Medicine and Health Sciences Commons^™

School Of Pharmacy Intellectual Property Report Fy21, Third Quarter Report - Revised July 6, 2021, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

School of Pharmacy Intellectual Property Report FY21, Third Quarter Report (as of 3/31/2021) – Revised July 6, 2021

Development And Clinical Validation Of Knowledge-Based Planning Models For Stereotactic Body Radiotherapy Of Early-Stage Non-Small-Cell Lung Cancer Patients, Justin David Visak

Theses and Dissertations--Radiation Medicine

Lung stereotactic body radiotherapy (SBRT) is a viable alternative to surgical intervention for the treatment of early-stage non-small-cell lung cancer (NSCLC) patients. This therapy achieves strong local control rates by delivering ultra-high, conformal radioablative doses in typically one to five fractions. Historically, lung SBRT plans are manually generated using 3D conformal radiation therapy, dynamic conformal arcs (DCA), intensity-modulated radiation therapy, and more recently via volumetric modulated arc therapy (VMAT) on a C-arm linear accelerator (linac). Manually planned VMAT is an advanced technique to deliver high-quality lung SBRT due to its dosimetric capabilities and utilization of flattening-filter free beams to improve …

Exploring The Relationships Between Cultural Values And Diet Patterns Among Mexican And Cuban Immigrants In Kentucky, Nasreen Omran

Theses and Dissertations--Nutrition and Food Systems

The number of Latinx in the U.S. is expected to grow to about 28 percent of the population by the year 2060. As the number of Latinx increases in the U.S. it is important to understand how cultural beliefs influence dietary behaviors as Latinx are disproportionately affected by diet related disease such as diabetes mellitus, cancer, and cardiovascular disease. The aim of this secondary data analysis is to examine the relationship between family values, gender roles, and religious values on diet patterns in adult Mexican and Cuban immigrants in Kentucky utilizing the Mexican American Cultural Values Scale. The study findings …

Evaluating The Impact Of Tobacco Retailer Density On Smoking Among Patients With Serious Mental Illness And Diabetes In New York State, Amani Alharthy

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT

Therapy And Medical Imaging Applications Of Focusing Polycapillary X-Ray Optics, Weiyuan Sun

Legacy Theses & Dissertations (2009 - 2024)

Focusing polycapillary optics yield high gains in intensity and increased spatial resolution for a variety of clinical, lab-based, synchrotron, or in situ analysis applications. In this dissertation we investigate the extension of two applications of focusing polycapillary optics. The first is the application of polycapillary optics in radiation therapy. This discussion includes measurements and calculation of dose for focused beam orthovoltage therapy. A system has been designed to investigate whether the polycapillary optics can produce an X-ray beam which can give more accurate dose painting due to the higher dose concentration at the focal spot. X-ray exposures were measured with …

Applied Methodologies Demonstrated Through Three Independent Studies For Assessing The Effects Of Socioeconomic, Environmental Chemical Exposure, And Therapeutic Factors On Oncological Diseases And Covid-19, Bayarmagnai Maggie Munkhjargal

Legacy Theses & Dissertations (2009 - 2024)

When trying to understand risk factors for a disease, even before we know the causal agents, it is necessary to create a surveillance data set that answers the questions of who, when, and where, and includes any potential covariates which may either promote or prevent the disease. There are a wide variety of surveillance data. For example, hospital discharge data, such as the New York Statewide Planning and Research Cooperative System (SPARCS) data, encompass all hospitalized cases in the state, while clinical datasets cover a specially constructed population in pursuit of research of a certain disease type. Analysis of surveillance …

Legacy And Emerging Per- And Polyfluoroalkyl Substances : Analysis, Environmental Distribution, And Bioconcentration, Richard Anthony Brase

Legacy Theses & Dissertations (2009 - 2024)

Per- and polyfluoroalkyl substances (PFAS) constitute a broad class of anthropogenic chemicals that have been used in numerous industrial and consumer-product applications since the late 1940s. The environmental persistence of these compounds in combination with their widespread commercial use have led PFAS to be recognized as contaminants of concern on the global scale. Despite regulatory efforts calling for the decreased use of certain perfluorocarboxylic and -sulfonic acids referred to as “legacy” PFAS, these compounds continue to be detected in both environmental and biological matrices. Moreover, manufacturers have begun to replace the legacy PFAS with emerging alternatives for which the regulations …

Mapping Of Auditory Cortical Functions Using Electrocorticography, James Robert Swift

Legacy Theses & Dissertations (2009 - 2024)

Communication is a dynamic process through which we translate our inner thoughts in such a way that they can be shared with another person. This complex neurological phenomenon is a key predictor of our productivity and health. When our ability to communicate is compromised, our quality of life suffers. Although numerous methods to investigate the neuroscientific underpinnings of human language exist, our understanding of this process remains incomplete. Improving our understanding of where, when, and how auditory cortical activity occurs can enhance diagnostic techniques and improve treatment methods for neurological conditions that can impact auditory processing, such as epilepsy, or …

Promoting Patient Safety Using Virtual Safety Huddles, Rachael Burris-Alcala, Julie Baker, Ann Gosdin

2021

Background: Staff Safety Huddles have been shown to improve communication and to help make patient safety a priority. Conducting daily safety huddles in Plano ACS are difficult because of how each nursing unit is structured. There are four units with 12 beds in each unit. The units are separated from each other and only have one charge nurse for all four units. Finding a solution to conduct daily huddles was a priority. Safety huddles occurred daily on both day and night shifts. Although the safety huddles helped identify safety concerns, it did not solve the problem of the entire …

Long Noncoding Rna Ak001796 As A Mediator Of Epithelial-To-Mesenchymal Transition In Metastatic Breast Cancer, Sumayya Adib Alchalabi

Legacy Theses & Dissertations (2009 - 2024)

Long noncoding RNAs (lncRNAs) are emerging as key molecules regulating several cellular pathways and contributing to the development and progression of different diseases including cancer. The epithelial-to- mesenchymal transition (EMT), a molecular reprogramming process that plays a critical role in cancer metastasis, involves a complex interaction between protein coding and non-coding transcripts including lncRNAs. Understanding the biological significance of those lncRNAs of relatively unknown function, may help to uncover potential therapeutic targets for the aggressive subtypes of breast and other cancers. In this study, we examined the expression profiles of more than 17,000 lncRNAs in a large set of patients’ …

The Association Between Medical Students' Motivation With Learning Environment, Perceived Academic Rank, And Burnout, Ronen Zalts, Nathaniel Green, Sean Tackett, Robert Lubin

Touro University Worldwide Publications and Research

Objectives: To assess the correlations between extrinsic and intrinsic motivation, personal growth and quality of life with learning environment perceptions, perceived academic rank and burnout among medical students.

Methods: Cross-sectional questionnaires were administered to medical students at three medical schools in Israel, Malaysia, and China, at the end of one academic year. Surveys included demographic data, students' perceived academic rank, two learning environment perceptions scales, and scales for personal growth, goal orientation, burnout and quality of life. Comparative analyses were made to determine the significance of relationships between the outcome measures and control variables, using a series of t-tests. Pearson …

Cultural Diversity In The Practice Of Physical Therapy: A Review Of The Literature, James M. Mckivigan

College of Health & Human Services (TUN) Publications and Research

Background: Cultural competence is a term that encompasses one’s capacity for understanding, communication, and effective interactions with individuals across the cultural spectrum. Recognition of these principles and practical training focused on relevant skills and abilities are needed to prevent discriminatory practices based on patient age, ethnicity, socioeconomic status, race, religion, gender identification, and sexual orientation. A culturally competent physical therapist will be able to use these skills and abilities to promote effective communication with all patients and remove barriers to obtaining appropriate health care.

Methods: Toward this end, this study includes a review of the recent literature and focuses on …

A Novel Role For Neurotensin In Regulation Of Stem Cell Function In The Small Intestine, Stephanie Rock

Theses and Dissertations--Toxicology and Cancer Biology

Neurotensin (NT) is a nutrient-regulated gut hormone that plays important roles in lipid absorption, obesity, metabolic disorders, and normal and neoplastic growth in the intestine. In this study, we 1) elucidate the mechanisms regulating NT release from endocrine cells, 2) examine the role of NT on proliferation and stem cell function in the small intestine and 3) define the effects of NT on colorectal cancer stem cells. We report that NT release from endocrine cells is enhanced by the MAPK scaffold protein Kinase Suppressor of Ras 1 (KSR1) and the exocyst complex component 70 (Exo70). Moreover, free fatty acid stimulated …

Monstrous And Beautiful: Jungian Archetypes In Wilde’S Salomé, Nayana Rajnish

English (MA) Theses

The subject of my research is the 1891 play Salomé, by Oscar Wilde and my thesis addresses the modern psychological implications of the cultural truths revealed by Wilde's re-vision of the myth of that biblical femme fatale. I argue that in fashioning a tragic heroine out of a female monster figure of “Immortal Vice”, Oscar Wilde created a document that captures two contradictory narratives: one in which Salomé plays the heroine of a tragedy and another in which she performs the role and functions of a villain. By employing Carl Jung's psychology of the archetypes, I am enabled …

Effects Of Season And Nutrition On Insulinemic Responses In Insulin Dysregulated Horses, Erica Lyn Macon

Theses and Dissertations--Veterinary Science

Insulin dysregulation (ID) is the main risk factor for the development of hyperinsulinemia-associated laminitis (HAL). ID in the equid has been extensively researched; however, recommendations for diagnosing and managing ID horses have originated from work completed in other models, such as the ID pony and healthy horse. Therefore, our overall objective was to improve current diagnostic tools and nutritional management strategies by investigating the effect of season, the fed and fasted state on the oral sugar test (OST) and dietary nutrient content on insulinemic responses in the ID horse. To address this, four main objectives with three specific aims were …

Evaluating The Incidence Of Melanoma And Lung Cancer Of Current And Former Active-Duty U.S. Military Who Were Deployed In Support Of Operation Enduring Freedom And Operation Iraqi Freedom, Brian Kovacic

Theses and Dissertations--Epidemiology and Biostatistics

The incidence of melanoma and lung cancer has been gradually increasing in the United States over the past three decades with the reputed causes due to etiological and environmental exposures, and tobacco usage. There has been concern that melanoma and lung cancer incidence among military personnel may be associated with deployment to environments with intense sun exposure and increased smoking rates due to post-traumatic stress disorder. The aim of this study was to examine associations between deployment in support of Operation Enduring Freedom (OEF) or Operation Iraqi Freedom (OIF), from 2001 through 2015, with subsequent melanoma and lung cancer incidence. …

Sexual Behaviors Associated With Online Partner-Seeking Among Men Who Have Sex With Men From Small/Midsized Towns Or Rural Areas In Kentucky, Vira Pravosud

Theses and Dissertations--Epidemiology and Biostatistics

The HIV epidemic remains one of the most significant public health issues in the United States, particularly among men who have sex with men (MSM). New avenues for partner-seeking have emerged over the past three decades, including through the Internet, social media, and geosocial networking applications. Consisting of three cross-sectional studies, this dissertation research aimed to determine associations between the use of various online tools for partner-seeking (hereafter collectively referred to as “apps”) and HIV-related sexual behaviors among 252 young adult MSM residing in small/midsized towns or rural areas in Central Kentucky, a group that has been under-represented in the …

Human Development, Portland State University. Human Development Teaching And Learning Group

PDXOpen: Open Educational Resources

This open textbook is designed for Human Development, a core Psychology course. This course provides a bird’s eye view of major milestones and developmental tasks during each age period, starting at conception and ending with old age.

Improving Pediatric Healthcare Workers Personal Safety Through The Implementation Of A Behavioral Rapid Response Team, Jennifer Brown, Diana Montoya

2021

From 2017 to 2018, a metropolitan pediatric hospital noted a 62.6% increase in calls to security for uncooperative patients related to physical aggression and acute behavioral decompensation. Even with annual de-escalation and restraint training, a 2019 survey conducted by clinical educators discovered only 27% of staff felt safe when handling an aggressive patient. This drove a collaborative initiative to formulate a multidisciplinary Behavioral Emergency Response Team (BERT) to standardize care, emergently respond in behavioral situations, and act as a resource to staff. Nurse professional development (NPD) specialists were used to create and develop a multifaceted education approach including instructor-led training, …

Toward An Evidence-Based Definition And Classification Of Carbohydrate Food Quality: An Expert Panel Report., Judith C. Rodriguez, Kevin B. Comerford, Yanni Papanikolaou, Julie Miller Jones, Joanne Slavin, Siddhartha Angadi, Adam Drewnoski

Showcase of Faculty Scholarly & Creative Activity

(Article Abstract) Carbohydrate-containing crops provide the bulk of dietary energy worldwide. In addition to their various carbohydrate forms (sugars, starches, fibers) and ratios, these foods may also contain varying amounts and combinations of proteins, fats, vitamins, minerals, phytochemicals, prebiotics, and anti-nutritional factors that may impact diet quality and health. Currently, there is no standardized or unified way to assess the quality of carbohydrate foods for the overall purpose of improving diet quality and health outcomes, creating an urgent need for the development of metrics and tools to better define and classify high-quality carbohydrate foods. The present report is based on …

Advocates And Researchers Working Together To Improve School Health Education, Joseph Donnelly, Michael Young, Katherine J. Roberts

Department of Public Health Scholarship and Creative Works

Purpose: This article discusses the need for continued evaluation of health education interventions/curricula and provides tools and resources to facilitate the selection of appropriate, evidencebased interventions/curricula for school health education programs. Methods: We review the literature related to the evaluation of school health education programs, provide a review of the basics for understanding evaluation design and results, and identify resources for selecting effective curricula. Conclusions: There is a need for additional rigorously designed evaluations of school health education programs. School health educators and other advocates for school health education must have a basic understanding of evaluation design and how to …

Building Assets Toolkit: Developing Positive Benchmarks For Adolescent Girls—Instruction Guide [Arabic], Judith Bruce, Sarah Engebretsen, Kimberly Glazer

Poverty, Gender, and Youth

English Summary:
The Building Assets Toolkit is an approach for developing programs for specific segments of girls that will prepare them to better face the challenges of growing up. It will help program managers understand the needs of the girls in their community, engage stakeholders at different levels and with different viewpoints, and build concrete and meaningful programming for adolescent girls. The toolkit contains all the materials needed to help make a preliminary assessment of the assets a girl should acquire and the age by which she should acquire them. This document contains the Building Assets Toolkit’s List of …

Exploring The Evolution Of Professional Identity Formation In Health Professions Education, Lindsey E. Moseley, Lauren Mcconnell, Kimberly B. Garza, Channing R. Ford

Research, Publications & Creative Work

This article provides a general overview of professional identity formation (PIF) in health professions education, a summary of relevant theories related to PIF, and a description of pedagogical models which promote PIF.

Assessment Of Professional Identity Formation: Challenges And Opportunities, Kimberly B. Garza, Lindsey E. Moseley, Channing Ford

Research, Publications & Creative Work

This final chapter will discuss challenges of assessing PIF, available assessment tools, and future directions.

How Did We Learn About Sex? —— Sex Education And Sexual Health In Chinese Youth, Yujuan Liu

Theses and Dissertations (Comprehensive)

Attitudes toward sexuality among Chinese youth have become more liberal in recent generations, but sex education remains controversial and limited. Due to the lack of awareness of sexual risks, many Chinese youth engage in unprotected sexual activities resulting in unintended pregnancy, abortions, and STIs. Therefore, understanding successful pathways and unique challenges are crucial to develop adequate sex education for youth’s sexual health in China. The current study used semi-structured in-depth interviews and investigated 28 Chinese youths’ experiences of sex education and sexual health. The results mapped out youth’s sex education experiences by age and sources and demonstrated the impacts of …

A Comprehensive Review On Genetic Diversity And Phylogenetic Relationships Amongnative Turkish Cattle Breeds Based On Microsatellite Markers, Eymen Demi̇r, Taki̇ Karsli, Murat Soner Balcioğlu

Turkish Journal of Veterinary & Animal Sciences

Many local breeds belonging to different livestock species such as cattle are in danger of extinction, since farmers prefer high-yielding breeds as well as intensive selection pressure. This fact leads to conduct suitable breeding and conservation programs in worldwide. Revealing genetic diversity is the first step for applying breeding and conservation programs. In this respect, this is the first comprehensive study aimed to review current genetic diversity and phylogenetic relationships among native Turkish cattle breeds based on previous microsatellite marker studies. Compared to other local cattle breeds reared in different regions of the world, native Turkish cattle breeds hold a …

Pelvic Limb Thermography In Dogs Submitted To Different Thermotherapy Modalities, Samyla Paiva De Albuquerque, Orimacelio Da Costa Martins, Ariel De Aguiar, Lorena Oliveira Silva, Acácio Duarte Pacheco, Lourdes Marina Bezerra Pessoa, Luís Eduardo Maggi, Soraia Figueiredo De Souza

Turkish Journal of Veterinary & Animal Sciences

Veterinary physiatry is an area in need of further studies and a discipline in which the protocols used in the veterinary clinical routine are often extrapolated from studies in medicine. This study aimed to evaluate the effectiveness of different types of thermotherapy and massage, through thermography, in promoting heating or cooling in the pelvic limb of healthy dogs. Five healthy adult dogs (male and female) of different breeds were subjected to 5 treatments: G1: massage without oil; G2: oil massage; G3: heating with a thermal bag at 43 ± 1 °C; G4: cryotherapy with ice pack; and G5: therapeutic ultrasound. …

Effect Of Eggshell Temperatures On Hatching Performance, Egg Production, And Bonemorphology Of Laying Hens, Serdar Kamanli, Zi̇şan Servet Yalçin, Ahmet Nuri̇ Taşdemi̇r, Bülent Tarim, Engi̇n Tülek, Hüseyi̇n Aygören, Öğünç Meral, Bi̇rkan Karsli, Tansel Ansal Balci, Mehmet Bozkurt

Turkish Journal of Veterinary & Animal Sciences

The present study aims to evaluate the effect of lower or higher eggshell temperatures from days 7 to 21 on hatching performance, bone and blood parameters, and egg production along with the age of laying chickens. A total of 3150 eggs obtained from a white egg-type breeder were divided randomly into 3 groups of 1050 eggs. From 7 to 21 days, eggs were incubated at one of three eggshell temperatures: Control (IC) 37.5 °C, low (IL) 36.9 °C, and high (IH) 38.5 °C. At hatch, chicks were weighed, and blood was collected to measure total Ca, inorganic P, and ALP …

The Effect Of Jatropha Multifida L. As A Natural Dietary Additive On Anthelmintic Activity And Performance In Lambs Infected By Trichostrongylus Spp., Juju Julaeha, Diky Ramdani, Endang Yuni Setyowati

Turkish Journal of Veterinary & Animal Sciences

Jatropha multifida leaf powder (JMLP) is rich in phenolic tannins and it has the potential to be a natural dietary additive for ruminants. A 4 × 5 factorial design was used to study the effects of 4 different doses of JMLP treatment (dry matter, DM basis) at 0% (JMLP-0), 0.5% (JMLP-0.5), 0.75% (JMLP-0.75), and 1% (JMLP-1) in the diet of ewe lambs infected by Trichostrongylus spp. at 2332 ± 248 eggs/g feces on fecal egg counts (FEC, eggs/g feces) of 5 different measurement times (0, 14, 28, 42, and 84 days) using 5 replicates. Average daily gain (ADG, g/head/day) and …

The Curative Effects Of Dietary Yeast Beta-1,3/1,6-Glucan On Oxidative Stress And Apoptosis In Laying Quails (Coturnix Coturnix Japonica) Exposed To Lead, İsmai̇l Seven, Pinar Tatli Seven, Seda İflazoğlu Mutlu, Gözde Arkali, Nurgül Bi̇rben, Aslihan Sur Arslan, Mesut Aksakal

Turkish Journal of Veterinary & Animal Sciences

The objective of this study was to investigate the effects of supplementation of beta-glucan to the basal diet of laying quails exposed to lead (Pb) toxicity. A total of 112 birds were randomly divided into 4 groups. The first group was fed a corn-soybean based basal diet without any supplementation (control). The second (Pb) and third (beta-glucan) groups were supplemented with 100 mg/kg of Pb (as Pb acetate) and 100 mg/kg of beta-glucan, respectively. The fourth group (Pb + beta-glucan) was fed a basal diet supplemented with 100 mg/kg of Pb and 100 mg/kg of beta-glucan. It was determined that …