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Articles 4771 - 4800 of 21399
Full-Text Articles in Medicine and Health Sciences
Renal Involvement And Its Treatment In Pediatric Patients With Proteinase-3 Anti-Neutrophil Cytoplasmic Antibody Positive Granulomatosis With Polyangiitis: A Case Series, Xiaoyan Wu, Elizabeth Mancuso, Isabel Armendi, David Krasinski, Lin Liu, Shauna Tarsi, Wayne R Waz, Rabheh Abdul-Aziz, Ewa Elenberg
Renal Involvement And Its Treatment In Pediatric Patients With Proteinase-3 Anti-Neutrophil Cytoplasmic Antibody Positive Granulomatosis With Polyangiitis: A Case Series, Xiaoyan Wu, Elizabeth Mancuso, Isabel Armendi, David Krasinski, Lin Liu, Shauna Tarsi, Wayne R Waz, Rabheh Abdul-Aziz, Ewa Elenberg
Faculty, Staff and Students Publications
We describe three pediatric patients between the ages of 10 and 14 years old who were diagnosed with granulomatosis with polyangiitis (GPA) between 2014 and 2019. Each case involves variations in presentation, symptomatology, diagnostics, and induction and maintenance therapy regimens. Patient 1 presented with significant renal involvement, hypertensive emergency, and focal alveolar hemorrhage, a rare presentation of GPA that causes up to 60% mortality.Patient 2 presented with minimal renal involvement and a diffuse petechial rash, which is the most common cutaneous presentation of GPA. Finally, patient 3 presented with significant renal involvement and later on with symptoms of idiopathic intracranial …
Use Of Human Tissue Stem Cell-Derived Organoid Cultures To Model Enterohepatic Circulation, Sarah E Blutt, Sue E Crawford, Carolyn Bomidi, Xi-Lei Zeng, James R Broughman, Matthew Robertson, Cristian Coarfa, Mary Elizabeth M Tessier, Tor Savidge, F Blaine Hollinger, Steven A Curley, Mark Donowitz, Mary K Estes
Use Of Human Tissue Stem Cell-Derived Organoid Cultures To Model Enterohepatic Circulation, Sarah E Blutt, Sue E Crawford, Carolyn Bomidi, Xi-Lei Zeng, James R Broughman, Matthew Robertson, Cristian Coarfa, Mary Elizabeth M Tessier, Tor Savidge, F Blaine Hollinger, Steven A Curley, Mark Donowitz, Mary K Estes
Faculty, Staff and Students Publications
The use of human tissue stem cell-derived organoids has advanced our knowledge of human physiological and pathophysiological processes that are unable to be studied using other model systems. Increased understanding of human epithelial tissues including intestine, stomach, liver, pancreas, lung, and brain have been achieved using organoids. However, it is not yet clear whether these cultures recapitulate in vivo organ-to-organ signaling or communication. In this work, we demonstrate that mature stem cell-derived intestinal and liver organoid cultures each express functional molecules that modulate bile acid uptake and recycling. These organoid cultures can be physically coupled in a Transwell system and …
Hemodynamic Outcomes After Valve-In-Valve Transcatheter Aortic Valve Replacement: A Single-Center Experience, R Yazan Kherallah, Srikanth Koneru, Zvonimir Krajcer, Ourania Preventza, Kathryn G Dougherty, Melissa L Mccormack, Briana T Costello, Stephanie Coulter, Neil E Strickman, Juan Carlos Plana Gomez, Ali Mortazavi, Jose G Díez, James J Livesay, Joseph S Coselli, Guilherme V Silva
Hemodynamic Outcomes After Valve-In-Valve Transcatheter Aortic Valve Replacement: A Single-Center Experience, R Yazan Kherallah, Srikanth Koneru, Zvonimir Krajcer, Ourania Preventza, Kathryn G Dougherty, Melissa L Mccormack, Briana T Costello, Stephanie Coulter, Neil E Strickman, Juan Carlos Plana Gomez, Ali Mortazavi, Jose G Díez, James J Livesay, Joseph S Coselli, Guilherme V Silva
Faculty, Staff and Students Publications
BACKGROUND: Valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) has emerged as a safe, effective alternative to redo aortic valve surgery in high-risk patients with degenerated surgical bioprosthetic valves. However, ViV-TAVR has been associated high postprocedural valvular gradients, compared with TAVR for native-valve aortic stenosis.
METHODS: We performed a retrospective study of all patients who underwent ViV-TAVR for a degenerated aortic valve bioprosthesis between January 1, 2013 and March 31, 2019 at our center. The primary outcome was postprocedural mean aortic valve gradient. Outcomes were compared across surgical valve type (stented versus stentless), surgical valve internal diameter (≤19 versus >19 mm), and …
Continuous-Flow Left Ventricular Assist Device Support In Patients With Ischemic Versus Nonischemic Cardiomyopathy, Brendan P Chou, Andre Critsinelis, Harveen K Lamba, Gregory Long, Andrew B Civitello, Reynolds M Delgado, Subhasis Chatterjee
Continuous-Flow Left Ventricular Assist Device Support In Patients With Ischemic Versus Nonischemic Cardiomyopathy, Brendan P Chou, Andre Critsinelis, Harveen K Lamba, Gregory Long, Andrew B Civitello, Reynolds M Delgado, Subhasis Chatterjee
Faculty, Staff and Students Publications
To determine whether the cause of cardiomyopathy affects outcomes in patients who undergo continuous-flow left ventricular assist device support, we compared postimplant adverse events and survival between patients with ischemic and nonischemic cardiomyopathy. The inclusion criteria for the ischemic group were a history of myocardial infarction or revascularization (coronary artery bypass grafting or percutaneous coronary intervention), ≥75% stenosis of the left main or proximal left anterior descending coronary artery, or ≥75% stenosis of ≥2 epicardial vessels. From November 2003 through March 2016, 526 patients underwent device support: 256 (48.7%) in the ischemic group and 270 (51.3%) in the nonischemic group. …
Transcatheter Pulmonic Valve Implantation In Adult Patients With Prior Congenital Heart Surgery, Zachary A Spigel, Iki Adachi, Ziyad M Binsalamah, Dhaval Parekh, Athar M Qureshi
Transcatheter Pulmonic Valve Implantation In Adult Patients With Prior Congenital Heart Surgery, Zachary A Spigel, Iki Adachi, Ziyad M Binsalamah, Dhaval Parekh, Athar M Qureshi
Faculty, Staff and Students Publications
BACKGROUND: Transcatheter pulmonary valve replacement (TPVR) is now an established modality for pulmonary valve replacement in suitable candidates. We aim to describe our experience with TPVR in adults.
METHODS: This is a descriptive study of all TPVR performed in adults with congenital heart disease at a single institution from 2010-2020. All adult patients (defined as 18 years old or older at TPVR) were included. Time-to-event outcomes were described using Kaplan-Meier estimates with 95% confidence intervals (CIs).
RESULTS: Out of a total of 200 patients that had undergone TPVR, 81 patients (57% male) met the inclusion criteria, with a median age …
Cd11c Participates In Triggering Acute Graft-Versus-Host Disease During Bone Marrow Transplantation, Qianqian Wang, Xiuhua Su, Yi He, Mei Wang, Donglin Yang, Rongli Zhang, Jialin Wei, Qiaoling Ma, Weihua Zhai, Aiming Pang, Yong Huang, Sizhou Feng, Christie M Ballantyne, Huaizhu Wu, Xiaolei Pei, Xiaoming Feng, Mingzhe Han, Erlie Jiang
Cd11c Participates In Triggering Acute Graft-Versus-Host Disease During Bone Marrow Transplantation, Qianqian Wang, Xiuhua Su, Yi He, Mei Wang, Donglin Yang, Rongli Zhang, Jialin Wei, Qiaoling Ma, Weihua Zhai, Aiming Pang, Yong Huang, Sizhou Feng, Christie M Ballantyne, Huaizhu Wu, Xiaolei Pei, Xiaoming Feng, Mingzhe Han, Erlie Jiang
Faculty, Staff and Students Publications
CD11c is a canonical dendritic cell (DC) marker with poorly defined functions in the immune system. Here, we found that blocking CD11c on human peripheral blood mononuclear cell‐derived DCs (MoDCs) inhibited the proliferation of CD4+ T cells and the differentiation into IFN‐γ‐producing T helper 1 (Th1) cells, which were critical in acute graft‐versus‐host disease (aGVHD) pathogenesis. Using allogeneic bone marrow transplantation (allo‐BMT) murine models, we consistently found that CD11c‐deficient recipient mice had alleviated aGVHD symptoms for the decreased IFN‐γ‐expressing CD4+ Th1 cells and CD8+ T cells. Transcriptional analysis showed that CD11c participated in several immune regulation functions including maintaining antigen …
Hiv-1 Viral Protein R Couples Metabolic Inflexibility With White Adipose Tissue Thermogenesis, Neeti Agarwal, Dinakar Iyer, Pradip Saha, Aaron R Cox, Yan Xia, Netanya S Utay, Anoma Somasundaram, Ulrich Schubert, Jordan E Lake, Sean M Hartig, Ashok Balasubramanyam
Hiv-1 Viral Protein R Couples Metabolic Inflexibility With White Adipose Tissue Thermogenesis, Neeti Agarwal, Dinakar Iyer, Pradip Saha, Aaron R Cox, Yan Xia, Netanya S Utay, Anoma Somasundaram, Ulrich Schubert, Jordan E Lake, Sean M Hartig, Ashok Balasubramanyam
Faculty, Staff and Students Publications
Persons living with HIV (PLWH) manifest chronic disorders of brown and white adipose tissues that lead to diabetes and metabolic syndrome. The mechanisms that link viral factors to defective adipose tissue function and abnormal energy balance in PLWH remain incompletely understood. Here, we explored how the HIV accessory protein viral protein R (Vpr) contributes to adaptive thermogenesis in two mouse models and human adipose tissues. Uncoupling protein 1 (UCP1) gene expression was strongly increased in subcutaneous white adipose tissue (WAT) biopsy specimens from PLWH and in subcutaneous WAT of the Vpr mice, with nearly equivalent mRNA copy number. Histology and …
A Simplified Approach To Identification Of Risk Status In Patients With Atherosclerotic Cardiovascular Disease, Aparna Sajja, Hsin-Fang Li, Kateri J Spinelli, Amir Ali, Salim S Virani, Seth S Martin, Ty J Gluckman
A Simplified Approach To Identification Of Risk Status In Patients With Atherosclerotic Cardiovascular Disease, Aparna Sajja, Hsin-Fang Li, Kateri J Spinelli, Amir Ali, Salim S Virani, Seth S Martin, Ty J Gluckman
Faculty, Staff and Students Publications
OBJECTIVE: The 2018 American Heart Association/American College of Cardiology (AHA/ACC) Blood Cholesterol Guideline recommendation to classify patients with atherosclerotic cardiovascular disease (ASCVD) as very high-risk (VHR) vs not-VHR (NVHR) has important implications for escalation of medical therapy. We aimed to define the prevalence and clinical characteristics of these two groups within a large multi-state healthcare system and develop a simpler means to assist clinicians in identifying VHR patients using classification and regression tree (CART) analysis.
METHODS: We performed a retrospective analysis of all patients in a 28-hospital US healthcare system in 2018. ICD-10 codes were used to define the ASCVD …
Sudden Cardiac Death In Athletes, Darren C Tsang, Mark S Link
Sudden Cardiac Death In Athletes, Darren C Tsang, Mark S Link
The Texas Heart Institute Journal
No abstract provided.
Medical And Device Therapy For Stroke Prevention In Patients With Atrial Fibrillation, Sophia Huang, Payam Safavi-Naeini, Abdi Rasekh
Medical And Device Therapy For Stroke Prevention In Patients With Atrial Fibrillation, Sophia Huang, Payam Safavi-Naeini, Abdi Rasekh
The Texas Heart Institute Journal
No abstract provided.
Avoidance Of St-Segment-Elevation Myocardial Infarction Treatment For >1 Week Due To Covid-19 Fears, Rahul V Annabathula, Gregory J Sinner, Talal S Alnabelsi, Rachel P Goodwin, Vincent L Sorrell
Avoidance Of St-Segment-Elevation Myocardial Infarction Treatment For >1 Week Due To Covid-19 Fears, Rahul V Annabathula, Gregory J Sinner, Talal S Alnabelsi, Rachel P Goodwin, Vincent L Sorrell
The Texas Heart Institute Journal
During the coronavirus disease 2019 (COVID-19) pandemic, social distancing guidelines have negatively affected the care-seeking behavior of patients with chronic medical conditions, including those with cardiovascular disease. We report the case of a 60-year-old man with vague gastrointestinal symptoms who waited more than 1 week to seek treatment for fear of COVID-19 infection. On presentation at another hospital, he was found to have had an anterior myocardial infarction, and he underwent percutaneous coronary intervention to stent an occluded proximal left anterior descending coronary artery. Subsequently, the patient experienced refractory cardiogenic shock and, during his transfer to our hospital, refractory ventricular …
Cognitive Correlates Of Instrumental Activities Of Daily Living Performance In Parkinson Disease Without Dementia, Erin R Foster, Tasha Doty
Cognitive Correlates Of Instrumental Activities Of Daily Living Performance In Parkinson Disease Without Dementia, Erin R Foster, Tasha Doty
2020-Current year OA Pubs
OBJECTIVE: To investigate cognitive correlates of instrumental activities of daily living (IADL) performance among people with Parkinson disease (PD) without dementia.
DESIGN: Cross-sectional.
SETTING: Academic medical center.
PARTICIPANTS: Volunteer sample (N=161) comprising participants with PD without dementia (n=102) and healthy comparison (HC) participants (n=59).
INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURES: Performance-based assessment of cognitively-demanding IADL (meal preparation, bill paying, shopping, medication management, small home repair), neuropsychological tests (attentional control/flexibility, planning, working memory, memory, crystallized intelligence), and measures of motor function and other characteristics (eg, depressive symptoms).
RESULTS: There were no group differences in neuropsychological test performance (
CONCLUSIONS: The PD …
An Evaluation Of An Integrated Multidisciplinary Early Identification And Triage Of College Students At Risk For Anxiety And Depression, Sarah J. Templeton
An Evaluation Of An Integrated Multidisciplinary Early Identification And Triage Of College Students At Risk For Anxiety And Depression, Sarah J. Templeton
Electronic Theses and Dissertations
College students across the U.S. are experiencing an increasing prevalence of mental health concerns, such as anxiety and depression. Suicide is currently the second most common cause of death among U.S. college students. At the project site, the university health services report that mental health issues significantly impact the students’ academic progress, contributing to poor performance, inability to complete assignments, and sometimes forces attrition. Campus providers traditionally respond when students approach, often at the point of crisis or exacerbation. This Doctor of Nursing Practice (DNP) project evaluated the impact of a pilot program using an interdisciplinary approach to universal proactive …
Food Addiction And Obesity, Lisa Ling
Food Addiction And Obesity, Lisa Ling
Electronic Theses and Dissertations
The obesity rate in the U.S. adult population has increased to epidemic levels despite attempts to decrease obesity through evidence-based knowledge, clinical practice guidelines, medical interventions, and individual efforts. For certain individuals, food addiction behaviors such as food cravings, loss of control, and binge eating contribute to obesity and require a different approach to care. Little work has been done on adding the possibility of food addiction to obesity screening and treatment. This study utilized a quasi-experimental quantitative pre- and postsurvey research design based on Lewin’s change theory. Nurse practitioners were surveyed regarding the provider’s perceptions, attitudes, and beliefs about …
Bioactive In Situ Crosslinkable Polymer-Peptide Hydrogel For Cell Delivery To The Intervertebral Disc In A Rat Model, Marcos N Barcellona, Julie E Speer, Liufang Jing, Deepanjali S Patil, Munish C Gupta, Jacob M Buchowski, Lori A Setton
Bioactive In Situ Crosslinkable Polymer-Peptide Hydrogel For Cell Delivery To The Intervertebral Disc In A Rat Model, Marcos N Barcellona, Julie E Speer, Liufang Jing, Deepanjali S Patil, Munish C Gupta, Jacob M Buchowski, Lori A Setton
2020-Current year OA Pubs
Degeneration of the intervertebral disc (IVD) is associated with significant biochemical and morphological changes that include a loss of disc height, decreased water content and decreased cellularity. Cell delivery has been widely explored as a strategy to supplement the nucleus pulposus (NP) region of the degenerated IVD in both pre-clinical and clinical trials, using progenitor or primary cell sources. We previously demonstrated an ability for a polymer-peptide hydrogel, serving as a culture substrate, to promote adult NP cells to undergo a shift from a degenerative fibroblast-like state to a juvenile-like NP phenotype. In the current study, we evaluate the ability …
Amygdala Functional Connectivity And Negative Reactive Temperament At Age 4 Months, Courtney A. Filippi, Sanjana Ravi, Maya Bracy, Anderson M. Winkler, Chad Sylvester, Daniel Samuel Pine, Nathan A. Fox
Amygdala Functional Connectivity And Negative Reactive Temperament At Age 4 Months, Courtney A. Filippi, Sanjana Ravi, Maya Bracy, Anderson M. Winkler, Chad Sylvester, Daniel Samuel Pine, Nathan A. Fox
School of Medicine Publications
Objective
Infant amygdalaconnectivity correlates with maternal reports of infant temperament characterized by novelty-evoked distress and avoidance. However, no studies have examined how human infant amygdala connectivity relates to direct observations of novelty-evoked distress. This study examined the link between amygdala connectivity and infant novelty-evoked distress using direct observation of temperament.
Method
Novelty-evoked distress was assessed at 4 months of age (N = 90) using a standardized reactivity assessment and parent report. Within 3 weeks of assessment, resting-state functional magnetic resonance imaging was collected in a subset of infants (n = 34). Using a whole-brain voxelwise approach, amygdala connectivity associated …
An In-Vivo 1h-Mrs Short-Echo Time Technique At 7t: Quantification Of Metabolites In Chronic Multiple Sclerosis And Neuromyelitis Optica Brain Lesions And Normal Appearing Brain Tissue, George Tackley, Yazhuo Kong, Rachel Minne, Silvia Messina, Anderson M. Winkler, Ana Cavey, Rosie Everett, Gabriele C. Deluca, Andrew Weir, Matthew Craner
An In-Vivo 1h-Mrs Short-Echo Time Technique At 7t: Quantification Of Metabolites In Chronic Multiple Sclerosis And Neuromyelitis Optica Brain Lesions And Normal Appearing Brain Tissue, George Tackley, Yazhuo Kong, Rachel Minne, Silvia Messina, Anderson M. Winkler, Ana Cavey, Rosie Everett, Gabriele C. Deluca, Andrew Weir, Matthew Craner
School of Medicine Publications
Highlights
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NAAG likely contributes to the total NAA differences between multiple sclerosis lesion and normal appearing brain tissue.
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myo-Inositol was not shown to be different between chronic AQP4Ab-NMOSD brain lesions and normal appearing brain tissue.
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An optimised MRS methodology is described, using 7T field strength and correcting for tissue T2 water relaxion differences.
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7-tesla MRS profiles of chronic brain lesions and normal appearing white matter are presented for MS and AQP4Ab-NMOSD.
Abstract
Magnetic Resonance Spectroscopy (MRS) allows for the non-invasive quantification of neurochemicals and has the potential to differentiate between the pathologically distinct diseases, multiple sclerosis (MS) and …
Emergence Of Cationic Polyamine Dendrimersomes: Design, Stimuli Sensitivity And Potential Biomedical Applications, Partha Laskar, Christine Dufès
Emergence Of Cationic Polyamine Dendrimersomes: Design, Stimuli Sensitivity And Potential Biomedical Applications, Partha Laskar, Christine Dufès
School of Medicine Publications
For decades, self-assembled lipid vesicles have been widely used in clinics as nanoscale delivery systems for various biomedical applications, including treatment of various diseases. Due to their core–shell architecture and versatile nature, they have been successfully used as carriers for the delivery of a wide range of therapeutic cargos, including drugs and nucleic acids, in cancer treatment. Recently, surface-modified polyamine dendrimer-based vesicles, or dendrimersomes, have emerged as promising alternatives to lipid vesicles for various biomedical applications, due to their ease of synthesis, non-immunogenicity, stability in circulation and lower size polydispersity. This mini-review provides an overview of the recent advances resulting …
Mortality In Children Treated With Maintenance Peritoneal Dialysis: Findings From The International Pediatric Peritoneal Dialysis Network Registry., Sophie Ploos Van Amstel, Marlies Noordzij, Dagmara Borzych-Duzalka, Nicholas C. Chesnaye, Hong Xu, Lesley Rees, Il-Soo Ha, Zenaida L. Antonio, Nakysa Hooman, William Wong, Karel Vondrak, Yok Chin Yap, Hiren Patel, Maria Szczepanska, Sara Testa, Monica Galanti, Jameela A. Kari, Charlotte Samaille, Sevcan A. Bakkaloglu, Wai-Ming Lai, Luisa Fernanda Rojas, Mabel Sandoval Diaz, Biswanath Basu, Alicia Neu, Bradley A. Warady, Kitty J. Jager, Franz Schaefer
Mortality In Children Treated With Maintenance Peritoneal Dialysis: Findings From The International Pediatric Peritoneal Dialysis Network Registry., Sophie Ploos Van Amstel, Marlies Noordzij, Dagmara Borzych-Duzalka, Nicholas C. Chesnaye, Hong Xu, Lesley Rees, Il-Soo Ha, Zenaida L. Antonio, Nakysa Hooman, William Wong, Karel Vondrak, Yok Chin Yap, Hiren Patel, Maria Szczepanska, Sara Testa, Monica Galanti, Jameela A. Kari, Charlotte Samaille, Sevcan A. Bakkaloglu, Wai-Ming Lai, Luisa Fernanda Rojas, Mabel Sandoval Diaz, Biswanath Basu, Alicia Neu, Bradley A. Warady, Kitty J. Jager, Franz Schaefer
Manuscripts, Articles, Book Chapters and Other Papers
RATIONALE & OBJECTIVE: Research on pediatric kidney replacement therapy (KRT) has primarily focused on Europe and North America. In this study, we describe the mortality risk of children treated with maintenance peritoneal dialysis (MPD) in different parts of the world and characterize the associated demographic and macroeconomic factors.
STUDY DESIGN: Prospective cohort study.
SETTING & PARTICIPANTS: Patients younger than 19 years at inclusion into the International Pediatric Peritoneal Dialysis Network registry, who initiated MPD between 1996 and 2017.
EXPOSURE: Region as primary exposure (Asia, Western Europe, Eastern Europe, Latin America, North America, and Oceania). Other demographic, clinical, and macroeconomic (4 …
J Mich Dent Assoc September 2021
J Mich Dent Assoc September 2021
The Journal of the Michigan Dental Association
Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!
In this issue, the reader will find the following original content:
- A cover story with “Reports from the Dental School Deans”, Dr. Mert Aksu and Dr. Laurie McCauley.
- A feature article from the Journal’s DEI series, “Building a Culturally Competent Practice”.
- A feature article, “Disability Insurance: 10 Things You Need to Know”.
- News you need, Editorial and regular department articles on MDA Foundation activities, Dentistry and …
Statement Based On The 4 Th International Conference On Global Food Security – December 2020: Challenges For A Disruptive Research Agenda, Patrick Caron, Martin Van Ittersum, Tessa Avermaete, Gianluca Brunori, Jessica Fanzo, Ken Giller, Etienne Hainzelin, John Ingram, Lise Korsten, Yves Martin-Prével, Moses Osiru, Cheryl Palm, Marta Rivera Ferre, Mariana Rufino, Sergio Schneider, Alban Thomas, Daniel Walker
Statement Based On The 4 Th International Conference On Global Food Security – December 2020: Challenges For A Disruptive Research Agenda, Patrick Caron, Martin Van Ittersum, Tessa Avermaete, Gianluca Brunori, Jessica Fanzo, Ken Giller, Etienne Hainzelin, John Ingram, Lise Korsten, Yves Martin-Prével, Moses Osiru, Cheryl Palm, Marta Rivera Ferre, Mariana Rufino, Sergio Schneider, Alban Thomas, Daniel Walker
All Peer-Reviewed Publications
The 4th Global Food Security conference highlighted four major developments: the shift from food security to food systems; a focus on diets and consumption patterns; the importance of unknown futures and inherent uncertainties and risks; and the central role of multi-level connections between local- and global-oriented research. These shifts highlight the importance for research to contribute to dialogue and collective intelligence through evidence-based brokerage, and to move beyond polarization of debates. These shifts also call for the involvement of scientists in multi-stakeholder arrangements to strengthen innovation and learning at different levels, and for their participation in foresight studies to help …
Hemorrhagic Stroke Outcomes Of Kapsr Patients With Co-Morbid Diabetes And Alzheimer’S Disease, Amanda L. Trout, Christopher J. Mclouth, Patrick Kitzman, Michael R. Dobbs, Lisa Bellamy, Kelley Elkins, Justin F. Fraser
Hemorrhagic Stroke Outcomes Of Kapsr Patients With Co-Morbid Diabetes And Alzheimer’S Disease, Amanda L. Trout, Christopher J. Mclouth, Patrick Kitzman, Michael R. Dobbs, Lisa Bellamy, Kelley Elkins, Justin F. Fraser
School of Medicine Publications
Background: Vascular risk factors, such as diabetes mellitus (DM), are associated with poorer outcomes following many neurodegenerative diseases, including hemorrhagic stroke and Alzheimer’s disease (AD). Combined AD and DM co-morbidities are associated with an increased risk of hemorrhagic stroke and increased Medicare costs. Therefore, we hypothesized that patients with DM in combination with AD, termed DM/AD, would have increased hemorrhagic stroke severity.
Methods: Kentucky Appalachian Stroke Registry (KApSR) is a database of demographic and clinical data from patients that live in Appalachia, a distinct region with increased health disparities and stroke severity. Inpatients with a primary indication of hemorrhagic stroke …
Circulating Fatty Acids Associated With Advanced Liver Fibrosis And Hepatocellular Carcinoma In South Texas Hispanics, Jingjing Jiao, Suet-Ying Kwan, Caroline M. Sabotta, Honami Tanaka, Lucas Veillon, Marc O. Warmoes, Philip L. Lorenzi, Ying Wang, Peng Wei, Jose Luis Almeda, Joseph B. Mccormick, Susan P. Fisher-Hoch
Circulating Fatty Acids Associated With Advanced Liver Fibrosis And Hepatocellular Carcinoma In South Texas Hispanics, Jingjing Jiao, Suet-Ying Kwan, Caroline M. Sabotta, Honami Tanaka, Lucas Veillon, Marc O. Warmoes, Philip L. Lorenzi, Ying Wang, Peng Wei, Jose Luis Almeda, Joseph B. Mccormick, Susan P. Fisher-Hoch
School of Medicine Publications
Background: Hispanics in South Texas have high rates of hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Liver fibrosis severity is the strongest predictive factor of NAFLD progression to HCC. We examined the association between free fatty acids (FA) and advanced liver fibrosis or HCC in this population.
Methods: We quantified 45 FAs in plasma of 116 subjects of the Cameron County Hispanic Cohort, 15 Hispanics with HCC, and 56 first/second-degree relatives of Hispanics with HCC. Liver fibrosis was assessed by FibroScan.
Results: Advanced liver fibrosis was significantly associated with low expression of very long chain (VLC) saturated FAs …
Normal-Tension Glaucomatous Optic Neuropathy Is Related To Blood Pressure Variability In The Maracaibo Aging Study, Jesus D. Melgarejo, Gladys E. Maestre, Luis J. Mena, Joseph H. Lee, Michele Petitto, Carlos A. Chavez, Gustavo Calmon, Egle Silva, Lutgarde Thijs, Lama A. Al-Aswad
Normal-Tension Glaucomatous Optic Neuropathy Is Related To Blood Pressure Variability In The Maracaibo Aging Study, Jesus D. Melgarejo, Gladys E. Maestre, Luis J. Mena, Joseph H. Lee, Michele Petitto, Carlos A. Chavez, Gustavo Calmon, Egle Silva, Lutgarde Thijs, Lama A. Al-Aswad
School of Medicine Publications
Hypoperfusion of the optic nerve might be involved in the pathogenesis of normal-tension glaucomatous optic neuropathy (GON). Mean arterial pressure (MAP) drives ocular perfusion, but no previous studies have addressed the risk of GON in relation to blood pressure (BP) variability, independent of BP level. In a cross-sectional study, 93 residents of Maracaibo, Venezuela, underwent optical coherence tomography, visual field assessments and 24-h ambulatory BP monitoring between 2011 and 2016. We investigated the association of normal-tension GON with or without visual field defects with reading-to reading variability of 24-h MAP, as captured by variability independent of the MAP level (VIMmap). …
The Phoenix Sign: Is It Due To Vasodilation? Blinded Prospective Comparing The Effects Of Papaverine To Lidocaine Without Epinephrine, Julia Aguirre
The Phoenix Sign: Is It Due To Vasodilation? Blinded Prospective Comparing The Effects Of Papaverine To Lidocaine Without Epinephrine, Julia Aguirre
Symposium of Student Scholars
A neurological phenomenon has been observed clinically that when after a small amount of 1% lidocaine (usually less than .5cc’s) has been infiltrated adjacent to the Common Fibular (Peroneal) nerve under sonographic guidance, in patients with drop foot, or significantly weakened motor potentials of the lower extremity dorsiflexors (Extensor Hallucis Longus (EHL), Tibialis Anterior (TA), and Extensor Digitorum Longus (EDL)), the patient will regain partial or full dorsiflexion temporarily during the effect of this nerve block. This has been named the Phoenix Sign, in reference to ancient Greek folklore, as the non-functioning nerve (like the bird) becomes functional due to …
Therapeautic Cerium Oxide Nanoparticles, Angel E. Vasquez
Therapeautic Cerium Oxide Nanoparticles, Angel E. Vasquez
Symposium of Student Scholars
The overall goal of the research project is to create a glass that produces cerium oxide nanoparticles and as an efficient delivery mechanism. Cerium is able to exist as Ce3+ and Ce4+ because it has two partially filled subshells. This coexistence allows cerium oxide to have antioxidant properties that reduce the number of free radicals in that body that are associated with cancer, diabetes, and neurodegenerative diseases. In our laboratory, using a soluble borate glass, cerium oxide nanoparticles are created to coexist in Ce3+ and Ce4+ valences This borate glass composition is doped with different amounts of Cerium(IV) Oxide and …
S-Layer Increases Predation Ability Of Myxococcus Xanthus
S-Layer Increases Predation Ability Of Myxococcus Xanthus
Symposium of Student Scholars
Background: Myxococcus xanthus is a gram-negative soil bacterium that exhibits micro-predatory activities. When starved, M. xanthus produces resistant spores within fruiting bodies for survival. The S-layer is a paracrystalline structure intertwined in many different patterns and is composed of proteins or glycoproteins. A species that produces the S-layer is Aeromonas. A. salmonicida is a strain of Aeromonas that infects fish. A. hydrophila is another pathogenic strain that causes a wide range of human diseases. We investigated the ability of the S-layer to protect Aeromonas from predation by Myxobacteria. Methods: Myxococcus and prey Aeromonas cultures were standardized to a concentration …
The Antibiotic-Resistant Bacteria Crisis: Overcoming Methicillin-Resistant Staphylococcus Aureus (Mrsa) By Myxobacterial Predation, Basirat Olorunlambe
The Antibiotic-Resistant Bacteria Crisis: Overcoming Methicillin-Resistant Staphylococcus Aureus (Mrsa) By Myxobacterial Predation, Basirat Olorunlambe
Symposium of Student Scholars
With the growing threat of antibiotic-resistant bacteria, the need for finding new antibiotics is at an all-time high. According to the Center for Disease Control and Prevention (CDC), there were over 2.8 million cases of antibiotic-resistant infections in the United States in 2019 and over 35,000 individuals have died from them. Methicillin-Resistant Staphylococcus Aureus (MRSA) accounts for 323,700 of these cases, with 10,600 deaths. MRSA is a common cause of nosocomial infections. Although antibiotics are available to treat MRSA, such as Vancomycin, the possibility remains that these strains are likely to develop a resistance to these compounds as it has …
The Relationship Of Delivery Method, Birth Weight And Race On Infant Mortality, Anjie Adeyemo
The Relationship Of Delivery Method, Birth Weight And Race On Infant Mortality, Anjie Adeyemo
Symposium of Student Scholars
Infant mortality is defined as the number of deaths per 1000 births. The U.S. infant mortality rate in 2014 was reported as 5.8 deaths per 1000 births which is very high compared to other countries such as Japan where the rate 2.1 deaths per 1000 births. The leading causes of infant death are congenital malformations, SIDS, low birthweight, pre-term births and maternal complications. For this project, I will analyze birthweight in addition to other factors related to infant death. My research aims to see how the factors of delivery method, birthweight, and race influence infant mortality to see how it …
Ksu Sna Period Party Project: Advocating For Women’S Health In The Homeless Population Of Kennesaw State University, Alice Barry
Ksu Sna Period Party Project: Advocating For Women’S Health In The Homeless Population Of Kennesaw State University, Alice Barry
Symposium of Student Scholars
In one of the wealthiest countries in the world, women are being deprived of the basic human right of access to proper feminine hygiene products and education. The purpose of this service leadership project was to review current literature to describe menstrual hygiene as a basic human right, to explore the cost/access to feminine hygiene products in multiple studies, to examine political and international initiatives surrounding access to feminine hygiene products, and to synthesize how nursing students can advocate for primary care and health promotion in the community in which they live. The project aimed to address the overwhelming need …