expression system. The full length S2 domain of the S gene of the PEDV G2b Thai isolate was amplified using a PCR technique and was cloned into the …

Retrospective Analysis Of The Incidence, Aetiology And Risk Factors Of Sepsis Based On Post-Mortem Examination Records In Ruminants, Batrisyia Syazana Faridon, Mohd Zamri-Saad, Annas Salleh

The Thai Journal of Veterinary Medicine

Sepsis is an important disease in both humans and animals. In animals, it is usually caused by septicaemia after infection and has not been well-studied. This article describes a retrospective analysis of sepsis cases in small and large ruminants submitted to the Post-Mortem Laboratory, Faculty of Veterinary Medicine, Universiti Putra Malaysia between the years 2007 and 2017. The incidence of sepsis was found to be at 40.5% in small ruminants and 38.6% in large ruminants. In both small and large ruminants, sepsis was mainly caused by bacterial infection, which was significantly (p<0.05) higher compared to parasitic and viral infections. Most cases of sepsis occur due to infections originating from the gastrointestinal tract and this is followed by the respiratory tract. Escherichia coli has been found to be the most common bacterial pathogen of sepsis in ruminants; significantly (p<0.05) higher compared to other bacterial pathogens like Klebsiella pneumoniae, Pasteurella sp., and Staphylococcus aureus. Sepsis involving E. coli has often resulted in pure isolation of the pathogen, thus being suggestive of a single infection. Underlying or concurrent infection is the most important risk factor leading to sepsis in ruminants, with significant difference (p<0.05) compared to other risk factors such as stress or malnutrition. Associations between the gastrointestinal system as the point of entry and sepsis caused by either E. coli or K. pneumoniae have been noted. This study provides an insight into a basic understanding of sepsis in ruminants.

Multidrug Resistant Escherichia Coli Harboring Extendedspectrum Β-Lactamase-Encoding Genes Isolated From Clinically Healthy Pigs, Khin Khin Lay, Haidee E. Torio, Asinamai Athliamai Bitrus, Wanida Mala, Nuananong Sinwat, Rungtip Chuanchuen

The Thai Journal of Veterinary Medicine

A total of 292 E. coli isolates obtained from fecal samples from pigs in Central (n = 103) and Northeastern (n = 189) provinces of Thailand were included in this study. Eighty-six E. coli isolates were phenotypically confirmed to be β- lactamases producers and screened for the presence of β-lactamase genes. The CTX-M family was most frequently identified (90.7%). The blaCTX-M-15 gene belonging to CTX-M group I (59.3%) was the most predominantly identified CTX-M genotype followed by blaCTX-M-14 (31.4%) and blaCTX-M-4 (25.6%). The blaTEM-1 gene was prevalent (75.6%). The blaCTX-M-4 and blaCTX-M-14 genes were located on conjugative plasmid. The results …

Immune-Responsiveness, Performance And Blood Chemistry Of Broiler Chickens Fed Black Cumin Seed And/Or Turmeric, Sabry M. El-Bahr, A. Al-Ankari, Saad Shousha

The Thai Journal of Veterinary Medicine

Two hundred and fifty one-day old broiler chicks were used to evaluate the effect of black seeds and/or turmeric on performance and immune response to Newcastle Disease Virus (NDV), Infectious Bronchitis Virus (IBV) and Infectious Bursal Disease virus (IBDV) in broiler chickens of six weeks of age. The birds were divided into five groups (50 birds in each) with 5 replicates (10 birds each). Birds in the first group were fed a basal diet and served as a control. Birds of groups 2-5 were fed a basal diet mixed with black seed (20g/ kg basal diet), turmeric (20g/ kg basal …

Possibility Of Trypsin Treated Dog Erythrocytes As Universal Blood: Evaluation By Ftir Microspectroscopy, Pornphimon Metheenukul, Kanjana Thumanu, Thanit Metheenukul

The Thai Journal of Veterinary Medicine

A common canine erythrocyte antigen is DEA 1.1 but it is the most immunogenic. In this study, Fourier transformed infrared (FTIR) microspectroscopy was used to examine the alterations of membrane biomolecules in trypsin-treated DEA 1.1+ canine erythrocytes. Production of canine DEA 1.1- erythrocytes was achieved by treating DEA 1.1+ red cells (5% cell suspension) with 1 mg/ml trypsin for 120 mins, without affecting the intracellular 2,3-diphosphoglycerate level. FTIR microspectroscopy was employed to study the effects of trypsin-treatment on canine trypsinized red cell membrane components. Production of canine DEA 1.1- erythrocytes was achieved without affecting the intracellular 2,3-diphosphoglycerate level. The FTIR …

Effects Of Medium-Chain Free Fatty Acids On Performance, Some Biochemical Parameters And Meat Fatty Acids Profile Of Broiler Chickens, Mehmet Demi̇rci̇, Mehmet Başalan

The Thai Journal of Veterinary Medicine

In this study, it was aimed to investigate the effects of the addition of caprylic (octanoic, C8:0), capric (decanoic, C10:0) and lauric (dodecanoic, C12:0) acids from medium-chain free fatty acids to broiler diets. A total of 120 one-dayold male broiler chicks (Ross 308) were used and the study was conducted on 4 main groups of broilers; one control and three trials. The birds in the control group was fed an unadulterated basal diet and those in the experimental groups were fed with 0.2% of caprylic, capric and lauric acids (in addition to a basal diet) respectively. In the study, there …

Active Implantable Cardioverter-Defibrillators In Continuous-Flow Left Ventricular Assist Device Recipients, Kuldeep Shah, Rahul Chaudhary, Mohit K. Turagam, Mahek Shah, Brijesh Patel, Gregg Lanier, Dhanunjaya Lakkireddy, Jalaj Garg

Division of Cardiology Faculty Papers

Introduction

Implantable cardioverter-defibrillator (ICD) in patients with heart failure with reduced ejection fraction reduces mortality secondary to malignant arrhythmias. Whether end-stage heart failure (HF) with continuous-flow left ventricular assist device (cf-LVAD) derive similar benefits remains controversial.

Methods

We performed a systematic literature review and meta-analysis of all published studies that examined the association between active ICDs and survival in advanced HF patients with cfLVAD. We searched PubMed, Medline, Embase, Ovid, and Cochrane for studies reporting the association between ICD and all-cause mortality in advanced HF patients with cfLVAD. Mantel-Haenszel risk ratio (RR) random-effects model was used to summarize data.

Results …

Optimization Of School Reintegration For Pediatric Oncology Patients And Their Peers, Savannah Fotheringham, Patrick Karabon, Tracy Wunderlich-Barillas, Janis Traynor, L. Kate Gowans

Conference Presentation Abstracts

Improved survival rates of pediatric oncology patients give them the opportunity to return to school. This can present a significant challenge, as returning students often become vulnerable to peer rejection. The objective of this double-arm descriptive study was to establish a framework from which to optimize a school reintegration intervention for the peers of pediatric oncology patients. Ultimately, the study aimed to promote increased knowledge, acceptance by peers, and a smooth transition back to school for childhood cancer survivors. We utilized age-appropriate surveys to evaluate the knowledge and concerns of 3rd to 8th-grade students in Michigan regarding friends with cancer …

Peripheral Intravenous Replacement In Adults: Routine Vs. Clinically Indicated, Carol A. Hunt

Department of Education

No abstract provided.

May / June 2021, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy.

Innovative, Sustainable, And Circular Agricultural Systems For The Future, Gerold Rahmann, Khalid Azim, Irena Brányiková, Mahesh Chander, Wahyudi David, Jan Willem Erisman, Daniel Grimm, Andrew Hammermeister, Li Ji, Anja Kuenz, Anne Kristin Løes, Wan Abd Al Qadr Imad Wan-Mohtar, Daniel Neuhoff, Saliou Niassy, Victor Olowe, Mia Schoeber, Jessica Shade, Jörg Ullmann, Arnold Van Huis

All Peer-Reviewed Publications

This special issue presents the outcomes from “Designing sustainable and circular agricultural systems for the year 2100,” the joint scientific workshop of ISOFAR, the Thünen-Institute, and INRA-Morocco, which was held from November 14 to 16, 2019 in Marrakesh, Morocco. Nineteen scientists from a broad array of background and nationalities came together with the understanding that food security globally is at risk, especially in the post-2050 timeframe. Current concepts, strategies, measures, and scientific efforts carried out by governments, NGOs, businesses, and societies do not deliver satisfying solutions for how to sustainably produce enough healthy and affordable food to support the global …