Medicine and Health Sciences Commons^™

The Effect Of Twist1b And Twist2 Knockdown On Tgf-Beta Signaling Expression In Tendon Progenitors, Marinia N. Bishay

Honors Scholars Collaborative Projects

Somites are important mesoderm structures that form in regularly timed intervals from the anterior end of the paraxial mesoderm at the end of gastrulation during embryogenesis. Cells of the ventromedial portion of the somite, the sclerotome, undergo epithelial to mesenchymal transition, surround the notochord, and give rise to connective tissues of the axial skeleton including the vertebrae, tendons, and ligaments. We are interested in understanding how the sclerotome is compartmentalized into the region that makes tendons. Genes expressed in the sclerotome, twist1 and twist2, are likely involved in the downstream differentiation of sclerotome to tendon progenitors. Previous studies have shown …

2021-12-06_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102057---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

Can Repurposing Drugs Play A Role In Malaria Control?, Roland A. Cooper, Laura Kirkman

Natural Sciences and Mathematics | Faculty Scholarship

Innovative drug treatments for malaria, optimally with novel targets, are needed to combat the threat of parasite drug resistance. As drug development efforts continue, there may be a role for a host-targeting, repurposed cancer drug administered together with an artemisinin combination therapy that was shown to improve the speed of recovery from a malaria infection.

Implementation And Efficacy Of Interprofessional Education (Ipe) Initiatives, Javed A. Mohammed

Department of Occupational Therapy Entry-Level Capstone Projects

The literature demonstrates many benefits of interprofessional education (IPE) simulations in various types of formats that facilitate greater student knowledge and understanding of professions outside their own (O’Hara et al., 2018; Clauser et al., 2020; Cooper, Spencer-Dawe & Mclean, 2005; Djukic et al., 2015; Lazinski et al., 2021). The goals of my doctoral capstone experience (DCE) were to: 1) Develop IPE curriculum and active learning sessions along with assessment plans for professional programs on the Nova Southeastern University (NSU) – Tampa Bay Regional Campus with emphasis on advocacy for the occupational therapy (OT) profession, 2) Lead educational opportunities for students …

2021-12-06 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Evaluation Of The Equivalence Of Different Intakes Of Fruitflow In Affecting Platelet Aggregation And Thrombin Generation Capacity In A Randomized, Double-Blinded Pilot Study In Male Subjects, Ranjit Kumar Das, Tanushree Datta, Dipankar Biswas, Ruedi Duss, Niamh O’Kennedy, Asim K. Duttaroy

Health & Biomedical Sciences Faculty Publications

Background

The water-soluble tomato extract, Fruitflow® is a dietary antiplatelet which can be used to lower platelet aggregability in primary preventative settings. We carried out a pilot study to investigate the range of intakes linked to efficacy and to make an initial assessment of variability in response to Fruitflow®.

Methods

Platelet response to adenosine diphosphate (ADP) agonist and thrombin generation capacity were monitored at baseline and 24 h after consuming 0, 30, 75, 150 or 300 mg of Fruitflow® in a randomized, double-blinded crossover study in male subjects 30–65 years of age (N = 12). Results were evaluated for …

Dual-Mobility Implants And Constrained Liners In Revision Total Hip Arthroplasty, Emanuele Chisari, Blair Ashley, Ryan Sutton, Garrett Largoza, Marco Dispagna, Nitin Goyal, P. Maxwell Courtney, Javad Parvizi

Rothman Institute Papers

Background

Instability remains the most common complication after revision total hip arthroplasty (THA). The purpose of this study was to determine whether there was a difference in aseptic revision rates and survivorship between dual-mobility (DM) and constrained liners (CL) in revision THA.

Methods

We reviewed a consecutive series of 2432 revision THA patients from 2008 to 2019 at our institution and identified all patients who received either a CL or DM bearing. We compared demographics, comorbidities, indications, dislocations, and aseptic failure rates between the two groups. Bivariate and multivariate regression analyses were used to determine risk factors for failure, and …

It Takes Courage To Pause: Rapid Goals-Of-Care Conversations In The Emergency Department, Anita N. Chary, Aanand D. Naik, Kei Ouchi

Journal of Geriatric Emergency Medicine

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Metabolic Pathways And Targets In Chondrosarcoma, Ida Micaily, Megan E Roche, Mohammad Y Ibrahim, Ubaldo E. Martinez-Outshoorn, Atrayee Basu Mallick

Department of Medical Oncology Faculty Papers

Chondrosarcomas are the second most common primary bone malignancy. Chondrosarcomas are characterized by the production of cartilaginous matrix and are generally resistant to radiation and chemotherapy and the outcomes are overall poor. Hence, there is strong interest in determining mechanisms of cancer aggressiveness and therapeutic resistance in chondrosarcomas. There are metabolic alterations in chondrosarcoma that are linked to the epigenetic state and tumor microenvironment that drive treatment resistance. This review focuses on metabolic changes in chondrosarcoma, and the relationship between signaling via isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), hedgehog, PI3K-mTOR-AKT, and SRC, as well as histone acetylation and …

Caregiver Decision-Making Concerning Involuntary Treatment In Dementia Care At Home, Vincent Ra Moermans, Angela Mhj Mengelers, Michel Hc Bleijlevens, Hilde Verbeek, Bernadette Dierckx De Casterle, Koen Milisen, Elizabeth Capezuti, Jan Ph Hamers

Publications and Research

Background: Dementia care at home often involves decisions in which the caregiver must weigh safety concerns with respect for autonomy. These dilemmas can lead to situations where caregivers provide care against the will of persons living with dementia, referred to as involuntary treatment. To prevent this, insight is needed into how family caregivers of persons living with dementia deal with care situations that can lead to involuntary treatment.

Objective: To identify and describe family caregivers’ experiences regarding care decisions for situations that can lead to involuntary treatment use in persons living with dementia at home.

Research design: A qualitative …

Pain Assessment In The Emergency Department, Lynnette Huddle

Master of Science in Nursing Final Projects

Aim: The aim of this integrative review was to synthesize studies that explore barriers to pain management in the Emergency Department.

Background: Pain remains one of the main reasons a person seeks help from the Emergency Department. However, patient's pain levels continue to be under-assessed and under-treated in Emergency Departments.

Design: Integrative Review Data Sources: A systematic review of Medline, PubMed, CINAHL, and Google Scholar electronic databases was performed. The articles were searched using the keywords, and the inclusion/exclusion criteria. Eleven studies published between 2011 and 2021 were found.

Review Methods: Studies were appraised using the John Hopkins Nursing Evidence-Based …

Implementation Of An Oral Hygiene Protocol For Adults Patients On Acute Care Units, Sharon J. Boler

Student Scholarly Projects

Practice Problem: Patients diagnosed with non-mechanically ventilated aspiration pneumonia can result in increased levels of care, longer lengths of stay, and are 8.4 more likely to die while hospitalized. Oral hygiene protocols have led to promising outcomes, evidenced by fewer cases of aspiration pneumonia in adult patients on medical surgical units.

PICOT: The PICOT question that guided this project was in adult non-mechanically ventilated hospital patients, does an Oral Hygiene Protocol (OHP) compared to current practice affect hospital acquired aspiration pneumonia during hospitalization.

Evidence: Fourteen studies met inclusion criteria that support the implementation of an evidence – based oral hygiene …

Micrornas: New Non-Invasive Diagnostic Biomarkers And Therapeutic Method For Cancer Treatment: Micrornas: New Non-Invasive Diagnostic Biomarkers And Therapeutic Method For Cancer Treatment, Tamadir Aledani, Kassim Abdulkareem

Iraqi National Journal of Medicine

Background: Cancer is a global health problem and the main cause of mortality. Most cancer-associated cases of mortality are the consequences of lack of effective treatment and biomarkers for early diagnosis. New hopes for the improvement of the early diagnosis and treatment of cancer synchronize with the emergence of microRNAs (miRNAs). MicroRNAs are small, noncoding, single-stranded RNAs, the length of which is approximately 18–25 nucleotides and which bind to 3’ untranslated region (3’UTR) of the target messenger RNAs (mRNAs), leading to mRNA degradation or translational inhibition; thereby regulating gene expression post-transcriptionally._x000D_ Aim: Using microRNAs as promising and potential biomarkers for …

Seminal Fluid Analysis Changes After Testicular Varicocelectomy In A Sample Of Iraqi Patients: Seminal Fluid Analysis Changes After Testicular Varicocelectomy In A Sample Of Iraqi Patients, Anwar Majed, Manal Rasheed, Mohammed Jasim

Iraqi National Journal of Medicine

Background:_x000D_ Semen analysis measures ejaculate volume, pH, sperm count, motility, forward progression, and morphology. Although semen analysis is not a test for infertility, it is considered the most important laboratory test in the evaluation of male fertility. There are many factors affecting the seminal fluid parameters and testicular varicocele is one of them. Varicoceles are the most commonly seen and correctable male infertility factor. Varicocelectomy is a common operation performed for infertile males with clinical varicocele. The aim of study:_x000D_ to evaluate the seminal fluid parameters changes after testicular varicocelectomy.Patients and Method: A prospective cohort study was done at the …

Role Of Videolaryngostroboscopy In The Diagnosis Of Dysphonic Patients With Normal Fiberoptic Laryngoscopy: Role Of Videolaryngostroboscopy In The Diagnosis Of Dysphonic Patients With Normal Fiberoptic Laryngoscopy, Sajad Al-Helo, Ahmed Al-Safi, Rahma Aljanabi

Iraqi National Journal of Medicine

Background: Dysphonia is altered voice quality, pitch, loudness, or vocal effort that impairs people’s quality of life. It is a very common complaint affecting nearly one-third of a population at some point in their life and could be caused by infection, tumor, trauma, vocal cord paralysis, etc._x000D_ Indirect mirror or endoscopic laryngoscopy is used to assess the laryngeal condition in dysphonic patients seeking mainly for the cause, but frequently the findings were normal or unremarkable._x000D_ Videolaryngoscopy (VLS) is very useful in dysphonic patients who have an otherwise normal indirect or flexible laryngoscopic examination. In addition to providing information regarding vocal …

Evaluation Of Vegf-A In Relation To Childhood Acute Lymphoblastic Leukemia (In Basrah, Iraq): Evaluation Of Vegf-A In Relation To Childhood Acute Lymphoblastic Leukemia (In Basrah, Iraq), Zainab Badr, Wijdan Al-Moosawi, Sadiq Ali

Iraqi National Journal of Medicine

Background: Cancer angiogenesis demonstrates an important role in the progression and pathogenesis of blood malignant disorders including acute lymphoblastic leukemia (ALL). Vascular endothelial growth factor (VEGF)-A is one of the most effective elements of endothelial cell growth; it promotes vascular permeability of endothelial cells and provides the new vasculature with oxygen and nutrients. Higher VEGF-A levels in childhood acute lymphoblastic leukemia (ALL) is associated with poorer patient outcomes._x000D_ Aim of the study: to assess the level of VEGF-A in plasma of children with ALL._x000D_ Subject and method: Forty children with ALL and 40 healthy children as control were enrolled in …

Sepsis-Associated Cholestasis: The Impact Of Mitochondrial Dysfunction (A Case Report): Sepsis-Associated Cholestasis: The Impact Of Mitochondrial Dysfunction (A Case Report), Behzad Noroozi, Ali Had, Bita Shahrami, Ayda Ardabili, Fatemeh Yoonesi

Iraqi National Journal of Medicine

Introduction: Hyperbilirubinemia – a condition of elevated serum bilirubin above the reference range, is common in hospitalized patients. The reasons for the increase in the bilirubin level can be pre-hepatic, hepatic, and post-hepatic. Sepsis is one of the most important causes of hyperbilirubinemia in critically ill patients._x000D_ Case report: We present a 30-year-old woman with no past medical and drug history who was admitted to the intensive care unit (ICU) due to multiple trauma and fractures due to a fall from height. During the ICU stay, the patient developed jaundice with a high increase in the bilirubin level. A diagnosis …

Antisocial Behavior Etiologies: Antisocial Behavior Etiologies, Sundus Hantoosh, Rasha Ameen, Seenaa Amin

Iraqi National Journal of Medicine

Antisocial behavior is a broad term that encompasses many facets of destructive behavior, most of which bring harm to another person or involve the violation of rights of others. Main antisocial behavior victims are young individuals, women and children. Numerous factors interact together for the development of aggression and antisocial behavior; these factors are social, environmental, physiological, neurological, and genetic. Consequently, this paper addresses the principal etiologic factors that participate in the development of antisocial behaviors for children, adolescents, and adult individuals._x000D_  _x000D_

The Challenges, Risks, And Concerns Perceived By Iraqi Medical Doctors: A Cross Sectional Study: The Challenges, Risks, And Concerns Perceived By Iraqi Medical Doctors: A Cross Sectional Study, Alaa Abed, Basim Abdul-Hassan, Dhurgham Abdulwahid

Iraqi National Journal of Medicine

Background: The current situation of the health system in Iraq, under the difficult conditions the country has been experiencing, generates great pressures on doctors because they are in the field of confrontation between the growing needs of patients day after day and the dilapidated capabilities and government neglect of the health sector with the absence of security and stability and weak law enforcement.The imposition of state authority has led to an increase in violence in the country in general and against doctors in particular. Moreover, there are other pressures that doctors are subjected to, such as security, economic, professional, social, …

Doppler-Guided Hemorrhoid Artery Ligation With Recto-Anal Repair Outcome On Female Patients In Basra: Assessment Study: Doppler-Guided Hemorrhoid Artery Ligation With Recto-Anal Repair Outcome On Female Patients In Basra: Assessment Study, Ohood Leabi, Alaa Abed, Wafa Al-Maliki

Iraqi National Journal of Medicine

Background: Hemorrhoidal disease is a common morbidity seen by general surgery clinics. Transanal Doppler guided (DG) hemorrhoidal artery ligation (HAL) with rectoanal repair (RAR) has been invented as a new treatment option. HAL-RAR was associated with mild to moderate postoperative complications in the literatures; and considered easy, safe, mostly painless procedure with very good results in treating hemorrhoids._x000D_ Objective: This study was conducted to evaluate the outcome of using DG-HAL-RAR procedure through documenting postoperative complications during a median follow-up period of 18 months._x000D_ Method: The study included 151 women presented with hemorrhoids in Basra, operated upon using the DG-HAL-RAR and …

Acceptance Of Covid-19 Vaccine Among General Population In Iraq: Acceptance Of Covid-19 Vaccine Among General Population In Iraq, Hasanain Ghazi, Taqi Taher, Shaymaa Alfadhul, Sumayah Al-Mahmood, Shaimaa Hassan

Iraqi National Journal of Medicine

COVID19 emerged as one of the biggest global public health crises in recent history. Many pharmaceutical companies have raced against time to develop a vaccine, so that the pandemic can be brought under control.  The aim of the current study was to assess the acceptance of the COVID19 vaccine among the general population in Iraq. A cross-sectional study was conducted among 1069 respondents from different states of Iraq using questionnaires administered online. Though a total of 77.6% of the respondents agreed to take the COVID19 vaccine when available, a majority (64.3%) said they would wait for some time before taking …

Clinical Course And Outcome Of Eleven Maintenance Hemodialysis Patients With Covid-19 In Iraq: Clinical Course And Outcome Of Eleven Maintenance Hemodialysis Patients With Covid-19 In Iraq, Hayder Aledan, Safa Mezban, Mohammed Albadran, Jawad Rasheed, Muhammed Al Atbee

Iraqi National Journal of Medicine

Background and objectives: SARS-CoV-2 may affect the hemodialysis population as well as be possibly associated with their higher mortality rate. The objectives of the study were to describe the clinical presentations, assess laboratory markers, and risk factors for mortality._x000D_ Methods: This was an observational single-center retrospective study of two hemodialysis units in Basra from May 1, 2020 to June 1, 2020._x000D_ Results: Among the 11 patients, four (36.4%) died. Compared to the survivors, non-survivors had significantly longer dialysis vintage (16 ± 14.7 vs 9 ± 5.2; P = 0.048) and lower day 10 lymphocyte count (3.75 ± 0.96 vs 9.4 …

A Study On Diabetic Foot Disorders In Basrah, Southern Iraq: A Study On Diabetic Foot Disorders In Basrah, Southern Iraq, Majid Alabbood, Abdulhussein Marzoq

Iraqi National Journal of Medicine

Background: Diabetic foot disorders (DFD) involve several pathologies affecting the foot of patients suffering with diabetes, such as diabetic peripheral neuropathy, peripheral arterial disease, foot deformity, diabetic foot ulcer and amputation._x000D_ Objectives: To measure the prevalence and associated risk factors of DFD in a cohort of patients in Basrah, Iraq._x000D_ Methods: This is a cross sectional study that was performed in Basrah Province, Iraq, from 1/1/2019 to 1/8/2019. Patients with diabetes attending Faiha Specialized Diabetes Endocrine and Metabolism Center were screened for DFD. The participants were divided into four groups according to the International Working Group on the Diabetic Foot …

Comparison Of Rectus Muscle Resection And Rectus Muscle Plication For Ocular Horizontal Strabismus: Comparison Of Rectus Muscle Resection And Rectus Muscle Plication For Ocular Horizontal Strabismus, Mohammed Al Ashoor

Iraqi National Journal of Medicine

Objectives: This study aimed to compare the surgical outcomes of rectus muscle plication with those of standard rectus muscle resection in combination with recession in patients with horizontal ocular deviations._x000D_ Methods: This comparative prospective case-control study was conducted in the Department of Ophthalmology of Basra Teaching Hospital in Iraq from March 2017 to August 2019. Fifty-eight patients (25 male, 33 female; mean age = 3.86 years), including 32 with esotropia and 26 with exotropia, were divided randomly into two treatment groups after a comprehensive preoperative assessment and selection process. They underwent the indicated rectus muscle tightening procedures. During a postoperative …

Assessment Of Serum Urea, Creatinine And Uric Acid In Sudanese Hypertensive Patients: Assessment Of Serum Urea, Creatinine And Uric Acid In Sudanese Hypertensive Patients, Ashwag Abdallah, Shereen Abdelrahman, Suhair Ahmed, Abdelmula Abdalla, Abuagla Dafalla

Iraqi National Journal of Medicine

Background: Hypertension It is one of major public health problems in developing counties like Sudan, and increases the risk of mortality. Biochemical renal parameters are necessarily routinely tested to check for renal efficiency of patients when hypertension is a chronic disease and has many complications for long time such as renal failure._x000D_ Objective: The aim of present study was to assess serum urea, creatinine and uric acid in Sudanese patients with hypertension._x000D_ Patients and Methods: This study was analytical case control hospital based study, carried out in Wad Madani city, Gezira state from December 2019 to February 2020. Hundred subjects …

Barriers To Accessing Antenatal Care Services In Primary Health Care Centers In Rural Areas Of Basrah : Barriers To Accessing Antenatal Care Services In Primary Health Care Centers In Rural Areas Of Basrah, Jhood Molan

Iraqi National Journal of Medicine

Introduction: Antenatal care (ANC) includes preventive and curative care services delivered during pregnancy. The World Health Organization (WHO) suggests that pregnant women should receive at least four ANC visits. ANC is provided in Iraq in the public sector mainly in primary health care (PHC) centers with referral to higher care if required. Private sector contributes to ANC, both private clinics and private hospitals have outpatient services as well._x000D_ Objectives: This study aims to describe the ANC use among women attending PHC centers in Basrah, determine associations of ANC utilization rate with sociodemographic characteristics, and ascertain barriers to the utilization of …

The Efficacy Of Monomeric Acrylic In Cranioplasty Surgery Five-Year Follow-Up: The Efficacy Of Monomeric Acrylic In Cranioplasty Surgery Five-Year Follow-Up, Ghassan Abd Al Ratha, Yasir Hamandi

Iraqi National Journal of Medicine

Background: Cranioplasty refers to the surgical repair of a defect or deformity of skull that may result from trauma, growing skull fracture, congenital encephalocele, neoplasm._x000D_ Objectives: To evaluate the efficacy of monomeric acrylic implant material in cranioplasty_x000D_ Patients and methods: Retrospective analyses of (64) patients undergoing cranioplasty over five years from January 2010 to December 2015 were performed in AL- Kadhimiya teaching hospital Baghdad, Iraq. Monomeric Acrylic was used in all patients and cranioplasty were performed under general anesthesia. 26 RTA, 19 bullet injuries, 7 FFH, 5 fan injuries, 4 congenital encephalocele, 3 brain tumors._x000D_ Results: A total of 64 …

Comparison Of The Outcome Of Combined Ultrasonic And Fluoroscopic Versus Fluoroscopic Guidance Percutaneous Nephrolithotomy: Comparison Of The Outcome Of Combined Ultrasonic And Fluoroscopic Versus Fluoroscopic Guidance Percutaneous Nephrolithotomy, Majed Mohammed, Firas Attar, Hakeem Mohammed

Iraqi National Journal of Medicine

Background: Renal stone is one of the most common renal diseases worldwide. There are several modalities for treatment of renal stone disease, one of these modalities is the use of percutaneous nephrolithatomy (PCNL) surgery which can be done either under fluoroscopic or ultrasonic or even combined fluoroscopic and ultrasonic gaudiness. The purpose of this study is to compare the outcome of combined ultrasonic and fluoroscopic versus fluoroscopic guided PCNL.Materials and Method: This is a prospective study done in AL Basrah teaching hospital from May 2015 to December 2019, 200 patients with the diagnosis of renal stone indicated for PCNL surgery …

Knowledge, Attitude, And Practice Regarding Mammography Among Women In Baghdad City, Iraq: Knowledge, Attitude, And Practice Regarding Mammography Among Women In Baghdad City, Iraq, Taqi Taher, Thamer Hilfi, Hasanain Ghazi

Iraqi National Journal of Medicine

Background: A low-dose X-ray mammogram is considered the most useful tool for detecting early-stage breast cancer among women. Both mortality and morbidity prove to be reduced when cancer is detected early, before any signs and symptoms appear. This study aims to determine the knowledge level, attitude, and practice of women at general hospitals/consulting clinics in Baghdad city in 2017.Methods: This cross-sectional study was conducted on a sample of 657 women in general hospitals/consulting clinics in Baghdad. The women were selected as an improbability sample. Their average age was between 20 and 59 years. Data collection extended from 1st April to …

Burden Of Care Among Caregivers Of Patients With Schizophrenia In Baghdad City: Burden Of Care Among Caregivers Of Patients With Schizophrenia In Baghdad City, Jamal Muzil, Numan Ali, Aqeel Alsabbagh, Zainab Kammad

Iraqi National Journal of Medicine

Background: The family members of schizophrenic patients frequently report that caring for the patient imposes a great burden on them and hampers the typical structure and functioning of the family to the detriment of its members.Objectives: To assess the level of the burden of care (objective and subjective) shouldered by the primary caregivers of schizophrenic patients and to determine the relationship between the objective and subjective level of such burdens.Method: A descriptive analytical study was conducted on a purposive sample of 50 primary caregivers of schizophrenic patients who were hospitalized in Ibn-Rushd Psychiatric Teaching Hospital in Baghdad. The data were …