Medicine and Health Sciences Commons^™

The Potential Economic Benefits Of Controlling Trypanosomiasis Using Waterbuck Repellent Blend In Sub-Saharan Africa, Zewdu Abro, Menale Kassie, Beatrice Muriithi, Michael Okal, Daniel Masiga, Gift Wanda, Ouedraogo Gisèle, Abah Samuel, Etienne Nguertoum, Rock Aimé Nina, Philémon Mansinsa, Yahaya Adam, Mamadou Camara, Pamela Olet, Diarra Boucader, Susana Jamal, Abdoul Razak Issa Garba, Joseph Joachim Ajakaiye, Jean Felix Kinani, Mohamed Adam Hassan, Hezron Nonga, Joyce Daffa, Ambrose Gidudu, Kalinga Chilongo

All Peer-Reviewed Publications

Trypanosomiasis is a significant productivity-limiting livestock disease in sub-Saharan Africa, contributing to poverty and food insecurity. In this paper, we estimate the potential economic gains from adopting Waterbuck Repellent Blend (WRB). The WRB is a new technology that pushes trypanosomiasis-transmitting tsetse fly away from animals, improving animals' health and increasing meat and milk productivity. We estimate the benefits of WRB on the production of meat and milk using the economic surplus approach. We obtained data from an expert elicitation survey, secondary and experimental sources. Our findings show that the adoption of WRB in 5 to 50% of the animal population …

How Does Adoption Of Labor Saving Agricultural Technologies Affect Intrahousehold Resource Allocations? The Case Of Push-Pull Technology In Western Kenya, Gracious M. Diiro, Monica Fisher, Menale Kassie, Beatrice W. Muriithi, Geoffrey Muricho

All Peer-Reviewed Publications

Considerable research documents why women farmers have lower technology adoption rates than men farmers, but relatively little is known about what happens within a household after technology uptake. This study contributes through an investigation of the intrahousehold distribution of benefits and costs of agricultural technology adoption in western Kenya. Using gender-disaggregated data and an endogenous switching regression approach, we elucidate the causal effects of push pull technology (PPT) adoption on intrahousehold labor and expenditure allocation. Results show that adoption increases household labor allocation for harvesting of maize, the staple crop, but reduces the labor required for other tasks (e.g., ploughing …

Effects Of Phytochemicals On Predatory Decision Making In A Spider, Ximena J. Nelson, Andrew J. Pratt, Stephen Abok Aluoch, Robert R. Jackson

All Peer-Reviewed Publications

Animals with small nervous systems may be prone to limitations in processing ability when confronted with a diversity of stimuli, especially if these involve multiple sensory modalities. We investigated the effect of the odour of the plant Lantana camara and its dominant volatile compound, β-caryophyllene, on the prey choice decisions of Evarcha culicivora, a jumping spider (Salticidae) that frequently visits L. camara as a site to mate and to obtain nectar. Evarcha culicivora expresses a strong preference for blood-fed female Anopheles mosquitoes as prey. We tested juvenile and adult E. culicivora in experiments involving live prey, lures made from dead …

Covid-19 Vaccines And Thrombosis—Roadblock Or Dead-End Street?, Kenneth Lundstrom, Debmalya Barh, Bruce D. Uhal, Kazuo Takayama, Alaa A.A. Aljabali, Tarek Mohamed Abd El-Aziz, Amos Lal, Elrashdy M. Redwan, Parise Adadi, Gaurav Chauhan, Samendra P. Sherchan, Gajendra Kumar Azad, Nima Rezaei, Ángel Serrano-Aroca, Nicolas G. Bazan, Sk Sarif Hassan, Pritam Kumar Panda, Pabitra Pal Choudhury, Damiano Pizzol, Ramesh Kandimalla

School of Medicine Faculty Publications

Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and Ad26.COV2.S, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19). Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the …

Endoscopic Proximal Median Nerve Decompression: An Alternative Treatment For Pronator Syndrome, Scott A. Barnett, Sagar A. Shah, Rasheed I. Ahmad

School of Medicine Faculty Publications

Proximal forearm median nerve compressive neuropathy, termed as pronator syndrome, is difficult to diagnose and often overlooked. Its symptoms include vague proximal volar forearm pain that may be associated with paresthesia and numbness in the median nerve distribution. Weakness is typically not present. The treatment of pronator syndrome is largely nonsurgical, consisting of activity modification, anti-inflammatory medication, corticosteroid injections, stretching, and periods of splinting. Surgery is indicated when conservative therapy fails; however, there is no consensus on the treatment approach or technique. Most decompressions are performed using an open technique through a variety of incisions. Recently, endoscopic approaches have drawn …

Value-Based Focused Global Population Health Management, John F. Gibbs, Ashley Newman, Richard G. Stefanacci Do,Mgh,Mba,Agsf,Cmd

College of Population Health Faculty Papers

In 2018, approximately 18 million people worldwide were diagnosed with cancer and are predicted to double by 2040. The global quality chasm in improving health care worldwide requires “systems thinking” as the key to success. Aligning the goal around person-centered care captures the total needs of care of a population and not just disease categories. The integration of the Institute of Medicine’s (IOM) six aims of quality termed “value-based focused” and population health management (PHM) provides all health care leaders grappling with improving the health care of the populations a framework for the communities they serve. In this context, the …

Value-Based Chronic Care Model Approach For Vulnerable Older Patients With Multiple Chronic Conditions, John F. Gibbs, Ellen Guarnieri, Quyen D. Chu, Kenneth Murdoch, Arif Asif

College of Population Health Faculty Papers

“Old age, itself, is not a disease” (Suborne 2007). The rising rate of the global aging population is predicted to create a health care crisis within the next three decades. Vulnerable older adults suffer from multiple chronic conditions (MCCs) in addition to cognitive and physical decline during the process of aging resulting in an inability to optimally achieve self-management. In terms of resource utilization, complex inpatient, and outpatient care results in higher physician visits, polypharmacy, and higher prescription costs. Health literacy has become known as an important social determinant of health affecting the older population. Both reductions in health literacy …

Does Performing Endoscopy Sooner Have An Impact On Outcomes In Patients With Acute Nonvariceal Upper Gastrointestinal Hemorrhage? A Systematic Review., Zahid Ijaz Tarar, Muhammad Usman Zafar, Umer Farooq, Ghulam Ghous, Hafiz Muhammad Hassan Shoukat, Vanessa Kuwajima

Department of Emergency Medicine

Background Endoscopy is the cornerstone for the diagnosis and treatment of nonvariceal upper gastrointestinal bleeding. Regarding the management of nonvariceal bleeding, the administration of crystalloid solution and proton pump inhibitors before endoscopy is well established, but the optimal timing of endoscopy has been a matter of debate and a subject of many investigational studies. The need for urgent endoscopy arises to provide prompt redress to acute bleeding, decrease the length of stay, and lower mortality from ongoing bleeding. Objective This study aimed to determine if endoscopy performed within 24 hours of presentation improves outcomes in terms of mortality, hospital length …

Detection Of Central Retinal Artery Occlusion By Point-Of-Care Ultrasound In The Emergency Department: A Case Series., Kevin R Caja, Kaylan M Griffith, Kevin R. Roth Do, Facoep, Charles C. Worrilow Md, Marna R. Greenberg Do, Mph, Facep, Theodore Doherty Do

Department of Emergency Medicine

Central retinal artery occlusion (CRAO) is a rare, but serious, diagnosis that can lead to blindness, most often due to thromboembolic disease. In the emergency department (ED), CRAO can present as acute, painless loss of vision. Physicians need quick ways to rule in this diagnosis due to the time-sensitive nature of the event. We describe two patients in this cases series who present to the same ED with unilateral painless vision loss and histories that include notable risk factors such as thromboembolic and atherosclerotic disease. Upon arrival, point-of-care ultrasound (POCUS) done at the bedside allowed for quick determination of CRAO. …

Incidence Of Secondary Hemophagocytic Lymphohistiocytosis In Critically-Ill Covid-19 Patients., Jamie Allen, Matthew M Mccambridge, Hope Kincaid, Joshua A Kalter

Department of Emergency Medicine

Objective Coronavirus disease 2019 (COVID-19) is associated with diffuse lung injury that can progress to acute respiratory distress syndrome, multisystem-organ failure, and death. The inflammatory storm seen in many COVID-19 patients closely resembles secondary hemophagocytic lymphohistiocytosis (sHLH) which has been described in other virus-associated severe sepsis. We sought to describe the incidence of sHLH in COVID-19 infected patients. Design In this retrospective study, we reviewed the records of critically ill COVID-19 positive patients to determine the incidence of sHLH. An H-score for sHLH diagnosis was determined for each study participant, with a score greater than 169 points needed for diagnosis. …

Optimization Of Vaccine Supply Chains In Low- And Middle-Income Countries Utilizing Drones, Maximilian Kolter

Graduate Theses and Dissertations

Despite tremendous efforts from governments and humanitarian organizations, millions of children in low- and low-middle-income countries (LICs and LMICs) are still excluded from the benefits of immunization. The vaccine distribution in LICs and LMICs is challenging for several reasons, such as limited cold chain capacities, vaccine wastage, uncertain demand, and lack of access to immunization services. A promising avenue to address these issues is the utilization of drones for vaccine delivery. Drones can fly at high speed on direct paths and could enable on-demand deliveries to mitigate limited storage capacities. Further, their independence of road networks could allow them reaching …

Child-Centered Play Therapy’S Impact On Externalized Behaviors Of Children Who Have Experienced Trauma: A Single-Case Research Design, Timothy "T.J." Schoonover

Graduate Theses and Dissertations

Adverse childhood experiences (ACEs) are defined as exposure to emotional abuse, physical abuse, sexual abuse, emotional neglect, physical neglect, loss of a parent, domestic violence, family member with addiction, family member with depression or mental illness, and family member incarcerated (Felitti et al., 1998). ACEs have been studied for many years and have shown to have long term negative health and social-emotional outcomes and costs the world over $1 trillion a year (Bellis et al., 2019; Felitti et al., 1998; Hughes et al., 2017). Due to the emotional, physical, and dollar amount cost to not addressing the impact of ACEs …

A Comparative Study On Cannabidiol In Melanoma Migration And Invasion: Charlotte's Web Vs. Purified Cbd, 2020–2021, Ruby Thamert

Theses

Over the last decade, much attention has been focused on compounds from Cannabis sativa in treating a variety of diseases including cancer. This study examines the abilities of two different cannabidiol oils to decrease the migration and invasion of melanoma cells in vitro. Skin cancers are the most common cancers in the world. While malignant melanoma is the least common type of skin cancer, it is the deadliest. Patients diagnosed with stage IV disease have only a 15-20% five-year survival rate even with aggressive multimodal treatment, demonstrating the need for additional therapeutic options. Because melanoma is often fatal when …

Image Segmentation For Neuroscience: Lymphatics, Nazia Tabassum, Jie Wang, Michael Ferguson, Jasmin Herz, Michael Dong, Antoine Louveau, Jonathan Kipnis, Scott Thomas Acton

Division of Internal Medicine Faculty Papers & Presentations

A recent discovery in neuroscience prompts the need for innovation in image analysis. Neuroscientists have discovered the existence of meningeal lymphatic vessels in the brain and have shown their importance in preventing cognitive decline in mouse models of Alzheimer s disease. With age, lymphatic vessels narrow and poorly drain cerebrospinal fluid, leading to plaque accumulation, a marker for Alzheimer s disease. The detection of vessel boundaries and width are performed by hand in current practice and thereby suffer from high error rates and potential observer bias. The existing vessel segmentation methods are dependent on user-defined initialization, which is time-consuming and …

Nanomaterial-Based Biosensors For Detection Of Salmonella Typhimurium And Avian Influenza Virus H5n1 In Poultry, Xinge Xi

Graduate Theses and Dissertations

This research focused on developing biosensing method and biosensing device for rapid detection of pathogens in poultry: Salmonella Typhimurium and avian influenza virus H5N1. The first part of the dissertation reports an original research on the development of a portable biosensing device for Salmonella detection. The device was designed and constructed based on a previously developed optical biosensing method, using immuno-magnetic nanoparticles to specifically capture target bacteria, and immuno-quantum dot beads to label the target bacteria for fluorescence detection. All the actions of sample mixing, magnetic separation, and fluorescence detection were controlled automatically in a disposable microfluidic chip in the …

Campus Mental Health Service Use Among Female Survivors Of Sexual Violence: An Interpretative Phenomenological Analysis, Hannah Coffman

Graduate Theses and Dissertations

Description: Despite the increase in resources to address the alarming rates of collegiate sexual violence (SV), survivors consistently do not disclose or seek mental health treatment from campus supports (Halstead et al., 2017). The purpose of this study was to understand the lived experiences of women who survived SV during college.

Method: Seven women who experienced SV during college completed a series of two semi-structured interviews using a HIPAA-compliant, web-conferencing software (Seidman, 2013). The interviews were transcribed verbatim and analyzed using an interpretative phenomenological analysis (IPA) framework (IPA; Smith, 2004; Smith et al., 2009). A six-step data analysis procedure identified …

An Educational Workshop To Improve Neurology Resident Understanding Of Burnout, Substance Abuse, And Mood Disorders., Ryan Donaghy, Shiori Tomatsu, Patrick Kerns, Courtney White, Jeffrey Ratliff

Department of Neurology Faculty Papers

Introduction: Burnout, substance abuse, and mood disorders are prevalent among neurology residents. Increased recognition of concerning behaviors might encourage more access to mental health resources and reduce burnout.

Methods: We created an educational resource reviewing burnout, substance abuse, and mood disorders for neurology residents. This resource included an online module (control) and a role-play scenario offered only to one cohort (intervention). Online surveys assessed knowledge as well as confidence in the ability to recognize concerning behaviors. A practical assessment using a previously published "Stressed Resident" video was also conducted among resident cohorts.

Results: Of neurology residents, 18 participated in the …

Exploring Colorectal Cancer Research And Its Connection To Occupational Therapy: A Critical Review, Brook L. Burns, Megan L. Foster, Tosha L. Tunney, Riane B. Wubbenhorst

Older Adult

This article aims to critically review the current literature related to occupational therapy (OT) and colorectal cancer (CRC). The GVSU electronic library system was used to identify articles using keywords and MeSH terms related to CRC and OT. Articles were analyzed for key variables related to the OT scope of practice and were evaluated for quality using the Physiotherapy Evidence Database (PEDro) scale. Findings show that CRC was referenced in 76.47% of the 34 articles, OT in 20.59%, ADLs in 50%. Pain and quality of life (QoL) were explicitly measured in 17.65% of the articles. Of the reviewed articles, 52.94% …

Occupational Therapy Practitioners Use Of Surface Functional Electrical Stimulation On Individuals With Tetraplegia, Raquel M. Besey, Elizabeth T. Dawkins, Hannah A. Gove, Madison N. Reid

Adult

A survey, distributed to occupational therapy (OT) practitioners, was conducted to investigate how functional electrical stimulation (FES) is currently used during OT intervention sessions on clients with tetraplegia. There were a total of 24 survey respondents, the results demonstrated that both occupations and activities were used in combination with FES interventions. OT practitioners most frequently combined FES with the following occupation-based tasks during intervention sessions: feeding, grooming, playing a board/card game, and handwriting. During activity-based tasks, FES was reported to be most frequently combined with upperbody cycling, picking up foam cubes, and cones. Future research should focus on identifying the …

Scoping Review Of Eating Disorders And Occupational Therapy Interventions, Jessica Goethals, Olivia Keeley, Justyna Leja, Anna Riccius

Systematic Reviews

A scoping review was conducted to determine which occupational therapy interventions are used with individuals with eating disorders and what effect they have, if any. Four databases were searched to identify sources of evidence, initially resulting in 527 sources. Inclusion and exclusion criteria were used to further review and determine the eligibility of each source. A total of 48 studies were included in the final scoping review. Data extraction of eligible articles resulted in 11 categories of eating disorder based interventions. The research showed the significant role occupational therapy has in the treatment of individuals with eating disorders, although there …

Evaluating Current Outcome Measures For Persistent Post-Concussion Syndrome, Alayna Dakers, Rachel Dickerson, Clare Visscher

Systematic Reviews

This systematic review examines the current literature of reliable and/or valid outcome measures for adults who have persistent post-concussion syndrome (PPCS) and their ability to engage in occupations.

Occupational Therapy In Outpatient Behavioral Health, Kailee Moran, Jaclyn Oldenburg, Mallory Vanregenmorter, Kate Williams

Mental Health

Mental illness and substance use disorders are common in the United States and can significantly inhibit occupational participation. The aim of this study was to evaluate existing outpatient behavioral health services and determine if occupational therapists can make a distinct contribution to this population’s needs. An electronic survey created via Qualtrics was provided to licensed outpatient behavioral health providers in the United States utilizing a convenience sampling method. Results revealed provider concerns related to their clients' areas of daily life and barriers to function, which are within the scope of occupational therapy practice. Results highlight gaps in current outpatient behavioral …

Negative Urgency's Influence On State-Level, Emotion-Based Changes In Alcohol-Related Cognitions, Noah Wolkowicz

Graduate Theses and Dissertations

This project expanded on the Acquired Preparedness Model of Risk (APMR) by examining how Negative Urgency (NU), the tendency to act rashly in negative emotional states, affects emotion-based changes in alcohol cognitions to produce risk for alcohol use. The APMR prioritizes the role of outcome expectancies as the means through which traits such as NU, convey alcohol use risk. However, this model treats these cognitions as static and often fails to assess their valence; further, alcohol-cognitions fluctuate in response to negative emotions and may become more salient during these states. Therefore, this study examined: 1) how NU impacts negative emotion-based, …

Impact Of Covid-19 On The Severe Acute Malnutrition Admissions Among Children Under 5 Years Of Age Seeking Nutrition Services In Afghanistan, Sahar Sayedy

Graduate Theses and Dissertations

The purpose of the study was to assess the impact of COVID-19 on the number of admissions of severe acute malnutrition among children under 5 years of age seeking nutrition services in Afghanistan especially in the provinces where the prevalence of COVID-19 was high, for the period of February – September 2020. The study used comparison and analysis of secondary datasets of the Integrated Management of Acute Malnutrition – a national program for detection and management of moderate and severe acute malnutrition in the country.

This study analyzed the association between COVID-19 cases and severe acute malnutrition (SAM) admissions of …

Black Lips Don't Turn Blue: A Womanist Critique Of Discriminatory Language In Medical Education, Alison Lawrence

Augustana Center for the Study of Ethics Essay Contest

This paper examines race and gender inequities in healthcare as it pertains to the unequal presentation of descriptors of illness in medical textbooks. The author adopts a womanist perspective to criticize the use of the white male body as the standard for all patients, which causes signs and symptoms in women and people of color to be dismissed as less important. Following an analysis of normalizing language in current medical texts as well as its consequences for patients, the author calls for a system-wide shift to more inclusive, intersectional medical education that not only acknowledges differences among patient groups, but …

Effects Of Fluoride On Corrosion Properties Of Orthodontic Retention Wires, John J. Simindinger

Master's Theses (2009 -)

Objective: Alloys used in retention wires corrode in the oral environment. Previous studies have examined the effects of fluoride on archwires used in active treatment, but not on retention wires. The goal of this study was to determine what effect fluoride exposure has on corrosion of various lingual bonded retainer wires in the mouth. Methods: Twenty samples from six different wire types were tested in two solutions. Half were tested in Fusayama-Meyer artificial saliva, while the other half were tested in Fusayama-Meyer plus fluoride correlated to the concentration of toothpaste. A potentiostat was used to measure open circuit potential (OCP) …

Content Analysis Of Digital Media Coverage Of The Human Papillomavirus Vaccine School-Entry Requirement Policy In Puerto Rico, Vivian Colón-López, Vilnery Rivera-Figueroa, Glizette O. Arroyo-Morales, Diana T. Medina-Laabes, Roxana Soto-Abreu, Manuel Rivera-Encarnación, Olga L. Díaz-Miranda, Ana P. Ortiz, Katelyn B. Wells, Coralia Vázquez-Otero, Pamela C. Hull

Behavioral Science Faculty Publications

BACKGROUND: In August 2018, Puerto Rico (PR) became the 4th state or territory in the United States to adopt a human papillomavirus (HPV) vaccine school-entry requirement, for students 11-12 years old. Evidence suggests that the content of media coverage may impact people's perception of HPV vaccine and their willingness to vaccinate. This study aimed to analyze the content of digital news coverage related to the implementation of the policy in PR.

METHODS: A content review was conducted of digital media published from January 2017 through December 2018. The content reviewed was carried out in two steps: 1) creating a matrix …

Closed-Form Solution For Shock Wave Propagation In Density-Graded Cellular Material Under Impact, Vjendra Gupta, Addis Kidane, Michael A. Sutton

Faculty Publications

Density-graded cellular materials have tremendous potential in structural applications where impact resistance is required. Cellular materials subjected to high impact loading result in a compaction type deformation, usually modeled using continuum-based shock theory. The resulting governing differential equation of the shock model is nonlinear, and the density gradient further complicates the problem. Earlier studies have employed numerical methods to obtain the solution. In this study, an analytical closed-form solution is proposed to predict the response of density-graded cellular materials subjected to a rigid body impact. Solutions for the velocity of the impinging rigid body mass, energy absorption capacity of the …

Rabies Postexposure Prophylaxis In The United States: Opportunities To Improve Access, Coordination, And Delivery, Gavin T. Howington, Huy-Binh Nguyen, P Brandon Bookstaver, Peter Akpunonu, Joshua T. Swan

Faculty Publications

No abstract provided.

Smoking-Induced Sex Differences In Clinical Outcomes In Patients Undergoing Mechanical Thrombectomy For Stroke, Jacqueline A. Frank, Kara Jo Swafford, Jill M. Roberts, Amanda L. Trout, Ann M. Stowe, Douglas E. Lukins, Stephen Grupke, Keith R. Pennypacker, Justin F. Fraser

Neurology Faculty Publications

OBJECTIVE: Ischemic stroke is the fifth leading cause of death in the United States. Smoking accelerates the onset of stroke by 10 years. The effects of smoking status on percent change in National Institutes of Health Stroke Scale (NIHSS) score, infarct volume, and edema volume were examined following mechanical thrombectomy for large vessel occlusion in patients with acute ischemic stroke.

METHODS: Subjects (N = 90; >18 years old) were divided into 3 groups based on smoking status: current smokers, previous smokers (defined as having quit >6 months before the ischemic event), and nonsmokers. Percent change in NIHSS score was …