Medicine and Health Sciences Commons^™

Evaluation Of Student Pharmacists’ Attitudes And Perceptions Of Hormonal Contraception Prescribing In Indiana, J. Henry Papineau, Jenny L. Newlon, Ryan S. Ades, Veronica Vernon, Tracey A. Wilkinson, Lynn M. Thoma, Ashley H. Meredith

Department of Pharmacy Practice Faculty Publications

Community pharmacists’ scope of practice is expanding to include hormonal contraceptive prescribing. Prior to introducing statewide legislation, it is important to assess the perceptions of future pharmacists. A cross-sectional survey was distributed to 651 third- and fourth-year professional students enrolled at three colleges of pharmacy in Indiana. Data were collected between September and October 2019 to assess students’ attitudes about prescribing hormonal contraceptives, readiness to prescribe, perceived barriers, and desire for additional training. In total, 20.9% (n = 136) students responded. Most (89%, n = 121) believe that pharmacist-prescribed hormonal contraceptives would be beneficial to women in Indiana, and 91% …

Ifit3 (Interferon Induced Protein With Tetratricopeptide Repeats 3) Modulates Stat1 Expression In Small Extracellular Vesicles., Nicole M Naranjo, Israa Salem, Maisha A Harris, Lucia R Languino

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

We have previously shown that the αvβ6 integrin plays a key role in promoting prostate cancer (PrCa) and it can be transferred to recipient cells via small extracellular vesicles (sEVs). Furthermore, we have reported in a proteomic analysis that αvβ6 integrin down-regulation increases the expression of IFIT3 (interferon induced protein with tetratricopeptide repeats 3) in PrCa cells and their derived sEVs. IFIT3 is a protein well known for being an antiviral effector, but recently its role in cancer has also been elucidated. To study the relationship between IFIT3 and STAT1 (signal transducer and activator of transcription 1), an upstream regulator …

Biotinylation As A Tool To Enhance The Uptake Of Small Molecules In Gram-Negative Bacteria, Ankit Pandeya, Ling Yang, Olaniyi Alegun, Chamikara Karunasena, Chad Risko, Zhenyu Li, Yinan Wei

Chemistry Faculty Publications

Antibiotic resistance is a major public health concern. The shrinking selection of effective antibiotics and lack of new development is making the situation worse. Gram-negative bacteria more specifically pose serious threat because of their double layered cell envelope and effective efflux systems, which is a challenge for drugs to penetrate. One promising approach to breach this barrier is the “Trojan horse strategy”. In this technique, an antibiotic molecule is conjugated with a nutrient molecule that helps the antibiotic to enter the cell through dedicated transporters for the nutrient. Here, we explored the approach using biotin conjugation with a florescent molecule …

Investigating The Growth Of Algae Under Low Atmospheric Pressures For Potential Food And Oxygen Production On Mars, Leena M. Cycil, Elisabeth M. Hausrath, Douglas W. Ming, Christopher T. Adcock, James Raymond, Daniel Remias, Warren P. Ruemmele

Geoscience Faculty Research

With long-term missions to Mars and beyond that would not allow resupply, a self-sustaining Bioregenerative Life Support System (BLSS) is essential. Algae are promising candidates for BLSS due to their completely edible biomass, fast growth rates and ease of handling. Extremophilic algae such as snow algae and halophilic algae may also be especially suited for a BLSS because of their ability to grow under extreme conditions. However, as indicated from over 50 prior space studies examining algal growth, little is known about the growth of algae at close to Mars-relevant pressures. Here, we explored the potential for five algae species …

Contribution Of Retinal Ganglion Cells To Brown-Norway Rat Spatiotemporal Visual Perception And The Electroretinogram, Nicholas P. Johnson

USF Tampa Graduate Theses and Dissertations

Retinal Ganglion Cells (RGCs) are the sole cells through which visual information is transmitted from the eye to the brain. As such, RGC dysfunction has a dramatic effect on vision and perception. Retinal neurodegenerative diseases, such as glaucoma, are one of the leading causes of blindness worldwide. The study of these diseases requires well-characterized models in order to swiftly and effectively develop diagnostic tools and therapeutics. This dissertation aims to characterize specific properties of the visual system of the Brown-Norway rat. First, visual processing was evaluated in awake, freely moving rats. Contrast sensitivities of Brown-Norway rats were characterized by discrimination-driven …

Decisions And How Doctors Make Them: Modeling Multilevel Decision-Making Within Diagnostic Medicine, Michelle S. Kaplan

USF Tampa Graduate Theses and Dissertations

Effective decision-making is critical and necessary for organizational success across a wide range of occupations, situations, and industries. However, decision making, by its nature, is not always a direct process of a single decision leading to a direct outcome. Rather, it can often become a multilevel process whereby one decision’s outcome leads to information that is used in subsequent larger or other types of decisions. The decision-making process then becomes progressively more complex and more difficult to navigate as these decisions compound within one another. Thus, decision-makers must find an appropriate way to approach such decisions. Understanding the multilevel nature …

Managing Incomplete Data In The Patient Discharge Summary To Support Correct Hospital Reimbursements, Fadi Naser Eddin

USF Tampa Graduate Theses and Dissertations

The patient discharge summary is a document that conveys the patient's story to other healthcare practitioners, external users, and, most importantly from a financial perspective, health insurers. A defect or incompleteness in the patient's discharge summary will result in delays in the collection process through denial of the entire or partial reimbursement claim or, in the best-case scenario, delay until the discharge summary issue is resolved. The purpose of this project is to address the issue of the incompleteness of discharge summary from the perspective of healthcare providers, with the goal of understanding, diagnosing, and intervening in the research problem. …

Moving In Fluid: Exploring How Fishes Manipulate Water To Swim Efficiently, Nils B. Tack

USF Tampa Graduate Theses and Dissertations

Moving through a dense fluid such as water presents some unique challenges to minimizing energy use and maximizing performance (i.e., speed). Due to animal-fluid interactions during swimming (drag and thrust production) fish have evolved a variety of morphological structures and locomotor mechanisms. For instance, fish rely on body bending and/or fins to interact with the surrounding water such that energy can be transferred to generate thrust. Typically, this synergy promotes morphologies and behaviors aimed at enhancing propulsive efficiency and/or minimizing metabolic activity to lessen the cost of transport (COT). This work focuses on quantifying the energetic and hydromechanical benefits of …

Mapk6-Akt Signaling Promotes Tumor Growth And Resistance To Mtor Kinase Blockade, Qinbo Cai, Wolong Zhou, Wei Wang, Bingning Dong, Dong Han, Tao Shen, Chad J Creighton, David D Moore, Feng Yang

Faculty, Staff and Students Publications

Mitogen-activated protein kinase 6 (MAPK6) is an atypical MAPK. Its function in regulating cancer growth remains elusive. Here, we reported that MAPK6 directly activated AKT and induced oncogenic outcomes. MAPK6 interacted with AKT through its C34 region and the C-terminal tail and phosphorylated AKT at S473 independent of mTORC2, the major S473 kinase. mTOR kinase inhibitors have not made notable progress in the clinic. Our identified MAPK6-AKT axis may provide a major resistance pathway. Besides repressing growth, inhibiting MAPK6 sensitized cancer cells to mTOR kinase inhibitors. MAPK6 overexpression is associated with decreased overall survival and the survival of patients with …

Development And Immunogenicity Of A Prototype Multivalent Group B Streptococcus Bioconjugate Vaccine, Jeremy A Duke, Amy V Paschall, Lloyd S Robinson, Cory J Knoot, Evgeny Vinogradov, Nichollas E Scott, Mario F Feldman, Fikri Y Avci, Christian M Harding

2020-Current year OA Pubs

Group B

Impact Of Registered Nurse Burnout On Patient Satisfaction, Addie Mctyre, Emily Herring, Caitlin Kelley, Michala Le, Modupe Adewuyi

Symposium of Student Scholars

BACKGROUND

The Covid-19 pandemic has drawn more attention to burnout, a self-reported job-related syndrome experienced by registered nurses. Despite studies showing that poor self-health and job satisfaction are associated with registered nurses’ burnout, little synthesized evidence is known about the impact on patient’s safety and satisfaction, especially during the Covid-19 pandemic.

OBJECTIVE

To determine the impact of registered nurse burnout on patient safety and satisfaction.

METHODS

Through the guidance of our PRISMA 2020 statement, a systematic review was performed. The databases; Pubmed, ScienceDirect, Cochrane Library, Pubmed Central, and MEDLINE were searched using specific keywords to find relevant studies. Fifteen of …

Evidence-Based Practice: Nurse-To-Patient Ratios And Length Of Stay In The Emergency Department, Gina Hicks, Christine Landers, Rachel Abukhdeir, Quanta Bailey, Alem Assefa, Modupe Adewuyi

Symposium of Student Scholars

Background: The emergency department plays an essential role in delivering quality patient care. Factors that have contributed to fewer ED registered nurses are aging out of the field, lack of educators to teach nursing students which leads to fewer graduates entering the field, and burnout and exhausting of current registered nurses.

Purpose: The objective of our study was to determine the impact of the ratio of registered nurses to patients on length of stay in the emergency department.

Methods: We performed a systematic review identifying varying staffing levels and how they play a role in patient care. The PRISMA 2020 …

Important Message From Board Of Regents President Michael Richards, University Of Northern Iowa

UNI Response to COVID-19

Memo from the President of the Iowa Board of Regents concerning the state law regarding COVD-19 vaccinations and the Federal Executive Order 14042. Regents universities are to make recording employee status on vaccinations a voluntary option.

Standardized Screening For Peripheral Artery Disease In Primary Setting, Tamara Tomlin

Dissertations

Problem: Peripheral artery disease (PAD) affects eight million Americans and is the third leading cause of death in the U.S. in people 60-85 years of age. Veterans are at a 45% greater risk to develop PAD than non-veterans. Left untreated, PAD can progress to hospitalization for revascularization, amputation, or death. The American Heart Association (AHA) recommends using a standardized screening tool for the diagnosis of PAD; however, a lack of standardized screening is problematic in veterans receiving proper intervention.

Methods: This quality improvement (QI) project utilized a descriptive, observational design. The American Heart Association (AHA) screening tool was administered by …

Acceptance And Perception Of Digital Health For Managing Nutrition In People With Parkinson's Disease And Their Caregivers And Their Digital Competence In The United States: A Mixed-Methods Study, Dara Lobuono, K. Shea, A. Tovar, S. N. Leedahl, L. Mahler, F. Xu, I. E. Lofgren

Rita & Larry Salva School of Nursing and Health Professions Departmental Research

Background and aims: This mixed-methods study examined participants' acceptance and perception of using digital health for managing nutrition and participants' digital competence. The results will be formative for making digital nutrition education more effective and acceptable for people with Parkinson's disease (PwPD) and their informal caregivers. Methods: Qualitative data were collected through in-person semi-structured, dyadic interviews, and questionnaires from 20 dyads (20 PwPD and their caregivers) in the Northeastern United States and analyzed throughout the 2018 to 2019 academic year. Interview transcripts were deductively coded using the framework analysis method. Phrases related to acceptance of digital health were sub-coded into …

Acceptance And Perception Of Digital Health For Managing Nutrition In People With Parkinson's Disease And Their Caregivers And Their Digital Competence In The United States: A Mixed-Methods Study, Dara Lobuono, Kyla S. Shea, Alison Tovar, Skye N. Leedahl, Leslie Mahler, Furong Xu, Ingrid E. Lofgren

Rita & Larry Salva School of Nursing and Health Professions Departmental Research

Background and aims: This mixed-methods study examined participants' acceptance and perception of using digital health for managing nutrition and participants' digital competence. The results will be formative for making digital nutrition education more effective and acceptable for people with Parkinson's disease (PwPD) and their informal caregivers. Methods: Qualitative data were collected through in-person semi-structured, dyadic interviews, and questionnaires from 20 dyads (20 PwPD and their caregivers) in the Northeastern United States and analyzed throughout the 2018 to 2019 academic year. Interview transcripts were deductively coded using the framework analysis method. Phrases related to acceptance of digital health were sub-coded into …

Brain Fitness Program For Aging Individuals: Prevention Focused Program For Alzheimer’S Disease And Related Dementias, Mary M. Eisele

Department of Occupational Therapy Entry-Level Capstone Projects

The culminating project for my capstone experience was the introduction of a Brain Fitness course. This literature review assessed the public’s knowledge regarding the etiology of Alzheimer’s disease and related dementias (ADRD) as well as the need for a program focused on prevention and intervention for cognitive related diseases, such as ADRD. Studies have shown an association between modifiable lifestyle factors and the development of ADRD, however, there is a lack of knowledge regarding available interventions and preventions. The number of individuals in the community with a diagnosis of ADRD has risen exponentially and so has the need for family …

Allergic Bronchopulmonary Aspergillosis Misdiagnosed As Smear Negative Pulmonary Tuberculosis; A Retrospective Study From Pakistan, Nousheen Iqbal, Muhammad Dawood Amir Sheikh, Kauser Jabeen, Safia Awan, Muhammad Irfan

Section of Pulmonary & Critical Care

Background: Undiagnosed allergic bronchopulmonary aspergillosis (ABPA) can lead to chronic persistent symptoms. In country like Pakistan where tuberculosis (TB) is endemic, a significant proportion of ABPA patients are misdiagnosed as smear negative TB before reaching a diagnosis of ABPA due to chronicity of symptoms.This lead to empiric use of ATT(Anti-tuberculous therapy) and delay in primary diagnosis. The aim of the study is to determine such proportion of ABPA patients.|
Material and methods: This retrospective study was conducted at the outpatient pulmonology clinic of a tertiary care hospital in Karachi, Pakistan from January 2017 to December 2018. Xpert MTB/Rif, TB smear …

Sedation And Acute Encephalopathy In A Pediatric Patient Following Ingestion Of Delta-8-Tetrahydrocannabinol Gummies, Peter Akpunonu, Regan A. Baum, Andrew Reckers, Blake Davidson, Ross Ellison, Matthew Riley, Jordan Trecki, Roy Gerona

Emergency Medicine Faculty Publications

BACKGROUND Delta-8 tetrahydrocannabinol (delta-8 THC) is an isomer of delta-9-tetrahydrocannabinol (delta-9 THC), the primary psychoactive cannabinoid in the marijuana plant. Typically found at lower concentrations in marijuana, delta-8 THC exhibits psychoactive properties similar to delta-9 THC. Products containing delta-8 THC are readily available across the US and currently there is a lack of available confirmatory testing specific to delta-8 THC as there is cross-reactivity to other naturally occurring cannabinoids in standard immunoassays. Pediatric exposures to this substance are on the rise.

CASE REPORT We present a case with laboratory confirmation of a previously healthy 2-year-old girl ingesting approximately 15 mg/kg …

Examining Eating Attitudes And Behaviors In Collegiate Athletes, The Association Between Orthorexia Nervosa And Eating Disorders, Nancy A. Uriegas, Zachary K. Winkelmann, Kelly Pritchett, Toni M. Torres-Mcgehee

All Faculty Scholarship for the College of Education and Professional Studies

Purpose: Orthorexia nervosa (Orthorexia) is an eating attitude and behavior associated with a fixation on healthy eating, while eating disorders (EDs) are clinically diagnosed psychiatric disorders associated with marked disturbances in eating that may cause impairment to psychosocial and physical health. The purpose of this study was to examine risk for Orthorexia and EDs in student-athletes across sex and sport type and determine the association between the two.

Methods: Student-athletes (n = 1,090; age: 19.6 ± 1.4 years; females = 756; males = 334) completed a survey including demographics, the ORTO-15 test (values), the Eating Attitudes Test-26 (EAT-26; >20 …

A Novel Method For Ecg Signal Classification Via One-Dimensional Convolutional Neural Network, Xuan Hua, Jungang Han, Chen Zhao, Haipeng Tang, Zhuo He, Qinghui Chen, Shaojie Tang, Jinshan Tang, Weihua Zhou

Faculty Publications

This paper develops an end-to-end ECG signal classification algorithm based on a novel segmentation strategy and 1D Convolutional Neural Networks (CNN) to aid the classification of ECG signals and alleviate the workload of physicians. The ECG segmentation strategy named R-R-R strategy (i.e., retaining ECG data between the R peaks just before and after the current R peak) is used for segmenting the original ECG data into segments to train and test the 1D CNN models. The novel strategy mimics physicians in scanning ECG to a greater extent, and maximizes the inherent information of ECG segments for diagnosis. The performance of …

Managing Covid-19: Legal And Institutional Issues, Yon-Shik Lee

Minnesota Journal of Law, Science & Technology

No abstract provided.

Surgical Treatment Of Femoroacetabular Impingement: Minimum 10-Year Outcome And Risk Factors For Failure, Hamed Vahedi, Steven Yacovelli, Claudio Diaz, Javad Parvizi

Rothman Institute Papers

Background: Femoroacetabular impingement (FAI) is a well-known cause of hip pain and dysfunction in young adults. Surgical treatment has been widely popularized during the past decade. However, most reported results have been limited to short-term and intermediate-term follow-up. The long-term success rate and risk factors for failure are largely unknown. This study aimed to report the long-term (minimum, 10 years) clinical outcomes of surgical treatment of FAI and to describe the clinical and radiographic parameters associated with the failure of treatment involving femoroacetabular osteoplasty (FAO) and labral repair.

Methods: Using our prospective hip preservation database, 164 patients (178 hips) who …

The Fate Of Periprosthetic Joint Infection Following Megaprosthesis Reconstruction, Kamolsak Sukhonthamarn, Timothy L Tan, John Strony, Scot A. Brown, David Nazarian, Javad Parvizi

Rothman Institute Papers

Background: A megaprosthesis may be used for reconstruction in patients with massive bone loss or a periprosthetic fracture. Periprosthetic joint infection (PJI) may occur after a megaprosthesis reconstruction and may pose a major challenge. The outcomes of managing PJI in patients with a megaprosthesis is relatively unclear. The aim of this study was to investigate the clinical course and outcomes of PJI in patients with a megaprosthesis in place.

Methods: From a total of 219 patients who underwent megaprosthesis replacement for non-oncologic conditions, 38 (17.4%) developed subsequent PJI. A retrospective review of the medical record was performed to ascertain the …

Microbial Profile Of Lacrimal System Dacryolith In Midwest Patient Population, Peter Kally, Olivia Cheng, Thai Do, Dianne Schachter, Francesca Nesi-Eloff

Conference Presentation Abstracts

Introduction: Dacryoliths of the lacrimal excretory system are found in patients undergoing surgical treatment of primary canaliculitis and nasolacrimal duct obstruction.1,2 Dacryoliths of the canalicular pathway are classically attributed to Actinomyces species, yet a growing body of literature throughout Asia and the Middle East supports a shift towards Streptococcus and Staphylococcus species being the most common cultured organism.1–4 The Midwest microbial profile in 2009 was reported to maintain Actinomyces as the most common organism.1 The objective of this paper is to update the American Midwest demographic and microbial profile of lacrimal system dacryoliths to direct tailored regional approaches to treatment. …

Estimated Cost-Effectiveness Of Atezolizumab Plus Cobimetinib And Vemurafenib For Treatment Of Braf V600 Variation Metastatic Melanoma, Chao Cai, Ismaeel Yunusa Ph.D., Ahmad Tarhini

Faculty Publications

Importance In the IMspire150 trial, triplet treatment with atezolizumab and vemurafenib plus cobimetinib significantly improved progression-free survival (PFS) compared with vemurafenib plus cobimetinib alone for treatment of BRAF V600 variation metastatic melanoma. However, considering high cost of this combination, it is unclear if the incremental cost is worth the additional survival benefit.

Objective To evaluate the cost-effectiveness of atezolizumab and vemurafenib plus cobimetinib vs vemurafenib plus cobimetinib alone in patients with newly diagnosed unresectable BRAF V600 variation metastatic melanoma from the US health care perspective.

Design, Setting, and Participants This economic evaluation study used a 3-state partitioned survival model to …

Fibroblast Growth Factor 19 Increases The Excitability Of Pre-Motor Glutamatergic Dorsal Vagal Complex Neurons From Hyperglycemic Mice, Jordan B. Wean, Bret N. Smith

Physiology Faculty Publications

Intracerebroventricular administration of the protein hormone fibroblast growth factor 19 (FGF19) to the hindbrain produces potent antidiabetic effects in hyperglycemic mice that are likely mediated through a vagal parasympathetic mechanism. FGF19 increases the synaptic excitability of parasympathetic motor neurons in the dorsal motor nucleus of the vagus (DMV) from hyperglycemic, but not normoglycemic, mice but the source of this synaptic input is unknown. Neurons in the area postrema (AP) and nucleus tractus solitarius (NTS) express high levels of FGF receptors and exert glutamatergic control over the DMV. This study tested the hypothesis that FGF19 increases glutamate release in the DMV …

Association Between Neighborhood Social Deprivation And Stage At Diagnosis Among Breast Cancer Patients In South Carolina, Oluwole Adeyemi Babatunde, Whitney Zahnd Ph.D., Jan Eberth Ph.D., Andrew B. Lawson, Swann Arp Adams, Eric Adjei Boakye, Melanie S. Jefferson, Caitlin G. Allen, John L. Pearce, Hong Li, Chanita Hughes Halbert

Faculty Publications

The purpose of this study was to examine the association between neighborhood social deprivation and individual-level characteristics on breast cancer staging in African American and white breast cancer patients. We established a retrospective cohort of patients with breast cancer diagnosed from 1996 to 2015 using the South Carolina Central Cancer Registry. We abstracted sociodemographic and clinical variables from the registry and linked these data to a county-level composite that captured neighborhood social conditions—the social deprivation index (SDI). Data were analyzed using chi-square tests, Student’s t-test, and multivariable ordinal regression analysis to evaluate associations. The study sample included 52,803 female patients …

Alterations In Functional Connectivity Measured By Functional Magnetic Resonance Imaging And The Relationship With Heart Rate Variability In Subjects After Performing Orgasmic Meditation: An Exploratory Study, Andrew B. Newberg, Nancy Wintering, Chloe Hriso, Faezeh Vedaei, Marie Stoner, Reneita Ross

Department of Radiology Faculty Papers

Background: We measured changes in resting brain functional connectivity, with blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI), associated with a creative meditation practice that is augmented by clitoral stimulation and is designed to not only achieve a spiritual experience but to help individuals manage their most intimate personal relationships. Briefly, the meditative state is attained by both the male and female participants while the male stimulates the woman's clitoris. The goal of this practice, called orgasmic meditation (OM), according to the practitioners is not sexual, but to use the focus on clitoral stimulation to facilitate a meditative …

In Memoriam: Dr. Michael T. Caley, Editorial Board

The International Journal of Ecopsychology (IJE)

No abstract provided.