Medicine and Health Sciences Commons^™

The Efficacy Of Neurofeedback In The Treatment Of Individuals With Anxiety-Spectrum Disorders: A Meta-Analysis, Gordon Michael Russo

Electronic Theses and Dissertations

A number of authors have published articles that assert the efficacy of neurofeedback (NFB) in the treatment of people with anxious symptomatology. Despite this, many insurance companies identify NFB as experimental, which prohibits individuals from utilizing benefits to obtain this therapeutic treatment. In order to examine these discrepancies, the present meta-analyses were conducted and guided by research questions designed to examine the overall effectiveness of NFB, the impact of participant characteristics, and identify the if there is a significant difference in anxiety-spectrum outcomes. Twenty-six trials were divided based on design (14 single group [SG]; 12 between group [BG]) and analyzed …

Group Sandtray Therapy With Adult Survivors Of Childhood Sexual Assault: A Single-Case Research Design, Jana Elaine Scott

Electronic Theses and Dissertations

Childhood sexual assault (CSA) is a growing problem in our society. A child who experiences a sexual assault not only deals with the immediate trauma surrounding this event, but also the aftermath of this event as they progress into adulthood. Trauma and sexual trauma is an umbrella term that incorporates all of the various implications of experiencing a negative event. In the instance of trauma, neurobiological implications have been well researched and established. This knowledge highlights the need for counseling techniques to be developed and studied that target those who have experienced CSA. The aim of this single-case research design …

Type 2 Diabetes Mellitus And Oral Health Problems Cross-Sectional Study, Asmaa Ras, Eman Khalil

Dentistry

ABSTRACT In Egypt, diabetes mellitus is considered to be a foremost health issue with a major influence on the disease and the rate of death. Diabetes mellitus is a communal disorder having affiliated oral disorders that influence dental care. The purpose of this study was to study the prevalence of oral changes in diabetes type 2 in the Egyptian participants to raise awareness between diabetic patients and dental professionals. Methods: This was a cross-sectional study that was done on 200 patients who were diagnosed with diabetes mellitus type 2 at Diabetes and Endocrinology Clinic in Kasr Al Ainy, Cairo University …

The Effect Of Egf On Vegf Expression On Submandibular Salivary Gland Of Albino Rats Receiving Doxorubicin, Mohamed Shamel, Mohamed Mansy, Rabab Mubarak

Dentistry

Background: Vascular endothelial growth factor (VEGF) has two prominent biological effects of inducing mitogenesis and migration of vascular endothelial cells and to produce permeability on the microvasculature. Epidermal growth factor (EGF), known by its mitogenic activity on different types of cells, could induce the proliferation and differentiation of the epithelial cells and stimulate its regeneration. Doxorubicin (DXR) is a widely used anticancer drug and is one of most commonly used chemotherapeutic drugs, however it may cause some serious complications such as toxicity in various tissues in the body. Aims: The present study aims to investigate the effect of EGF on …

Peculiarities Of Neurostimulation By Intense Nanosecond Pulsed Electric Fields: How To Avoid Firing In Peripheral Nerve Fibers, Vitalii Kim, Emily Gudvangen, Oleg Kondratiev, Luis Redondo, Shu Xiao, Andrei G. Pakhomov

Bioelectrics Publications

Intense pulsed electric fields (PEF) are a novel modality for the efficient and targeted ablation of tumors by electroporation. The major adverse side effects of PEF therapies are strong involuntary muscle contractions and pain. Nanosecond-range PEF (nsPEF) are less efficient at neurostimulation and can be employed to minimize such side effects. We quantified the impact of the electrode configuration, PEF strength (up to 20 kV/cm), repetition rate (up to 3 MHz), bi- and triphasic pulse shapes, and pulse duration (down to 10 ns) on eliciting compound action potentials (CAPs) in nerve fibers. The excitation thresholds for single unipolar but not …

Factors Contributing To Diminished Long-Term Outcomes Of Secondary Infections, Alia Tayara

Honors Theses

It is widely known that patients suffer diminished long-term outcomes in the years following secondary infections, infectious diseases that occur during or after treatment of a primary infection such as influenza or COVID-19. One common secondary infection is pneumonia, which has become the most fatal hospital-acquired infection. The bacterium responsible for pneumonia is known as Pseudomonas aeruginosa. The cytotoxic supernatant in these studies was generated from a PA103 strain of Psuedomonas aeruginosa with a type III secretion system that maintains the ability to transfer exoenzymes ExoU and ExoT into target cells during infection. The focus of the following studies was …

Assessment Of Hypothermia As A Correlate Of Pde4 Inhibitor-Induced Nausea In Mice, Marianna Susan Oditt

Honors Theses

Type-4-cAMP-phosphodiesterases (PDE4s) are a group of isoenzymes that hydrolyze the second messenger cyclic adenosine monophosphate (cAMP). PDE4 inhibitors have many therapeutic uses including reducing inflammation, however, they also have side effects like nausea and emesis, which have diminished the clinical utility of PDE4 inhibitors. When administered to mice, PDE4 inhibitors have been shown to cause hypothermia. Given that nausea and emesis in humans are also associated hypothermia, this project served to determine whether PDE4 inhibitor-induced hypothermia may represent a correlate of nausea and/or emesis in mice. To this end, the current literature was screened for articles that explore nausea, emesis …

Unusual Teenage Growing Pains: If The Genes Fit, Kourtney Rudzinski Do, Rebecca Sharim Md

Department of Pediatrics

No abstract provided.

Nurses’ Perceptions Of Caring For Patients In The Prone Position, Brianna Jean Judkins

Honors Theses and Capstones

Introduction: Prone positioning has been used for decades to supplement the treatment of patients diagnosed with Acute Respiratory Distress Syndrome (ARDS). The effects it has on improving lung aeration, reducing compression, and increasing alveolar recruitment, have become evident through continued research. As a result of the H1N1 and COVID-19 pandemics, proning has become a popular and effective adjunct to treatment. Despite its increased use, there continues to be minimal research regarding nurses’ perceptions of the maneuver and patient care. Objectives: The purpose of this study is to understand the perceptions of nurses caring for patients in the prone position. Identifying …

Healthcare And Substance Use Service Accessibility And Barriers For Syringe Service Program (Ssp) Participants In Manchester, Nh, Faith Mackenzie Farnham

Honors Theses and Capstones

No abstract provided.

Stressful Life Events And Postpartum Depression, Madison E. Laurent

Honors Theses and Capstones

No abstract provided.

Evaluating The Relationship Between Confidence And Anxiety During The Covid-19 Pandemic, Althea M. Devereux

Honors Theses and Capstones

No abstract provided.

Sars-Cov-2: An Investigation On Mutagenicity And Its Effects On Infectivity And Mortality, Tyler Elliott Silverwood

Honors Theses and Capstones

SARS-CoV-2, the etiological agent of the COVID-19 pandemic, has rapidly become a worldwide public health concern. Classified as a betacoronavirus, it is the third human coronavirus (HCoV) to emerge in the 21st century that causes severe disease, alongside SARS-CoV and MERS-CoV. The genome consists of open reading frames encoding accessory proteins and four structural proteins, including the spike protein which is a key determinant of host cell tropism. Mutations within the genome, particularly the spike gene, have been linked in-vitro to increased binding affinity to the human receptor angiotensin-converting enzyme 2 (hACE2), increased fitness in human hosts, and immune evasion. …

Occurrence Of Pulmonary Arteritis With Lungworm Infections In Gray Seals From New England, 2013-2020, Jillian R. Broadhurst, Inga Sidor Dvm, Ms, Dacvp

Honors Theses and Capstones

Gray seals (Halichoerus grypus) are a common pinniped species in New England coastal waters. Parasitic infection is an important cause of mortality for this species, and lungworm species are frequently implicated in cases of respiratory infection, especially in pups and weanling seals. The most common of these is Otostrongylus circumlitus, a large nematode found in the bronchi and bronchioles of affected seals. The full life cycle is unknown but its presence in lungs and sometimes pulmonary arteries suggests that migration via arterial circulation occurs. Signs and microscopic findings are widely variable; our cases included dyspnea, bloody mucoid …

Mimicking The Effect Of Prolactin On Stat3/Stat5 Activity In Breast Cancer, Jennifer N. Barbuto, Sarah R. Walker

Honors Theses and Capstones

Signal transducers and activators of transcription (STAT) 3 and 5 are commonly constitutively activated in breast cancer. STAT5 can outcompete STAT3 and reduce cell proliferation and metastasis. STAT5 activation is stimulated by prolactin, a natural hormone that can be harmful at high levels. The aim of this study is to identify some possible previously developed drugs that mimic the effect of prolactin and STAT5 without the added risk in MDA-MB231 breast cancer cells. Using the CLUE database query app and STAT5 up- and downregulation signatures, three drugs (X, K, and M) were chosen based on their similarity in signatures to …

Long-Term Disability Following A Hamstring Injury, Savannah Mclain

College of Graduate Studies: Theses & Dissertations

PURPOSE: Injuries to the hamstring complex are one of the most commonly seen lower extremity injuries in athletic populations. It is currently unknown how psychological or sociological factors affect an athlete after the recovery process has ended and if these factors play a role in re-injury rates relating to the hamstring. It is also unknown if athlete confidence level changes while in a fatigued state after an athlete returns to play from a hamstring injury. METHODS: Twenty-six physically active adults with and without a previous hamstring injury were recruited for this study. Participants completed a Qualtrics survey that …

Firefighters Self-Efficacy Of Injuries And Willingness To Report Injuries Within The Southeast Region Of The United States, Marissa Villafuerte

College of Graduate Studies: Theses & Dissertations

CONTEXT: Firefighting is a dangerous profession often leading to minor and severe injuries. Injuries range from basic first aid to fatalities. Over a third of injuries linked to muscular-skeletal injuries (MSKI). To address MSKI, the fire service has turned to preventative and rehabilitation care such as on-site health care professionals.

OBJECTIVE: The purpose of this study was 1) to understand rural firefighters' self-efficacy of injury care and willingness to report MSKIs, 2) compare on-site preventative care fire departments to traditional fire departments and 3) describe the influence of on-site self-efficacy of MSKI care and willingness to report injuries based on …

"Who's The Man?" Examining The Relationships Between Black Masculinity, Perceived Social Support, And Sexual Behavior In Black Male College Students, James Thomas

College of Graduate Studies: Theses & Dissertations

Introduction: Sexual health disparities in college-aged Black men remains a critical public health issue. Black men are likely to have an earlier sexual debut, acquire sexually transmitted infections (STIs) and HIV at higher rates, and enter fatherhood at earlier ages than their White counterparts. Previous research has identified masculinity and perceived social support as predictors of sexual risk behavior for men in the U.S. However, when exploring masculinity’s influence on sexual behavior, studies that are culturally sensitive to Black men’s experiences and perspectives on manhood are few. The purpose of this study was to explore the relationship between Black masculinity, …

Design, Synthesis And Applications Of Nanoparticles In Suppression Of Mosquito-Born Flaviviridae Viruses, Maria R. Blahove

College of Graduate Studies: Theses & Dissertations

Recently, nanoparticles have become an origin of exploration in the chemistry field due to their unique medical uses. The current drug delivery models of nanoparticles often include a metal base with a drug conjugated to its surface. However this raises concerns regarding toxicity. A novel approach to solving this dilemma is the development of nanosized biocompatible polymer-based micelles, created from PEG-PCL-PEG triblock polymer, and formed around a drug of choice. The goal is to create a drug carrier nanoparticle system that is labile at a specific intracellular pH, without undue toxicity to the cell. This creates a drug-loaded nanoparticle that …

An Exploration Of Depression In African American Adults With Sickle Cell Disease: Symptoms, Coping Strategies And The Potential Benefits Of Religiosity, Delores P. Quasie-Woode

College of Graduate Studies: Theses & Dissertations

Depressive symptoms in adults with Sickle Cell Disease (SCD) often go unrecognized and untreated. SCD is one of the most common inherited hemoglobin disorders in the United States, affecting 1 in 365 African Americans. Individuals with SCD and co-morbid Depression lead to high hospitalization rates and healthcare utilization. The objective of this study is to explore depressive symptoms and preferred coping strategies among African American Adults with SCD. Furthermore, the aim is to explore the acceptability of religiosity among those who self-identify as religious.

Interviews were conducted with 30 African American adults, recruited during their hematology appointment at the Center …

College Athletes' Experiences With A Lower Body Re-Injury: A Phenomenological Investigation, Samantha Holder

College of Graduate Studies: Theses & Dissertations

Lower extremity injuries are the most common musculoskeletal sport injuries and are an inevitable risk to sport participation (Chalmers, 2002; Dane et al., 2004; Kay et al., 2017). When an athlete sustains an injury, fear of re-injury is a salient emotion many athletes experience (e.g., Disanti et al., 2018; Kvist et al., 2005; Lentz et al., 2015). Previous research has identified fear of re-injury as a risk factor to suffering a subsequent injury (e.g., An et al., 2019; Andersen & Williams, 1988; Paterno et al., 2018; Podlog et al., 2011; Tagesson & Kvist, 2016). Epidemiology studies have highlighted that re-injuries …

Development Of A Unique Screening Tool For Acute Care Occupational Therapy Services In Patients Following Total Joint Replacement Surgery, Stephanie Hack Pt, Dpt, Stacy Wentz Ms, Otr/L

Department of Medicine

No abstract provided.

Does Obesity Affect Outcomes In Acute Pancreatitis?, Rajesh Essrani Md, Muhammad Usman Zafar, Hiral N. Shah Md

Department of Medicine

No abstract provided.

Don’T Take My Breath Away: A Case Of High-Risk Pulmonary Embolism In The Setting Of Patent Foramen Ovale Requiring Extracorporeal Membrane Oxygenation, Amy Lam Do, Sonali Bishnoi, Jeffrey Wright Do, Kaitlyn Musco Md, Scott Blumof Do

Department of Medicine

No abstract provided.

Ethical Price For Essential Pharmaceuticals?, Sang T. Truong

Student Research

Azidothymidine or AZT is an antiretroviral medication used to prevent and treat HIV/AIDS. Nowadays, AZT remains to be the primary active drug that can elongate the life of infected patients. Without treatment, patients can live for 5 to 10 years after infected. With the treatment, their life expectancy approaches the norm.

However, it is important to note that AZT is a life-saver for HIV patients only if they can afford it. An HIV patient needs to spend about $17,000 for AZT every year until the end of his life. Therefore, the estimated lifetime cost of HIV will be $600,000. This …

Computer Gamification: Addressing Symptoms Of Inattentive Adhd In Children, Shavonne Victoria Halterman

Masters Theses

“Computer gamification has the potential to help meet the educational needs of children with Inattentive Attention Deficit/Hyperactivity disorder (ADHD). The elements of computer gamification are mapped to distinct kinds of interventions for Inattentive ADHD and show certain types of computer gamified learning are better than others for those who experience Inattentive ADHD”--Abstract, page iii.

A Systematic Analysis Of Eye-Tracking Metrics For Sleepiness, Debasis Roy

Masters Theses

”Sleepiness or sleep deprivation is a serious hazard that can be life-threatening in carrying out certain tasks (e.g., when driving or executing attention-critical tasks). Eye movement can provide cues on sleepiness. Hence, eye-tracking metrics have the potential to detect sleepiness.

In this research, we used a systematic analysis approach to identify eye-tracking metrics for sleepiness. We used several databases to identify independent experimental studies that have used eye-tracking metrics to assess sleepiness. We identified 25 studies that included 674 participants where the participants’ data were captured both in an alert state and in a sleep-deprived state. In the analysis, we …

Teacher Perception On Integrating School Psychology In The Developing Nation Of Grenada, Carla Erica Maria St. Louis

Walden Dissertations and Doctoral Studies

AbstractInternationally, formalized school psychology and related services strive to address the academic and mental health of students in schools. In developing nations, teachers are the primary professionals to address students’ needs in schools. Little research has focused on teachers’ perceptions of students’ needs, available services’ quality, and how formalized structures with qualified certified professionals can further address students’ needs. Bronfenbrenner’s ecological systems and Nastasi’s participatory culture-specific intervention model are the theoretical underpinnings of this qualitative study and focus group interviews were used to investigate special education needs (SEN) teachers’ perceptions. Data were collected using open ended questions and probes with …

Staff Education On Medication Screening Tool For Nursing Home Residents, Jinkee Sarah Beltran

Walden Dissertations and Doctoral Studies

The prevalence of potentially inappropriate medications (PIMs) among nursing home residents continues to be high. Researchers have demonstrated that the use of a medication screening tool identifying PIMs can improve medication safety among older adults. Screening tools, such as the Beers criteria and the Screening Tool for Older Persons’ Prescriptions (STOPP), are evidence-based guidelines that use several validated criteria to identify PIMs in older adults’ medication regimens. While the use of these tools is standard in the acute care setting, limited studies have been conducted regarding their use in the nursing home setting. The purpose of this project was to …

Demographic Characteristics And Response Preparedness Of Employed Adults To Ebola Virus Disease In Monrovia, Liberia, Beth Ann Sexton

Walden Dissertations and Doctoral Studies

AbstractEbola virus disease (EVD) is a deadly disease with no known cure and it caused an outbreak from 2014-2016 in Western Africa. Liberia had the highest morbidity and mortality; its capital city, Monrovia, was the focus of this study. The purpose of this research was to explore the association between sociodemographic and socioeconomic factors (gender, religion, age, occupation, education, and ward) and the use of preventative hygiene measures and understanding of EVD among working Monrovian adults. This population was chosen because 97% of the Monrovian population is employed, and thus serves as a good source for future public health campaigns. …