Medicine and Health Sciences Commons^™

The Characterization Of Purified Citrate-Coated Cerium Oxide Nanoparticles Prepared Via Hydrothermal Synthesis, Matthew L. Hancock, Robert A. Yokel, Matthew J. Beck, Julie L. Calahan, Travis W. Jarrells, Eric J. Munson, George A. Olaniyan, Eric A. Grulke

Chemical and Materials Engineering Faculty Publications

Hypothesis

Cerium oxide nanoparticles were synthesized using a hydrothermal approach with citric acid as a stabilizing agent. Citric acid adsorption onto the nanoceria particle surface can cease particle formation and create a stable dispersion for an extended shelf life. The product was dialyzed immediately following the synthesis to remove unreacted cerium that could contribute to biological effects. Nanoparticle characterization results are expected to help identify the surface citrate bonding structure.

Experiments

Many characterization techniques were utilized to determine size, morphology, surface properties, and citrate complexation on the nanoceria particle surface. These included transmission electron microscopy, electron energy loss spectroscopy, dynamic …

Research News, Publications, 2021, Volume 4, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of October 1 through December 31, 2021

Research News, Grants, 2021, Volume 4, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during October - December 2021.

Analysis Of Circadian Rhythm Irregularities On The Health Of Shift Workers, Sahil Rajan

Williams Honors College, Honors Research Projects

Circadian rhythms involve the natural 24 wake-sleep cycle that governs proper maintenance of biological sleep schedules. Circadian rhythm disruption has been associated with health issues such as diabetes, obesity, and mental health disorders such as bipolar and sleep disorders. In this study, a survey method was utilized in order to analyze specific population demographics to determine whether working day or night shifts predisposed individuals to health issues due to disruptions in their circadian rhythms. This study was also carried out to observe popular coping strategies among night shift workers. Of all the variables tested comparing the difference between day and …

Identifying Molecular Pathways Underlying Noise-Induced Tinnitus, Mckenzie Rice

Williams Honors College, Honors Research Projects

Tinnitus is a serious neurological condition effecting 10-15% of adults, and can lead to other symptoms such as difficulty concentrating and sleeping, anxiety, and depression. Currently there are no FDA approved drugs to prevent or treat tinnitus, mainly due to a lack of understanding of its cellular and molecular pathways. T- and L- type calcium channels have been implicated in the modulation of tinnitus, as well as the dysfunction of gamma-aminobutyric acid (GABA) neurons. This study used the sound-based avoidance detection (SBAD) method in order to detect tinnitus and determine whether pharmacological treatments had an effect in mediating tinnitus. T-type …

Examination Of Nurses’ Perceptions, Beliefs, And Conceptions Related To Rapid Bedside Implementation Of Prone Therapy During The Covid-19 Pandemic, Alyssa Poghen, Emily La Riviere

Doctor of Nursing Practice Projects

The COVID-19 pandemic of the SARS-CoV-2 virus created significant challenges for healthcare agencies and front-line healthcare workers. The SARS-CoV-2 virus has demonstrated a unique propensity to induce severe lung injury in the form of acute respiratory distress syndrome (ARDS). High rates of COVID-19 illness in the initial months of the pandemic in the United States led to a rapid influx of patients admitted to critical care units (CCUs) for ARDS. Prone positioning therapy (PPT) has shown substantial promise in treating refractory hypoxemia in people with severe ARDS but historically received poor acceptance as a first-line therapy. With the onset of …

Catching Up With Hpv Immunization: An Educational Video For College Students, Behrooz R. Soleimani

Doctor of Nursing Practice Projects

HPV is the most common sexually transmitted infection in the US, and it can lead to minor health problems such as genital warts and serious problems like cancer in men and women. HPV vaccination can effectively prevent HPV-related cancers and is recommended by ACIP to individuals aged 9-26. HPV vaccine uptake is low among adolescents and young adults in the US. College students have a window of opportunity to catch up with their HPV immunizations, and are often uninformed about HPV, the HPV vaccine, their eligibility to receive the HPV vaccine, and where they can obtain the HPV vaccine. An …

Implementation Of A Proactive Rapid Response Team Nurse Rounding Protocol To Address Afferent Limb Failure In A Mature Rapid Response System, Sarah Welch

Doctor of Nursing Practice Projects

Background: Rapid response system afferent limb failure (ALF) is associated with increased hospital mortality rates, unplanned transfer to the ICU, and increased hospital length of stay. Factors contributing to ALF are complex, including individual, team, organizational, and systemic barriers. The aims of this study were to evaluate the impact of implementation of a proactive rapid response team nurse (RRT RN) rounding protocol on the frequency of ALF preceding adverse events, patient disposition following RRT activation, and discharge disposition of patients experiencing adverse events during their hospital stay at a 281 bed community hospital.

Methods: This was a two part quantitative, …

Pain Neuroscience Education As An Intervention For Chronic Pain, Corissa A. Sutton

Doctor of Nursing Practice Projects

Purpose: The purpose of this project was to evaluate the ability of Pain Neuroscience Education (PNE) to increase knowledge of pain as a biopsychosocial process and influence more health-promoting interpretations of pain among low-income adults as a preventative health education approach.

Background: PNE is a promising treatment approach for addressing chronic pain. However more data is needed to understand how to most effectively utilize this intervention.

Design: A program evaluation was conducted using a pre- and post- test design to elicit quantitative and qualitative data. Nine Seattle Housing Authority (SHA) buildings were invited to participate in two online pain neuroscience …

Context Matters: Evaluating The Influence Of Patient Demographics And In-Patient Care Parameters On Breastfeeding Outcomes Associated With The Baby Friendly Hospital Initiative, Sarah Vivian Martin

Doctor of Nursing Practice Projects

Objective: Evaluate the effectiveness of the global Baby Friendly Hospital Initiative (BFHI) as an intervention to improve breastfeeding outcomes and to explore factors that are most supportive and predictive of exclusive breastfeeding.

Design: Program evaluation of the BFHI using a retrospective pre and post implementation electronic health record chart review.

Setting: A tertiary level hospital in WA. BFHI designation was achieved in November 2017.

Participants: Patients with a low-risk pregnancy, who gave birth (vaginal or cesarean) to a healthy term infant in Quarter one of 2015 (N=145) and Quarter four of 2018 (N=131).Patient and infant must have been discharged home …

Building Resilience: Piloting A Mindful Self-Compassion And Stress-Management Program For Youth, John A. Hinrichs

Doctor of Nursing Practice Projects

Anxiety disorders, representing the most prevalent classification of mental health disorders across the world, pose a significant public health problem associated with burdensome costs (Baxter, Vos, Scott, Ferrari, & Whiteford, 2014; Greenberg et al., 1999). Although understanding about the etiology and effective treatments for anxiety disorders has grown, general preventative measures are not well-understood or implemented but are needed to reduce the disability and morbidity associated with this debilitating class of disorders. Research has identified perfectionism and self-criticism as risk factors for the development of anxiety disorders and mindful self-compassion (MSC) as a promising intervention to alleviate anxiety disorders (Dunkley, …

Screening For Adverse Childhood Experiences And Other Determinants Of Health In School Based Health Centers: A Program Evaluation, Olivia A. Domini

Doctor of Nursing Practice Projects

Introduction: Adverse Childhood Experiences (ACEs), such as abuse, neglect, and various household stressors, are common, connected, and contribute to multiple adverse health and wellbeing outcomes throughout life. Consequently, there has been a push to screen for adversity and toxic stress in primary care to facilitate prevention and early intervention. The purpose of this project was to evaluate and optimize the use of the Broad Level Integrated Screener (BLIS) in Neighborcare Health (NCH) School Based Health Centers (SBHCs) in Seattle, WA.

Methods: An online survey including nineteen Likert-scale questions and five open-ended free response questions was administered to all middle school …

Barriers To Effective Implementation Of Contingency Management In Outpatient Treatment Of Methamphetamine, Emma A. Nauman

Doctor of Nursing Practice Projects

The objective of this project is to: 1) identify current understanding, attitudes, and beliefs of clinicians at a midsized urban outpatient substance use treatment clinic regarding contingency management (CM) treatment modality; 2) examine how this data contributes to barriers to implementation of contingency management for methamphetamine treatment; and 3) make recommendations to improve implementation strategies. A ten-question survey was developed based on Social Ecological Theory (U.S. Department of Health and Human Services, 2005), and was administered to 31 clinicians. A key informant interview was conducted using theoretical sampling (LoBiondo-Wood & Haber, 2018) of emergent themes. Three major barriers emerged from …

The Interactive Effects Of Brain-Derived Neurotrophic Factor (Bdnf) Polymorphisms And Posttraumatic Stress Disorder On Neurocognitive Functioning In U.S. Military Veterans, Colton Shafer Rippey

Theses and Dissertations--Psychology

Posttraumatic Stress Disorder (PTSD) is associated with mild-to-moderate deficits in neurocognitive functioning. Single nucleotide polymorphisms (SNPs) in the brain-derived neurotrophic factor (BDNF) gene, namely, the Met allele, may also be associated with mild deficits in neurocognitive functioning. However, findings are inconsistent and may be sensitive to environmental epigenetic moderators such as psychopathology.

The current study analyzed data from European-American U.S. military veterans (n = 1,244) who participated in the 2011 National Health and Resilience in Veterans Study (NHRVS). Multivariate analyses of covariances were conducted to evaluate the unique and interactive effects of the Met allele and probable PTSD on …

Psychosocial Preoperative Preparation In A Non-Children's Hospital Without Child Life Supports, Haley M. Fricke

EWU Masters Thesis Collection

On average, 6 million children undergo general anesthesia for surgery annually in the United States (Shah et al., 2021).Anesthesia can be one of the most stress provoking experiences, with 40% to 60% of children displaying emotional and behavior stress before surgery (Boles, 2016). Psychosocial preoperative preparation in pediatrics has been seen to lower children’s stress levels, enhance understanding, increase compliance, decrease length of time in recovery, and decrease analgesic use (Aranha et al., 2017; Al-Yateem et al., 2016; Dolidze et al., 2013; Tunney & Boore 2013; Wenstrom et al., 2011). The purpose of this exploratory case study was to better …

Demographic Characteristics Of The Covid-19 Vaccine Trial Participant Population, Mortality Population, And Individuals Fully Vaccinated In The United States: A Comparative Analysis, Lisa Walters

Master's Theses and Doctoral Dissertations

The purpose of this study was to compare the demographic variables of three populations, COVID-19 vaccine trial participants, COVID-19 deaths, and individuals vaccinated for COVID-19, to determine if the trial participants were appropriately representative. Demographic data (age, sex, race and ethnicity, and presence of comorbidities) were collected from publicly available datasets, organized, and compared. The demographic characteristics of the vaccine clinical trials participants were comparable to those who died due to COVID-19, but less comparable to those who were the first to receive a COVID-19 emergency-use-authorized vaccine.

What Is The Relationship Between Vigorous Physical Activity And Physical And Mental Health Indicators In Young Adults?, Fatimah Aldarwish

Master's Theses and Doctoral Dissertations

Young adults (18-24 years) are only slightly older than adolescents but are encouraged to follow adult physical activity (PA) guidelines. PA guidelines for adults do not specifically recommend regular vigorous-intensity PA (VPA), unlike guidelines for adolescents. This thesis aimed to conduct a systematic review to ascertain the influence of VPA on anxiety, body mass index [BMI], and blood pressure [BP] in young adults. Literature searches were conducted in PubMed, CINHAL, and MEDLINE. After applying inclusion/exclusion criteria and removing duplicates, 21 studies were reviewed (6 for anxiety, 10 for BMI, 8 for BP). The reviewed studies indicate that VPA can reduce …

A Systematic Review Of The Efficacy Of Hydroxychloroquine In Covid-19 Patients, Soumy Maria Joseph

Master's Theses and Doctoral Dissertations

Hydroxychloroquine is a highly effective and commonly used disease-modifying anti-rheumatic drug (DMRD) for the treatment of various autoimmune diseases. Recently this medication received lot of attention in the medical world as a potential treatment for COVID-19. The goal of this research is to perform a systematic review of literature to focus on the efficacy of hydroxychloroquine in COVID-19 patients and any evidence of adverse reactions. The database used to conduct this research was PubMed, using four keywords and phrases: effects, side effects, adverse events, and serious adverse events of hydroxychloroquine in COVID-19 patients. Out of the 15 articles selected for …

Impact Of A Global Pandemic On Surgical Education And Training- Review, Response, And Reflection, Sabah Uddin Saqib, Omair Saleem, Amna Riaz, Qamar Riaz, Hasnain Zafar

Section of General Surgery

The catastrophic effects of the coronavirus disease-2019 global pandemic have revolutionised human society. The unprecedented impact on surgical training needs to be analysed in detail to achieve an understanding of how to deal with similar situations arising in the foreseeable future. The challenges faced by the surgical community initiated with the suspension of clinical activities and elective practice, and included the lack of appropriate personal protective equipment, and the self-isolation of trainees and reassignment to coronavirus patient-care regions. Together, all these elements had deleterious effects on the psychological health of the professionals. Surgical training irrespective of specialty is equally affected …

Statins In Patients With Covid-19: A Retrospective Cohort Study In Iranian Covid-19 Patients., Payam Peymani, Tania Dehesh, Farnaz Aligolighasemabadi, Mohammadamin Sadeghdoust, Katarzyna Kotfis, Mazaher Ahmadi, Parvaneh Mehrbod, Pooya Iranpour, Sanaz Dastghaib, Ahmad Nasimian, Amir Ravandi, Biniam Kidane, Naseer Ahmed, Pawan Sharma, Shahla Shojaei, Kamran Bagheri Lankarani, Andrzej Madej, Nima Rezaei, Tayyebeh Madrakian, Marek J Los, Hagar Ibrahim Labouta, Pooneh Mokarram, Saeid Ghavami

Center for Translational Medicine Faculty Papers

Background: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has profoundly affected the lives of millions of people. To date, there is no approved vaccine or specific drug to prevent or treat COVID-19, while the infection is globally spreading at an alarming rate. Because the development of effective vaccines or novel drugs could take several months (if not years), repurposing existing drugs is considered a more efficient strategy that could save lives now. Statins constitute a class of lipid-lowering drugs with proven safety profiles and various known beneficial pleiotropic effects. Our previous …

Heritability Of Ocular Traits In Hispanics, Aaron T. Gomez, Gladys E. Maestre, Jesus D. Melgarejo, Vincent P. Diego, Nicholas B. Blackburn, Juan B. Yepez, Michele Petitto, Felipe A. Murati, Rosa V. Pirela, Carlos A. Chavez, Winston Lee, Lama A. Al-Aswad, Matthew P. Johnson, Joseph H. Lee, John Blangero

MEDI 9331 Scholarly Activities Clinical Years

Purpose: The burden of glaucoma disease among Hispanics is significantly higher than in their white counterparts. It remains unclear to what extent these differences are determined by genetic factors in Hispanics. We therefore examined a highly inbred family population-based cohort in Venezuela to estimate the proportion of genetic contribution of ocular traits relevant to glaucoma disease.

Methods: A subset of 67 participants ≥40y from the Maracaibo Aging Study (MAS) with family pedigree were randomly included. The papillary retinal nerve fiber layer (RNFL) and macular thickness were measured with Spectralis Domain-OCT. Heritability analyses (h², expressed as %) …

Antibiotic Stewardship In Skin And Soft Tissue Infections, Shah Z. Ali, Jose Campo Maldonado

MEDI 9331 Scholarly Activities Clinical Years

Antibiotic use during inpatient hospitalizations have a significant impact on both patient care and healthcare costs. Using data collected over a one month period in 2019 from inpatient hospitalizations, we aim to determine the most common indicated uses for vancomycin and piperacillin-tazobactam, along with the average days of therapy for their use in treating skin and soft tissue infections.

Mortality Outcomes In Therapeutic Versus Prophylactic Anticoagulation In Obese Patients In Predominantly Hispanic Population, Dave Patel, Moktar Ahmed Sheikh-Salah, Raul Garcia, Jewel Udenwagu, Jose Campo Maldonado, Christopher Romero

MEDI 9331 Scholarly Activities Clinical Years

Introduction: As of January 26, 2021, there have been 1,988,063 confirmed cases with 34,701 fatalities from COVID-19 in the state of Texas. As the fatalities increased in Rio Grande Valley, there was overwhelming evidence that showed that obesity, an already hypercoagulable state, was a risk factor that contributed to the severity of COVID-19 infection (Sanchis-Gomar, et. Al. 2020). The prevalence of obesity amongst the population in in the RGV presents an opportunity to correlate trends in outcomes with the obese population that are admitted for inpatient management of COVID-19.

Materials and Methods: This retrospective cohort study looks at patient’s electronic …

Retinoblastoma Transfection For Vegf Synthesis By Malat 1 (Preliminary Study), Ronkino T. Mccoy, Laura Valdez, Kyle Doxtater, Andrew Tsin

MEDI 9331 Scholarly Activities Clinical Years

Metastasis associated lung adenocarcinoma transcript 1 (MALAT 1) is a long non-coding RNA that has been implicated as a promotor of neovascularization in patients with diabetic retinopathy. The upregulation of vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of diabetic retinopathy by increasing angiogenesis, vasculogenesis, and vascular permeability. The purpose of this experiment is to investigate the relationship between MALAT 1 and VEGF in high and low glucose conditioned environment. Based on previous studies, MALAT 1 has been determined to be a possible target for treatment in patients with diabetic retinopathy. Further examination needs to be …

Spinal Cord Mri Analysis Techniques In Post-Stroke Patients, Sarvani Uppati, Sravani Mannuru, Kelsey Baker

MEDI 9331 Scholarly Activities Clinical Years

Stroke, also termed cerebral infarction, results in neurodegeneration and neuroinflammation in the brain at area of the infarct and peri-infarct regions. Recent research has shown involvement of alternate motor pathways of the spinal cord in disease progression. Creating optimal techniques to study spinal cord MRI can give way to higher prognostic methods and enhanced treatment modalities in post-stroke patients. Here, we will review current research proposing various spinal cord MRI analysis techniques in different neurological conditions that can be applied to analyzing post-stroke spinal cord.

Improving Ob Trauma Care Using A Standardized Protocol, Johanna Renee Ridley, Madeline Elaine Huff, Abaigeal Thompson

MEDI 9331 Scholarly Activities Clinical Years

Introduction

Timely evaluation of a pregnant woman experiencing trauma has significant implications. To optimize trauma care for obstetrical patients, our Level I Trauma Center at Doctors Hospital at Renaissance initiated a Standard Operating Procedure (SOP) which puts an OBGYN at bedside within 15 minutes of arrival. This involves calling an ‘OB Trauma Alert’ and arranging expedited travel to the center. We performed a quality improvement initiative to evaluate operational compliance.

Methods

The IRB deemed this project non-regulated research. Therefore, we reviewed obstetrical trauma admissions and subsequent deliveries of pregnant women >20 weeks presenting within 2 years before SOP implementation through …

Intense Monochromatic Photons Above 100 Kev From An Inverse Compton Source, Kirsten Deitrick, Georg H. Hoffstaetter, Carl Franck, Bruno D. Muratori, Peter H. Williams, Geoffrey A, Krafft, Balša Terzić, Joe Crone, Hywel Owen

Physics Faculty Publications

Quasimonochromatic x rays are difficult to produce above 100 keV, but have a number of uses in x-ray and nuclear science, particularly in the analysis of transuranic species. Inverse Compton scattering (ICS) is capable of fulfilling this need, producing photon beams with properties and energies well beyond the limits of typical synchrotron radiation facilities. We present the design and predicted output of such an ICS source at CBETA, a multiturn energy-recovery linac with a top energy of 150 MeV, which we anticipate producing x rays with energies above 400 keV and a collimated flux greater than 108 photons per second …

Solutions For Fermi Questions, March 2021, Larry Weinstein

Physics Faculty Publications

No abstract provided.

The Effect Of Implementing Ob Trauma Activation Standards On Maternal & Fetal Outcomes, Johanna Renee Ridley, Abaigeal Thompson

MEDI 9331 Scholarly Activities Clinical Years

The risk of trauma during pregnancy is not well established in the United States but is associated with significant morbidity and mortality. The overall goal of this study is to to initiate a formal ongoing process by which DHR can utilize objective measures to monitor and evaluate the quality of OB trauma services. We will use a Continuous Quality Improvement (CQI) approach to evaluate the effect of implementing an OB Trauma Activation Procedure, which places an OB team (obstetrician and labor RN) at the bedside within 15 minutes on maternal and fetal outcomes. 1,285 subjects were initially filtered to remove …

A Comparison Of The Prevalence Of Cirrhosis In A Hispanic And Non-Hispanic Population Based On Body Mass Index, Alexa Perlick, Abaigeal Thompson, Colton Wayne, Jose Campo Maldonado, Angel Rendon

MEDI 9331 Scholarly Activities Clinical Years

Background and Significance

The obesity epidemic is a growing public health concern. In addition to the already known complications and comorbidities associated with obesity, data suggest that obesity is an independent risk factor for the development of liver disease. ^1,2 However, there is a paucity of data regarding the clinical correlation of obesity and cirrhosis in a predominantly Hispanic population. Therefore, the aim of this study is to investigate the prevalence of cirrhosis stratified by BMI in a predominately Hispanic population.

Materials and Methods

This retrospective single-centered study was approved by the University of Texas Rio Grande Valley institutional ethics …