Copper Sulfide Manganese Nanoparticles For Multimodality Imaging And Therapy, Ali S. Gawi Ermi

Theses and Dissertations

Abstract

COPPER SULFIDE MANGANESE NANOPARTICLES FOR MULTIMODALITY IMAGING AND THERAPY

By Ali S. Gawi Ermi, MSc

Inorganic nanoparticles (NPs) are compatible with metal-based multi-modality molecular imaging and targeted therapy. Copper sulfide nanoparticles (CuS NPs) are attractive photoacoustic and photothermal agents and are amenable to incorporation of radionuclides and paramagnetic elements to facilitate image-guided therapy. The aim of this work is to develop manganese (Mn)- doped CuS NP, intrinsically radiolabeled with radionuclides such as (Zirconium-89 (⁸⁹Zr), Copper-64/67 (^64/67Cu) and Manganese-52/55 (^52/55Mn)). This novel approach combines Photoacoustic (PA), Positron emission tomography (PET), Single-photon emission computed tomography …

The Association Between An Established Chief Experience Officer Role And Hospital Patient Experience Scores, W. Breen, Seongwon Choi, K. Herald, S. J. O'Connor, E. Rafalski, N. Borkowski

Health Care Administration Faculty Research

The healthcare industry is currently reacting to multiple stakeholders demanding improvements to the patient experience. Some healthcare organizations are implementing new management structures, i.e., the role of Chief Experience Officer (CXO). This study statistically reviewed descriptors associated with hospitals that have and have not created and filled the role of CXO and, more importantly, measured the association between the CXO role and results of patients’ perceptions of their experience of care as measured by publicly reported Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) results. This study was conducted utilizing data gather on hospitals in three states, California, Florida, …

Is Germline Gene Editing Exceptional?, Myrisha S. Lewis

Faculty Publications

Advances in gene editing have recently received significant scientific and media attention. Gene editing, especially CRISPR-Cas9, has revived multiple longstanding ethical debates, including debates related to parental autonomy, health disparities, disability perspectives, and racial and economic inequalities. Germline, or heritable, gene editing generates several newer, neglected bioethical debates, including those about the shared human germline and whether there is a "line" that humans should not cross.

This Article addresses several interrelated ethical and legal questions related to germline gene editing. Those questions address why, if at all, germline gene editing needs to be regulated and, if germline gene editing needs …

Analyzing Tweets On New Norm: Work From Home During Covid-19 Outbreak, Swapna Gottipati, Kyong Jin Shim, Hui Hian Teo, Karthik Nityanand, Shreyansh Shivam

Research Collection School Of Computing and Information Systems

The COVID-19 pandemic triggered a large-scale work-from-home trend globally in recent months. In this paper, we study the phenomenon of “work-from-home” (WFH) by performing social listening. We propose an analytics pipeline designed to crawl social media data and perform text mining analyzes on textual data from tweets scrapped based on hashtags related to WFH in COVID-19 situation. We apply text mining and NLP techniques to analyze the tweets for extracting the WFH themes and sentiments (positive and negative). Our Twitter theme analysis adds further value by summarizing the common key topics, allowing employers to gain more insights on areas of …

Risk Factors For Amyotrophic Lateral Sclerosis: A Regional United States Case-Control Study., Angeline S Andrew, Walter G Bradley, Daniel Peipert, Tanya Butt, Kwadwo Amoako, Erik P Pioro, Rup Tandan, John Novak, Adam Quick, K Doug Pugar, Komal Sawlani, Bashar Katirji, Todd A Hayes, Pamela Cazzolli, Jiang Gui, Paul Mehta, D Kevin Horton, Elijah W Stommel

Ambulatory and Primary Care Articles

Most amyotrophic lateral sclerosis (ALS) cases are considered sporadic, without a known genetic basis, and environmental exposures are thought to play a causal role. To learn more about sporadic ALS etiology, we recruited n = 188 ALS patients from northern New England and Ohio and matched controls 2:1 from the general population of the same regions. Questionnaires evaluated the association between a variety of lifestyle, behavioral (ie, hobbies and activities), and occupational factors and the risk of ALS, including the duration of time between exposure and ALS onset, and exposure frequency. Head trauma was associated with increased ALS risk (adjusted …

Annual Cost Burden By Level Of Relapse Severity In Patients With Multiple Sclerosis., Jacqueline Nicholas, Huanxue Zhou, Chinmay Deshpande

Ambulatory and Primary Care Articles

INTRODUCTION: The severity of relapses varies in multiple sclerosis (MS) and may lead to a differential cost burden. This study aimed to characterize the direct healthcare costs associated with relapses in patients with MS by the level of relapse severity.

METHODS: This retrospective analysis used claims data extracted from the MarketScan

RESULTS: In total, 8775 patients with MS were analyzed: 6341 (72%) in the NR cohort, 1929 (22%) in the MMR cohort, and 505 (6%) in the SR cohort. Overall, patients were mostly female (76%), mean age was 50 years, and 25% were on a disease-modifying therapy. Mean (standard deviation …

Tsetse Blood-Meal Sources, Endosymbionts And Trypanosome-Associations In The Maasai Mara National Reserve, A Wildlife-Human-Livestock Interface, Edward Edmond Makhulu, Jandouwe Villinger, Vincent Owino Adunga, Maamun M. Jeneby, Edwin Murungi Kimathi, Enock Mararo, Joseph Wang’Ang’A Oundo, Ali Abdulahi Musa, Lillian Wambua

All Peer-Reviewed Publications

African trypanosomiasis (AT) is a neglected disease of both humans and animals caused by Trypanosoma parasites, which are transmitted by obligate hematophagous tsetse flies (Glossina spp.). Knowledge on tsetse fly vertebrate hosts and the influence of tsetse endo-symbionts on trypanosome presence, especially in wildlife-human-livestock interfaces, is limited. We identified tsetse species, their blood-meal sources, and correlations between endosymbionts and trypanosome presence in tsetse flies from the trypanosome-endemic Maasai Mara National Reserve (MMNR) in Kenya. Among 1167 tsetse flies (1136 Glossina pallidipes, 31 Glossina swynnertoni) collected from 10 sampling sites, 28 (2.4%) were positive by PCR for trypanosome DNA, most (17/28) …

Agency, Gender And Development In Oromia, Ethiopia, Kristie Drucza, Lemlem Aregu, Mulunesh Tsegaye

All Peer-Reviewed Publications

This paper argues that the postcolonial revolution in knowledge about gender and power relations has not touched the agricultural sector nor literature. Using the validation data from a medium-n qualitative data study in Amhara and Oromia, Ethiopia, the paper presents a case study on farm gate selling to show how a nuclear family model is shaped by power relations that are seeded in the colonial past and yet are reproduced in the present. Ethiopian men do not share resources equally with their wife/family. So, women need to ‘help themselves’ to the stored harvest to manage the household’s needs. The paper …

Visual Perception And Action In Reaching During Upper Limb Obstacle Avoidance, Nondon Chakraborty

Theses and Dissertations (Comprehensive)

During everyday activities, people reach to specific objects with their hands and avoid obstacles. For people to move successfully through an obstacle gap, it is necessary to be able to accurately perceive the actions that the surroundings afford and adjust hand movements accordingly. Reaching behaviours, including planning (perception) and execution (action), depend on visual information. This study aimed to understand and detect the differences between perceptual judgment and actual performance of both hands during a reaching task at the time of obstacle avoidance by using a hand-scaled approach. Participants were young adults (male (n=7) and female (n=10) aged 18 to …

The Experiences Of Women Who Have A Child Diagnosed With An Eating Disorder: A Narrative Inquiry, Jennifer Scarborough

Theses and Dissertations (Comprehensive)

Eating disorders (EDs) are serious, life-threatening illnesses that typically occur in adolescence. Immediate intervention is necessary in order to interrupt the associated behaviours. Typically, adolescents struggling with EDs minimize the severity the illness has on their psychological and physiological wellbeing. For this reason, family involvement in the intervention is strongly recommended. Additionally, family involvement has shown to increase the likelihood of better outcomes. Parents are typically tasked with the responsibility of making and monitoring meals and/or interrupting compensatory behaviours. These tasks often lead to high conflict. Despite the importance of parental involvement, predominantly, it is mothers who fulfill the intensive …

The Impact Of Combined Flexion And Compression On The Mechanical Integrity Of The Annulus Fibrosus, Keaton Briar

Theses and Dissertations (Comprehensive)

Introduction: Intervertebral disc (IVD) herniation is characterized by an expulsion of nucleus pulposus (NP) material through the annulus fibrosus (AF). The AF contains two major adhesive structures, the intralamellar matrix and the interlamellar matrix, which act to maintain the strength of the AF and prevent NP material migration. As a herniation occurs, clefts form within the intralamellar matrix, pushing the NP between adjacent collagen fibres; meanwhile, delamination of the interlamellar matrix causes the NP to pool between layers of the AF. Further, herniation more readily occurs in a combined loading scenario of both compression and flexion. Flexion, and in particular …

The Lived Experiences Of Developmental Disability Caregivers And Service Providers In Ontario, Tetyana Ali

Theses and Dissertations (Comprehensive)

Providing care for children with developmental disabilities (CwDD) is complex and is a life-long journey. Caregivers (CGs) of CwDD experience higher levels of stress, declining mental and physical health, feelings of isolation, diminished financial outcomes, and an overall lower quality of life. Additionally, they often face marginalization and numerous barriers when trying to access funding and supports. This study explored the experiences of CGs of CwDD in the context of Ontario and included the perspectives of CGs and service providers (SPs) to investigate the role the government played in CGs ability to provide adequate care.

Twenty participants were recruited through …

Second Generation Christian Korean Canadians: Exploring Their Lived Experiences Of Mental Health Issues And Services, Kyoung Jung Kim

Theses and Dissertations (Comprehensive)

Abstract

This study explores the lived experiences of second-generation Christian Korean Canadian young adults with mental health issues (MHI) and their use of health services (MHS). In addition, this study asked this cohort to discuss their beliefs about the views their parents held about MHI and MHS. All research participants were born and raised in Canada by Korean born immigrant parents. This study was descriptive, phenomenological, and qualitative in nature; it consisted of in-depth interviews with six male and six female participants. In their experience with MHI, seven participants experienced fear and sadness (depression and anxiety) and three of them …

Don’T Take My Breath Away: A Case Of High-Risk Pulmonary Embolism In The Setting Of Patent Foramen Ovale Requiring Extracorporeal Membrane Oxygenation, Amy Lam Do, Sonali Bishnoi, Jeffrey Wright Do, Kaitlyn Musco Md, Scott Blumof Do

Department of Medicine

No abstract provided.

Physical Therapy Evaluations In The Emergency Department Can Reduce Costs For Patients Presenting With Dizziness, Daniel Sawyer Pt, Dpt, Nicholas Boyd, Arielle Burris

Department of Medicine

No abstract provided.

Establishing An Interprofessional Care Pathway Across The Continuum For Patients Following Implantation Of Left Ventricular Assist Device, Katy Blessing Dpt, Katelin Gorski, Nicholas Hoster, Joseph Paluck, Julie Patterson, Hannah Simko, Stephen Walker, Elizabeth A. Wetzler

Department of Medicine

No abstract provided.

Does Obesity Affect Outcomes In Acute Pancreatitis?, Rajesh Essrani Md, Muhammad Usman Zafar, Hiral N. Shah Md

Department of Medicine

No abstract provided.

Sulfasalazine-Induced Neutropenic Enterocolitis, Rajesh Essrani Md, Anastasia Shnitser Md

Department of Medicine

No abstract provided.

Effect Of Clostridium Difficile Infection On Hospita, Rajesh Essrani Md, Muhammad Usman Zafar, Hiral N. Shah Md

Department of Medicine

No abstract provided.

To Determine The Efficacy Of Bilateral Inferior Petrosal Sinus Sampling In Differentiating Cushing Disease From Ectopic Cushing Syndrome, Muhammad Azeemuddin, Tanveer Ul Haq, Shahmeer Khan, Raza Sayani, Ayesha Shoukat Hussain, Rumaisa Khan

Department of Radiology

Management of endogenous Cushing syndrome is based on its aetiology. Increased Adrenocorticotropic Hormone (ACTH) levels are the most common cause of this disorder and, therefore, it is critical to determine the source of ACTH before further management. Dynamic post contrast MRI is currently the most common investigation implied to diagnose pituitary adenoma; however, it comes with the drawback of low specificity and high false positive results. Inferior petrosal sinus sampling (IPSS) is an established invasive procedure performed to differentiate central versus peripheral source of ACTH which, in turn, results in hypercortesolaemia. This is a series of 14 patients who underwent …

Canine-Assisted Exposure Therapy, Stephanie B. Bono

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Fear and anxiety are natural reactions to actual threat conditions but can become “pathological” when over-generalized avoidance interferes with long-term wellbeing and valued living. Pervasive experiential avoidance hinders natural extinction processes as it reduces repeated contact with feared stimuli, a condition necessary for extinction to occur. Exposure therapy (ET) is a clinical analogue of extinction, and one of the best evidence-based treatments for fear and anxiety. However, ET’s usefulness suffers in real-world clinical conditions. The current conceptual paper proposes that ET’s limitations may be overcome through a tailored approach that integrates animal-assisted therapy (AAT), specifically the use of dogs, to …

White Paper On Engineering Controls For Bioaerosols In Non-Industrial/ Non-Healthcare Settings, Cheri L. Marcham, American Conference Of Governmental Industrial Hygienists

Publications

The list of disease pathogens that can be transmitted in the air is extensive. This list includes the common cold, SARS, measles, Hansen's disease (leprosy), polio, influenza, Legionella (Legionnaires’ disease and Pontiac fever), and tuberculosis (TB). TB, SARSCoV-1, avian influenza, varicella, and now SARS-CoV-2 all have received public notice due not only to their known or assumed ability to be transmitted in the air rapidly from one individual to another, but also for their virulence. Other bioaerosols that can be transmitted through the air include bacteria, fungal spores and fragments, dust mites, and pollen. This document was developed to address …

Divergent Attitudes Regarding The Benefits Of Face Masks In Aviation Colleges And Universities, Andrew R. Dattel, Peiheng Gao, Hanzi Xie, Maxine E. Lubner

Publications

Opinions and practices regarding face masks (FM) to attenuate COVID-19’s spread remains polarized across the United States. We examined whether these attitudes extend to the aviation collegiate community. A 14-question survey was sent to 90 aviation colleges and universities throughout the country. Responses were solicited from students, faculty, and staff. Of the 598 respondents, 77% were students, 13% were faculty, and 10% were staff. Pilots comprised 66% of the respondents. A Principal Component Analysis reduced the questions to two scales: Benefits and Inconvenience. Females, non-pilots, and older respondents reported greater benefits to wearing a FMand fewer inconveniences. A multiple regression …

An Examination Of The Impact Of The Covid-19 Health Threat, Stress, And Social Isolation On Lifestyle Habits As Analyzed Through The Protection Motivation Theory, Luciana Adib Soares

UNF Graduate Theses and Dissertations

The COVID-19 emerged in China in 2019 and quickly spread to other countries, leading to mandated lockdowns and social isolation. This cross-sectional study examined the impact of the COVID-19-generated stress, health threat, and social isolation on dietary, physical activity, and self-care habits of adults in Florida, utilizing the PMT as a framework. Participants (n = 478) completed online surveys about demographics, perceived stress, and changes in lifestyle habits. Significant positive changes were reported in cooking at home (p < .001) frequency, sweets (p < .001), and breakfast (p = .009) consumption, outdoors physical activity (p = .005), self-care (p < .001), relaxation (p < .001), and rest (p < .001) habits. Significant negative changes were reported in fast food (p = .004) and snack (p < .001) consumption. A significant relationship existed between self-reported stress, perceived threat, (r = .33, p < .001), and perceived efficacy, (r = -.15, p = .002). Perceived threat was the most important predictor of changes …

Parents' Attitudes And Beliefs Towards Dietary Behaviors Of Children With Autism Aged 5-13 Years, Subashree Narayanan

UNF Graduate Theses and Dissertations

Autism is a neurodevelopmental disability that may affect nutritional management of children with autism. Parent’s attitudes and their behavior towards healthy eating reflects on the child’s eating habits and thus, their nutritional health. This study aimed to describe the diet quality of children with autism using the Healthy Eating Index (HEI) scores. It also aimed to assess the relationship between parent’s perceived barriers and self-efficacy and children’s dietary behavior and dietary intake (age 5-13 years). The relationship was assessed using 2 questionnaires, Nutrition and Health Awareness and BAMBI questionnaire for parent’s attitudes and beliefs and dietary behavior, respectively. Dietary intake …

Discrimination Of Immune Cell Activation Using Ramanmicro-Spectroscopy In Anin-Vitro & Ex-Vivo Model, Neha Chaudhary, Thi Nguyet Que Nguyen, Daniel Cullen, Aidan Meade, Claire Wynne

Articles

Activation and proliferation of immune cells such as lymphocytes and monocytes are appropriate inflammatory responses to invading pathogens and are key to overcoming an infection. In contrast, uncontrolled and prolonged activation of these cellular signalling pathways can be deleterious to the body and result in the development of autoimmune conditions. The understanding of cellular activatory status therefore plays a significant role in disease diagnosis and progression. Conventional automated approaches such as enzyme linked immunosorbent assays (ELISA) and immune-labelling techniques are time-consuming and expensive, relying on a commercially available and specific antibody to identify cell activation. Developing a label-free method for …

Optical Fibre Based Real-Time Measurements During An Ldr Prostate Brachytherapy Implant Simulation: Using A 3d Printed Anthropomorphic Phantom, P. Woulfe, Francis John Sullivan, L. Byrne, Andrea Jane Doyle, W. Kam, M. Martin, S. O'Keeffe

Articles

An optical fbre sensor based on radioluminescence, using the scintillation material terbium doped gadolinium oxysulphide (Gd2O2S:Tb) is evaluated, using a 3D printed anthropomorphic phantom for applications in low dose-rate (LDR) prostate brachytherapy. The scintillation material is embedded in a 700 µm diameter cavity within a 1 mm plastic optical fbre that is fxed within a brachytherapy needle. The high spatial resolution dosimeter is used to measure the dose contribution from Iodine-125 (I-125) seeds. Initially, the efects of sterilisation on the sensors (1) repeatability, (2) response as a function of angle, and (3) response as a function of distance, are evaluated …

Extending Postpartum Medicaid: State And Federal Policy Options During And After Covid-19, Jamie R. Daw, Emily Eckert, Heidi Allen, Kristen Underhill

Faculty Scholarship

The United States is facing a maternal health crisis with rising rates of maternal mortality and morbidity and stark disparities in maternal outcomes by race and socioeconomic status. Among the efforts to address this issue, one policy proposal is gaining particular traction: extending the period of Medicaid eligibility for pregnant women beyond 60 days after childbirth. The authors examine the legislative and regulatory pathways most readily available for extending postpartum Medicaid, including their relative political, economic, and public health trade-offs. They also review the state and federal policy activity to date and discuss the impact of the COVID-19 pandemic on …

The Big Data Regulator, Rebooted: Why And How The Fda Can And Should Disclose Confidential Data On Prescription Drugs And Vaccines, Christopher J. Morten, Amy Kapczynski

Faculty Scholarship

Medicines and vaccines are complex products, and it is often extraordinarily difficult to know whether they help or hurt. The Food and Drug Administration (FDA) holds an enormous reservoir of data that sheds light on that precise question, yet currently releases only a trickle to researchers, doctors, and patients. Recent examples show that data secrecy can be deadly, and existing laws such as the Freedom of Information Act (FOIA) cannot solve the problem. We present here a wealth of new evidence about the urgency of the problem and argue that the FDA must “reboot” its rules to proactively disclose all …

Strategic Implications Of Covid-19: Considerations For Georgia’S Rural Health Providers, Bettye A. Apenteng, Linda Kimsey, Charles Owens, Samuel T. Opoku, Angela Peden, William Mase

Health Policy & Community Health: Faculty Publications

Whether rural hospitals and providers have seen a surge in COVID-19 cases or a reduction in patients seeking care since the pandemic began, their financial condition has been negatively impacted. Many providers have now received some emergency funding through the Coronavirus Aid, Relief, and Economic Security Act and the Payroll Protection Program but these are likely only short-term fixes. For many, the crisis has exacerbated already existing problems. Notable among these problems are volume declines, supply chain disruptions, and workforce concerns. While these problems require immediate action, two longer-term systemic changes to rural healthcare delivery are needed to address them. …