Medicine and Health Sciences Commons^™

Plasma Concentrations Of Per- And Polyfluoroalkyl Substances And Body Composition From Mid-Childhood To Early Adolescence, Jaclyn Janis, Sheryl Rifas-Shiman, Shravanthi M. Seshasayee, Clifford J Rosen, Abby F Fleisch, Sharon Sagiv, Emily Oken

Costas T. Lambrew Research Retreat 2021

BACKGROUND

• Per- and polyfluoroalkyl substances (PFAS) may alter body composition by lowering anabolic hormones and increasing inflammation.

Prior studies have found positive, inverse, and null associations of PFAS concentrations with adiposity among children and adolescents.

Few studies have examined associations of PFAS concentrations with changes in body composition longitudinally.

No study has examined the association of PFAS plasma concentrations with lean mass.

Parent Experience Of Hie And Hypothermia: A Call For Trauma Informed Care, Anna Sagaser, Betsy Pilon, Annie Goeller, Monica Lemmon, Alexa Craig

Costas T. Lambrew Research Retreat 2021

Objective:

To assess parents’ experience of communication with the medical team and involvement with their infant during HIE treatment.

Naloxone Co-Prescribing Across A Large Health System: A Quality Improvement Project, Marc D. Kimball, Sarah Hemphill, Kristen Silvia

Costas T. Lambrew Research Retreat 2021

Introduction:

• Naloxone availability and administration saves lives

• The CDC recommends naloxone co-prescribing for patients with OUD and other eligibility criteria

• Maine Medical Center’s baseline was found to be 6% in one clinic. This held true across the entire MaineHealth system.

Perceptions Of Self-Efficacy And Experiences Of Mindfulness On Pain And Anxiety In Patients Undergoing A Colorectal Surgery: A Prospective Mixed Methods Study, Rebecca Brown, Julie Fitzgibbons, Rachel Farrington

Costas T. Lambrew Research Retreat 2021

Introduction

• Pain and anxiety have a physiological response on the body.

• Increased heart rate, respiratory rate and blood pressure can lead to complications, and thus longer hospitalization along with decreased patient satisfaction.

Resilience Of Regional Hospital Nursing Staff Working During The Covid-19 Pandemic Measured By The Connor-Davidson Resilience Scale, Jill Petzel Baer

Costas T. Lambrew Research Retreat 2021

Low resilience is widespread in nursing staff during the COVID-19 pandemic

The Effect Of High Fat Diet On Marrow Adipocytes From C57bl/6j (B6) Mice, Gisela Pachón-­Peña, Clifford J. Rosen, Samantha Costa

Costas T. Lambrew Research Retreat 2021

In mice models, the administration of a high fat diet (HFD) is an accelerating factor for metabolic syndrome, impaired glucose tolerance, and early type 2 diabetes mellitus (T2DM) (1)

Telemedicine Consultation To Assess Neonatal Encephalopathy In Rural Community Hospitals, Rachel Coffey, Misty Melendi, Anya J. Cutler, Alexa K. Craig

Costas T. Lambrew Research Retreat 2021

We studied the feasibility of tele consults in community hospitals for neonatal encephalopathy evaluation.

Studying Emotions In Tele-Palliative Care, A Small Formative Study, Eric Anderson, Rebecca Hutchinson, Mollie Ruben, Noah Manning, Kathleen Walsh, Robert Gramling, Paul Han

Costas T. Lambrew Research Retreat 2021

Can emotional connection be formed in virtual consults?

Standardized Ekg Curriculum, Michael Ellerman, Jon Nichols, Sanjeev Francis

Costas T. Lambrew Research Retreat 2021

Goal: To study the effect of a standardized EKG curriculum on competency of interpreting common EKGs among internal medicine residents

Spiritual/Religious Orientation And Moral Distress In Pulmonary Care Nurses: An Exploration Of Ethical Norms, Moral Agency And Moral Resilience, Kristiina Hyrkas, Myrna Koonce

Costas T. Lambrew Research Retreat 2021

Introduction

• Nurses who provide care which they perceive as increasing suffering often experience moral distress (MD).

• Response to MD is a key factor in nurse wellbeing and retention, and is widely studied in nurses.

• Less research exists on foundations of moral belief and practice among nurses.

Safe Injection To Prevent Infection: Specific Injection Practices Are Associated With Hepatitis C Exposure, Suggesting Opportunities For Targeted Harm Reduction Intervention For People Who Inject Drugs In Maine, N P. Sankar, K Murray, D Burris, K Thakarar

Costas T. Lambrew Research Retreat 2021

Background

• The U.S. opioid epidemic has contributed to an increase in infections related to IDU, such as HCV

• Transmission of HCV has been linked to unsafe injection practices

• This study aims to characterize risk factors associated with HCV exposure amongst people who inject drugs in Maine Methods

Resident Instruction In Social Emergency Medicine, Heidi Roche, Christine Knettel, Brandon Knettel, Justin Myers, Jessica Dunn, Timothy S. Fallon

Costas T. Lambrew Research Retreat 2021

Understanding social determinants of health (SDH) and their intersection with emergency medicine, also known as social emergency medicine (SEM), is an important area of EM training.

Prolonged Thunder Before The Storm – Diagnosis Of Aortobronchial Fistula After 28 Months Of Recurrent Hemoptysis, Hilamber Subba, Truc Ta, Edmund Sears

Costas T. Lambrew Research Retreat 2021

Aortobronchial fistula (ABF) should always be considered in patients with hemoptysis and previous thoracic surgery, however the diagnosis is known to be difficult both clinically and radiographically1. We present a case with the longest indolent course of hemoptysis reported to date .

Preventive Healthcare Services Receipt And Primary Care Provider Utilization Among People Who Inject Drugs, E K. Nenninger, Kinna Thakarar

Costas T. Lambrew Research Retreat 2021

Introduction:

People who inject drugs (PWID) face barriers to accessing primary care providers (PCPs) and preventive services, but are at increased risk for preventable infections

Preventive services can be accessed through PCPs, or while hospitalized or at community organizations like syringe service programs (SSPs)

Phq 9 Utilization In Maine Health, Steven Gerrish, Kerri Barton, Neil Korsen

Costas T. Lambrew Research Retreat 2021

The PHQ is a brief patient survey for diagnosing depression and monitoring response to treatment.

Would Surgeons Opt For Polypropylene Mesh If They Hypothetically Had Stress Urinary Incontinence Or Pelvic Organ Prolapse?, William J. Devan, Sanchita Bose, Dayron Rodriguez, Ricardo Munarriz, Linda Ng

Costas T. Lambrew Research Retreat 2021

Introduction

• Controversy surrounding vaginal mesh kits

• Many patients have negative connotations regarding mesh

• If patients were shown that their surgeons would opt for mesh –maybe this would help lessen the negativity?

Exploring Ob/Gyn Provider Knowledge, Practice And Confidence Levels Before And After Aces Training, Nadi Nina Kaonga, Alexandra Turnbull, Paula Vokey, Julia Brock

Costas T. Lambrew Research Retreat 2021

Trauma-informed training on ACEs improves provider confidence on screening and treating their prenatal patients.

Process Evaluation Of A Smoking Cessation Group For Adults With Serious Mental Illness, David M. Weiss, Thomas Styron

Costas T. Lambrew Research Retreat 2021

Tobacco cessation strategies are needed to improve health outcomes among individuals with serious mental illness

The Nci/Nih Cancer Moonshot Biobank (Cmb) And The Maine Cancer Genetics/Genomics Education Core (Me-Cgec) Collaborate To Improve Cancer Care In Maine, Anne C. Breggia, Sue Miesfeldt, Neil Korsen, Jill Prescott, Lisa Lemire, Meghan Searight, Jamie Saunders, Scot Remick

Costas T. Lambrew Research Retreat 2021

Goal: To better understand drug resistance and sensitivity in patients with late stage (Stage III & IV) cancers that are receiving standard of care molecularly targeted therapies through next generation sequencing (NGS) of biopsy and blood samples collected longitudinally (diagnosis-- treatment--progression).

The Maine Lung Cancer Coalition: A Statewide, Multi-Sector Partnership To Improve Evidence-Based Lung Cancer Prevention & Screening, Leo B Waterston, Liz Scharnetzki, Susan Leeds, Jaclyn A. Janis, Lee Lucas, Deborah Deatrick, Rebecca Boulos, Neil Korsen, Paul K.J. Han

Costas T. Lambrew Research Retreat 2021

MLCC has two primary goals:

1. Engage and educate about evidence based lung cancer prevention and screening practices

2. Develop, implement, and evaluate innovative programs to increase access to prevention, screening, and treatment services for all Mainers

The Introduction Of A Multimodal Clinical Pathway For Outpatient Total Knee Arthroplasty In The Era Of Covid-19, D Bunch, R Mountjoy, G Korsunsky, A Rana, C Sturgeon

Costas T. Lambrew Research Retreat 2021

The combination of a short acting spinal and muscle-sparing regional blocks, including adductor canal and iPACK blocks, can allow for successful outpatient total knee arthroplasty.

The Development Of A Cancer-Targeting Peptide-Drug Conjugate For The Treatment Of Melanoma, Cassandra Dill

Pharmaceutical Sciences (MS) Theses

Cancer is an ongoing global pandemic which has caused a dramatic shift in research priorities. One of the most aggressive and difficult to treat has invariably remained metastatic melanoma. Although encompassing only 4% of overall skin cancer diagnoses, chances for recovery were slim until recent revolutionary development of immunotherapy adding to its regimen spectrum. This is due to its resistance to many standard-of-care treatment methods, along with its relatively high-metastatic potential. Within the past decade, eight new targeted and immune checkpoint inhibitors have gained FDA approval. The median life survival has increased significantly from 9 months to over 2 years …

Amphiphilic Cell-Penetrating Peptides Containing Natural And Unnatural Amino Acids As Drug Delivery Tools And Antimicrobial Agents, David Salehi

Pharmaceutical Sciences (MS) Theses

Cell-penetrating peptides containing arginine as positively charged residues and tryptophan or diphenylalanine as hydrophobic residues were synthesized. The synthesis was accomplished through the Fmoc solid-phase peptide synthesis in the presence of HBTU and DIPEA. The side-chain protected linear peptides were cleaved from the resin and cyclized in the presence of DIC and HOAt in the solution phase overnight. MALDI-TOF mass spectrometry was used to characterize the peptides.

The cytotoxicity of the synthesized peptides was determined in CCRF-CEM (human, lymphoblast peripheral blood), and HEK-293 (human, embryonic epithelial kidney healthy) cells using the MTS assay. A concentration of 10 µM was found …

Invasive Mammary Carcinoma In Young Women, Jessica Ravert

Medical Imaging Senior Posters

Invasive Mammary Carcinoma in Young Women

Jessica Ravert

Gina Capitano Ed.D.,R.T. (R)

Abstract

This research is a case study of a 34-year-old patient that presented with a right breast lump measuring 1.9cm found to have invasive mammary carcinoma. Diagnostic mammogram and ultrasound were followed by ultrasound guided breast biopsy to make the diagnosis.

Breast cancer is the leading cause of cancer-related death in women between the ages of 15-39 inthe United States. Annual mammograms are recommended to begin at age 40, therefore younger women often do not have mammograms or breast ultrasounds unless they have symptoms. As a result, younger …

Low-Dose Lung Cancer Screening Computed Tomography, Makalie Blazick

Medical Imaging Senior Posters

Abstract

Low dose Computed Tomography (CT) screening is essential when finding and treating suspicious lung nodules. A CT machine uses a highly advanced detector assembly that measures the amount of radiation exiting the patient and records data. A CT machine also conducts three-dimensional reconstructions of images that is used for surgical planning, CT angiography (CTA), radiation therapy planning, and virtual reality imaging. The low dose lung cancer screening is usually reserved for older patients with the greatest risk of lung cancer, including former or current smokers. To determine if someone is eligible for low dose CT screening, the pack years …

Computed Tomography And Adrenocortical Carcinoma, Rebecca Witmer

Medical Imaging Senior Posters

Computed Tomography and Adrenocortical Carcinoma focuses on key statistics of adrenocortical carcinoma (ACC). The equipment used to diagnose ACC and the specific types of studies used to diagnose ACC is discussed. Symptoms of ACC and how they affect adults and children are outlined. The research outlines potential genetic defects/other cancers that are associated with ACC. Research discusses the treatment of ACC and the therapies associated with ACC. The research describes certain characteristics of an ACC that are found on a CT scan. Multiple CT tools for diagnosing ACC are also mentioned. The research discusses the survival rate of ACC based …

Strengthening Orthopaedic Care At National Level: Output Of A Structured Residency Programme At Aga Khan University, Fateh Ali Janjua, Shah Fahad, Tashfeen Ahmad, Masood Umer

Section of Orthopaedic Surgery

This descriptive review of the output of the orthopaedic residency programme of Aga Khan University, Karachi, comprised information regarding the number of graduated residents and their educational background which was retrieved from departmental records. Information about their work location, subspecialty, current working status, participation in medical camps and national disaster relief efforts were obtained from various sources, including fellow surgeons, and social media profiles. From 1989 to 2017, a total of 48 residents graduated from the programme, with only 2(4.2%) of them being females. Overall, 19(39.6%) residents hailed from areas outside Karachi; 28(58.3%) belonged to Karachi; 1(2%) came from Kenya; …

Simulation-Based Training In The Paediatric Surgery Population: A Review Of Current Trends And Future Direction, Areej Saleem, Zorays Moazzam, Sohail Asghar Dogar, Saqib Hamid Qazi

Section of Paediatric Surgery

In recent years, simulation-based training in surgery has emerged as a viable accompaniment to traditional teaching methods. Multiple studies have highlighted the benefits of simulation-based training in both learning and teaching aspects of surgical training, with a particular emphasis on the honing of technical skills. However, multiple issues still exist in widespread implementation of simulation-based training, especially in the developing countries. Furthermore, the existing literature needs to be expanded upon in both quantity and quality domains to ensure a more evidence-based transition to simulation-based training in surgery. The current review article was planned to take a look at the existing …

Current Standards Of Postgraduate Surgical Education And Training In Pakistan: Time To Bridge The Gaps In Lieu Of National Necessity, Sabah Uddin Saqib, Abdul Hakeem Memon, Omair Saleem, Amir Hafeez Shariff

Section of General Surgery

The provision of good-quality surgical care is a salient feature of every public health system. Pakistan is ranked among low and middle-income countries where the burden of surgical disease is rapidly increasing, but the capacity of the health system has not expanded at the same pace to cater current needs. One of the key components is the dearth of trained surgical specialists and lack of easy access to surgical care. College of Physicians and Surgeons, Pakistan is the main certifying institution for surgeons, while public and private teaching hospitals bear the burden of responsibility for surgical education and training. The …

Apprenticeship To Simulation - The Metamorphosis Of Surgical Training, Muhammad Rizwan Khan, Saleema Begum

Section of General Surgery

Surgery is a dynamic specialty and surgical competencies are a combination of both technical and non-technical skills. After the inception of the art of surgery, surgical education and training has undergone incredible evolution. The first model of surgical training was introduced in the 19th century and is known as the 'apprenticeship model', followed by the famous 'Halstedian' model. However, a report by the Institute of Medicine challenged the teaching institutions to formulate alternative methods of surgical education to ensure patients' safety and to reduce the fear among patients of them being practised on. Teaching surgical skills outside the operating room …