Medicine and Health Sciences Commons^™

Ucp3 (Uncoupling Protein 3) Insufficiency Exacerbates Left Ventricular Diastolic Dysfunction During Angiotensin Ii-Induced Hypertension, Xu Chen, Sadia Ashraf, Nadia Ashraf, Romain Harmancey

Faculty, Staff and Student Publications

Background Left ventricular diastolic dysfunction, an early stage in the pathogenesis of heart failure with preserved ejection fraction, is exacerbated by joint exposure to hypertension and obesity; however, the molecular mechanisms involved remain uncertain. The mitochondrial UCP3 (uncoupling protein 3) is downregulated in the heart with obesity. Here, we used a rat model of UCP3 haploinsufficiency (ucp3

Apoc3 Genetic Variation, Serum Triglycerides, And Risk Of Coronary Artery Disease In Asian Indians, Europeans, And Other Ethnic Groups, Shiwali Goyal, Yosuke Tanigawa, Weihua Zhang, Jin-Fang Chai, Marcio Almeida, Juan M. Peralta, Donna M. Lehman, Joanne E. Curran, Ravi Duggirala, John Blangero

School of Medicine Publications

Background

Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of-function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides (TG) and are cardioprotective in American Indians and Europeans. However, there is a lack of data in other Europeans and non-Europeans. Also, whether genetically increased plasma TG due to ApoC-III is causally associated with increased CAD risk is still unclear and inconsistent. The objectives of this study were to verify the cardioprotective role of earlier reported six LoF variants of APOC3 in South Asians and other multi-ethnic cohorts and to evaluate the causal association …

Considerations For Recommending Service Dogs Versus Emotional Support Animals For Veterans With Post-Traumatic Stress Disorder, Macy Porter, Melissa Y. Winkle, Ellen Herlache-Pretzer

People and Animals: The International Journal of Research and Practice

Background: Health care providers must understand factors that may guide the decision-making process for determining whether a veteran with post-traumatic stress disorder (PTSD) is appropriate for a service dog (SD) versus an emotional support animal (ESA), and assist SD training organizations in determining trained tasks that are suitable for the veteran’s needs.

Purpose: This study explored the perspectives of SD training organizations and factors for human health care providers to consider before recommending a veteran with PTSD for a SD versus an ESA. The researchers identified information that providers should give organizations to guide the SD training and placement process. …

A Literature Review On The Development Of Upper Limbs In Humans, Anh T. Phan

The Cardinal Edge

The development of tetrapod upper limbs shares an evolutionary origin and has been adapted and specialized for different functions for different species, such as flight in birds, swimming and balance in sea mammals, and coordination and grabbing objects in humans. The basis of tetrapod limb development has common developmental patterns, starting with the formation of the limb bud via Sonic hedgehog (Shh) signaling, where later developmental steps are modified for specialized functions. This review covers the basic developmental patterns of mammalian tetrapod development seen in humans, beginning with the formation of the limb bud, to the axis development of the …

Angiogenesis' Effect Overall On Health And Disease, Wendy Tang

The Cardinal Edge

Angiogenesis plays a major role in the development of diseases and cancer. The development of illnesses like metastatic breast cancer, cell carcinomas, tumors and various other illnesses, originate from the activation of endothelial cells. When the vascular endothelial growth factor (VEGF) is released from hypoxic tissues, they bind to vascular endothelial growth factor receptors (VEGFR). The binding of VEGF and VEGFR allows for cellular proliferation, increased migration of lattice networks, and the invasion of endothelial cells, which stimulate the formation of new blood vessels from pre-existing ones. As a result, it can be concluded that the inhibition of VEGFs would …

Microbial Influence On Alzheimer's Disease, Ashley N. Hamby

The Cardinal Edge

No abstract provided.

Sexual Health Misinformation And Potential Interventions Among Youth On Social Media, Jahnavi Sunkara

The Cardinal Edge

With the rise of the internet and social media, many adolescents and young adults have turned to the internet and social media for sexual health information. However, this can be problematic because sexual health misinformation on social media utilizes a variety of techniques to quickly disseminate and retain that misinformation in users. Historically, the spread of sexual health misinformation has specifically negatively impacted adolescents and young adults regarding two sexual health topics: contraceptives and HPV vaccination. Current evidence demonstrates that a combination of corrections and inoculation would be effective against general health misinformation. However, there is a lack of research …

Comparing Medical Student Nonverbal Behavior With Cisgender And Transgender Standardized Patients, Meghan M. Schneider, Emily J. Noonan, Laura Weingartner

The Cardinal Edge

It is essential for medical students to effectively communicate with patients of all gender identities. Evaluating nonverbal behavior is one way to assess the quality of patient care – examining providers’ behaviors while working with cisgender and transgender patients can identify potential biases linked to patient identity. To evaluate nonverbal behavior, the authors analyzed video-recorded training sessions with medical students interviewing standardized patients who identified as cisgender or transgender women. All students identified as cisgender men or cisgender women. The authors rated ten nonverbal behaviors from 1-7 and noted whether these behaviors were perceived to detract from the encounter. Average …

Segmental Maxillomandibular Rotational Advancement (Smmra) In The Treatment Of Adult Patients With Severe Obstructive Sleep Apnea, Hsien-Ching Hung, Ya-Ying Teng, Yuh-Jia Hsieh, Yi-Chin Wang, Yu-Chih Wang

Taiwanese Journal of Orthodontics

Obstructive sleep apnea (OSA) occurs as an increased collapsibility of the upper airway during sleep, which threatens health and quality of life. Asian men with greater severity of OSA presents less obese and are connected with craniofacial abnormalities. Although the traditional maxillomandibular advancement (MMA) had the comparable effectiveness to the continuous positive airway pressure therapy, the midfacial esthetics might be compromised in Asian individuals. The modified MMA procedure was proposed to balance the esthetic demands and improvement of OSA symptoms. The case report showed a 25-year-old man presented with a diagnosis of severe OSA. The pretreatment Apnea Hypopnea Index (AHI) …

Protraction Of Maxillary Single Side Teeth For Substitution Of Missing Canine And 1st Molar, Wan-Jung Tsai, Szu-Ching Lee, Tzu-Ying Wu

Taiwanese Journal of Orthodontics

This case report presents a 24-year-old female with Class III skeletal pattern, anterior cross-bite, retroclined upper incisors with missing teeth (23, 26, 46). Upper dental midline was shifted to left for 3.5 mm due to early missing of tooth 23. Maxillary sinus pneumatization was noted at both sides.

Our treatment goal was to correct upper dental midline and anterior crossbite. On the other hand, the patient requested to close all of the extraction space and solve the problem of poor prognostic tooth 36. Therefore, we extracted tooth 14 for crowding relief and midline correction. Interdental screw was used to protract …

Surgical Alteration Of Occlusal Plane Angulation Followed By Orthodontic Application Of Tads And Yin-Yang Arch Wire In Hypodivergent Prognathic Malocclusion, Chih-Hsun Hou, Yi-Min Liu, Chia-Yi Pan, Huei-Mei Tsai

Taiwanese Journal of Orthodontics

Surgical clockwise pitch rotation of the maxillo-mandibular complex could change the occlusal plane angulation and thereby open the bite. This procedure also increases the mandibular plane angle by forcing the lower face to turn backward and downward; it is the key to correct both skeletal and dental Class III malocclusions.

This case report presents a skeletal deformaty which primarily resulted from excessive transverse growth and reduced vertical growth in the midface and upper dentition. The counterclockwise growth rotation and excessive forward growth mandible aggravated the sagittal jaw bone discrepancy. The dental effect included canted maxillary occlusal plane and severe attrition …

Indication And Timing Of Mucogingival Soft Tissue Augmentation Associated With Orthodontic Treatment, Shun-Jen Yu, Yi-Hao Lee, Aaron Yu-Jen Wu

Taiwanese Journal of Orthodontics

Gingiva recession is defined as an apical shift of the gingival margin caused by different conditions/pathologies. It is associated with clinical attachment loss. Several studies showed prevalence of gingiva recession in orthodontic patients. Some predisposing factors should be taken carefully considering the effect of the treatment modality. No consensus agreement was identified about the timing of the soft tissue augmentation intervention for orthodontic patients with the risk of gingival recession. However, several critical factors can guide the decision making to obtain the most preferred treatment option.

This article reviews the factors regarding the correlation of gingival margin alteration and orthodontic …

Perception Of And Attitudes On Malocclusion: A Literature Review, Gannaran Narangerel, Hsin-Chung Cheng, Bolormaa Sainbayar, Ganjargal Ganburged

Taiwanese Journal of Orthodontics

Purpose: This study aimed to review published evidence on the perception of and attitude on malocclusion and to examine existing assessment tools and influencing factors.

Methods: PubMed, Cochrane Library, and Scopus databases, as well as electronic archives of the European Journal of Orthodontics, American Journal of Orthodontics and Dentofacial Orthopedics, and Angle Orthodontist, were searched to collect articles that compared perception differences between dental professionals and laypeople. Articles that investigated perceptions of dental professionals were excluded.

Results: The literature search identified 94 articles. A total of 31 suitable studies from 1970 to 2019 were finally considered in the review. …

Could Cephalometric Landmarks Serve As Boundaries Of Maxillary Molar Distalization? A Comparison Between Two- And Three-Dimensional Assessments, Jhong-An Ye, Chi-Yu Tsai, Yi-Hao Lee, Yu-Jen Chang, Shiu-Shiung Lin, Jui-Pin Lai, Te-Ju Wu

Taiwanese Journal of Orthodontics

Purpose: This study aimed at measuring the differences between the two-dimensional (2D) and three-dimensional (3D) radiographic boundaries for molar distalization, and their correlations for the amount of maxillary molar distalization.

Patients and Methods: A total of 250 consecutive adult patients were retrospectively reviewed. All the enrolled patients possessed Angle Class III malocclusion with moderate maxillary crowding and suitable for camouflage treatment. The spatial differences between the 2D and 3D radiographic boundaries were compared and measured. The correlation among the range of the distalization boundary and studied clinical variables were assessed by Pearson correlation and the linear regression to determine the …

Rapid 3d Reconstruction Guided Embolization For Catastrophic Bleeding Following Vacuum Assisted Breast Biopsy; A Case Report And Review Of The Literature, Martin Halicek, Chenghao Qian, Driss Raissi, Xiaoqin Wang, Yevgen Chornenkyy, William B. Bates, Michael Winkler

Radiology Faculty Publications

The most clinically significant complication associated with stereotactic core needle biopsy of the breast is hematoma formation, which only occurs in less than 1% of biopsies and may require treatment. Cases of uncontrollable bleeding, refractory to repeated compression, resulting from biopsy are exceedingly rare. We present a case of catastrophic, uncontrollable bleeding and large hematoma formation resulting from stereotactic vacuum-assisted breast biopsy of a breast mass identified in screening mammography. Percutaneous embolization was planned and guided using 3D reconstructions from computed tomographic angiography, and bleeding was successfully controlled with micro-coil embolization.

Application Of The Aho-Corasick Algorithm To Create A Network Intrusion Detection System, Komil Tashev, Mokhinabonu Agzamova, Nozima Axmedova

Bulletin of TUIT: Management and Communication Technologies

Nowadays the Internet is very massive and the need for a system to protect the networks from being attacked becomes very important. One of the main goals of studying pattern matching techniques is their significant role in real-world applications, such as the intrusion detection systems branch. The purpose of the network attack detection systems NIDS is to protect the infocommunication network from unauthorized access. This article provides an analysis of the exact match and fuzzy matching methods, and discusses a new implementation of the classic Aho-Corasick pattern matching algorithm at the hardware level. The proposed approach to the implementation of …

2021-09-20_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.

2021-09-20_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-09-20_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Covid-19 Et Gestion Des Troubles Gastro-Intestinaux : Expérience D’Un Centre Hospitalier Marocaincovid-19, Gastrointestinal Disorders, Pandemic., Hanane Delsa, Mohamed Cherkaoui Jaouad Reda, Amine Benfaida, Anass Nadi, Fedoua Rouibaa

Health Sciences

Pandemic Covid-19 is a real challenge for the medical profession. SARS-CoV-2 virus attacks several human organs, including the digestive tract. Digestive disorders have been described as revealing symptoms or accompanying signs of infection. The treatment of these symptoms must be early and codified. At Cheikh Khalifa International University Hospital in Casablanca, a codified treatment protocol has been proposed to facilitate the management of these disorders.

2021-09-20_Michiganoverview_Covidschooloutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The School Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102480---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

In accordance with the Council of State and Territorial Epidemiologists’ outbreak definition, schools that have been found by their local health department to have two (2) or more COVID-19 cases who may have shared exposure on school grounds and are from different households are included. Case counts for school-related outbreaks include those associated with before and after school programs (e.g., school-sponsored …

2021-09-20_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102057---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

2021-09-20_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

Intouch September 20, 2011, New York Medical College

InTouch

• Social Media Ambassadors Share NYMC Experience
• NYMC Hosts 2021 Club Fair with Record Number of Approved Clubs
• Martin Katzenstein, M.D. '78, is Appointed Assistant Dean for Clinical Affiliations
• Hospitalist Alice Cha, M.D. '13, Balances Patient Care with Her Passion for Educating Aspiring Young Medical Professionals

Advancing Use Of Nutrition Knowledge To Improve Practice By Policy And Program Communities In India During A Political Transition, Edward A. Frongillo Jr., Jessica L. Escobar-Alegria

Faculty Publications

Models are needed for how to advance use of knowledge by programs and policy officials to make evidence-based decisions about nutrition. How to advance use of nutrition knowledge in India from 2011 to 2015 during a political transition was investigated through studying a knowledge initiative led by the International Food Policy Research Institute. Semistructured interviews were conducted with 37 diverse participants, and 1091 news articles, 318 Twitter and 175 Facebook posts, 12 YouTube events, 65 knowledge products, and 130 engaging events were assessed. Open-axial coding, content and themes analysis, triangulation, and process tracing were used. The knowledge initiative analyzed the …

Rapid Morphologic Changes To Microglial Cells And Upregulation Of Mixed Microglial Activation State Markers Induced By P2x7 Receptor Stimulation And Increased Intraocular Pressure, Keith E. Campagno, Wennan Lu, Assraa Jassim, Farraj Albalawi, Aurora Cenaj, Huen-Yee Tso, Sophia P. Clark, Puttipong Sripinun, Néstor Más Gómez, Claire H. Mitchell

Health & Biomedical Sciences Faculty Publications

Background

The identification of endogenous signals that lead to microglial activation is a key step in understanding neuroinflammatory cascades. As ATP release accompanies mechanical strain to neural tissue, and as the P2X7 receptor for ATP is expressed on microglial cells, we examined the morphological and molecular consequences of P2X7 receptor stimulation in vivo and in vitro and investigated the contribution of the P2X7 receptor in a model of increased intraocular pressure (IOP).

Methods

In vivo experiments involved intravitreal injections and both transient and sustained elevation of IOP. In vitro experiments were performed on isolated mouse retinal and brain microglial cells. …

Fabrication And Comparative Study Of Horizontal And Vertical Electrospun Protein-Polysaccharide Nanofiber Biomaterials, Ashley Rivera-Galleti

Theses and Dissertations

The use of biocompatible and biodegradable composite materials for biomedical applications has attracted the attention of many researchers in the past few years. In this study, we fabricated nanofibers of silk fibroin and cellulose and its derivatives to amalgamate their unique properties into a single material. The production of these nanofibers via electrospinning is of particular interest, and whereas several studies have been done on normal nanofibers, the formation of branched nanofibers is an exciting area not currently explored. Blend solutions are formed by dissolving silk and cellulose/cellulose acetate in formic acid separately and mixing to achieve the desired ratios. …

Structural Variants Are A Major Source Of Gene Expression Differences In Humans And Often Affect Multiple Nearby Genes, Alexandra J Scott, Colby Chiang, Ira M Hall

2020-Current year OA Pubs

Structural variants (SVs) are an important source of human genome diversity, but their functional effects are poorly understood. We mapped 61,668 SVs in 613 individuals from the GTEx project and measured their effects on gene expression. We estimate that common SVs are causal at 2.66% of eQTLs, a 10.5-fold enrichment relative to their abundance in the genome. Duplications and deletions were the most impactful variant types, whereas the contribution of mobile element insertions was small (0.12% of eQTLs, 1.9-fold enriched). Multitissue analysis of eQTLs revealed that gene-altering SVs show more constitutive effects than other variant types, with 62.09% of coding …

Using Macros In Microsoft Excel To Facilitate Cleaning Of Research Data, Justin Bauzon, Caleb Murphy, Sandhya Wahi-Gururaj

School of Medicine Faculty Research

Background: Retrospective chart review studies may be delayed by inability to export clean clinical data from an electronic medical record (EMR) or data repository. Macros are pre-programmed procedures that can be used in Microsoft Excel to help streamline the process of cleaning clinical datasets. Objectives: To demonstrate how macros may be useful for researchers at community hospitals and smaller academic health centers that lack informatics support. Methods: Using an intrinsic function of our institution’s EMR, vital signs and lab results from 20 individual hospitalizations were exported to a spreadsheet. Two macros were developed to sort through these datasets and output …

Developing Cultural Responsive Care: Children With Cleft Lip And Palate And Their Families, Brenda Louw

ETSU Faculty Works

The aim of this presentation is to report on the application and outcomes of an ETSU Cultural Competency grant awarded in 2021.The purpose of the grant was to allow students enrolled in CDIS 5240 (M.Sc. SLP Program) the opportunity to demonstrate understanding of multicultural multilingual issues and their application in the assessment and treatment of children with cleft lip and palate to better prepare them for the workforce, contribute to meeting the requirements of American Speech-Language Hearing Association (ASHA), and most importantly ensure that Hispanic children and other culturally and linguistically diverse (CALD) children with CLP receive improved services to …