Medicine and Health Sciences Commons^™

Immunometabolic Dysregulation At The Intersection Of Obesity And Covid-19, Collins N. Khwatenge, Marquette Pate, Laura C. Miller, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

Obesity prevails worldwide to an increasing effect. For example, up to 42% of American adults are considered obese. Obese individuals are prone to a variety of complications of metabolic disorders including diabetes mellitus, hypertension, cardiovascular disease, and chronic kidney disease. Recent meta-analyses of clinical studies in patient cohorts in the ongoing coronavirus-disease 2019 (COVID-19) pandemic indicate that the presence of obesity and relevant disorders is linked to a more severe prognosis of COVID-19. Given the significance of obesity in COVID-19 progression, we provide a review of host metabolic and immune responses in the immunometabolic dysregulation exaggerated by obesity and the …

Glycoscience Center Of Research Excellence (Glycore), Karin King Ballering

Annual Poster Session 2021

Presenter: Karin King Ballering

Coupling Fdm 3d Printing With Hot-Melt Extrusion To Produce Hypertensive Dual Therapy Fixed Dose Combination Tablet, Abdullah Alzahrani, Sagar Narala, Dinesh Nyavanandi, Mashan Almutairi, Ahmed Almotairy, Suresh Bandari, Michael Repka

Annual Poster Session 2021

Presenter: Abdullah Alzahrani

Schottiin, A New Prenylated Isoflavone From Psorothamnus Schottii And Antibacterial Synergism Studies Between Methicillin And Fremontone Against Mrsa, Mallika Kumarihamy, Siddharth K. Tripathi, Shabana Khan, Ilias Muhammad

Annual Poster Session 2021

Presenter: Mallika Kumarihamy

New Hydroxy-1,4-Naphthoquinone And Phenoxy-Phenyl-Naphthoquinone Compounds As Drug-Resistant Antimalarials, Seong Jong Kim, Md Imdadul H. Khan, Yuexin Li, Benjamin Sawyer, Michael K. Riscoe, Shabana I. Khan, Babu L. Tekwani, Hoang V. Le

Annual Poster Session 2021

Presenter: Benjamin Sawyer

Negative Impacts Of Flood-Associated Water Quality Stressors On Early Oyster Life Stages, Jessica Pruett, Ann Fairly Pandelides, Kristine Willett, Stephanie Showalter Otts, Deborah Gochfeld

Annual Poster Session 2021

Presenter: Jessica Pruett

Discovery Of 5Α-Pregnan-2Β,3Α-Diol-20-One As A Neurohiv Protective Agent, Md Imdadul H. Khan, Mohammed F. Salahuddin, Nicholas S. Akins, Fakhri Mahdi, Seong Jong Kim, Jing Li, Jason J. Paris, Hoang V. Le

Annual Poster Session 2021

Presenter: Md Imdadul Khan

Liquid Chromatography- Tandem Mass Spectrometry (Lc-Ms-Ms) As A Detection Method For Cocaine As A Perfomance Enhancing Drug, Isha Kalaria, Shrishti Dubey

Annual Poster Session 2021

Presenters: Isha Kalaria, Shrishti Dubey

Scanning Electron Microscopy Core, Vijayasankar Raman, Soumyajit Majumdar

Annual Poster Session 2021

Presenter: Vijayasankar Raman

Biomolecular Sciences, University Of Mississippi. Department Of Biomolecular Sciences

Annual Poster Session 2021

Presenter: Department of BioMolecular Sciences

2021 October 19 - Medical Student Education Committee Retreat Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Hiv-1 Tat Protein Promotes Neuroendocrine Dysfunction Concurrent With The Potentiation Of Oxycodone’S Psychomotor Behavioral Effects In Female Transgenic Mice, Salahuddin Mohammed, Fakhri Mahdi, Jason J. Paris

Annual Poster Session 2021

Presenter: Salahuddin Mohammed

Environmental Enrichment Provided To Adult Zebra Finches (Taeniopygia Guttata) Differentially Influences Sexes On A Spatial Learning Task, Arma'rosa Wilks-Mohead, Laura West, Lainy B. Day

Annual Poster Session 2021

Presenter: Arma'Rosa Wilks-Mohead

Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice, Alaa Qraeya, Fakhri Mahdi, Marc Kaufman, Nicole M. Ashpole, Jason J. Paris

Annual Poster Session 2021

Presenter: Alaa Qraeya

Hippocampal And Thalamic Afferents Form Distinct Synaptic Microcircuits In The Mouse Infralimbic Frontal Cortex., Kourtney Graham, Nelson Spruston, Erik B Bloss

Faculty Research 2021

The selection of goal-directed behaviors is supported by neural circuits located within the frontal cortex. Frontal cortical afferents arise from multiple brain areas, yet the cell-type-specific targeting of these inputs is unclear. Here, we use monosynaptic retrograde rabies mapping to examine the distribution of afferent neurons targeting distinct classes of local inhibitory interneurons and excitatory projection neurons in mouse infralimbic frontal cortex. Interneurons expressing parvalbumin, somatostatin, or vasoactive intestinal peptide receive a large proportion of inputs from the hippocampus, while interneurons expressing neuron-derived neurotrophic factor receive a large proportion of inputs from thalamic regions. A similar dichotomy is present among …

A Young Female With Chronic Debilitating Tinnitus And A Middle-Aged Male With Life-Long Noise Exposure And Bothersome Tinnitus, Lindsey Petras, Antony Joseph

AuD Capstone Projects - Communication Sciences and Disorders

Introduction: Tinnitus is characterized by a sporadic or constant ringing, chirping, buzzing, or related characteristics that are perceived auditorily and can range in intensity. Case Presentation: A young adult female with normal hearing sensitivity presented to the clinic with constant unilateral pulsatile tinnitus in the right ear that was intensified with physical activity and caffeine. It was reported as sudden in onset and classified as severely debilitating. After extensive audiologic testing, personalized counseling, and a thorough medical evaluation, the patient received an open-fit monaural hearing aid to promote safe sound therapy and tinnitus habituation. Discussion: Thorough audiologic and medical evaluation, …

2021-10-19_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Care) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

Regulation Of Brain Primary Cilia Length By Mch Signaling: Evidence From Pharmacological, Genetic, Optogenetic, And Chemogenic Manipulations, Wedad Alhassen, Yuki Kobayashi, Jessica Su, Brianna Robbins, Henry Nguyen, Thant Myint, Micah Yu, Surya M. Nauli, Yumiko Saito, Amal Alachkar

Pharmacy Faculty Articles and Research

The melanin-concentrating hormone (MCH) system is involved in numerous functions, including energy homeostasis, food intake, sleep, stress, mood, aggression, reward, maternal behavior, social behavior, and cognition. In rodents, MCH acts on MCHR1, a G protein-coupled receptor, which is widely expressed in the brain and abundantly localized to neuronal primary cilia. Cilia act as cells’ antennas and play crucial roles in cell signaling to detect and transduce external stimuli to regulate cell differentiation and migration. Cilia are highly dynamic in terms of their length and morphology; however, it is not known if cilia length is causally regulated by MCH system activation …

Covid-19 Newsletter (Vol. 91), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Health And Economic Benefits Of Achieving Hepatitis C Virus Elimination In Pakistan: A Modelling Study And Economic Analysis, Aaron G. Lim, Nick Scott, Josephine G. Walker, Saeed Hamid, Margaret Hellard, Peter Vickerman

Section of Gastroenterology

Background: Modelling suggests that achieving the WHO incidence target for hepatitis C virus (HCV) elimination in Pakistan could cost US$3.87 billion over 2018 to 2030. However, the economic benefits from integrating services or improving productivity were not included.
Methods and findings: We adapt a HCV transmission model for Pakistan to estimate the impact, costs, and cost-effectiveness of achieving HCV elimination (reducing annual HCV incidence by 80% by 2030) with stand-alone service delivery, or partially integrating one-third of initial HCV testing into existing healthcare services. We estimate the net economic benefits by comparing the required investment in screening, treatment, and healthcare …

Precision Food Parenting: A Proposed Conceptual Model And Research Agenda, Tom Baranowski, Debbe Thompson, Sheryl O Hughes, Teresia M O'Connor

Children’s Nutrition Research Center Staff Publications

Precision medicine, nutrition and behavioral interventions are attempting to move beyond the specification of therapies applied to groups, since some people benefit, some do not and some are harmed by the same therapy. Instead, precision therapies are attempting to employ diverse sets of data to individualize or tailor interventions to optimize the benefits for the receiving individuals. The benefits to be achieved are mostly in the distant future, but the research needs to start now. While precision pediatric nutrition will combine diverse demographic, behavioral and biological variables to specify the optimal foods a child should eat to optimize health, precision …

Characterizing Human Random-Sequence Generation In Competitive And Non-Competitive Environments Using Lempel-Ziv Complexity, Alice Wong, Garance Merholz, Uri Maoz

Psychology Faculty Articles and Research

The human ability for random-sequence generation (RSG) is limited but improves in a competitive game environment with feedback. However, it remains unclear how random people can be during games and whether RSG during games can improve when explicitly informing people that they must be as random as possible to win the game. Nor is it known whether any such improvement in RSG transfers outside the game environment. To investigate this, we designed a pre/post intervention paradigm around a Rock-Paper-Scissors game followed by a questionnaire. During the game, we manipulated participants’ level of awareness of the computer’s strategy; they were either …

Health Care Policy And Congenital Heart Disease: 2020 Focus On Our 2030 Future, Devyani Chowdhury, Jonathan N Johnson, Carissa M Baker-Smith, Robert D B Jaquiss, Arjun K Mahendran, Valerie Curren, Aarti Bhat, Angira Patel, Audrey C Marshall, Stephanie Fuller, Bradley S Marino, Christina M Fink, Keila N Lopez, Lowell H Frank, Mishaal Ather, Natalie Torentinos, Olivia Kranz, Vivian Thorne, Ryan R Davies, Stuart Berger, Christopher Snyder, Arwa Saidi, Kenneth Shaffer

Division of Cardiology Faculty Papers

The congenital heart care community faces a myriad of public health issues that act as barriers toward optimum patient outcomes. In this article, we attempt to define advocacy and policy initiatives meant to spotlight and potentially address these challenges. Issues are organized into the following 3 key facets of our community: patient population, health care delivery, and workforce. We discuss the social determinants of health and health care disparities that affect patients in the community that require the attention of policy makers. Furthermore, we highlight the many needs of the growing adults with congenital heart disease and those with comorbidities, …

Oxidative Stress Induced By Reactive Oxygen Species (Ros) And Nadph Oxidase 4 (Nox4) In The Pathogenesis Of The Fibrotic Process In Systemic Sclerosis: A Promising Therapeutic Target, Sonsoles Piera-Velazquez, Sergio A. Jimenez

Department of Dermatology and Cutaneous Biology Faculty Papers

Numerous clinical and research investigations conducted during the last two decades have implicated excessive oxidative stress caused by high levels of reactive oxygen species (ROS) in the development of the severe and frequently progressive fibrotic process in Systemic Sclerosis (SSc). The role of excessive oxidative stress in SSc pathogenesis has been supported by the demonstration of increased levels of numerous biomarkers, indicative of cellular and molecular oxidative damage in serum, plasma, and other biological fluids from SSc patients, and by the demonstration of elevated production of ROS by various cell types involved in the SSc fibrotic process. However, the precise …

Iatrogenic Withdrawal Syndrome In The Pediatric Cardiac Intensive Care Unit: Incidence, Risk Factors And Outcome, Eiad Habib, Abdul Hakim Almakadma, Mohieddin Albarazi, Somiya Jaimon, Rayd Almehizia, Abdullah Al Wadai, Raja Abouelella

Journal of the Saudi Heart Association

Objectives: Critically ill children and neonates routinely receive opioids and benzodiazepines for analgesia and sedation in the pediatric intensive care unit (PICU). Prolonged opioid therapy often leads to tolerance and is associated with iatrogenic withdrawal syndrome (IWS) when opioids and benzodiazepines are weaned or discontinued. Our aim is to study the incidence, risk factors and outcome of IWS following use of a withdrawal protocol on pediatric patients after cardiac surgery. Methods: We prospectively included all postoperative pediatric patients who developed IWS after being assessed by the Withdrawal Assessment Tool (WAT-1) score (WAT-1 ≥3) over 9 months. Unit-based withdrawal management protocol …

2021-10-18_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102057---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

Zero Balancing: Conscious Touch And Transformation Book Review, Misty L. Rhoads

Journal of Transformative Touch

Zero Balancing: Conscious Touch and Transformation by pioneering transformative touch practitioner and teacher James McCormick is a profound and engaging textbook that teaches readers a multi-layered approach to working with the body, mind, and spirit through skilled, conscious touch.

2021-10-18_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

2021-10-18_Michiganoverview_Covidschooloutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The School Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102480---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

K-12 School-Related Outbreak Reporting: In accordance with the Council of State and Territorial Epidemiologists' outbreak definition, a K-12 school-associated COVID-19 case (confirmed or probable) is defined as a student, teacher, or staff member physically present in the school setting or participated in a school sanctioned extracurricular activity within 14 days prior to illness onset (or a positive test result) OR …

2021-10-18_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …