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2021

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Articles 2251 - 2280 of 21400

Full-Text Articles in Medicine and Health Sciences

Validity Of The K5 Wearable Metabolic System During The Ymca Bench Press Test - A Pilot Study, Kyle Cruz, James W. Navalta, Dustin W. Davis, Bryson Carrier Nov 2021

Validity Of The K5 Wearable Metabolic System During The Ymca Bench Press Test - A Pilot Study, Kyle Cruz, James W. Navalta, Dustin W. Davis, Bryson Carrier

International Journal of Exercise Science: Conference Proceedings

The accelerated advancements in exercise technology have resulted in the development of wearable metabolic units, allowing measurements to occur outside traditional laboratories. The validation of new equipment is essential in various applications. PURPOSE: The pilot study's purpose was to validate the metabolic measurements of the COSMED K5 wearable metabolic system against the criterion Parvo Medics TrueOne 2400 during a modified YMCA Bench Press Test. METHODS: Nine resistance weight-trained participants (six male, three female, age 29.3 ± 8.0 yrs, 78.1 ± 13.8 kg, 173.3 ± 11.5 cm) performed two identical tests on the same day. Because of equipment warm-up times, the …


Coordination Of Ankle, Knee, And Hip Joint Torques During An American Football Long Snap, Faith Cottam, Travis Peterson Ph.D Nov 2021

Coordination Of Ankle, Knee, And Hip Joint Torques During An American Football Long Snap, Faith Cottam, Travis Peterson Ph.D

International Journal of Exercise Science: Conference Proceedings

Research has studied upper-body kinematics (Balentine 2020) and whole-body kinetics during the American Football long snap (Goldstein 2020). There are no studies describing lower extremity (LE) joint kinetics during this movement. PURPOSE: This study aimed to understand how players coordinate LE torques while completing a long snap. We hypothesized there would be plantarflexor torques at the ankle and extensor torques at the knee and hip. METHODS: Subjects included college-aged football players (n=5) and high school football (n=5) players with >2years experience. All subjects provided informed consent per local IRB. Average age of participants was 18.9±1.3 years, average mass was 99.57±7.49 …


Impact Of High Intensity Interval Training Versus Moderate Intensity Continuous Training On Critical Power, Jessica Collins, Olivia Leach, Abigail Dorff, Jessica Linde, Jason Kofoed, Megan Sherman, Meagan Proffit, Jaron Quirante, Kiese Mpongo, Jayson Gifford Nov 2021

Impact Of High Intensity Interval Training Versus Moderate Intensity Continuous Training On Critical Power, Jessica Collins, Olivia Leach, Abigail Dorff, Jessica Linde, Jason Kofoed, Megan Sherman, Meagan Proffit, Jaron Quirante, Kiese Mpongo, Jayson Gifford

International Journal of Exercise Science: Conference Proceedings

Critical Power (PCRIT) is the greatest power that a person can sustain for prolonged periods of time while maintaining steady-state, submaximal aerobic conditions. Work-prime (W’) is the amount of work that can be tolerated when exercising in non-steady-state conditions above PCRIT. PURPOSE: Compare the effect of equal amounts of moderate intensity continuous training (MICT) and high intensity interval training (HIIT) on PCRIT and W’. METHODS: Twenty-two (10 female) untrained, young adults completed 8 weeks of cycling training (40 minutes, 3x per week) administered as either MICT (44% max power achieved during a graded …


Moderate Intensity Arm Cycling As A Viable Exercise Alternative For Overfat And Obese Individuals With Poor Cardiorespiratory Fitness, Nicolas W. Clark, Valeria Panissa, Jeffrey R. Stout Ph.D., Adam J. Wells, Dale Wagner, David H. Fukuda Ph.D. Nov 2021

Moderate Intensity Arm Cycling As A Viable Exercise Alternative For Overfat And Obese Individuals With Poor Cardiorespiratory Fitness, Nicolas W. Clark, Valeria Panissa, Jeffrey R. Stout Ph.D., Adam J. Wells, Dale Wagner, David H. Fukuda Ph.D.

International Journal of Exercise Science: Conference Proceedings

The prescription of aerobic exercise engaging the arms may extend the reach of physical activity and improve cardiorespiratory fitness in individuals with obesity. PURPOSE: This study compared the acute cardiopulmonary responses obtained during isocaloric arm and leg cycling trials performed at different intensities among individual’s with and without excess body fat. METHODS: Participants were 37 young adults divided into two groups based on their fat mass index, lean and average (LA) and overfat and obese (OFO). They were tested for mode-specific work rate at the ventilatory threshold (VT) and volitional fatigue (VF) during two randomized ramp tests. The …


Assessing The Validity Of Several Heart Rate Monitors In Wearable Technology While Mountain Biking, Bryson Carrier, R. W. Salatto, Dustin W. Davis, Jacquelyn V.L. Sertic, Brenna Barrios, Peyton Cater, James W. Navalta Nov 2021

Assessing The Validity Of Several Heart Rate Monitors In Wearable Technology While Mountain Biking, Bryson Carrier, R. W. Salatto, Dustin W. Davis, Jacquelyn V.L. Sertic, Brenna Barrios, Peyton Cater, James W. Navalta

International Journal of Exercise Science: Conference Proceedings

The development of fitness trackers and other wearable technology designed for health and fitness purposes is growing in popularity and sophistication every day. These devices have the ability to measure or estimate a variety of physiological and physical variables, such as step count, energy expenditure, VO2max, lactate threshold, heart rate, stride length, vertical oscillation, ground contact time, blood oxygen saturation (via pulse oximetry), and many others. PURPOSE: In order to properly use these devices, independent validation needs to take place to determine the device’s accuracy and ability to properly measure or estimate each variable. Therefore, the purpose of this …


Step It Up: A Pilot Study Of The Physical Demands Of Division I Team’S Soccer Matches Versus Semi-Professional And Collegiate Competition, Madalyn Carrasco, Robert G. Lockie Nov 2021

Step It Up: A Pilot Study Of The Physical Demands Of Division I Team’S Soccer Matches Versus Semi-Professional And Collegiate Competition, Madalyn Carrasco, Robert G. Lockie

International Journal of Exercise Science: Conference Proceedings

In spring, Division I (DI) men’s soccer teams have the opportunity to play collegiate and semi-professional (SP) teams. It could be expected that players on a collegiate team express higher workloads in a match against better competition. GPS data could be used to measure these workloads. However, at the collegiate level some coaches may takeaway GPS use in matches from some players as disciplinary action. This could impact data recorded by team sport scientists. PURPOSE: To compare physical demands measured by GPS metrics of a DI team in matches versus collegiate and SP competition in a real-world environment. METHODS: GPS …


Qualitative Analysis Of A Novel Approach By Kinesiology Students To Increase Population Physical Activity In Underserved Communities, Joshua Carlos, Lisa Chaudhari, Rachel Lang-Balde, Steven Loy Nov 2021

Qualitative Analysis Of A Novel Approach By Kinesiology Students To Increase Population Physical Activity In Underserved Communities, Joshua Carlos, Lisa Chaudhari, Rachel Lang-Balde, Steven Loy

International Journal of Exercise Science: Conference Proceedings

3 WINS Fitness (3W) is a free exercise program delivered by kinesiology students to underserved communities. Without external funding it has grown and been sustained since 2011. PURPOSE: With an intention of developing students’ professional skills, 3W also aims to reduce health disparities and increase community health by increasing physical activity. With 74% of the US population failing the Physical Activity Guidelines for cardiovascular/strength training, programs like 3W are needed. There has been no qualitative analysis of 3W to determine benefits for students/participants until now. METHODS: The analysis of 3W involved nine on-line focus groups (FG). The FG …


Autonomic And Cardiovascular Responses To Acute Exercise In Children With Autism Spectrum Disorder, Allison T. Bui, Gustavo Aldama, Kauionalani P. Kekuawela, Jacob A. Manriquez, Areum K. Jensen Nov 2021

Autonomic And Cardiovascular Responses To Acute Exercise In Children With Autism Spectrum Disorder, Allison T. Bui, Gustavo Aldama, Kauionalani P. Kekuawela, Jacob A. Manriquez, Areum K. Jensen

International Journal of Exercise Science: Conference Proceedings

Autism Spectrum Disorder (ASD) is a complex neurological disorder identified in early childhood and is characterized by impaired social interaction and atypical behaviors. Limited studies reported that children with ASD tend to have higher heart rate (HR) and blood pressure (BP) at rest compared to typically developing children (TDC). Previously, we reported that HR and blood flow (BF) did not alter during exercise while BP significantly increased in ASD. Thus, we thought that ASD may have impaired autonomic control of cardiac output via differential contribution of HR and stroke volume (SV) to regulate BP during acute exercise. PURPOSE: To …


College Student Self-Efficacy For Exercise In Relation To Reported Physical Activity Levels During The Covid-19 Pandemic, Angelez Becerra, Andrea Hughes, Sarah L. Dunn Ph.D. Nov 2021

College Student Self-Efficacy For Exercise In Relation To Reported Physical Activity Levels During The Covid-19 Pandemic, Angelez Becerra, Andrea Hughes, Sarah L. Dunn Ph.D.

International Journal of Exercise Science: Conference Proceedings

The global COVID-19 pandemic may be detrimental to a college student’s motivation to exercise with less physical activity (PA) levels recorded, possibly due to the closure of gyms or home isolation. While little is known about self-efficacy for exercise (SEE) in college students, how it relates to age in this population during a pandemic needs further investigation. PURPOSE: The aim of this study was to analyze the relationship between SEE and PA levels in college students and if age was a factor. It was hypothesized that SEE would be positively associated with PA status and negatively to college student age, …


Arch Characteristics Among Habitual Users Of Minimalist Footwear, Kaleb M. Barker, Kirk E. Bassett, Spencer G. Straddeck, Sarah T. Ridge Nov 2021

Arch Characteristics Among Habitual Users Of Minimalist Footwear, Kaleb M. Barker, Kirk E. Bassett, Spencer G. Straddeck, Sarah T. Ridge

International Journal of Exercise Science: Conference Proceedings

Purported to mimic the benefits of barefoot walking, minimalist footwear (MF) is becoming popular for daily use among the general public. Though evidence suggests that MF may have a positive effect on foot health, further investigation is required to determine the mechanisms which contribute to these observed effects. PURPOSE: The purpose of the study was to measure differences in medial longitudinal arch characteristics between Habitual users of Minimalist shoes (HM) and Habitual users of Cushioned shoes (HC). This information may provide insight regarding the causes of MF benefits. METHODS: Arch height data was collected from twelve healthy HC …


Genetic Drivers Of Cardiac Remodeling In Health And Disease In Female Mice, Alexander R. Strumwasser Nov 2021

Genetic Drivers Of Cardiac Remodeling In Health And Disease In Female Mice, Alexander R. Strumwasser

International Journal of Exercise Science: Conference Proceedings

SWACSM Abstract

Genetic drivers of cardiac remodeling in health and disease in female mice

Alexander R. Strumwasser1, Timothy M. Moore1, Zhenqi Zhou1, Lorraine P. Turcotte2, Aldons J. Lusis1, Andrea L. Hevener1

1Department of Medicine, University of California, Los Angeles 2Department of Biological Sciences, University of Southern California

Hevener Laboratory; Department of Medicine; University of California Los Angeles Laboratory

Category: Masters

Advisor / Mentor: Hevener, Andrea L. [email protected]

ABSTRACT

PURPOSE: Sex differences in cardiac metabolism and cardiometabolic disease susceptibility are well documented. However, the mechanisms underlying sexual dimorphism and …


Kinematics And Motor Responses Of Law Enforcement Officers In A Spontaneous Lethal Threat Scenario, Michael A. Kantor, Dane Bartz, William Lewinski, Robert Pettitt Facsm Nov 2021

Kinematics And Motor Responses Of Law Enforcement Officers In A Spontaneous Lethal Threat Scenario, Michael A. Kantor, Dane Bartz, William Lewinski, Robert Pettitt Facsm

International Journal of Exercise Science: Conference Proceedings

When law enforcement officers (LEOs) face a spontaneous act of lethal force, there is no “warning or foreperiod” as in typical assessments of motor response, causing a startle response to occur. The firearm draw has been tested in controlled settings; however, such an analysis when under duress has not been examined for motor response. PURPOSE: The purpose of the present study was to evaluate LEOs firearm draw and motor response following a spontaneous presentation of lethal force in a training scenario. METHODS: A total of 22 active duty LEOs engaged in training scenario under the ruse of a …


The Effects Of Transcranial Direct Current Stimulation Of Dorsolateral Prefrontal Cortex Over Multiple Days On Shooting Performance In Elite Deaflympic Athletes: A Case Series, Nicholas Pudar, Milan Pantovic, Sheniz Mooney, Brach Poston Nov 2021

The Effects Of Transcranial Direct Current Stimulation Of Dorsolateral Prefrontal Cortex Over Multiple Days On Shooting Performance In Elite Deaflympic Athletes: A Case Series, Nicholas Pudar, Milan Pantovic, Sheniz Mooney, Brach Poston

International Journal of Exercise Science: Conference Proceedings

Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation method that has shown the ability to enhance motor learning in numerous studies. However, only a few of these studies have been conducted on elite level performers or in complex motor tasks that have been practiced extensively. Rifle shooting is a difficult motor task that has real-world implications in military, police, and sport settings. Although a few studies have investigated the influence of tDCS on shooting performance, these were all acute studies conducted on novice performers. The PURPOSE was to determine the effects of DLPFC-tDCS on motor learning over multiple days …


Methodology For Organizing Rugby Trainings Among Schoolchildren, Farrukh Israil O’G’Li Ismailov Nov 2021

Methodology For Organizing Rugby Trainings Among Schoolchildren, Farrukh Israil O’G’Li Ismailov

Eurasian Journal of Sport Science

Purpose: The aim of the study is to modernize the process of physical education of younger schoolchildren by means of rugby, since rugby classes also contribute to the socio-psychological formation of the student's personality. Rugby educates character, promotes the manifestation of leadership qualities, the development of creative skills.

Methods: The main organizational and methodological conditions for the implementation of the developed technology are: the predominant use of the competitive game method in the process of teaching technical and tactical rugby actions; modeling of competitive conditions in training; the formation of creative thinking in solving problem problems, the acquisition of practical …


The Effectiveness Of The Formation During The Experiment Of The Accuracy Of The Impact On The Right And Left Foot When Exposed To The Load On The Rotational Movement In Taekwondo At The Age Of 15-16 Years, Komil Dekhkonovich Yarashev, Bektosh Shomurodovich Rakhmatov Nov 2021

The Effectiveness Of The Formation During The Experiment Of The Accuracy Of The Impact On The Right And Left Foot When Exposed To The Load On The Rotational Movement In Taekwondo At The Age Of 15-16 Years, Komil Dekhkonovich Yarashev, Bektosh Shomurodovich Rakhmatov

Eurasian Journal of Sport Science

Purpose: It consists in studying the dynamics of changes in the course of pedagogical experience of the accuracy of kicks under the influence of body rotation to the left and right in 15-16 year old taekwondo athletes. Taekwondo athletes aged 15-16 years, consisting of 12 people from the control and experimental groups, were involved in pedagogical practice classes held for 7 months.

Methods: In the practice of taekwondo training, the specialized technical and vestibulosomatic exercises developed by us were carried out using questionnaires, video recordings, operational strength, statistic chronometry (time to maintain balance), vestibulo chronometry (maintaining balance during rotational movement …


2021 November 2 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University Nov 2021

2021 November 2 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.


2021-11-02_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services Nov 2021

2021-11-02_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …


Ethanol And Opioids Do Not Act Synergistically To Depress Excitation In Carotid Body Type I Cells, Ryan J. Rakoczy, Kajal Kamra, Yoon-Jae Yi, Christopher N. Wyatt Nov 2021

Ethanol And Opioids Do Not Act Synergistically To Depress Excitation In Carotid Body Type I Cells, Ryan J. Rakoczy, Kajal Kamra, Yoon-Jae Yi, Christopher N. Wyatt

Neuroscience, Cell Biology & Physiology Faculty Publications

The combination of opioids and ethanol can synergistically depress breathing and the acute ventilatory response to hypoxia. Multiple studies have shown that the underlying mechanisms for this may involve calcium channel inhibition in central neurons. But we have previously identified opioid receptors in the carotid bodies and shown that their activation inhibits calcium influx into the chemosensitive cells. Given that the carotid bodies contribute to the drive to breathe and underpin the acute hypoxic ventilatory response, we hypothesized that ethanol and opioids may act synergistically in these peripheral sensory organs to further inhibit calcium influx and therefore inhibit ventilation.

Methods …


An Innovative Approach For Integrating Mandatory, Longitudinal Spirituality Training Into The Medical School Curriculum, David W. Fleenor, Holly G. Atkinson, Reena Karani, Susan Lerner, Staci Leisman, Deborah Marin Nov 2021

An Innovative Approach For Integrating Mandatory, Longitudinal Spirituality Training Into The Medical School Curriculum, David W. Fleenor, Holly G. Atkinson, Reena Karani, Susan Lerner, Staci Leisman, Deborah Marin

Publications and Research

Problem:

Most Americans indicate they are religious and/or spiritual and wish to have their beliefs taken into account when engaging with health care providers, yet gaps in medical education and health care practice remain. To underscore the importance of spirituality as a significant social determinant of health, a team at the Icahn School of Medicine at Mount Sinai in New York developed mandatory spirituality and health training for students integrated into all 4 years of the undergraduate medical education curriculum.

Approach:

From 2014 to 2020, a small group of faculty took an innovative approach, launching the initiative and expanding the …


Hypothalamic Hamartomas: Evolving Understanding And Management., Nathan T. Cohen, J Helen Cross, Alexis Arzimanoglou, Samuel F Berkovic, John F Kerrigan, Ilene Penn Miller, Erica Webster, Lisa Soeby, Arthur Cukiert, Dale K Hesdorffer, Barbara L Kroner, Clifford B Saper, Andreas Schulze-Bonhage, William D. Gaillard Nov 2021

Hypothalamic Hamartomas: Evolving Understanding And Management., Nathan T. Cohen, J Helen Cross, Alexis Arzimanoglou, Samuel F Berkovic, John F Kerrigan, Ilene Penn Miller, Erica Webster, Lisa Soeby, Arthur Cukiert, Dale K Hesdorffer, Barbara L Kroner, Clifford B Saper, Andreas Schulze-Bonhage, William D. Gaillard

Neurology Faculty Publications

No abstract provided.


Changes In Histone H3 Acetylation On Lysine 9 Accompany Aβ 1-40 Overexpression In An Alzheimer’S Disease Yeast Model, Muna M. Hugais, Samantha N. Cobos, Seth A. Bennett, Jailene Paredes, Genevieve Foran, Mariana P. Torrente Nov 2021

Changes In Histone H3 Acetylation On Lysine 9 Accompany Aβ 1-40 Overexpression In An Alzheimer’S Disease Yeast Model, Muna M. Hugais, Samantha N. Cobos, Seth A. Bennett, Jailene Paredes, Genevieve Foran, Mariana P. Torrente

Publications and Research

Alzheimer’s Disease (AD), the most common type of dementia, is a neurodegenerative disease characterized by plaques of amyloid-beta (Aβ) peptides found in the cerebral cortex of the brain. The pathological mechanism by which Aβ aggregation leads to neurodegeneration remains unknown. Interestingly, genetic mutations do not explain most AD cases suggesting that other mechanisms are at play. Epigenetic mechanisms, such as histone post-translational modifications (PTMs), may provide insight into the development of AD. Here, we exploit a yeast Aβ overexpression model to map out the histone PTM landscape associated with AD. We find a modest decrease in the acetylation levels on …


2021-11-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services Nov 2021

2021-11-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Care) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …


Systematic Review Comparing All-Cause Mortality Rates Between Tavr And Savr To Treat High Risk Surgical Patients With Severe Aortic Stenosis, Emily Belz Nov 2021

Systematic Review Comparing All-Cause Mortality Rates Between Tavr And Savr To Treat High Risk Surgical Patients With Severe Aortic Stenosis, Emily Belz

Physician Assistant Studies | Student Authored Articles

Background: Our goal was to conduct a systematic review of available randomized controlled trials to compare the safety and efficacy of TAVR to SAVR by looking at absolute risk reduction in all-cause mortality for high risk surgical patients with severe aortic stenosis at 1, 2 and 5 years post-intervention.

Methods/Results: The PubMed database was searched according to the PRISMA guidelines from inception until September 2020. 6 high quality randomized controlled trials analyzing all-cause mortality for TAVR versus SAVR in the CoreValve US High-Risk Clinical Study and Placement of Aortic Transcatheter Valves (PARTNER) Trial populations at 1, 2 and 5 years …


The Kardashian Index Of Cardiologists: Do More Social Media Followers Mean More Citations Or Merely Celebrity Status In Academia?, Talal Almas, Maheera Farooqi, Vikneswaran Raj Nagarajan, Muhammad Ali Niaz, Absam Akbar, Yohan Porus Irani, Jung Hur, Josef Finsterer Nov 2021

The Kardashian Index Of Cardiologists: Do More Social Media Followers Mean More Citations Or Merely Celebrity Status In Academia?, Talal Almas, Maheera Farooqi, Vikneswaran Raj Nagarajan, Muhammad Ali Niaz, Absam Akbar, Yohan Porus Irani, Jung Hur, Josef Finsterer

Medical College Documents

No abstract provided.


Impact Of Front-Of-Pack Labels On The Perceived Healthfulness Of A Sweetened Fruit Drink: A Randomised Experiment In Five Countries, Alejandra Jauregui, Christine M. White, Lana Vanderlee, Marissa G. Hall, Alejandra Contreras-Manzano, Claudia Nieto, Gary Sacks, Jim Thrasher Ph.D., Ma, Ms, David Hammond, Simón Barquera Nov 2021

Impact Of Front-Of-Pack Labels On The Perceived Healthfulness Of A Sweetened Fruit Drink: A Randomised Experiment In Five Countries, Alejandra Jauregui, Christine M. White, Lana Vanderlee, Marissa G. Hall, Alejandra Contreras-Manzano, Claudia Nieto, Gary Sacks, Jim Thrasher Ph.D., Ma, Ms, David Hammond, Simón Barquera

Faculty Publications

Objective: Front-of-pack (FOP) nutrition labelling is a globally recommended strategy to encourage healthier food choices. We evaluated the effect of FOP labels on the perceived healthfulness of a sweetened fruit drink in an international sample of adult consumers.

Design: Six-arm randomised controlled experiment to examine the impact of FOP labels (no label control, Guideline Daily Amounts (GDA), Multiple Traffic Lights, the Health Star Ratings (HSR), Health Warning Labels, and 'High-in' Warning Labels (HIWL)) on the perceived healthfulness of the drink. Linear regression models by country examined healthfulness perceptions on FOP nutrition labels, testing for interactions by demographic characteristics.

Setting: Online …


Reproductive Health Policy Saga: Restrictive Abortion Laws In Low- And Middle-Income Countries (Lmics), Unnecessary Cause Of Maternal Mortality, Ngo Valery Ngoa, Ngambouk Vitalis Pemuntaa, Basil N. Nduma, Fokunang Estella Tembe, Mbong Sidonnie Eyambe, Keziah Ezra, Henry Che Ngwa, Emmanuel Ombugadu Sabo Nov 2021

Reproductive Health Policy Saga: Restrictive Abortion Laws In Low- And Middle-Income Countries (Lmics), Unnecessary Cause Of Maternal Mortality, Ngo Valery Ngoa, Ngambouk Vitalis Pemuntaa, Basil N. Nduma, Fokunang Estella Tembe, Mbong Sidonnie Eyambe, Keziah Ezra, Henry Che Ngwa, Emmanuel Ombugadu Sabo

Health & Biomedical Sciences Faculty Publications

Abortion is a common but controversial phenomenon globally. The discourse on the legality of abortion remains intricate, leaving a substantial number of women restricted from accessing safe abortion. There are evidence of an association between restrictive abortion laws, unsafe abortions, and maternal mortality in low-and middle-income countries (LMICs). We explore how restrictive abortion laws violate women’s right to health and bodily integrity. We used Carol Bacchi’s policy framework to analyze how restrictive abortion laws have been discursively framed (problematization); the assumptions that underpinned the representation; the consequences of the representation; what was left unproblematic; how the representation could be questioned, …


Resilience And Health Outcomes Of Sexual Minority Middle-Aged And Older Adults, Christi L. Nelson Nov 2021

Resilience And Health Outcomes Of Sexual Minority Middle-Aged And Older Adults, Christi L. Nelson

USF Tampa Graduate Theses and Dissertations

While research on lesbian, gay, and bisexual (hereafter referred to as sexual minority) middle-aged and older adults has increased over the past decade, there is still a critical need for more research on the health and resilience in this growing subpopulation. Research has provided evidence that sexual minority adults have an increased risk of negative health outcomes when compared to heterosexual adults. Research has also demonstrated possible resilience in sexual minority middle-aged and older adults; however, few studies have measured resilience in middle-aged and older adults. Gaining a better understanding of resilience in sexual minority adults may help identify modifiable …


A High-Resolution Hla Reference Panel Capturing Global Population Diversity Enables Multi-Ethnic Fine-Mapping In Hiv Host Response, Yang Luo, Masahiro Kanai, Wanson Choi, Xinyi Li, John Blangero, Joanne E. Curran, Ravi Duggirala, Harald H. H. Goring, Michael C. Mahaney, Juan M. Peralta Nov 2021

A High-Resolution Hla Reference Panel Capturing Global Population Diversity Enables Multi-Ethnic Fine-Mapping In Hiv Host Response, Yang Luo, Masahiro Kanai, Wanson Choi, Xinyi Li, John Blangero, Joanne E. Curran, Ravi Duggirala, Harald H. H. Goring, Michael C. Mahaney, Juan M. Peralta

School of Medicine Publications

No abstract provided.


Genetic Landscape And Emerging Therapies In Uveal Melanoma, Rino S Seedor, Marlana Orloff, Takami Sato Nov 2021

Genetic Landscape And Emerging Therapies In Uveal Melanoma, Rino S Seedor, Marlana Orloff, Takami Sato

Department of Medical Oncology Faculty Papers

Despite successful treatment of primary uveal melanoma, up to 50% of patients will develop systemic metastasis. Metastatic disease portends a poor outcome, and no adjuvant or metastatic therapy has been FDA approved. The genetic landscape of uveal melanoma is unique, providing prognostic and potentially therapeutic insight. In this review, we discuss our current understanding of the molecular and cytogenetic mutations in uveal melanoma, and the importance of obtaining such information. Most of our knowledge is based on primary uveal melanoma and a better understanding of the mutational landscape in metastatic uveal melanoma is needed. Clinical trials targeting certain mutations such …


Mirna-30e Downregulation Increases Cancer Cell Proliferation, Invasion And Tumor Growth Through Targeting Rps6kb1, Lin Wang, Xiang-Bo Ji, Li-Hong Wang, Zhong-Kun Xia, Yun-Xia Xie, Wen-Jing Liu, Jian-Ge Qiu, Bing-Hua Jiang, Ling-Zhi Liu Nov 2021

Mirna-30e Downregulation Increases Cancer Cell Proliferation, Invasion And Tumor Growth Through Targeting Rps6kb1, Lin Wang, Xiang-Bo Ji, Li-Hong Wang, Zhong-Kun Xia, Yun-Xia Xie, Wen-Jing Liu, Jian-Ge Qiu, Bing-Hua Jiang, Ling-Zhi Liu

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Human esophagus carcinoma (EC) is one of the most common malignant tumors, especially in Africa and Asia including China. In EC initiation and progression, genetic and epigenetic aberrations have been reported to play a major role, but the underlying molecular mechanisms are largely unknown. In this study, the miR-30e levels were analyzed in human EC tissues and TCGA databases, and the results demonstrated that miR-30e expression in EC tissues was significantly decreased compared to adjacent normal tissues. To further investigate the role of miR-30e in cancer cells, we found that forced expression of miR-30e dramatically inhibited cell proliferation, invasion, tube …