Medicine and Health Sciences Commons^™

The Ironman, Mary I. Fisher

Physical Therapy Faculty Publications

No abstract provided.

Practical Pearl: T2dm Screening - October 2021, Rushika Conroy Md

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

Heterogeneity Of Magnitude, Allergen Immunodominance, And Cytokine Polarization Of Cockroach Allergen-Specific T Cell Responses In Allergic Sensitized Children., Ricardo Da Silva Antunes, Aaron Sutherland, April Frazier, Veronique Schulten, Anna Pomés, Jill Glesner, Agustin Calatroni, Matthew C Altman, Robert A Wood, George T O'Connor, Jacqueline A Pongracic, Gurjit K Khurana Hershey, Carolyn M Kercsmar, Rebecca S Gruchalla, Michelle Gill, Andrew H Liu, Edward Zoratti, Meyer Kattan, Paula J Busse, Leonard B Bacharier, Stephen J. Teach, Lisa M Wheatley, Alkis Togias, William W Busse, Daniel J Jackson, Alessandro Sette

Pediatrics Faculty Publications

Background: Characterization of allergic responses to cockroach (CR), a common aeroallergen associated with asthma, has focused mainly on IgE reactivity, but little is known about T cell responses, particularly in children. We conducted a functional evaluation of CR allergen-specific T cell reactivity in a cohort of CR allergic children with asthma.

Methods: Peripheral blood mononuclear cells (PBMCs) were obtained from 71 children, with mild-to-moderate asthma who were enrolled in a CR immunotherapy (IT) clinical trial, prior to treatment initiation. PBMC were stimulated with peptide pools derived from 11 CR allergens, and CD4+ T cell responses assessed by intracellular cytokine staining. …

Kawasaki Disease Shock Syndrome Vs Classical Kawasaki Disease: A Meta-Analysis And Comparison With Sars-Cov-2 Multisystem Inflammatory Syndrome., Loubna Lamrani, Cedric Manlhiot, Matthew D Elias, Nadine F Choueiter, Audrey Dionne, Ashraf S. Harahsheh, Michael A Portman, Brian W Mccrindle, Nagib Dahdah

Pediatrics Faculty Publications

No abstract provided.

Incident Light And Morphology Determine Coral Productivity Along A Shallow To Mesophotic Depth Gradient, Michael P. Lesser, Marc Slattery, Curtis D. Mobley

Faculty and Student Publications

While the effects of irradiance on coral productivity are well known, corals along a shallow to mesophotic depth gradient (10–100 m) experience incident irradiances determined by the optical properties of the water column, coral morphology, and reef topography. Modeling of productivity (i.e., carbon fixation) using empirical data shows that hemispherical colonies photosynthetically fix significantly greater amounts of carbon across all depths, and throughout the day, compared with plating and branching morphologies. In addition, topography (i.e., substrate angle) further influences the rate of productivity of corals but does not change the hierarchy of coral morphologies relative to productivity. The differences in …

Computationally Assisted Lead Optimization Of Novel Potent And Selective Mao-B Inhibitors, Vedanjali Gogineni, Manal A. Nael, Narayan D. Chaurasiya, Khaled M. Elokely

Faculty and Student Publications

A series of dietary flavonoid acacetin 7-O-methyl ether derivatives were computationally designed aiming to improve the selectivity and potency profiles against monoamine oxidase (MAO) B. The designed compounds were evaluated for their potential to inhibit human MAO-A and-B. Compounds 1c, 2c, 3c, and 4c were the most potent with a Ki of 37 to 68 nM against MAO-B. Compounds 1c–4c displayed more than a thousand-fold selectivity index towards MAO-B compared with MAO-A. Moreover, compounds 1c and 2c showed reversible inhibition of MAO-B. These results provide a basis for further studies on the potential application of these modified flavonoids for the …

Sequentialdynamics Of Stearoyl-Coa Desaturase-1(Scd1)/Ligand Binding And Unbinding Mechanism: A Computational Study, Anna B. Petroff, Rebecca L. Weir, Charles R. Yates, Joseph D. Ng

Faculty and Student Publications

Stearoyl-CoA desaturase-1 (SCD1 or delta-9 desaturase, D9D) is a key metabolic protein that modulates cellular inflammation and stress, but overactivity of SCD1 is associated with diseases, including cancer and metabolic syndrome. This transmembrane endoplasmic reticulum protein converts saturated fatty acids into monounsaturated fatty acids, primarily stearoyl-CoA into oleoyl- CoA, which are critical products for energy metabolism and membrane composition. The present computational molecular dynamics study characterizes the molecular dynamics of SCD1 with substrate, product, and as an apoprotein. The modeling of SCD1:fatty acid interactions suggests that: (1) SCD1:CoA moiety interactions open the substrate-binding tunnel, (2) SCD1 stabilizes a substrate conformation …

Preparation And In Vitro/In Vivo Evaluation Of Orally Disintegrating/Modified-Release Praziquantel Tablets, Xuemei Wen, Zhaoyou Deng, Yangfeng Xu, Guoqing Yan

Faculty and Student Publications

This study was designed to develop orally disintegrating/sustained-release praziquantel (PZQ) tablets using the hot-melt extrusion (HME) technique and direct compression, and subse-quently evaluate their release in in vitro and in vivo pharmacokinetics. For the extrusion process, hypromellose acetate succinate (HPMCAS)-LG was the carrier of pure PZQ, with a standard screw configuration used at an extrusion temperature of 140◦ C and a screw rotation speed of 100 rpm. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), powder X-ray diffraction (PXRD) and Fourier-transform infrared spectroscopy (FTIR) were performed to characterize the extru-date. Orally disintegrating/sustained-release praziquantel tablets (PZQ ODSRTs) were prepared by direct compression …

The Scoop, Vol. 8 Issue 7, October 2021, Health Sciences Library

Volume 8

Latest news and updates from the Health Sciences Library in our monthly newsletter for October 2021.

Effect Of Pandemic On Endoscopic Utilization In Colonic Volvulus: A Global Multicentric Study, Abhilash Perisetti Md, Hermant Goyal Md, Syed Mahanazuddin Phd, Saurabh Chandan Md, Ruthvik Allala Ba, Mariajose Rojas Md, Jonathan Kopel Phd, Sonali Sachdeva Mbbs, Mark M. Aloysius Md, Phd, Benjamin Tharian, Neil Sharma Md

Other Specialties

Introduction- Acute colonic volvulus (ACV) is a gastrointestinal emergency that results from the torsion of a segment of the colon either at the level of the sigmoid colon or cecum. It can lead to severe complications such as bowel infarction and peritonitis which can increase mortality. The COVID-19 pandemic has led to a significant reduction in endoscopic utilization globally. However, the data about endoscopy utilization in a gastrointestinal emergency such as ACV is not non-existent. Hence, we attempted to evaluate the rates of endoscopy utilization in 2020 compared to 2019 for ACV patients.

Methods- We used TriNetX, a federated cloud-based …

How “Dirty” Are The Endoscope Channels? A Systematic Review And Meta-Analysis Of Reprocessed Endoscopes, Hermant Goyal Md, Sara Larsen Ms, Abhilash Perisetti Md, Pardeep Bansal Md, Aman Ali Md, Nikolaj B. Larsen Ms, Lotte Ockert, Sven Adamsen Md, Benjamin Tharian Md, Nirav Thosani Md

Other Specialties

Introduction:

The duodenoscope elevator mechanism has been considered a culprit for multiple outbreaks from contaminated reusable patient-ready duodenoscopes. These outbreaks necessitated FDA to issue various Safety Communications and recommend endoscopy units to transition to duodenoscopes with innovative designs that ease or eliminate reprocessing. However, numerous studies have documented microbes in the channels of reprocessed gastrointestinal (GI) endoscopes, including duodenoscopes and linear echoendoscopes. Our aim is to estimate the channel contamination rate of patient-ready reprocessed GI endoscopes based on the currently available data.

Methods:

We searched PubMed, Web of Science, and Embase from January 1, 2010, until October 10, 2020, for …

Peptic Ulcer With Adherent Clot—Treat It Or Leave It: A Systematic Review And Metanalysis Of Randomized Trials, Hermant Goyal Md, Sonali Sachdeva Mbbs, Abhilash Perisetti Md, Syed Ali Amir Sherazi Md, Mark M. Aloysius Md, Phd, Aman Ali Md, Greg Enders Md, Benjamin Tharian Md, Nirav Thosani Md

Other Specialties

Introduction:

Peptic ulcer diseases (PUD) remain the most common cause of hospitalized upper GI bleeding patients (30%-60%). Upper endoscopy is needed for diagnosis, stratification, and endoscopic hemostatic therapy of these ulcers depending on the presence of stigmata of increased risk of rebleeding. PUDs with adherent clot (Forrest classification IIb) are at 20-30% risk of rebleeding with a 7% mortality rate. Recent ACG guidelines could not reach a recommendation for or against endoscopic interventions for ulcers with adherent clot resistant to vigorous irrigation. This systematic review and meta-analysis aims to analyze the randomized studies for the treatment of PUD with adherent …

1-Day Vs 3-Day Low Residue Diet For Colonoscopy Bowel Cleansing: A Systematic Review, Hermant Goyal Md, Syed Ali Amir Sherazi Md, Shweta Gupta Md, Smit Deliwala Md, Pardeep Bansal Md, Abhilash Perisetti Md, Benjamin Tharian Md, Nirav Thosani

Other Specialties

Introduction:

Colonoscopy is the best method for colon cancer screening and to evaluate bowel abnormalities, including cancer. However, good bowel preparation is essential for a successful colonoscopy. Several studies have shown Low Residue Diet (LRD) to be better tolerated without any negative effects on bowel cleansing compared to Clear Liquid Diet. Several studies have compared 1-day vs. 3-day LRD for bowel cleansing. This study aims to compare the impact of the duration of LRD for colonoscopy bowel cleansing in adult patients.

Methods:

We studied the Cochrane and MEDLINE/Ovid databases from inception to November 2020 with keywords “colonoscopy,” “bowel preparation,” “bowel …

Don't Blame The Duodenoscope Elevator, The Channels Are Contaminated As Well: A Systematic Review And Meta-Analysis, Hermant Goyal Md, Sara Larsen Ms, Abhilash Perisetti Md, Aman Ali Md, Jiannis Anastasiou Md, Nikolaj B. Larsen Ms, Lotte Ockert, Sven Adamsen Md, Benjamin Tharian Md, Nirav Thosani Md

Other Specialties

Introduction:

The elevator mechanism has been suggested as the main reason for multiple outbreaks associated with contaminated reusable patient-ready duodenoscopes. The elevator is difficult to clean even with all precautions, and specially designed brushes are recommended for proper cleaning. However, the narrow channels of the duodenoscope might pose a risk of contamination since they are prone to scratches by the insertion of various accessories creating space for microbes to hide. Our aim is to estimate the contamination rate beyond the elevator of duodenoscopes based on currently available literature.

Methods:

We searched PubMed, Web of Science, and Embase from January 1, …

Continued Aspirin Use And Bleeding Risk After Endoscopic Submucosal Dissection Of Gastric Neoplasms: A Meta-Analysis, Hermant Goyal Md, Sonali Sachdeva Mbbs, Abhilash Perisetti Md, Mark M. Aloysius Md, Saurabh Chandan Md, Benjamin Tharian Md, Nirav Thosani Md

Other Specialties

Introduction:

With the development of endoscopic technologies, the detection rate of early gastric cancer (EGC) and precancerous lesions is gradually increasing. As an effective minimally invasive therapy, endoscopic submucosal dissection (ESD) has been accepted as a standard treatment for EGC and dysplasia. However, postprocedural bleeding is one of the most common complications of ESD, with a reported incidence of 5.1%. Moreover, the effect of continued low-dose aspirin (LDA) on bleeding during the peri-ESD period is not clear.

Methods:

We searched the OVID/Medline and Google Scholar databases through June 2021 to find studies relating to continued LDA use in patients undergoing …

Working With Fellows Improves Adenoma Detection Rate During Screening Colonoscopies., Mark M Aloysius, Hemant Goyal, Niraj James Shah, Abhilash Perisetti Md, Benjamin Tharian

Other Specialties

No abstract provided.

How To Reduce Employee Injuries, Jeannie Lyn Onaindia

IPS/BAS 495 Undergraduate Capstone Projects

This MDS Capstone Project’s purpose is to bring forth knowledge, various resources, and different perspectives to help reduce employee injuries at Bettencourt & Crossbred Dairies. I chose this project because I was interested in understanding why there had been a steady increase in employee injuries on the dairy farms. In addition, I wanted to explore which departments and locations had increased employee work-related injuries and understand the dynamics surrounding these findings. The conclusion from my research was a need to increase safety awareness across all departments and provide educational information for accident prevention. Along with this information, there was a …

Shedding Light With Trees, Mark D. Homme

IPS/BAS 495 Undergraduate Capstone Projects

This multidisciplinary capstone project focuses on education of the benefits of trees to incentivize the planting of trees at stakeholder homes or businesses. The approach of taking individual action to address a large-scale issue is also highlighted as a qualitative aspect of the capstone. The goal of the project is to understand the benefits of trees, plant more trees and to utilize the approach taken to address other large-scale issues in the future.

Global warming is a complex worldwide problem. The scope of the issue can be paralyzing, stymieing individual action. Tainter (2000, p 6) discusses our general aversion to …

Stress Management Podcast Capstone Project, Jessica A. Thomas

IPS/BAS 495 Undergraduate Capstone Projects

The Stress Management Podcast Capstone Project sought to answer the question of how I might raise awareness about integrating holistic mental health services into my health coaching practice. This relevant topic centered on developing an innovative solution by drawing together two opposing perspectives from public health opinions and holistic health mindset. Launching a podcast proved to be a creative means for offering value to all stakeholders involved. Listeners received free holistic stress support, community and mental health professionals gained additional tools for their clients, while I established myself as an expert on mental health coaching. Exercising emotional intelligence regarding the …

The Many Faces Of Covid19 Infection: A Case Of Multisystem Inflammatory Syndrome In Adults (Mis-A), Amy Lam Do, Kaitlyn Musco Md, Nicholas Hinds Md

Posters

No abstract provided.

Support For Me: Provider Focus Group Summary, Mary Lindsey Smith Phd, Katie Rosingana Ba, Evelyn Ali Bs, Tyler Egeland Ba, Karen Pearson Mlis, Ma, Mark Richards Bs

Substance Use Research & Evaluation

This summary highlights feedback from focus groups with providers across Maine who currently address the needs of persons with substance use disorder (SUD). These providers represent individuals working in the following organizations: Health Systems, Behavioral Health Agencies, Residential Treatment, Community Recovery Programs, Opioid Treatment Programs (OTP), Emergency Medical Services (EMS), First Responders (EMT, fire, police), and law enforcement (e.g., Sheriff’s Office, Corrections). This summary report is designed to provide feedback to the Office of MaineCare Services to help inform their strategic planning process to increase statewide capacity for SUD treatment and recovery service capacity to better meet the needs of …

Structural And Kinetic Analyses Of Holothurian Sulfated Glycans Suggest Potential Treatment For Sars-Cov-2 Infection, Rohini Dwivedi, Priyanka Samanta, Poonam Sharma, Fuming Zhang

Faculty and Student Publications

Certain sulfated glycans, including those from marine sources, can show potential effects against SARS-CoV-2. Here, a new fucosylated chondroitin sulfate (FucCS) from the sea cucumber Pentacta pygmaea (PpFucCS) (MW ∼10.60 kDa) was isolated and structurally characterized by NMR. PpFucCS is composed of {→3)-β-GalNAcX-(1→4)-β-GlcA-[(3→1)Y]- (1→}, where X = 4S (80%), 6S (10%) or nonsulfated (10%), Y = α- Fuc2,4S (40%), α-Fuc2,4S-(1→4)-α-Fuc (30%), or α-Fuc4S (30%), and S = SO3-. The anti-SARS-CoV-2 activity of PpFucCS and those of the FucCS and sulfated fucan isolated from Isostichopus badionotus (IbFucCS and IbSF) were compared with that of heparin. IC50 values demonstrated the activity of …

Barriers To Social Inclusion For The Children And Adolescents With Disabilities In India: A Scoping Review, Asish Das

Manipal College of Health Professions, Manipal Theses and Dissertations

INTRODUCTION: Social inclusion is a complex and often misunderstood concept by our society. Few studies have documented the degree of loneliness, bullying and exclusion often experienced by children and adolescents throughout their lives. Most of the articles talks about the barriers like physical, attitudinal, curricular, communication, economical, time and skills, environmental that confront with inclusion of children and adolescents with special needs. It has been realized that most of the people with disabilities can lead a better quality of life, if they have equal opportunities and effective access to rehabilitation measures. AIM: To identify the barriers in social inclusion for …

Use Of Occupation As Means And Ends: A Scoping Review On Occupation Based Intervention In Hand Therapy, Mamta Singh

Manipal College of Health Professions, Manipal Theses and Dissertations

Introduction: Hand therapy focuses on rehabilitating upper-extremity orthopaedic conditions to restore maximum participation and minimizes further infirmities (Aglen et al., 2019; Goggins & Williams, 2019). Occupations are an extremely important part of human life and the participation is central to a person’s health, sense of well-being and life satisfaction (Chen & Chippendale, 2018). Occupation based Intervention (OBI) has always benefitted client. It includes occupation as means and ends (Zamir et al., 2016). Occupation as means refers to occupations and purposeful tasks as a remediation agent to improve a client’s physical function (Zamir et al., 2016). Occupation as an end refers …

Use Of Katz Index Of Independence In Activities Of Daily Living In Older Adults: A Scoping Review, Koushik Sau

Manipal College of Health Professions, Manipal Theses and Dissertations

Background: The health of elderly individuals is closely linked to their functional independence, measured through functional evaluations. Katz Index of independence determines the ability to perform ADLs independently in 6 areas (bathing, dressing, toileting, transferring, continence, and feeding). The scale is focused on the loss and recovery of functions and assesses the dependence (0) /independence(1) degree from six daily life activities. Aims and objective: Aim of the study was to explore the currently available literature and utilization of the Katz Index Scale in the assessment and healthcare management of the older adult population in different world regions. Method: This scoping …

Hpv Vaccination In The Virginia Context: Demographic Disparities, Patient-Provider Gender Concordance And The Impact Of Changing Recommendations, Isha Patel, Norma M. Benitez, George L. Maxwell, Fabian T. Camacho, Rajesh Balkrishnan

Virginia Journal of Public Health

Objective: Despite its effectiveness in preventing several cancers, there are marked disparities in HPV vaccination initiation and series completion. The present study sought to understand disparities in HPV vaccinations among patients in northern Virginia (ages 9-26) and the impact of patient and provider gender concordance, in lieu of CDC’s vaccine recommendation changes in 2016, which reduced the recommended doses from three to two, in this population. Design: Analyses of electronic medical records collected from 2012 to 2017. Setting: A large health care system in Northern Virginia. Participants: A total of 37,427 patients, ages 9 to 26, were included in analyses. …

Knowledge Of The Human Papillomavirus Vaccine: An Analysis Using Together For Health Virginia Population Health Survey, Mythili Vigneshwar, Sunny Jung Kim, Carrie A. Miller, Bernard Fuemmeler, Rajesh Balkrishnan

Virginia Journal of Public Health

Purpose: The purpose of this analysis was to identify key predictors which impact knowledge of the Human Papillomavirus vaccine in adults aged 21 to 45 in Virginia.

Methods: Data was collected from the Together for Health Virginia Population Surveys administered by Virginia Commonwealth University and the University of Virginia. Logistic regression was performed on data using the variables sex, age, rurality, race, education, income, occupation, and type of health insurance coverage.

Results: There was a statistically significant positive relationship between knowledge of the HPV vaccine and part-time occupation (OR: 4.288, CI: 1.492-13.325), younger age (OR: 2.31, CI: 1.088-4.905), and …

Introducing The Vpha Policy Forum, Benjamin P. Barber

Virginia Journal of Public Health

Data before and during the pandemic indicates Virginia's public health system needs reform. This article suggests that reform requires policy change, and it introduces the VPHA forum as a place to examine current policies and explore new ideas. Finally, it encourages policymakers, advocates, and the public to focus on fundamental questions about how public health is financed and delivered in Virginia. Answering these questions is necessary to creating better public health policies - and better health - for all Virginians.

Ua19/16/2 Women's Basketball Press Releases, Wku Athletic Media Relations

WKU Administration Documents

Press releases, photos and game statistics for WKU women's basketball team from August to December 2021.

Understanding Pandemic Contact Tracing From A Design Thinking Perspective, Nancy K. Lankton, Avinandan Mukherjee, Kaustav Mukherjee

Accounting Faculty Research

Because of its highly infectious nature and ability to spread from non-symptomatic people, pandemics can bring society and businesses to a standstill and death to hundreds of thousands of people across the world. Public health experts point to four Ts in successful epidemiological control, namely, test, trace, track, and treat. Since COVID-19 has no effective treatment, contact tracing has been a vital part of COVID-19 disease control and focuses on identifying and isolating people who have come into contact with individuals who have tested positive for the disease. Early surveys show that individuals are not comfortable with all contact tracing …