Medicine and Health Sciences Commons^™

Raw And Pure Education In The Society, Iwasan D. Kejawa

Department of Educational Administration: Dissertations, Theses, and Student Research

What does education mean to individuals in the world today? Education is a way one can attain or improve his or her ability to lead and survive in the society of ours. Without educational training of the mind, it may be impossible to realize the importance of adaptability of living in the environment. Without education, It may also be difficult to embellish the use of both the mental and physical attributes possessed by individual beings.

What really is education? Education is the training of the mind to perform desire functions or to perpetuate the modality of obtaining an end or …

Getting Real: The Maryland Healthcare Ethics Committee Network’S Covid‑19 Working Group Debriefs Lessons Learned, Norton Elson, Howard Gwon, Diane Hoffmann, Adam M. Kelmenson, Ahmed Khan, Joanne F. Kraus, Casmir C. Onyegwara, Gail Povar, Fatima Sheikh, Anita J. Tarzian

Faculty Scholarship

No abstract provided.

Aadej Comm 7 2 2021

AADEJ - The Communicator

The Communicator is the official journal of the American Association of Dental Editors and Journalists (AADEJ). It is published quarterly, distributed digitally via email to members, and posted on the Association's website, AADEJ.org. Each issue includes regular updates from the editorial team and AADEJ board, as well as feature articles on current issues in the field.

The Effects Of Complex Listening Environments On Semantic Processing In Young And Middle-Aged Adults, Emily Ferguson B.S., Nicholas Stanley Ph.D. Au.D.

AuD Capstone Projects - Communication Sciences and Disorders

The purpose of this research study is to determine how young adults and middle-aged adults process speech in different complex listening environments. Young adult and middle-aged adult volunteers will complete a cognitive screening and audiological evaluation to establish inclusionary status for experimental speech understanding in noise testing. If they meet the requirements of the study and wish to participate further, they will continue with a semantic judgement task, in which they will be asked to listen and respond to words presented in different background noises. Within the task, participants will be asked to identify word pairs into either a "match" …

Etsu Health Annual Report - 2021, 2021

ETSU Health Annual Reports

No abstract provided.

Introduction To Special Issue Of Plant Virus Emergence, Michael M. Goodin, Jeanmarie Verchot

Plant Pathology Faculty Publications

No abstract provided.

Knee Extension Rate Of Torque Development Deficit Is Not Captured By Standard Functional Performance Measures Post- Anterior Cruciate Ligament Reconstruction, Michael Jeanfavre, Matthew Klein, Darragh Lynch, Luke Esquerra, Jonathan Dickey, Jessica Mena

Faculty Publications - College of Physical Therapy

Background

Criteria for full recovery following anterior cruciate ligament reconstruction (ACL-R) include the ability to achieve >90% limb symmetry in maximal quadriceps strength (QI) and functional hop tests. Additionally, knee extension rate of torque development (RTD) is an important performance metric post-ACL-R. This study investigated the rate of recovery of these performance metrics in a recreationally athletic population.

Purpose

To investigate RTD at 30% (RTD30), 50% (RTD50), and 90% (RTD90) of maximal voluntary isometric contraction (MVIC) recovery rate compared to knee extension peak torque and hop test performance post ACL-R.

Study Design

Descriptive, prospective, cross-sectional single-cohort study.

Methods

Subjects between …

What Is Toe Spring In Running Shoes?, Matthew Klein

Faculty Publications - College of Physical Therapy

The last several years have seen a dramatic change in the looks and design of modern running shoes. As maximal shoe design continues to influence the industry, a majority of shoes are seeing large increases in sole height and bending stiffness and increasing usage of plates. In addition to thicker, stiffer, and plated shoes, you may have noticed an increase in the frequency of another rarely discussed but important component of many running shoes, a large upward curve right under the toes. This feature is called toe spring. With it becoming increasingly prevalent, it’s worth knowing why it exists, …

It’S Okay To Be A Heel Striker, Matthew Klein

Faculty Publications - College of Physical Therapy

One of the most frequent questions I’m asked by runners is, “How should my foot land on the ground?” In the wake of the previous decade’s barefoot/minimal shoe movement, people continue to emphasize certain foot strikes over others. (Heel striking is the primary “other” in these discussions.)

Claims are often made about injury prevention, improved speed, improved running efficiency, and certain ways being more “natural.” As with most universal claims in running, there’s a great deal of misinformation here. Let’s look at the facts about foot strikes.

Identification Of Pyrrolizidine Alkaloids In Senecio Plants By Liquid Chromatography-Mass Spectrometry, An-Jing Lu, Yan-Liu Lu, Dao-Peng Tan, Lin Qin, Hua Ling, Chang-Hong Wang, Yu-Qi He

PCOM Scholarly Works

Pyrrolizidine alkaloids (PAs) are considered as the major constituents that cause hepatoxicity in Senecio plants. PAs can be found in about 3%-5% of the world's flowering plants. Nowadays, the identification method of PAs by separation and preparation was too slow and lacked effective power. A rapid method to identify PAs in plants must be developed. Based on the fragmentation regularity, the hepatoxic PAs and nonhepatoxic PAs were characterized by liquid chromatography-mass spectrometry (LC-MS). The detailed structures of PAs in five Senecio plants were identified based on tandem mass spectrometry (MS/MS) spectrum and chemical research information. In the present study, some …

Characterization Of Infliximab And Biosimilar Use In A Community Health System, Abigail Geyer Pharmd, Luke Keller Pharmd, Bcps, Bcccp, Curtis Stump Pharmd, Renu Johnson Pharmd, Bcps

Parkview Pharmacy Department

2021 ASHP Midyear Clinical Meeting / Virtual / Poster #1129769

Objective: To identify characteristics of infliximab and relevant biosimilar use within a community health system.

Laparoscopic Partial Splenectomy For A Splenic Hamartoma, Vashisht Madabhushi, Timothy Horrell, John M. Draus

Surgery Faculty Publications

Objective

We discuss current knowledge and management of splenic hamartoma, an uncommon form of benign tumor.

Summary background data

A splenic hamartoma is a rare form of benign splenic mass, often found incidentally while working up other complaints, and is typically treated by surgical resection of the mass. In this case, we discuss the management of an incidentally found splenic hamartoma that was treated with laparoscopic partial splenectomy.

Methods

The patient presented in the Emergency Department complaining of periumbilical pain after having been struck in the abdomen with a soccer ball the previous day. Following a physical exam and blood …

Dual-Functional Phosphorene Nanocomposite Membranes For The Treatment Of Perfluorinated Water: An Investigation Of Perfluorooctanoic Acid Removal Via Filtration Combined With Ultraviolet Irradiation Or Oxygenation, Joyner Eke, Lillian Banks, M. Abdul Mottaleb, Andrew J. Morris, Olga V. Tsyusko, Isabel C. Escobar

Internal Medicine Faculty Publications

Nanomaterials with tunable properties show promise because of their size-dependent electronic structure and controllable physical properties. The purpose of this research was to develop and validate environmentally safe nanomaterial-based approach for treatment of drinking water including removal and degradation of per- and polyfluorinated chemicals (PFAS). PFAS are surfactant chemicals with broad uses that are now recognized as contaminants with a significant risk to human health. They are commonly used in household and industrial products. They are extremely persistent in the environment because they possess both hydrophobic fluorine-saturated carbon chains and hydrophilic functional groups, along with being oleophobic. Traditional drinking water …

The Effects Of Nutritional Aids On Exercise Performance In A Fed State, Simon Devenney

Masters

Previous research has shown that mouth rinsing with a carbohydrate solution (CMR) can improve cycling performance while caffeine supplementation (CAFF) can improve power output in bouts of repeated sprints in a low carbohydrate availability state. The aim of the current thesis was to identify the effects of nutritional, in the form of CMR, CAFF supplementation & CAFF rinse, on exercise performance while athletes were in a fed state. A total of 32 recreationally active males (aged 22 ± 3yrs, body mass 71.5 ± 10.1kg, stature 173.5 ± 7.6cm, skinfolds 75.6 ± 19.3mm) participated across three studies, looking at time trial …

An Investigation Into Employee Exposure To Environmental Tobacco Smoke Within Designated Smoking Areas In The Hospitality Industry, With An Analysis Of Legislative Compliance Of Said Designated Smoking Areas, Hannah Byrne

Masters

Background: Occupational exposure to environmental tobacco smoke (ETS) is still occurring in the hospitality industry and the instance of non-compliant smoking areas required investigation. A designated smoking area covered by a roof where more than 50% of the perimeter of that part is surrounded by one or more walls is deemed a non-compliant smoking area. This study aimed to gather evidence of non-compliances across Dublin, determine current employee exposure whilst also measuring PM2.5 concentrations within smoking areas as well as providing insight into possible immediate health effects of ETS exposure.

Methods: Seventy-five smoking areas (41 located in high, 27 in …

Celebrating Women Scholars In Athletic Training, Julie M. Cavallario, Cailee E. Welch Bacon, Lindsey E. Eberman, Stacy E. Walker

Rehabilitation Sciences Faculty Publications

No abstract provided.

The Point In Which Peak Power Occurs In Relation To The Percentage Of One-Repetition Max For The Clean, Back Squat, And Bench Press Exercises Across Various Athlete Types, Maria Darling

Master's Theses or Doctor of Nursing Practice

ABSTRACT

The purpose of this study was to investigate the force-velocity curve in the athletic population. There was special interest in determining the point of peak-power (PP%), the point of peak power drop-off (PPDO%), and the range (RANGE) between these points for three different exercises: the bench press (BENCH), the back squat (SQUAT), and the floor clean (CLEAN). Further investigation looked to find differences in these points between different sub-groups within the athletes sampled. Data was retrieved from an existing database on 72 healthy Fort Hays State University athletes from five different teams during their off-season six-week training cycle. All …

Less Common Bacterial, Fungal And Viral Infections: Review Of Management In The Pregnant Patient, Alyssa P. Gould, Hana R. Winders, Kayla R. Stover, P Brandon Bookstaver, Brooke Griffin, Christopher M. Bland, Lea S. Eiland, Milena Murray

Faculty Publications

This review is a comprehensive summary of treatment options for pregnant patients with less common bacterial, fungal, and viral infections. It offers guidance to clinicians based on the most recently published evidence-based research and expert recommendations. A search of MEDLINE (inception to March 2021) and the CDC website was performed. Liposomal amphotericin B is the preferred therapy for cryptococcosis, histoplasmosis, oesophageal candidiasis, and coccidioidomycosis, especially during the first trimester due to teratogenic concerns with azole antifungals. For oral candidiasis, clotrimazole troches or miconazole mucoadhesive buccal tablets are recommended. A β-lactam antimicrobial is preferred over doxycycline for various manifestations of Lyme …

The Effect Of Endogenous Ligands Of The Aryl Hydrocarbon Receptor On Antibody Expression In A Human B-Cell Model, Valerie Benedict

Browse all Theses and Dissertations

Small changes in antibody expression have broad impacts on human health and disease. An environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces profound immune suppression in animal models in an aryl hydrocarbon receptor (AhR)-mediated fashion. In a human Burkitt's lymphoma cell line (CL-01), TCDD inhibited IgG secretion and differentially impacted Ig heavy chain expression. In addition to TCDD, the AhR has several endogenous, dietary, and bacterial ligands such as 6-formylindolo[3,2-b]carbazole (FICZ) and indole, which are present within the human body at varied concentrations (0.30 mM- 6.64 mM). Both FICZ (100 nM) and indole (100 µM) significantly reduced IgG secretion. Overall antibody secretion is …

Development Of Ibuprofen Tablet With Polyethylene Oxide Using Fused Deposition Modeling (Fdm) 3d Printing Coupled With Hot-Melt Extrusion, Sooyeon Chung

Electronic Theses and Dissertations

Ibuprofen is known to plasticize several polymers used in the pharmaceutical field, and it is considered challenging to achieve an immediate release by fused deposition modeling (FDM). Therefore, this study aimed to print ibuprofen tablet with a focus on achieving immediate release. Polyethylene oxide (Polyox WSR N80) was used as a main matrix to form the ibuprofen filament due to its water-soluble property and manifesting suitable mechanical property even with the high drug loading (40% w/w). Several release modifiers such as Kollidon VA64, Kollidon 12PF, Kollicoat IR, Kollidon CL, and Mannitol were added separately to the formulation to enhance the …

Manipulations Of A Memory Interference Paradigm, Lindsay Kyle Crawford

Electronic Theses and Dissertations

The AB/DE, AC/FG paired associate learning task, which has been utilized in numerous experimental studies, is purported to induce both proactive (PI) and retroactive interference (RI) simultaneously. However, until now, there have not been any studies validating or determining the optimal format of this paradigm. As such, the purpose of this series of experiments was to make manipulations to the task in order to maximize its efficacy. Across the series of experiments implemented herein, we manipulated various aspects of the paradigm (e.g., semantic relatedness of the word pairs, number of trials) driven by theoretical underpinnings of memory interference theory. Experiments …

Rap1a Overlaps The Age/Rage Signaling Cascade In Type 2 Diabetes Mellitus, Stephanie Burr

Electronic Theses and Dissertations

Diabetic individuals have an increased risk for developing cardiovascular disease due to stiffening of the left ventricle, which is thought to occur, in part, by increased AGE/RAGE signaling. Advanced glycation end products (AGEs) accumulate within the body over time, and under hyperglycemic conditions, the formation and accumulation of AGEs is accelerated. AGEs exert their effect by binding to their receptor (RAGE) and can induce myofibroblast differentiation, oxidative stress, cell-extracellular matrix contraction, and cell migration. Previous findings from our lab have demonstrated that preventing the production of Rap1a, a Ras-like GTPase signaling protein, in cardiac fibroblasts will decrease type 2 diabetes …

Methylene Blue As Light And Reactive Oxygen Species Sensitive Ligand: Appicability In Hybrid Drug And Material Synthesis, Huy Dao

Electronic Theses and Dissertations

Methylene blue (MB) with a 10-N-carbamoyl linkage was discovered and developed as a multifunctional far-red (660 nm) photocleavable ligand capable of rendering a series of MB conjugated compounds with off-to-on fluorescence switch properties through the controlled release of MB. The released MB was successfully demonstrated to be an effective photosensitizer, imaging probe, and therapeutic agent. The complete release of MB was achieved with a cumulative light dose of 15 J/cm2. The photosensitivity was demonstrated to be dependent on the type of chemical bond at 10-N of the phenothiazine ring which links MB to a side group. Specifically, the urea bond-based …

Hot-Melt Extrusion Based Fused Deposition Modeling 3d Printing Of Atorvastatin Calcium Tablets: Impact Of Shape And Infill Density On Printability And Performance, Preethi Mandati

Electronic Theses and Dissertations

The main objective of the current research is to investigate the effect of shapes (heart and round shape tablets) and infill densities (50% and 100%) on drug release profiles of tablets prepared by hot melt extrusion (HME) coupled fused deposition modeling (FDM) technique. Two different commercial FDM 3D printers with different filament feeding mechanisms were evaluated for suitability of printing. Drug-loaded filaments of 1.5 mm and 2.5 mm diameters were extruded using Process 11 mm HME, using atorvastatin as a model drug and Kollicoat® IR, Kollidon® VA64, Kollidon®12PF, and Kolliphor® P407 as hydrophilic polymers. Filaments of Kollicoat® IR in combination …

Subcutaneous Delivery Of Albumin, Vy Nguyen

Electronic Theses and Dissertations

An increasing number of protein drugs are used in the clinic to treat a broad range of diseases. However, because of their large molecular sizes and high hydrophilicity, protein drugs are not orally bioavailable, which commonly require intravenous, intramuscular or subcutaneous injection. Thermosensitive polymers have been widely investigated as in situ depots for sustained drug release delivered through subcutaneous route.Albumin is the most abundant proteins in bloodstream. It has long half-life (19 days in human) and plays important roles such as acting as carrier for fatty acids, amino acids, waste products and medical compounds. Albumin has been studied for decades …

Mechanism For The Unfolding Of The Top7 Protein In Steered Molecular Dynamics Simulations As Revealed By Mutual Information Analysis, Ognjen Perišić, Willy Wriggers

Mechanical & Aerospace Engineering Faculty Publications

We employed mutual information (MI) analysis to detect motions affecting the mechanical resistance of the human-engineered protein Top7. The results are based on the MI analysis of pair contact correlations measured in steered molecular dynamics (SMD) trajectories and their statistical dependence on global unfolding. This study is the first application of the MI analysis to SMD forced unfolding, and we furnish specific SMD recommendations for the utility of parameters and options in the TimeScapes package. The MI analysis provided a global overview of the effect of perturbation on the stability of the protein. We also employed a more conventional trajectory …

Prevalence And Correlates Of Secondary Syringe Exchange (Sse) Among People Who Inject Drugs (Pwid) In Rural Kentucky, Jordan R. Wilson

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Aim: To describe the prevalence of secondary syringe exchange (SSE) in a sample of syringe service program (SSP) clients in rural Appalachian Kentucky and to identify the correlates of SSE.

Methods: Participants (n=338) completed interviewer-administered questionnaires. Only those who reported having ever exchanged syringes at a SSP (n=140) were included in analysis. SSE was measured through self-report of obtaining syringes for someone else at a SSP in the past 6 months. Prevalence and correlates of SSE were examined using bivariate analysis and multiple logistic regression.

Results: Overall, 30% of participants reported SSE. Participants in the second [aOR= 3.83; 95% CI: …

The Relationship Between Health Insurance Literacy, Health Insurance Coverage, And Health Insurance Utilization In The United States, Elizabeth Graves

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The Affordable Care Act (ACA) made health insurance more accessible but that does not mean that individuals understand their health insurance or are more confident in using it. The knowledge and confidence that individuals have in health insurance impact their health insurance literacy. Health insurance literacy (HIL) is defined as the ability and capacity to seek, obtain, understand, and potentially use health insurance information and plans.

This capstone study assesses how having HIL, which includes having a knowledge of health insurance terms and confidence in utilizing health insurance services, is related to having health insurance and having a usual source …

Impact Of Smoking And Hpv Status On Cervical Cancer Survival In Women Living In Kentucky, 2004-2005 And 2014-2015, Brittany M. Mckinley

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

BACKGROUND/ OBJECTIVE: Cervical cancer is the fourth most commonly occurring malignancy in women worldwide, with an estimated 530,000 new cases and 270,000 new deaths each year (Small et al, 2017). While the incidence of cervical cancer has decreased by approximately 1.9% per year between 2007 and 2011, the death rate has remained stable (Bernard et al, 2014). Studies have shown that nearly all cervical cancer cases are associated with the Human Papilloma Virus (HPV). Many studies support the association of smoking with increased risk of invasive cervical cancer in women with high-risk HPV (Castle et al, 2002; Fang et al, …

Prevalence And Exacerbation Of Asthma Within Two Counties In Eastern Kentucky, Rachid Souleye

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background: Central Appalachia residents have one of the highest rates of serious respiratory diseases in the nation. Appalachian Kentuckians are 50% more likely to be diagnosed with adult asthma compared to the overall U.S. population. Yet, few epidemiologic studies have assessed risk factors for respiratory disease in this population. Using a community-based approach, the investigators of the Mountain Air Project (MAP), one of the largest adult cohorts from two disadvantaged communities in Central Kentucky, collected data to estimate the prevalence of asthma and assess various socioeconomic and environmental risk factors to determine their effect on asthma.

Methods: A cross-sectional epidemiologic …