Medicine and Health Sciences Commons^™

Association Between Health Literacy Levels And Behavioral Health Hospitalizations And Emergency Department Utilization In The United States, Rebecca Lynn Hoen

Legacy Theses & Dissertations (2009 - 2024)

Behavioral health disorders are common in the United States (US) and are associated with potentially preventable high-cost health care utilization, such as inpatient hospitalization and emergency department utilization. Health literacy (HL) may be an important modifiable contributing factor to this preventable utilization, as limited health literacy is common in the US and has been linked to increased risk of hospitalization and emergency department utilization. However, few published studies have examined the association between health literacy and behavioral health disorders, and no studies have examined either the association between health literacy and utilization or the potential effects HL interventions might have …

The Wingate Anaerobic Test: A Comprehensive Literature Review And Update On Reference Values In Athletes, Caleb Christie

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The Wingate Anaerobic test (WAnT) was developed in the 1970s as a measurement of lower extremity anaerobic power (Ayalon, Inbar, Bar-Or, 1974) and has long been used as a measurement tool in athletes, who are often defined by numbers. While numbers are not able to entirely predict or evaluate athletic ability, they are often used as a tool to predict or rate athletes. The WAnT has long been a gold standard in evaluating lower extremity power, which is a highly valuable aspect of many sprint and power-driven sports (e.g., hockey, football, or track and field). The WAnT was originally developed …

Generalized Deep Learning Eeg Models For Cross-Participant And Cross-Task Detection Of The Vigilance Decrement In Sustained Attention Tasks, Alexander J. Kamrud, Brett J. Borghetti, Christine M. Schubert Kabban, Michael E. Miller

Faculty Publications

Tasks which require sustained attention over a lengthy period of time have been a focal point of cognitive fatigue research for decades, with these tasks including air traffic control, watchkeeping, baggage inspection, and many others. Recent research into physiological markers of mental fatigue indicate that markers exist which extend across all individuals and all types of vigilance tasks. This suggests that it would be possible to build an EEG model which detects these markers and the subsequent vigilance decrement in any task (i.e., a task-generic model) and in any person (i.e., a cross-participant model). However, thus far, no task-generic EEG …

An Evaluation Of Cancer Nurse Providers’ Implementation Of The 2018 Commission On Cancer Survivorship Care Plan Requirement, Angelia Natascha Drake

Electronic Theses and Dissertations

There are apparent problems and fragmentation in the health care delivery system across all specialties, specifically oncology. Oncology is an area within the health care system that has an exponential growth of patients. The incidences of newly diagnosed cancer patients are increasing annually, and the improvements in cancer treatments allow patients to live beyond cancer, resulting in an increased volume of survivors annually as well. These increases place an incredible demand on our health care system, including, but not limited to, primary care physicians and specialists such as medical oncologists. With these increases, there is still an evident gap within …

Daratumumab In Patients With Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits., Salem Almaani, Samir V Parikh, Anjali A Satoskar, Naresh Bumma, Brad H Rovin, Nidhi Sharma, Yvonne Efebera, Isabelle Ayoub

Ambulatory and Primary Care Articles

No abstract provided.

A Preliminary Evaluation Of The Behavioral Gerontology Staff Training Protocols, Minyoung Kim

Masters Theses

Staff training in aging settings is integral to ensuring quality services, and such training has traditionally been conducted in person. With the COVID-19 outbreak, there is a need for innovative approaches to training that reduce exposure for trainers and staff. However, the efficacy of such an approach has not yet been demonstrated. To prevent the waste of staff resources at long-term care facilities, this study evaluates the efficacy of behavioral gerontology staff training protocols as a form of telehealth by utilizing graduate and undergraduate students as pilot participants. We use an additive concurrent multiple-probe design across participants to evaluate the …

White Coat Remediation: Understanding Medical Students’ Academic Remediation Experiences, Lauren Elizabeth Daly

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand the lived experience of academic remediation for medical students at an osteopathic medical school. Two theories guided this study: Bronfenbrenner and Ceci’s bioecological theory and Tajfel and Turner’s social identity theory. Research questions focused on understanding the emotional experience of failure within the medical education context, and the subsequent experience of involvement in the academic remediation process. Purposeful sampling was used to identify 10 medical students who did not pass one or more courses in their didactic curricula and underwent academic remediation as a result. The central question guiding this …

Variances In Bcg Protection Against Covid-19 Mortality: A Global Assessment, Zouina Sarfraz, Azza Sarfraz, Krunal Pandav, Sarabjot Singh Makkar, Saman Hasan Siddiqui, Gaurav Patel, Tania Platero-Portillo, Bishnu Mohan Singh, Mohamed Iburahim Haja Maideen, Deepika Sarvepalli, Muzna Sarfraz

Department of Paediatrics and Child Health

The BCG vaccine is known to impart nonspecific immunological benefits alongside conferring protection to tuberculosis in endemic regions. It is also known to protect against bladder cancer and other respiratory tract infections. During the coronavirus disease 2019 (COVID-19) pandemic, the BCG vaccine has gained attention due to its role in conferring protective immunity. We demonstrate the potential immunological protective mechanisms that play a role against COVID-19. We conduct a global assessment of the countries that have the highest and lowest mortality rates determined by an a priori methodology. Lastly, we discuss the potential limitations of incorporating BCG vaccines as potential …

Effectiveness Of Typhoid Conjugate Vaccine Against Culture-Confirmed Salmonella Enterica Serotype Typhi In An Extensively Drug-Resistant Outbreak Setting Of Hyderabad, Pakistan: A Cohort Study, Mohammad Tahir Yousafzai, Sultan Karim, Sonia Qureshi, Abdul Momin Kazi, Hina Memon, Amber Junejo, Zohra Khawaja, Najeeb Ur Rehman, Muhammad Sajid Ansari, Rafey Ali, Heera Mani Lohana, Farah Naz Qamar

Department of Paediatrics and Child Health

Background: Salmonella enterica serotype Typhi (S Typhi) is a major public health problem in low-income and middle-income countries. We aimed to investigate the effectiveness and impact of the typhoid conjugate vaccine Typbar-TCV against S Typhi among children in an outbreak setting of extensively drug-resistant (XDR) S Typhi in Pakistan.
Methods: This cohort study was done from Feb 21, 2018, to Dec 31, 2019. A census survey of all households located in the Qasimabad and Latifabad subdistricts of Hyderabad, Pakistan, was done at baseline, and 174 005 households were registered in the census. The Typbar-TCV immunisation campaign was initiated at temporary …

July / August 2021, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy.

Transmission Of ‘Candidatus Anaplasma Camelii’ To Mice And Rabbits By Camel-Specific Keds, Hippobosca Camelina, Joel L. Bargul, Kevin O. Kidambasi, Merid N. Getahun, Jandouwe Villinger, Robert S. Copeland, Jackson M. Muema, Mark Carrington, Daniel K. Masiga

All Peer-Reviewed Publications

Anaplasmosis, caused by infection with bacteria of the genus Anaplasma, is an important veterinary and zoonotic disease. Transmission by ticks has been characterized but little is known about non-tick vectors of livestock anaplasmosis. This study investigated the presence of Anaplasma spp. in camels in northern Kenya and whether the hematophagous camel ked, Hippobosca camelina, acts as a vector. Camels (n = 976) and > 10,000 keds were sampled over a three-year study period and the presence of Anaplasma species was determined by PCR-based assays targeting the Anaplasmataceae 16S rRNA gene. Camels were infected by a single species of Anaplasma, ‘Candidatus Anaplasma …

Perceptions And Challenges Experienced By African Physicians When Prescribing Methotrexate For Rheumatic Disease: An Exploratory Study, Carol A Hitchon, Girsh M Mody, Candace H Feldman, Yan Lau, Steven Shi, Michele Meltzer, Rosie Scuccimarri, Michael E Weinblatt, Ines Colmegna

Department of Medicine Faculty Papers

OBJECTIVE: Guidelines for methotrexate (MTX) use in rheumatic disease may not be feasible for physicians practicing in the least developed countries. We aimed to understand the experiences of MTX prescribers relating to MTX use for rheumatic disease in African countries to inform the development of culturally and geographically appropriate recommendations.

METHODS: African physicians who self-identified as MTX prescribers from countries classified as having a low versus a medium or high Human Development Index (L-HDI versus MH-HDI) participated in semistructured interviews between August 2016 and September 2017. Interviews were transcribed verbatim, coded thematically, and stratified by HDI.

RESULTS: Physicians (23 rheumatologists; …

Perceptions And Challenges Experienced By African Physicians When Prescribing Methotrexate For Rheumatic Disease: An Exploratory Study, Carol A Hitchon, Girsh M Mody, Candace H Feldman, Yan Lau, Steven Shi, Michele Meltzer, Rosie Scuccimarri, Michael E Weinblatt, Ines Colmegna

Department of Medicine Faculty Papers

Objective: Guidelines for methotrexate (MTX) use in rheumatic disease may not be feasible for physicians practicing in the least developed countries. We aimed to understand the experiences of MTX prescribers relating to MTX use for rheumatic disease in African countries to inform the development of culturally and geographically appropriate recommendations.

Methods: African physicians who self-identified as MTX prescribers from countries classified as having a low versus a medium or high Human Development Index (L-HDI versus MH-HDI) participated in semistructured interviews between August 2016 and September 2017. Interviews were transcribed verbatim, coded thematically, and stratified by HDI.

Results: Physicians (23 rheumatologists; …

Test-Retest Of The 5-Minute Psychomotor Vigilance Test, Katharine Dennison

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The purpose of this study was to evaluate the reliability of many variables in the 5-minute Psychomotor Vigilance Test (PVT). Many studies have looked at the validity of a 5-minute PVT, but few so far have looked at reliability. For this study, 13 adult females who worked 12-hr shifts were recruited to complete a two trial day study. The first trial day, the subjects submitted health questionnaire followed by a self-reported sleepiness scale and then a 5-minute PVT. The second trial session the subjects only competed the sleepiness scale followed by the 5-minute PVT. After analyzing the data, it was …

No Evidence Of Stochastic Resonance In Postural Sway Response To Noisy Galvanic Vestibular Stimulation In Healthy Young Adults, Dominique Rice

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The transcutaneous application of a sub-sensory electrical stimulation to the vestibular afferents, known as noisy galvanic vestibular stimulation (nGVS), is thought to cause a reduction in postural sway at optimal amplitude intensities due to a mechanism known as stochastic resonance (SR). SR is a phenomenon whereby the addition of low amplitude noise to a non-linear system can be beneficial rather than detrimental. In humans, behavioral markers of SR in postural sway have been inconsistent, potentially due to insufficient power or false positives. Therefore, the main purpose of this study was to determine whether the frequency of observing SR-like effects improves …

Mindfulness-Based Practices For The Impaired Performance Athlete, Mackenzie L. Campbell

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Mindfulness-based programs are becoming commonly considered for the improvement of athlete's mental and physical state. However, their usage in improving performance in impaired athletes is limited and not fully understood. The purpose of this thesis was to review the standing literature on the topic of the application of mindfulness to improving athletic performance in wellbeing-impaired athletes. Seventy-three articles were included as references for this paper describing functional mechanisms, clinical significance and anecdotal evidence that points to the effectiveness of mindfulness in sport for the treatment of pain, injury recovery, prevention of injury, and chronic illness. Ultimately, this review supports the …

Rare Silent Ischemic Ventricular Septal Aneurysm And Rupture: A Multimodality Diagnostic Approach, Hong Loan Nguyen, Nicolas Palaskas, Nasser Lakkis, Rashed Tabbaa

Faculty, Staff and Students Publications

A multimodality approach in addition to high level of clinical suspicion and thorough physical examination is important in the diagnosis and management of left ventricular aneurysm and rupture after a silent inferior infarction.

Deep Learning-Based Mixed-Dimensional Gaussian Mixture Model For Characterizing Variability In Cryo-Em, Muyuan Chen, Steven J Ludtke

Faculty, Staff and Students Publications

Structural flexibility and/or dynamic interactions with other molecules is a critical aspect of protein function. Cryogenic electron microscopy (cryo-EM) provides direct visualization of individual macromolecules sampling different conformational and compositional states. While numerous methods are available for computational classification of discrete states, characterization of continuous conformational changes or large numbers of discrete state without human supervision remains challenging. Here we present e2gmm, a machine learning algorithm to determine a conformational landscape for proteins or complexes using a three-dimensional Gaussian mixture model mapped onto two-dimensional particle images in known orientations. Using a deep neural network architecture, e2gmm can automatically resolve the …

The Effect Of Oncolytic Viruses In Aiding Cancer Immunotherapy, Anushka Singh

Honors Projects

Oncolytic viruses are known as genetically engineered viruses or ones that can be found in nature, that are used to selectively reproduce in cancer cells and kill them without harming the normal and healthy cells. Oncolytic viruses have been considered an effective form of immunotherapy and offer a new approach for cancer treatment. Only one oncolytic virus has been approved by the Food and Drug Administration (FDA) in the USA, which is T-Vec (talimogene laherparepvec). This is a second-generation oncolytic herpes simplex virus type 1 (HSV-1). Another oncolytic virus has been approved only in China in 2005, which is called …

“I Don’T Want The Next Generation Of Children To Be In Pain Like Me”: The Chab Dai Ten-Year Butterfly Longitudinal Research Project On Sex Trafficking Survivors In Cambodia, Glenn M. Miles, James Havey, Siobhan Miles, Eliza Piano, Lim Vanntheary, Nhanh Channtha, Sreang Phaly, Ou Sopheara

Dignity: A Journal of Analysis of Exploitation and Violence

The Butterfly Longitudinal Research Project started in 2010 and is the only research project of its kind listening to sex trafficking victims over ten years. The project was started in Cambodia by Chab Dai (translated “Hands Together”), a coalition of Non-Government Organisations since 2006 who have focused on human trafficking. The project was founded with the express purpose of listening to the survivors’ voices and recording their experiences in order to better understand their physical, emotional and spiritual needs during their initial recovery in shelters and reintegration back into their communities. The team of researchers and the participants, all of …

Thioredoxin Reductase Is A Major Regulator Of Metabolism In Leukemia Cells, Sheelarani Karunanithi, Ruifu Liu, Yongchun Hou, Giancarlo Gonzalez, Natasha Oldford, Anne Jessica Roe, Nethrie Idipilly, Kalpana Gupta, Chandra Sekhar Amara, Satwikreddy Putluri, Grace Kyueun Lee, Juan Valentin-Goyco, Lindsay Stetson, Stephen A Moreton, Vasanta Putluri, Shyam M Kavuri, Yogen Saunthararajah, Marcos De Lima, Gregory P Tochtrop, Nagireddy Putluri, David N Wald

Faculty, Staff and Students Publications

Despite the fact that AML is the most common acute leukemia in adults, patient outcomes are poor necessitating the development of novel therapies. We identified that inhibition of Thioredoxin Reductase (TrxR) is a promising strategy for AML and report a highly potent and specific inhibitor of TrxR, S-250. Both pharmacologic and genetic inhibition of TrxR impairs the growth of human AML in mouse models. We found that TrxR inhibition leads to a rapid and marked impairment of metabolism in leukemic cells subsequently leading to cell death. TrxR was found to be a major and direct regulator of metabolism in AML …

Dysphagia Should Be Reported As A Separate Legacy Outcome Measure After Anterior Cervical Discectomy And Fusion, Philip Zakko, Rafid Kasir, Nai-Wei Chen, Daniel K. Park

Conference Presentation Abstracts

INTRODUCTION: Dysphagia is a common complication after anterior cervical discectomy and fusion (ACDF) but is not a routinely asked question in legacy patient-reported outcome measures. This study looks to see whether there are associations between dysphagia and legacy outcome measures. METHODS: We retrospectively reviewed 168 patients who underwent ACDF surgery from 2017 to 2019 at a single institution. Demographics, anthropometric data, Neck disability index (NDI), visual analog scale (VAS) pain scores, PROMIS-Health and -Mental scores, Charlson Comorbidities Index (CCI), and Eating Assessment Tool (EAT-10) were obtained for each patient preop and 1, 3, 6, and 12 months postop. Repeated measure …

Comparison Of Selective Serotonin Reuptake Inhibitor Monotherapy And Dual Therapy With Physical Exercise In Mood Disorders, Sean Core

Physician Assistant Scholarly Project Papers

It is well known that exercise is an underutilized part of medical care and counseling that is recommended to patients. It is also estimated that roughly 21.4% of the general population will experience a mood disorder in their lifetime (Kessler, 2005). These two components together indicate a strong need to determine the effect that exercise will have on a significant patient population that is encountered in the primary care setting. The purpose of this paper is to look at the comprehensive amount of literature regarding exercise and Selective Serotonin Reuptake Inhibitor (SSRI) therapies in patients with mood disorders to determine …

Effect Of Ultrasound Pressure On The Distribution Of Bovine Serum Albumin Delivered By Focused Ultrasound-Mediated Blood-Brain Barrier Opening In Cleared Mouse Brains, Yajie Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Most common diagnosis and therapeutic methods have low effectiveness when used on brain diseases. The key obstacle is that the blood-brain barrier (BBB) prevents most drugs from entering the brain. Some strategies have been developed to improve the efficiency of drug delivery crossing BBB. Among all these strategies, focused ultrasound-mediated BBB opening (FUS-BBB Opening) stands out since it is noninvasive and can be located to the target area. Detailed studies are required on the distribution of drugs delivered by FUS-BBB opening and the effects of FUS parameters on the distribution. This thesis proposes a pipeline involving tissue clearing and lightsheet …

Exploring The Pain In Patellofemoral Pain: A Systematic Review And Meta-Analysis Examining Signs Of Central Sensitization, Kemery J. Sigmund, Marie K. Hoeger Bement, Jennifer E. Earl-Boehm

Physical Therapy Faculty Research and Publications

Background

Patellofemoral pain (PFP) has high recurrence rates and minimal long-term treatment success. Central sensitization refers to dysfunctional pain modulation that occurs when nociceptive neurons become hyperresponsive. Researchers in this area of PFP have been increasingly productive in the past decade.

Objective

To determine whether evidence supports manifestations of central sensitization in individuals with PFP.

Data Sources

We searched MeSH terms for quantitative sensory testing (QST) pressure pain thresholds (PPTs), conditioned pain modulation (CPM), temporal summation, sensitization, hyperalgesia, and anterior knee pain or PFP in PubMed, SPORTDiscus, CINAHL, Academic Search Complete, and EBSCOhost.

Study Selection

Peer-reviewed studies that were written …

J Mich Dent Assoc August 2021

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

• A cover story on “Diversity, Equity, Inclusion, and Dentistry: Understanding the MDA’s Perspective”.
• A feature article, “Diversity, Equity, Inclusion, and Dentistry: Its Impact on Oral Health — You Can Make a Difference!”.
• A feature article from the Journal’s DEI series, “Welcoming Diversity, Equity, and Inclusion with Students Considering Careers in Dentistry”.
• A feature clinical article …

Factors Influencing Emergency Medicine Residency Choice: Diversity, Community, And Recruitment Red Flags, Paul L Weygandt, Laura Smylie, Edgardo Ordonez, Jaime Jordan, Arlene S Chung

Faculty, Staff and Students Publications

BACKGROUND: Emergency medicine (EM) applicants consider many factors when selecting residency programs. Prior studies have demonstrated that applicants consider geography as well as modifiable/nonmodifiable program factors. Less attention, however, has been paid to underrepresented groups. Additionally, the prevalence and characteristics of "red flags," or factors that may lead an applicant to lower a program's rank or not rank it at all, remain unknown in EM. Our objective was to describe the factors that influence current EM-bound medical students' residency selection focusing on underrepresented applicants and red flags encountered during the recruitment process.

METHODS: We conducted a mixed-methods survey study of …

Utilizing Structured Worksheets To Strengthen Resident Teaching On The Ob/Gyn Clerkship, Matthew R Carroll, Charlie C Kilpatrick, Grace Johnson, Neelima Sukhavasi, Bani M Ratan

Faculty, Staff and Students Publications

OBJECTIVE: To determine if structured worksheets can aid resident teaching on the obstetrics and gynecology (OB/GYN) clerkship.

DESIGN: We developed structured worksheets to aid residents in teaching medical students. In this pilot study, we measured the impact of the material by conducting end of clerkship focus groups between October 2017 to June 2018 and administering surveys to medical students who had recently completed the clerkship. We performed analyses of the focus group transcriptions for positive and negative themes and analyzed questionnaire data utilizing unpaired t-test and chi-square test to determine whether resident use of structured worksheets influenced student perception of …

Enhancing The Teaching Environment: 3-Year Follow-Up Of A Resident-Led Residents-As-Teachers Program, Bani M Ratan, Grace J Johnson, Amanda C Williams, Jocelyn T Greely, Charlie C Kilpatrick

Faculty, Staff and Students Publications

BACKGROUND: Previous faculty-driven residents-as-teachers (RAT) models have had limited efficacy and sustainability.

OBJECTIVE: To evaluate the acceptability and effects of a

METHODS: In October 2016, obstetrics and gynecology (OB/GYN) residents at a large academic institution implemented a resident-led RAT program, consisting of a steering committee of peer-selected residents with 2 faculty mentors who planned education-focused resident didactics and journal clubs, organized resident involvement in clerkship activities, and recognized residents who excelled in teaching as Distinguished Educators (DEs). From July 2016 through June 2019, using the Kirkpatrick Model, we evaluated the program with annual resident surveys assessing self-perception of 13 teaching …

Transcriptional Milestones In Dictyostelium Development, Mariko Katoh-Kurasawa, Karin Hrovatin, Shigenori Hirose, Amanda Webb, Hsing-I Ho, Blaž Zupan, Gad Shaulsky

Faculty, Staff and Students Publications

Dictyostelium development begins with single-cell starvation and ends with multicellular fruiting bodies. Developmental morphogenesis is accompanied by sweeping transcriptional changes, encompassing nearly half of the 13,000 genes in the genome. We performed time-series RNA-sequencing analyses of the wild type and 20 mutants to explore the relationships between transcription and morphogenesis. These strains show developmental arrest at different stages, accelerated development, or atypical morphologies. Considering eight major morphological transitions, we identified 1371 milestone genes whose expression changes sharply between consecutive transitions. We also identified 1099 genes as members of 21 regulons, which are groups of genes that remain coordinately regulated despite …