Medicine and Health Sciences Commons^™

Assessment Of Knowledge And Understanding Of Professional Qualities In First-Year Medical Students - A Cross - Sectional Study, Harpreet Kour, Deepti Kadeangadi, M S. Shivaswamy, Parwati Patil

Manipal Journal of Medical Sciences

Background: Academic proficiency along with clinical skills are essential assets for a medical practitioner. Therefore, Attitudes, Ethics, and Communication (AETCOM) module has been implemented by the Medical Council of India (MCI) as a structured program to train and develop professional skills among the first year MBBS students in medical colleges in India since 2019. Objective: To assess the knowledge and understanding of professional qualities in first-year medical students. Methods: This questionnaire-based study was conducted among 156 first-year MBBS students. The questionnaire was divided into three parts, held during the AETCOM Module Classes. Categorical variables were given in the form of …

Clinical Teaching And Learning In The Covid-19 Era And Beyond: The Emergent And Emerging Scenarios, Shashikala K. Bhat, Veena Manja, Vinutha Shankar, Shashikiran Umakanth

Manipal Journal of Medical Sciences

The need for social distancing due to the COVID-19 pandemic has compromised traditional medical education. Educators and students in low-resource settings face diverse challenges in clinical teaching, learning, and assessment. The pandemic has necessitated a rapid transition from traditional pedagogical strategies to virtual platforms. Challenges in low resource settings include knowledge and training in technology, limited resource allocation for faculty development in virtual teaching methods, and financial constraints limiting the use of available technologies. There is also a lack of constructive alignment between outcomes, instructional strategies, and assessment of curriculum delivery in virtual platforms as the earlier curriculum design was …

Absent Oblique Fissure And Lingula In The Left Lung – A Rare Anatomical Variation, Amit Massand, Mamatha Tonse, Mangala Pai, B.V. Murlimanju, Latha Prabhu

Manipal Journal of Medical Sciences

In the course of a routine dissection class for medical students, it was observed that there was no oblique fissure, cardiac notch, and lingula in an embalmed cadaver. Due to their absence, the superior and inferior lobes of this lung could not be distinguished clearly. The lobes were attached together, however, there were no structural variations in its hilum. No variation was found in the fissures and hilum of the right lung in this cadaver. We opine that this variation can be helpful to cardiothoracic surgeons, mainly during the resection of the lobe of the left lung.

Student Attitude Towards Integrative Medicine In A Caribbean Medical School, Shankar Pr, Dwivedi Nr, Balasubramanium R, Nandy A, Dakubo G, Barton B

Manipal Journal of Medical Sciences

Background: Patients in developed nations increasingly use Complementary and Alternative Medicine (CAM) and Integrative Medicine (IM). Previous studies have not examined student attitudes towards IM at Xavier University School of Medicine (XUSOM), a Caribbean medical school. Most students are citizens of the United States or Canada and will practice in these countries after graduation. Hence, the present study was conducted using the integrative medicine attitude questionnaire (IMAQ), a previously validated questionnaire. Methods: First to fourth semester premedical and undergraduate medical (MD) students were involved in the study. Respondents’ gender, semester of study and nationality were noted. Their degree of agreement …

Solitary Plasmacytoma Of Manubrium Sterni - A Case Report, Shyamasunder N. Bhat, Sp Mohanty

Manipal Journal of Medical Sciences

Solitary plasmacytoma is a tumour consisting of neoplastic monoclonal plasma cells without systemic involvement. It constitutes about 5% of all plasma cell dyscrasias and is mainly detected in the spine, pelvis and ribs and rarely in the sternum.

Here we report a case of a 45-year-old man presenting with pain and swelling in the midline of the chest over manubrium sterni. Plain radiograph and CT scan revealed an expansile, osteolytic lesion in the manubrium sterni. There was no M Band in protein electrophoresis, and the iliac bone marrow aspirate did not show plasmacytoma. However, histopathology of the lesion was suggestive …

Proportion Of Pre-Dialysis Prolonged Qt Dispersion In Twiceweekly Chronic Hemodialysis Patients And Its Associated Factors, Arief Pattiiha, Muhammad Yamin, Aida Lydia, Murdani Abdullah

Jurnal Penyakit Dalam Indonesia

Introduction. Cardiovascular disease (CVD) is the common cause of mortality in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Causes of CVD in ESRD patients are multifactorial. Ventricular arrhythmia is known as the leading cause of sudden death in dialysis patients. QT dispersion, which is measured from electrocardiography (ECG), is known as one of the parameters to assess the risk of arrhythmia in HD patients. This study aimed to determine the proportion of pre-dialysis prolonged QT dispersion in chronic twice-weekly HD patients and the associated factors. Methods. A cross-sectional study was conducted among HD patients age ≥18 years with dialysis …

Analysis Of Genetic Variants Associated With Levels Of Immune Modulating Proteins For Impact On Alzheimer’S Disease Risk Reveal A Potential Role For Siglec14, Benjamin C. Shaw, Yuriko Katsumata, James F. Simpson, David W. Fardo, Steven Estus

Biostatistics Faculty Publications

Genome-wide association studies (GWAS) have identified immune-related genes as risk factors for Alzheimer’s disease (AD), including TREM2 and CD33, frequently passing a stringent false-discovery rate. These genes either encode or signal through immunomodulatory tyrosine-phosphorylated inhibitory motifs (ITIMs) or activation motifs (ITAMs) and govern processes critical to AD pathology, such as inflammation and amyloid phagocytosis. To investigate whether additional ITIM and ITAM-containing family members may contribute to AD risk and be overlooked due to the stringent multiple testing in GWAS, we combined protein quantitative trait loci (pQTL) data from a recent plasma proteomics study with AD associations in a recent …

The World Is At War, Sarriyah Hanif

Quill & Scope

No abstract provided.

Test Mode, Marisella Garcia

Quill & Scope

No abstract provided.

The Souls Of Our Shoes, Carly Carlin

Quill & Scope

No abstract provided.

Screen Time, Terry Park

Quill & Scope

No abstract provided.

The Upper East Side Vs. Central Harlem: What Is Responsible For The Dermatology Disparities That Shaped These Communities?, Zakiya M. Cush, Jeffrey Weinberg

Quill & Scope

No abstract provided.

End-Of-Life Care, Sara Heide

Quill & Scope

No abstract provided.

Fragile X Syndrome, Crystal Ukaegbu

Quill & Scope

No abstract provided.

Fungi: Are They Plants Or Animals?, Himanshu Yn, Sufyan Ibrahim, Revathi P. Shenoy Dr

Manipal Journal of Medical Sciences

The status of fungi in the phylogenetic setup still continues to be an intriguing question in biological sciences. Having long been considered as close relatives of plants, over the years, their resemblance towards animals has been brought into the greater limelight. While the vast diversity of the group demands a separate kingdom, evolution biology coaxes us to trace back their ancestry and establish similarities between different kingdoms and as newer pieces of evidence emerge up, the question as to whether fungi are plants or animals, remains contentious.

Comparison Of Turnaround Times (Tat) In Pathology Laboratories From Developed And Developing Countries, And Its Impact On Treatment, Rishikha Jeyapal, Shajeedth Suresh Naidu, Jeevan K K. Shetty, Venkatesh Ramaswamy Naik

Manipal Journal of Medical Sciences

The timeliness of histopathology reports is one of the most crucial aspects of patient care. Turnaround Time (TAT) is one such parameter that is often considered when performing tests in pathology labs. Simply put, it is the time interval between the day a specimen is accessed in the lab, to the day the final report is signed out. Aims: This study aimed to compare the turnaround times in histopathology labs of developed and developing countries and to explore the impact of turnaround times on medical treatment. Materials and Methods: Our current review on retrieved articles from databases such as PubMed, …

An Investigation Of A Novel Dural Repair Device For Intraoperative Incidental Durotomy Repair., Kartik Shenoy, Chester J. Donnally, Evan D. Sheha, Krishn Khanna, Srinivas K. Prasad

Rothman Institute Papers

Incidental durotomies, or dural tears, can be very difficult and time consuming to repair properly when they are encountered in confined spaces. A novel dural repair device was developed to address these situations. In this paper, the novel device was assessed against the use of traditional tools and techniques for dural repairs in two independent studies using an intricate clinical simulation model. The aim was to examine the results of the two assessments and link the outcomes to the clinical use of the novel device in the operating room. The novel device outperformed conventional techniques as measured by dural repair …

Autophagy, Apoptosis, The Unfolded Protein Response, And Lung Function In Idiopathic Pulmonary Fibrosis, Pawan Sharma, Javad Alizadeh, Maya Juarez, Afshin Samali, Andrew J Halayko, Nicholas J Kenyon, Saeid Ghavami, Amir A Zeki

Center for Translational Medicine Faculty Papers

Autophagy, apoptosis, and the unfolded protein response (UPR) are fundamental biological processes essential for manifold cellular functions in health and disease. Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal pulmonary disorder associated with aging that has limited therapies, reflecting our incomplete understanding. We conducted an observational study linking molecular markers of cell stress response pathways (UPR: BiP, XBP1; apoptosis: cleaved caspase-3; autophagy: LC3β) in lung tissues from IPF patients and correlated the expression of these protein markers to each subject's lung function measures. We hypothesized that changes in lung tissue expression of apoptosis, autophagy, and UPR markers correlate with …

Determinan Konsistensi Penggunaan Kondom Pada Laki-Laki Seks Dengan Laki-Laki (Lsl) Non-Pekerja Seks: Studi Potong Lintang, Arum Zulaikhah, Sudarto Ronoatmodjo

Jurnal Epidemiologi Kesehatan Indonesia

Kasus baru HIV di Indonesia cenderung terus mengalami peningkatan. Sedangkan, tren kasus baru di dunia sudah mengalami penurunan. Laki-laki Seks dengan laki-laki (LSL) merupakan kelompok risiko tinggi HIV. Upaya pencegahan penularan HIV erat kaitannya dengan perilaku seks. Studi ini menggunakan 1.161 sampel Survei Terpadu Biologi dan Perilaku (STBP) 2015 pada kelompok LSL yang termasuk bukan pekerja seks. Studi cross sectional ini bertujuan untuk menganalisis determinan perilaku seks konsistensi penggunaan kondom dengan analisis hingga bivariat dengan menggunakan chi-square dan prevalence ratio. Data didapatkan dengan metode respondent driven sampling (RDS) yang kemudian mengeksklusi LSL pekerja seks. Hasil menunjukkan bahwa faktor-faktor yang berhubungan …

A Rare Fatal Case Of Adenovirus Serotype 4 Associated Acute Disseminated Encephalomyelitis In An Adult: A Case Report, Zahra Qamar, Catherine Tucker, Lawrence C. Kenyon, Tricia. Royer

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Acute disseminated encephalomyelitis (ADEM) is an autoimmune demyelinating disease directed against the myelin sheath of the central nervous system that typically presents 1–4 weeks after an infection or vaccination, most commonly in children. We describe a case of a young female who presented with rapidly progressive mental deterioration and died secondary to ADEM following an adenovirus upper respiratory tract infection.

Nox4 Signaling Mediates Cancer Development And Therapeutic Resistance Through Her3 In Ovarian Cancer Cells., Wen-Jing Liu, Ying-Xue Huang, Wei Wang, Ye Zhang, Bing-Jie Liu, Jian-Ge Qiu, Bing-Hua Jiang, Ling-Zhi Liu

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Development of resistance to therapy in ovarian cancer is a major hinderance for therapeutic efficacy; however, new mechanisms of the resistance remain to be elucidated. NADPH oxidase 4 (NOX4) is responsible for higher NADPH activity to increase reactive oxygen species (ROS) production. In this study, we showed that higher levels of NOX4 were detected in a large portion of human ovarian cancer samples. To understand the molecular mechanism of the NOX4 upregulation, we showed that NOX4 expression was induced by HIF-1α and growth factor such as IGF-1. Furthermore, our results indicated that NOX4 played a pivotal role in chemotherapy and …

Analisis Produk Layanan Rawat Inap Di Rsud Wangaya Denpasar Berdasarkan Stp Dan 4 P (Product, Price, Place Dan Promotion), Ni Putu Sri Wahyuni

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Service marketing strategy will increase the level of customer satisfaction with marketing mix consisting of 4 P (product, price, place, promotion) and supported by modern STP marketing strategies (Segmenting, Targeting and Positioning) as a technique to look for market opportunities, so that the hospital is able to provide health services according to customer needs. The research conducted is descriptive research, which is a research method that aims to describe a situation objectively, to solve the problem being faced. The data used are secondary data that includes inpatient visit data, occupancy data for inpatient rooms, and community satisfaction data in inpatient …

Examining Inequities In Rates Of Undiagnosed Hiv And Rectal Stis In A Large Nationwide Cohort Study Of Sexual Minority Men, H Jonathon Rendina, Ali Talan, K Marie Sizemore, Nicola F. Tavella, Brian Salfas, Ore Shalhav, Drew Westmoreland, Brian Mustanski, Carlos E. Rodríguez- Díaz

Publications and Research

Objective Sexual minority men (SMM) of colour are disproportionately impacted by HIV and bacterial STIs (bSTIs). To better understand within-group heterogeneity and differential risk factors by race and ethnicity, we sought to examine rates of undiagnosed HIV and rectal bSTI at the intersection of racial and ethnic identity with other sociodemographic factors.

Methods We examined data from 8105 SMM conducting home-based self-testing at enrollment in a nationwide cohort study collected from November 2017 to August 2018. We conducted analyses stratified by racial and ethnic groups to examine within- group (ie, subgroup) unadjusted rates of HIV and rectal bSTI infection across …

The Shape Of The Oral Glucose Tolerance Test-Glucose Response Curve In Islet Cell Antibody-Positive Vs -Negative Obese Youth Clinically Diagnosed With Type 2 Diabetes, Joon Young Kim, Hala Tfayli, Fida Bacha, Silva Arslanian

Children’s Nutrition Research Center Staff Publications

BACKGROUND: The oral glucose tolerance test (OGTT)-glucose response curves (GRCs; incessant increase, monophasic, and biphasic) reflect insulin sensitivity and β-cell function, being worse in the former and superior in the latter. Here, we examined if the OGTT-GRC pattern is worse in obese antibody (glutamic acid decarboxylase 65-kDa [GAD65] and insulinoma-associated protein-2 [IA-2])-positive (Ab

METHODS: Forty-seven obese youth, 15 Ab

RESULTS: Incessant increase OGTT-GRC is the most frequent curve type and is three-fold higher in Ab

CONCLUSION: Severe insulin deficiency, a characteristic of type 1 diabetes, seems to be related to higher prevalence of incessant increase in Ab

Barbadin Potentiates Long-Term Effects Of Lorcaserin On Pomc Neurons And Weight Loss, Yang He, Hailan Liu, Na Yin, Yongjie Yang, Chunmei Wang, Meng Yu, Hesong Liu, Chen Liang, Julia Wang, Longlong Tu, Nan Zhang, Lina Wang, Yanlin He, Makoto Fukuda, Qi Wu, Zheng Sun, Qingchun Tong, Yong Xu

Children’s Nutrition Research Center Staff Publications

Obesity is a serious global health problem because of its increasing prevalence and comorbidities, but its treatments are limited. The serotonin 2C receptor (5-HT_2CR), a G-protein-coupled receptor, activates proopiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus (ARH) to reduce appetite and weight gain. However, several 5-HT analogs targeting this receptor, e.g., lorcaserin (Lor), suffer from diminished efficacy to reduce weight after prolonged administration. Here, we show that barbadin (Bar), a novel β-arrestin/β2-adaptin inhibitor, can prevent 5-HT_2CR internalization in cells and potentiate long-term effects of Lor to reduce appetite and body weight in male mice. Mechanistically, …

Needs Of Direct Support Professionals To Support People With Intellectual Disabilities In Leading A Healthy Lifestyle, Annelies Overwijk, Thessa I.M. Hilgenkamp, Cees P. Van Der Schans, Annette A.J. Van Der Putten, Aly Waninge

Physical Therapy Faculty Research

Background: For a healthy lifestyle, people with moderate, severe, and profound intellectual disabilities living in residential facilities and/or participating in day activity centers are dependent on their direct support professionals. However, it is unclear what knowledge and skills these direct support professionals require to support these individuals in living a healthy lifestyle. Therefore, the aim of this study was to identify the needs of direct support professionals for supporting these people with moderate to profound intellectual disabilities to achieve and maintain a healthy lifestyle. Method: Direct support professionals (n = 28) were interviewed with the use of a semi-structured protocol …

Clinical Characteristics And Treatment Regimen Of Pemphigus Patients: A Retrospective Study, Windy Keumala Budianti, Eyleny Meisyah Fitri, Puti Rineska Meilinda, Endi Novianto, Shafira Anindya, Arlha Aporia Debinta

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Pemphigus is a potentially life-threatening autoimmune bullous disease. In pemphigus, the therapeutic options are based on the clinical characteristics of each patient. However, other than corticosteroids, most therapeutic options for pemphigus are currently limited. Steroid-sparing agents might be considered since the initiation of therapy to prevent the side effects of corticosteroid. The objective of this study is to identify the clinical characteristics and therapy of choice in patients with pemphigus at Dr. Cipto Mangunkusumo General Hospital.

Method: All cases of pemphigus from 2016 to 2018 at Dermato-Allergo-Immunology Clinic, Department of Dermatology and Venerology Dr. Cipto Mangunkusumo General …

Alternative Modality In The Treatment Of Acne Vulgaris: Low Level Laser Therapy, Rudi Chandra, Nelva K. Jusuf

Journal of General - Procedural Dermatology and Venereology Indonesia

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit with polymorphic manifestations. The four key elements leading to the formation of acne lesions are alteration of follicular keratinization that leads to comedones, increased and altered sebum production under androgen control, follicular colonization by Propionibacterium acnes, and complex inflammatory mechanisms that involve both innate and acquired immunity. Phototherapy (light, lasers, and photodynamic therapy) has been proposed as an alternative therapeutic modality to treat acne vulgaris and is proposed to have less side effects compared to other treatment options. Recently, low-level laser (light) therapy (LLLT) which refers to the use …

Dermoscopy-Guided Carbon Dioxide Laser Destruction For Nevus Sebaceous: Two Case Reports, Larisa Paramitha Wibawa, Kuniaki Ohara

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Nevus sebaceous (NS) is a common hamartoma of the cutaneous adnexal structure, clinically appear as a well demarcated yellow-orange plaque, sometimes with verrucous surface. Dermoscopy may aid the diagnosis of NS and also guide carbon dioxide (CO2) laser therapy.

Case Illustration: Two cases of brown and yellowish plaque on the face, with clinical appearance, dermoscopic, and histopathological findings consistent with NS. The patients consented to undergo serial CO­2laser destruction, aimed to reduce recurrences and shorten the duration of the downtime. Dermoscopy aided in locating the area and the depth of each treatment.

Discussion: The dermoscopy finding …

Childhood-Onset Borderline Tuberculoid Leprosy With Reversal Reaction, Ramona D. Lubis, Mila Darmi, Rudi Chandra

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Leprosy is a chronic granulomatous infection caused by Mycobacterium lepraethat predominantly affects the skin and peripheral nerves. Leprosy among children is still common in endemic countries.

Case Illustration: A 12-year-old girl complained about a hypopigmented anesthetic patch on her face for 11 years, which became larger and spread slowly to her arms and legs. She had a history of close contact with her aunt, who was diagnosed with multibacillary leprosy. On slit-skin-smear test, acid-fast-bacilli (bacteriologic index +1) were found. She was diagnosed with multibacillary leprosy and treated with children’s multidrug therapy-multibacillary (MDT-MB) regimen. After 2 months of …