Medicine and Health Sciences Commons^™

Cost-Effectiveness Analysis Of Tisagenlecleucel, Blinatumomab, And Clofarabine For Treatment Of B-Cell Precursor Acute Lymphoblastic Leukemia, Kamron Lotfi

Pharmaceutical Sciences (MS) Theses

Acute lymphoblastic leukemia (ALL) is a common type of adolescent and young adult leukemia in the United States (U.S.). Patients who are refractory or relapsed after receiving two or more lines of systemic therapy have the option of taking tisagenlecleucel. Due to the high cost of this treatment, a cost-effectiveness analysis was performed to assess the treatments for tisagenlecleucel, clofarabine combination, and blinatumomab. Objectives

The objective of this study is to evaluate the cost-effectiveness of tisagenlecleucel; clofarabine, etoposide, cyclophosphamide; and blinatumomab for the treatment of relapse- refractory ALL for adolescents and young adults from the U.S. health care payer perspective. …

The Impact Of Public Reporting Schemes And Market Competition On Hospital Efficiency, Ahreum Han, Keon Hyung Lee

Health Care Administration Faculty Research

In the wake of growing attempts to assess the validity of public reporting, much research has examined the effectiveness of public reporting regarding cost or quality of care. However, relatively little is known about whether transparency through public reporting significantly influences hospital efficiency despite its emerging expectations for providing value-based care. This study aims to identify the dynamics that transparency brought to the healthcare market regarding hospital technical efficiency, taking the role of competition into account. We compare the two public reporting schemes, All-Payer Claims Database (APCD) and Hospital Compare. Employing Data Envelopment Analysis (DEA) and a cross-sectional time-series Tobit …

Practical Pearl: Thyroid Nodule - August 2021, Chelsea Gordner Do

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

The Degree Of Polymerization And Sulfation Patterns In Heparan Sulfate Are Critical Determinants Of Cytomegalovirus Entry Into Host Cells, Dipanwita Mitra, Mohammad H. Hasan, John T. Bates, Michael A. Bierdeman

Faculty and Student Publications

Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host membrane fusion and virus entry. Interfering with HS-herpesvirus interactions has long been known to result in significant reduction in virus infectivity indicating that HS play important roles in initiating virus entry. In this study, we provide a series of evidence to prove that specific sulfations as well as the degree of polymerization (dp) of HS govern human cytomegalovirus (CMV) binding and infection. First, purified CMV extracellular virions preferentially bind to sulfated longer …

(E)-2,6,10-Trimethyldodec-8-En-2-Ol: An Undescribed Sesquiterpenoid From Copaiba Oil, Mohammed F. Hawwal, Zulfiqar Ali, Mei Wang, Jianping Zhao

Faculty and Student Publications

The use of copaiba oil has been reported since the 16th century in Amazon traditional medicine, especially as an anti-inflammatory ingredient and for wound healing. The use of copaiba oil continues today, and it is sold in various parts of the world, including the United States. Copaiba oil contains mainly sesquiterpenes, bioactive compounds that are popular for their positive effect on human health. As part of our ongoing research endeavors to identify the chemical constituents of broadly consumed herbal supplements or their adulterants, copaiba oil was investigated. In this regard, copaiba oil was subjected to repeated silica gel column chromatography …

Red Algal Sulfated Galactan Binds And Protects Neural Cells From Hiv-1 Gp120 And Tat, Vitor H. Pomin, Fakhri Mahdi, Weihua Jin, Fuming Zhang

Faculty and Student Publications

The potential neuroprotective capacity of four different sulfated glycans: Botryocladia occidentalis-derived sulfated galactan (BoSG) (MW > 100 kDa), Lytechinus variegatus-derived sulfated fucan (LvSF) (MW~90 kDa), high-molecular weight dextran sulfate (DxS) (MW 100 kDa), and unfractionated heparin (UFH) (MW~15 kDa), was assessed in response to the HIV-1 proteins, R5-tropic glycoprotein 120 (gp120) and/or trans-activator of transcription (Tat), using primary murine neurons co-cultured with mixed glia. Compared to control-treated cells in which HIV-1 proteins alone or combined were neurotoxic, BoSG was, among the four tested sulfated glycans, the only one capable of showing significant concentration-dependent neuroprotection against Tat and/or gp120, alone or combined. …

Critical Interactions Between Opioid And Cannabinoid Receptors During Tolerance And Physical Dependence Development To Opioids In The Murine Gastrointestinal Tract: Proof Of Concept, Agata Szymaszkiewicz, Mikołaj Świerczyński, Marcin Talar, Prabhakar Reddy Polepally

Faculty and Student Publications

Introduction: Tolerance (TOL) and physical dependence (PD) constitute important limitations of opioid therapy. The aim of our study was to validate research tools to investigate TOL and PD and to characterize the interactions between opioid (OR) and cannabinoid (CB) receptors in these processes in the GI tract. Methods: TOL was assessed through the comparison of morphine ability to inhibit electrically evoked smooth muscles contractility in the mouse ileum that was previously incubated with/without morphine for 1 h. To evaluate the PD, the ileum was incubated with morphine for 10 min, then challenged with naloxone to induce withdrawal response (WR). The …

Evaluating Quality Of Life And Participant Satisfaction In A Cancer Support Community Yoga Program., Lauren Topp

Doctor of Nursing Practice Papers

Purpose: The purpose of this EBP project was to evaluate program processes and outcomes of an established cancer support community yoga program for persons impacted by cancer and explore the impact of the program on quality of life (QoL) in persons with cancer.

Design: This project was a quality improvement project with a pre-test/post-test design. QoL was explored through the EROTC QLQ C30 questionnaire. Descriptive and explorative methods were conducted through a survey of participants’ satisfaction with the yoga program. Feedback for future improvements around QoL services were provided.

Methods: Members of Gilda’s Club (440 persons) received an …

The Black Church, Social Media, And Vaccine Hesitancy: A Program Evaluation Of A Virtual Town Hall Meeting Intended To Educate, Empower And Expedite Covid-19 Vaccine Uptake Intent Among Black Americans., Nina Johnson

Doctor of Nursing Practice Papers

Background: Vaccines are among the most important public health interventions of the 20th century saving millions of lives each year. Notwithstanding, the United States has seen a growing resistance to vaccinations since the late 1990s. Vaccine hesitancy (VH) is a delay or decline to accept vaccines, despite the available of safe and effective vaccines (WHO, 2019). Combatting VH in Black communities is especially challenging, complex, and multifaceted due to an elevated sense of medical mistrust from persistent racial discrimination, injustices and medical malfeasance. The current coronavirus-19 disease (COVID-19) pandemic has further magnified the intersection of this structural racism, the associated …

Implementation And Evaluation Of A Quality Improvement Project To Increase Tdap Vaccination Rates For Primary Caregivers In The Neonatal Intensive Care Unit., Vickie Winner

Doctor of Nursing Practice Papers

Pertussis (whooping cough) is a highly contagious deadly disease for neonates. The Centers for Disease Control and Prevention (CDC) identifies primary caregivers (anyone caring for the infant in the home environment) as the most common source of neonatal pertussis. The CDC therefore recommends primary caregivers receive a booster tetanus, diphtheria, acellular pertussis (Tdap) vaccine to reduce the transmission of pertussis to neonates. The purpose of this quality improvement (QI) project is to implement and evaluate an intervention to increase Tdap vaccination rates among primary caregivers of NICU patients. The specific aims of this quality improvement project are to 1) implement …

Improving Patient Safety During The Emergency Department Discharge Process With The Use Of Two Patient Identifiers., Hannah English

Doctor of Nursing Practice Papers

Nurses are not always confirming two patient identifiers while conducting a patient discharge, resulting in patient identification errors. This problem has been shown to significantly affect patient safety and satisfaction, decreasing both when errors are made. These errors also have heavy financial and legal consequences on the affected facility and on the discharging nurses, warranting a need for improvement. The purpose of this quality improvement project was to decrease patient-identification errors at discharge by increasing nurse use of two patient-identifiers through the implementation of an education program. This ten-week program involved education sessions that presented evidence-based material specifically focused on …

Perioperative Management Of The Patient With Diabetes Mellitus, Alexa High

Nursing Student Class Projects (Formerly MSN)

Diabetes Mellitus is one of the most prevalent co-morbidities seen in hospitals today. As such, it is extremely important for healthcare providers to be well informed in order to care for their patients properly. This poster will adequately inform healthcare providers on key signs and symptoms, pathophysiology, diagnosis, and treatment for diabetes mellitus. This poster will also include significant information on how to care for the patient with diabetes mellitus during the perioperative period.

Short Versus Standard Esophageal Myotomy In Achalasia Patients: A Systematic Review And Meta-Analysis Of Comparative Studies., Saurabh Chandan, Antonio Facciorusso, Shahab R Khan, Daryl Ramai, Babu P Mohan, Mohammad Bilal, Banreet Dhindsa, Lena L Kassab, Hemant Goyal, Abhilash Perisetti Md, Ishfaq Bhat, Shailender Singh, Stephanie Mcdonough, Douglas G Adler

Other Specialties

Background and study aims Despite the clinical efficacy of peroral endoscopic myotomy (POEM), postoperative symptomatic gastroesophageal reflux disease (GERD) remains a major concern. While it is known that length of the gastric myotomy affects postoperative GERD, the clinical relevance of variation in esophageal myotomy length is not well known. We performed a systematic review and meta-analysis of studies comparing outcomes of short versus standard myotomy length in patients with achalasia. Patients and methods We searched multiple databases from inception through November 2020 to identify studies that reported on outcomes of achalasia patients who underwent short compared with standard esophageal myotomy. …

Enhancing Microbiome Host Disease Prediction With Variational Autoencoders, Celeste Manughian-Peter

Computational and Data Sciences (MS) Theses

Advancements in genetic sequencing methods for microbiomes in recent decades have permitted the collection of taxonomic and functional profiles of microbial communities, accelerating the discovery of the functional aspects of the microbiome and generating an increased interest among clinicians in applying these techniques with patients. This advancement has coincided with software and hardware improvements in the field of machine learning and deep learning. Combined, these advancements implicate further potential for progress in disease diagnosis and treatment in humans. The ability to classify a human microbiome profile into a disease category, and additionally identify the differentiating factors within the profile between …

Hair Toxicology Testing Among Children Evaluated For Physical Abuse: Evaluation Of A Practice Change., Ashley Dejarnette

Doctor of Nursing Practice Papers

Background: Despite a complete medical evaluation for child physical abuse, many suspected victims have indeterminant findings. The lack of a definitive diagnosis can impede child protection agencies’ ability to protect those children at high risk for abuse, leaving them vulnerable to subsequent injuries and potentially escalating violence by caregivers. Oftentimes, allegations of child physical abuse are accompanied by concerns for substance abuse by the caregiver as well. While we know that children living in homes where caregivers use illicit substances are at substantially higher risk for physical abuse, drug testing children for environmental exposure to illicit substances is not yet …

Mobbing And Job Satisfaction Among Registered Nurses In Mississippi, Brenda Collins

Dissertations

The incidences of mobbing or workplace bullying are a common occurrence among nurses. The practice has been associated with overwhelming and long-standing comprising emotional, psychosomatic, and psychosocial distress. Mobbing (workplace bullying) impacts the target, those close to them, and the organization in which they work. The experience of mobbing produces affective reactions in the target. Affective experiences on the job can impact job satisfaction within organizations. Job satisfaction plays an essential role in sustaining an adequate nursing workforce. Subsequently, some nurses become frustrated and opt for resigning or early retirement when they are no longer satisfied with the culture or …

Physical Education Teachers' Instructional Adaptations To Teach Motor Skills To Children With Language Disorders, Kristen Morgan

Dissertations

Children with language disorders have a unique blend of impairments related to communication, memory (Gray et al., 2019; Montgomery et al., 2019), executive functioning (Kapa & Plante, 2015), motor skills (Hill, 2001), imitation, gestures (Wray et al., 2017), and reaching early motor milestones (Diepeveen et al., 2018). These deficits may negatively affect learning motor skills in physical education (PE). Instructional adaptations to overcome these learning impairments in PE has not been greatly explored in the literature. Nor has teachers’ level of self-efficacy in providing adaptations to children with language disorders. The purpose of this study was to examine instructional adaptations …

Improving Pediatric Delirium Prevention To Decrease Pediatric Delirium Prevalence In The Pediatric Intensive Care Units., Kelsie Houchens

Doctor of Nursing Practice Papers

Background: Pediatric delirium has emerged as a common complication of childhood illness in the intensive care setting, with estimated delirium prevalence ranging from 15.9% to 65.6%. Critically ill pediatric patients in the ICU are at risk for pediatric delirium due to modifiable risk factors including mechanical ventilation, sedating medications, physical restraints, and nutrition. In 2019, the pediatric intensive care unit (PICU) in a Kentucky children’s hospital reported only 18 % of chart audits revealed that physicians activated the physician-directed pediatric ICUs Delirium Prevention and Treatment Order Set (DPTOS) on pediatric patients. A quality improvement (QI) project was developed to identify …

Why Targeted Testing Matters: Evaluation Of A Practice Change In Pediatric Ingestion Screening., Emily Neal

Doctor of Nursing Practice Papers

Background: The drug epidemic is plaguing the United States and more Americans than ever have been identified to use illicit substances regularly, including while caring for children. The practice of obtaining a standard urine or serum drug screen is outdated and ineffective in determining if children have been exposed to illicit substances. Often these immunoassay drug screens are negative despite pediatric patients having symptomatic responses to illicit drug exposures. Immunoassay drug screens are not designed for testing in children who are often passively and directly exposed as bystanders to adult drug use in their environment. This means that a “negative” …

4ms Framework For Aging Healthcare, Christine Zaki

Nursing Capstones

Background: At the beginning of the pandemic, primary care clinics in North Dakota (ND) had just a trickle of daily telehealth encounters. Over time, these encounters increased, primarily for the youngest seniors (55 – 70 years old). Due to increased COVID-19 cases among the elderly population in ND, the Geriatric Workforce Enhancement Program (GWEP) allocated a grant to the University of North Dakota (UND) to promote telehealth use in the elderly residing in rural ND and receiving home care through the desired home care agency. This project aims to promote telehealth to reduce exposure to COVID-19 among the geriatric populations …

The Role Of Phonological And Semantic Representations In Verbal Short-Term Memory And Delayed Retention, Lisa Archibald

Data and Test Instruments

No abstract provided.

Examining Correlates Of Feeding Practices Among Parents Of Preschoolers, Deepa Srivastava, Lucy R. Zheng, Dipti Dev

Department of Child, Youth, and Family Studies: Faculty Publications

Background: Parent feeding practices play a critical role in children’s eating behaviors. Limited research has explored child-level correlates of parent feeding practices.

Aim: To identify correlates of feeding practices (responsive and controlling) among parents of preschoolers in the United States.

Methods: Participants included parents (n = 273) of preschoolers (3–5 years), recruited from early care and education settings (n = 24) located in a metropolitan city in the US. Analysis included descriptives, correlations, and multiple regression.

Results: For responsive feeding practices, positive associations included child’s weight with unintentional modeling (β = .17, 95% CI [0.12, 0.53]), child vegetable …

Using Simulation To Prepare Nursing Students To Care For Covid-19 Patients., Erika Keithley

Doctor of Nursing Practice Papers

Background: The COVID-19 pandemic has impacted the state, nation, and globe resulting in significant death and healthcare strain. To minimize risks associated with potential illness and educational interruptions, nursing students have often been prohibited from caring for COVID-19 patients during clinical experiences. Simulation-based education immerses students in a realistic clinical environment providing a safe learning environment for novice practitioners.

Purpose: The purpose of this project was to implement simulation-based education related to acute care of COVID-19 patients for pre-licensure nursing students. Project objectives included: (a) to educate nursing students on the care of COVID-19 patients; (b) to assess competency through …

New Dentist News (August 2021), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.

Speech-Language-Hearing Clinic Handbook - August 2021, Department Of Audiology And Speech-Language Pathology, East Tennessee State University

Speech-Language Pathology Handbooks

No abstract provided.

People With Disabilities Still At Risk In Congregate Care Settings, University Of Montana Rural Institute

Health and Wellness

This report provides an analysis of data to better understand where cases and deaths are rising in nursing homes as of August 8 2021. We hope this analysis can help support local community planning and networking among rural partners to improve outcomes.

• COVID-19 cases among residents and staff are on the rise in nursing homes with the steepest increases in urban areas and in the South and Midwest.
• Disabled people are disproportionately overrepresented in the resident populations of unsafe congregate settings, such as nursing homes.
• Vaccination rates across both residents and staff in nursing homes have stagnated.
• Policy priorities should …

Regional Covid-19 Dynamics: Surrogate Synchrony In Case Infection Rates, Samantha Robinson

Mathematical Sciences Faculty Publications and Presentations

As many jurisdictions consider in-person learning strategies (including at Institutions of Higher Education, IHE), implementing travel restrictions or quarantines, and/or establishing interstate pacts to reduce COVID-19 spread, this study explores the degree to which COVID-19 case infection rates in a group of neighboring, Southern and Midwestern U.S. states (namely, Arkansas and its contiguous neighbors) are patterned in a non-random way known as synchrony. Utilizing surrogate synchrony (SUSY) to estimate the dyadic coupling between the COVID-19 case infection rate processes in this region from March to December 2020, results indicate that significant synchrony is present between Arkansas and three of its …

Regulation Of Antigenic Variation By Trypanosoma Brucei Telomere Proteins Depends On Their Unique Dna Binding Activities, Bibo Li Ph.D., Yanxiang Zhao

Biological, Geological, and Environmental Faculty Publications

Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, Variant Surface Glycoprotein (VSG), to evade the host immune response. Such antigenic variation is a key pathogenesis mechanism that enables T. brucei to establish long-term infections. VSG is expressed exclusively from subtelomere loci in a strictly monoallelic manner, and DNA recombination is an important VSG switching pathway. The integrity of telomere and subtelomere structure, maintained by multiple telomere proteins, is essential for T. brucei viability and for regulating the monoallelic VSG expression and VSG switching. Here we will focus on T. brucei TRF and RAP1, two telomere …

Investigations In The Cellular And Molecular Biology Of Human Airway Mucociliary Tissue, Vincent Manna

Graduate School of Biomedical Sciences Theses and Dissertations

Our laboratory has integrated the use of a human-derived, in vitro model of airway mucociliary tissue. We isolate human nasal epithelial cells (HNECs) from the nasal mucociliary tissue of donors with a small brush and expand the airway progenitor cells in culture. The HNECs are then seeded onto semi-permeable transwell inserts. The inserts are in contact with the media in the lower chamber but don’t contain media in the upper chamber therefore the cells are exposed to the air while drawing nutrients from the media below, this is called the Air-Liquid Interface (ALI). HNECs cultured at the ALI initiate a …

Experiences And Perceptions Of People Living With Narcolepsy, Teresa Sellstrom

Nursing ETDs

The purpose of this study was to investigate the experiences and perceptions of persons living with narcolepsy from their perspective. An anonymous, online survey that included both open-ended and structured questions was administered to adults with narcolepsy with or without cataplexy (N = 72; 65 F) recruited through the auspices of the Narcolepsy Network (NN). A total of 69 participants responded to at least one open-ended question about experiences of diagnosis, treatment, and living with the condition. An Interpretive Description approach was used to analyze open ended responses. The major themes included serious medical issues (e.g., misdiagnosis and difficulties with …