Medicine and Health Sciences Commons^™

Capacity Building For A New Multicenter Network Within The Echo Idea States Pediatric Clinical Trials Network, Robert D. Annett, Scott Bickel, John C. Carlson, Kelly Cowan, Sara Cox, Mark J. Fisher, J. Dean Jarvis, Alberta S. Kong, Jessica S. Kosut, Kurtis R. Kulbeth, Abbot Laptook, Pearl A. Mcelfish, Mary M. Mcnally, Lee M. Pachter, Barbara A. Pahud, Lee A. Pyles, Jennifer Shaw, Kari Simonsen, Jessica Snowden, Christine B. Turley, Andrew M. Atz

Journal Articles: Pediatrics

Introduction: Research capacity building is a critical component of professional development for pediatrician scientists, yet this process has been elusive in the literature. The ECHO IDeA States Pediatric Clinical Trials Network (ISPCTN) seeks to implement pediatric trials across medically underserved and rural populations. A key component of achieving this objective is building pediatric research capacity, including enhancement of infrastructure and faculty development. This article presents findings from a site assessment inventory completed during the initial year of the ISPCTN. Methods: An assessment inventory was developed for surveying ISPCTN sites. The inventory captured site-level activities designed to increase clinical trial research …

Health Service Experiences And Preferences Of Frail Home Care Clients And Their Family And Friend Caregivers During The Covid-19 Pandemic, Lori E. Weeks, Sue Nesto, Bradley Hiebert, Grace Warner, Wendy Luciano, Kathleen Ledoux, Lorie Donelle Phd, Rn, Fcan

Publications

OBJECTIVE: The COVID-19 pandemic has brought about a major upheaval in the lives of older adults and their family/friend caregivers, including those utilizing home care services. In this article, we focus on results from a qualitative component added to a pragmatic randomized controlled trial that focuses on the experiences of our study participants during COVID-19. A total of 29 participants responded to the COVID-19 related questions focused on their health services experiences and preferences from March-June 2020 including 10 home care clients and 19 family/friend caregivers in the provinces of Ontario and Nova Scotia, Canada. RESULTS: Many participants were affected …

Opioids And Dentistry, Anne E. Wampler

Pacific Journal of Health

Dental professionals are among the leading prescribers of opioids in the United States and play a significant role in the current opioid epidemic. While dental professionals prescribe these potent pain killers to provide relief to patients, the serious implications of their prescription and distribution must be considered. This manuscript covers the science behind opioids, history of the opioid epidemic, the affliction it is currently causing in the U.S., the immense impact dentists have in providing opioid prescriptions along with gross over-prescription practices, and much more. Other topics discussed include alternative pain management, safe prescribing practices, naloxone, and how dentists can …

What Children Learn About Death From Film, Elissa Miller, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Objectives

• Discuss popular films and how they affect what children know about death
• Discuss child development and development-related concepts of death and dying
• Discuss using films to help discuss death and dying with children

Crispr, Curing Huntington’S Disease, And Humanity’S Future In Isaacson's 'Code Breaker', Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Phenotypic And Functional Signatures Of Peripheral Blood And Spleen Compartments Of Cynomolgus Macaques Infected With T. Cruzi: Associations With Cardiac Histopathological Characteristics, Renato Sathler-Avelar, Danielle Marquete Vitelli-Avelar, Armanda Moreira Mattoso-Barbosa, Marcelo Antônio Pascoal-Xavier, Silvana Maria Elói-Santos, Ismael Artur Da Costa-Rocha, Andréa Teixeira-Carvalho, Edward J. Dick Jr, Jane F. Vandeberg, John L. Vandeberg, Olindo Assis Martins-Filho

School of Medicine Publications

We performed a detailed analysis of immunophenotypic features of circulating leukocytes and spleen cells from cynomolgus macaques that had been naturally infected with Trypanosoma cruzi, identifying their unique and shared characteristics in relation to cardiac histopathological lesion status. T. cruzi-infected macaques were categorized into three groups: asymptomatic [CCC(-)], with mild chronic chagasic cardiopathy [CCC(+)], or with moderate chronic chagasic cardiopathy [CCC(++)]. Our findings demonstrated significant differences in innate and adaptive immunity cells of the peripheral blood and spleen compartments, by comparison with non-infected controls. CCC(+) and CCC(++) hosts exhibited decreased frequencies of monocytes, NK and NKT-cell subsets in …

Extracorporeal Membrane Oxygenation Used In Acute Respiratory Distress Syndrome With Covid-19: A Systematic Review And Meta-Analysis, Novia Kusumawardhani, Ivana Purnama Dewi, Budi Baktijasa Dharmadjati

Journal of the Saudi Heart Association

Introduction: Protective pulmonary mechanical ventilation, higher positive end-expiratory pressure, neuromuscular blockade, prone positioning, and pulmonary recruitment procedures are all strategies in severe COVID-19 cases. Extracorporeal Membrane Oxygenation (ECMO) can be seen as an alternative to traditional treatment in certain patients when conventional therapy fails. We present a study that intends to systematically review and meta-analysis ECMO use in COVID-19 patients.

Methods: We search major medical databases (Cochrane Library, PubMed, EMBASE, MedRxiv) for clinical trials that were released between January 2020 until February 2021, had full-text availability, were written in English, and humans studies.

We used National Heart, Lung, and Blood …

Heart Involvement In A Moroccan Population With Spondyloarthritis: A Cross-Sectional Study, Jalila Eddarami, Hamida Azzouzi, Linda Ichchou

Journal of the Saudi Heart Association

Objectives: The aim of this study was to investigate the prevalence of cardiac manifestations and their predictive factors in Moroccan patients with spondyloarthritis (SpA). Methods: We have conducted a cross-sectional study over four months at the Department of Rheumatology in Mohammed VI University Hospital of Oujda, Morocco. All SpA patients fulfilled the 2009 Assessment SpondyloArthritis international Society (ASAS) criteria. Every patient had a cardiac check up including clinical examination, 12-lead electrocardiogram (ECG) and transthoracic echocardiography (TTE). Multiple logistic regression was used to analyze the associated factors with cardiac manifestations. Results: We included 64 men and 30 women with a mean …

Examining Cleaning Detergents Handling By Housewives In Wadi Al-Salqah – Gaza Strip, Nizam El-Ashgar

Journal of the Arab American University مجلة الجامعة العربية الامريكية للبحوث

In light of the deteriorating economic situation in the Gaza Strip, women have decided to shift to cheaper items when they buy household cleaning detergents, without taking much care of the chronic effects of these detergents on both health and skin. More specifically, the daily exposure to the chemical detergents puts women at a high risk, which may be doubled when these chemicals are not labeled properly, especially those bought from peddlers. Therefore, the absence of labels, which provide information about the detergents’ ingredients and how to handle them, makes the housewives unaware of the proper way to handle these …

2021-07-13_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-07-13_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-07-13_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

2021-07-13_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Tuesday and Friday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

2021-07-13_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.

Covid-19 Newsletter (Vol. 80), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Blue Biotechnology: Computational Screening Of Sarcophyton Cembranoid Diterpenes For Sars-Cov-2 Main Protease Inhibition, Mahmoud A A. Ibrahim, Alaa H M. Abdelrahman, Mohamed A M. Atia, Tarik A. Mohamed, Mahmoud F. Moustafa, Abdulrahim R. Hakami, Shaden A M. Khalifa, Fahad A. Alhumaydhi, Faris Alrumaihi, Syed Hani Abidi

Department of Biological & Biomedical Sciences

The coronavirus pandemic has affected more than 150 million people, while over 3.25 million people have died from the coronavirus disease 2019 (COVID-19). As there are no established therapies for COVID-19 treatment, drugs that inhibit viral replication are a promising target; specifically, the main protease (Mpro) that process CoV-encoded polyproteins serves as an Achilles heel for assembly of replication-transcription machinery as well as down-stream viral replication. In the search for potential antiviral drugs that target Mpro, a series of cembranoid diterpenes from the biologically active soft-coral genus Sarcophyton have been examined as SARS-CoV-2 Mpro inhibitors. Over 360 metabolites from the …

2021-07-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Tuesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

Fridge Magnets: Accessible Cbt For Anxiety/Depression In Young Adults, Brandon Askar, Samuel Cain, Lauren Kasmikha, Dana Labuda, Ruchi Mangal, Cameron Rubino, Rebecca White

Patient Education Projects

No abstract provided.

Chronic Illness: Heart Healthy Recipes, Fuad-Tahsin Abbas, Sara Farooqui, Stephanie Morgan, Emile Tadros, Ahmed Ayantayo, Omar Mahmood, Marina Ngassa Tayou

Patient Education Projects

No abstract provided.

Cascade Screening And Treatment Initiation In Young Adults With Heterozygous Familial Hypercholesterolemia., Amy L. Peterson, Matthew Bang, Robert C. Block, Nathan D. Wong, Dean G. Karalis

Division of Cardiology Faculty Papers

Heterozygous familial hypercholesterolemia (HeFH) creates elevated low-density lipoprotein cholesterol (LDL-C), causing premature atherosclerotic cardiovascular disease (ASCVD). Guidelines recommend cascade screening relatives and starting statin therapy at 8-10 years old, but adherence to these recommendations is low. Our purpose was to measure self-reported physician practices for cascade screening and treatment initiation for HeFH using a survey of 500 primary care physicians and 500 cardiologists: 54% "always" cascade screen relatives of an individual with FH, but 68% would screen individuals with "strong family history of high cholesterol or premature ASCVD", and 74% would screen a child of a patient with HeFH. The …

Attention Medical Students You Are Not Alone, Tala Al-Saghir, Deanna Harajli, Anneliese Rademacher, Abdullah Sahyouni, Matthew Trendowski, Thomas Vander Woude, Aubrey Neal

Patient Education Projects

No abstract provided.

Post-Acute Sequelae Of Covid-19 And Polypharmacy: If You Think There’S Too Much Polypharmacy Now, Just Wait, Demetra Antimisiaris

The University of Louisville Journal of Respiratory Infections

The intersection of increased chronic disease burden worldwide with the COVID-19 pandemic was called the “perfect storm”. This article discusses yet another perfect storm: Post COVID-19 (acute and non-acute) syndrome, high chronic disease burdens, advanced age, and polypharmacy. The expected hyper polypharmacy that should result from the added disease and symptom burden due to post COVID-19 syndrome is discussed, as well as the importance of studying the incidence and characteristics to be able to address avoidable medication-related problems.

The Importance Of Medication Adherence And Follow-Up In Adolescent Asthma, Sahar Galal, Zaina Khoury, Thomas Russo, Jazmine Skala-Wade, Niyaz Uddin, Trevor Wolterink, Donovan Watza

Patient Education Projects

No abstract provided.

Thanatechnology And The Living Dead: New Concepts In Digital Transformation And Human-Computer Interaction, Vural Özdemir, Simon Springer, Arif Ylldlrlm, Sehmus Biçer, Asllgül Kendirci, Semra Sardaş, Hakan Klllç, Nezih Hekim, Tanja Kunej, Kazlm Yalçln Arga, Kevin Dzobo, Wei Wang, Marius Geanta, Angela Brand, Mustafa Bayram

Research outputs 2014 to 2021

In a digital society, shall we be the authors of our own experience, not only during our lifetime but also after we die? We ask this question because dying and bereavement have become even harder, and much less private, in the digital age. New big data-driven digital industries and technologies are on the rise, with promises of interactive 3D avatars and storage of digital memories of the deceased, so they can continue to exist online as the "living dead"in a digital afterlife. Famous rock and roll icons like Roy Orbison, Frank Zappa, Ronnie James Dio, and Amy Winehouse have famously …

Hypertension-Protect Your Heart Health, Gregory Andrianov, Yusef Kunji, Leticia Metseegoum Simo, Anita Thompson, Jonah Yousif, Brandon Batarse

Patient Education Projects

No abstract provided.

What’S The Hype About Hypertension?, Youstina Abdallah, Kiernan Bloye, Joseph Files, La-Kiesha Hobbs, Gautham Pavar, Miranda Ratusznik, Farhan Chaudhry

Patient Education Projects

No abstract provided.

The Kids Cook Monday Program Can Help Reduce Child Obesity, Mary Kate Schutt

Population Health Research Brief Series

Childhood obesity is a growing U.S. population health problem. Regularly consuming fast food and other take-out meals is linked to higher rates of childhood obesity. While the COVID-19 pandemic exacerbated takeout, rates of takeout and delivery have been increasing since 2012. Engaging children in preparing family meals can protect against childhood obesity and other risky behaviors. The Healthy Monday program, Kids Cook Monday, can support families to regularly cook meals together.

Application Of The Multi-Facet Rasch Model To Evaluate The Chief Resident Selection Survey: A Two-Year Study., Kadriye O. Lewis, Haiqin Chen, Ross Newman

Manuscripts, Articles, Book Chapters and Other Papers

Introduction The Chief Resident (CR) selection process is described by many residency programs as a collective effort from the residency program leadership, key faculty members, and resident peers. Unfortunately, the literature does not show any established guidelines, methods, or psychometric sound instruments to aid this process. The purpose of this study was to evaluate the properties of the newly developed CRs selection survey across two years using the Multi-Facet Rasch Model (MFRM). Methods This study used the MFRM to analyze two-year data from the newly developed CRs selection survey. After the first implementation of the tool in 2015, this instrument …

Human Oncoprotein 5mp Suppresses General And Repeat-Associated Non-Aug Translation Via Eif3 By A Common Mechanism, Chingakham Ranjit Singh, M. Rebecca Glineburg, Chelsea Moore, Naoki Tani, Rahul Jaiswal, Ye Zou, Eric Aube, Sarah Gillaspie, Mackenzie Thornton, Ariana Cecil, Madelyn Hilgers, Azuma Takasu, Izumi Asano, Masayo Asano, Carlos R. Escalante, Akira Nakamura, Peter K. Todd, Katsura Asano

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

eIF5-mimic protein (5MP) is a translational regulatory protein that binds the small ribosomal subunit and modulates its activity. 5MP is proposed to reprogram non-AUG translation rates for oncogenes in cancer, but its role in controlling non-AUG initiated synthesis of deleterious repeat-peptide products, such as FMRpolyG observed in fragile-X-associated tremor ataxia syndrome (FXTAS), is unknown. Here, we show that 5MP can suppress both general and repeat-associated non-AUG (RAN) translation by a common mechanism in a manner dependent on its interaction with eIF3. Essentially, 5MP displaces eIF5 through the eIF3c subunit within the preinitiation complex (PIC), thereby increasing the accuracy of initiation. …

Comparative Genomics Methods And Applications, Emily N. Alden

Biomedical Sciences ETDs

Virtually all fields of biology have benefited from the advancements in comparative genomics technologies, specifically in the study of evolution. In this dissertation I develop and use comparative genomic technologies to investigate the novel SARS-CoV-2 virus, assembly the first genome of the black lace domestic angelfish and identify germline genetic variants associated with altered breast cancer-specific survival. Our genome tiling array for the novel coronavirus presents a rapid and cost-effective method to sequence the entire viral genome and can be used to track the rapid evolution of viral variants in the population. The domestic angelfish is a member of the …