Medicine and Health Sciences Commons^™

Randomized And Non-Randomized Designs For Causal Inference With Longitudinal Data In Rare Disorders., Rima Izem, Robert Mccarter

Pediatrics Faculty Publications

In the United States, approximately 7000 rare diseases affect 30 million patients, and only 10% of these diseases have existing therapies. Sound study design and causal inference methods are essential to demonstrate the therapeutic efficacy, safety, and effectiveness of new therapies. In the rare diseases setting, several factors challenge the use of typical parallel control designs: the small patient population size, genotypic and phenotypic diversity, and the complexity and incomplete understanding of the disorder's progression. Repeated measures, when spaced appropriately relative to disease progression and exploited in design and analysis, can increase study power and reduce variability in treatment effect …

Neural Correlates Of Infant Face Processing And Later Emerging Autism Symptoms In Fragile X Syndrome, Maggie W. Guy, John E. Richards, Abigail L. Hogan Ph.D., Jane E. Roberts

Faculty Publications

Fragile X syndrome (FXS) is the leading known genetic cause of autism spectrum disorder (ASD) with 60–74% of males with FXS meeting diagnostic criteria for ASD. Infants with FXS have demonstrated atypical neural responses during face processing that are unique from both typically developing, low-risk infants and infants at high familial risk for ASD (i.e., infants siblings of children with ASD). In the current study, event-related potential (ERP) responses during face processing measured at 12 months of age were examined in relation to ASD symptoms measured at ~48 months of age in participants with FXS, as well as siblings of …

Fever In A Returning Traveler: A Case And Literature Review Of Melioidosis, Akanksha Arya, Hamadullah Shaikh, Devin Weber, Matthew Pettengill, Sean Moss

Division of Infectious Diseases and Environmental Medicine Faculty Papers

Burkholderia pseudomallei is an aerobic, motile, non-spore-forming gram-negative bacillus found in tropical endemic environments that causes the disease melioidosis. Melioidosis displays a diversity of clinical presentations ranging from septic shock to chronic latent infection, often with characteristic abscesses in multiple organs. Melioidosis is an opportunistic infection, with risk factors, including diabetes, alcohol use, chronic lung disease, and chronic renal disease, and these risk factors increase the severity of disease (Wiersinga et al., 2006) [1]. In this case report, we illustrate a case of a 32 year old man with several risk factors and recent travel to an endemic region presenting …

Implications Of An Education Tool As A Noise Reduction Strategy In The Operating Room, Sona Wardius, Amanda Parker

College of Science and Health Theses and Dissertations

Noise in the operating room (OR) can be from many sources, including personnel and medical equipment. Excessive noise is prevalent in the OR and can lead to distractions, interruptions, stress, and medical errors. These distractions have been well-documented in the literature and can reduce the quality of patient care. Awareness and education have proven to be solutions to noise reduction, but there is little evidence in the literature regarding the adoption of a clinical guideline. The goal of this study is to bring awareness of noise levels in the OR, the most common noise distractions, and how these relate to …

A Study On The Efficacy Of A Naloxone Training Program, Gillian A. Beauchamp Md, Hoonani M. Cuadrado, Seth A. Campbell Pa-C, Bennie Eliason Chw, Chase Jones Do, Aaron Fedor Do, Lauren Grantz Pharmd, Csp, Paige Roth Lsw, Marna Greenberg

Department of Emergency Medicine

Introduction: The use of naloxone to reverse a potentially fatal opioid overdose is a harm reduction strategy that reduces mortality and increases the potential for referral to substance use treatment for affected individuals. In the setting of outreach performed by a street medicine team, we aimed to determine the effectiveness of an educational intervention involving distribution of naloxone accompanied by a brief instructive session about opioids, opioid overdose, and medication administration. Methods: Our street medicine outreach team distributed 200 naloxone kits to clinicians and volunteers involved in caring for patients on ‘street rounds,’ as well as in shelters, soup kitchens, …

Drug-Based Therapeutic Strategies For Covid-19-Infected Patients And Their Challenges, Khatereh Zarkesh, Elaheh Entezar-Almahdi, Parisa Ghasemiyeh, Mohsen Akbarian, Marzieh Bahmani, Shahrzad Roudaki, Rahil Fazlinejad, Soliman Mohammadi-Samani, Negar Firouzabadi, Majid Hosseini, Fatemeh Farjadian

Manufacturing & Industrial Engineering Faculty Publications

Emerging epidemic-prone diseases have introduced numerous health and economic challenges in recent years. Given current knowledge of COVID-19, herd immunity through vaccines alone is unlikely. In addition, vaccination of the global population is an ongoing challenge. Besides, the questions regarding the prevalence and the timing of immunization are still under investigation. Therefore, medical treatment remains essential in the management of COVID-19. Herein, recent advances from beginning observations of COVID-19 outbreak to an understanding of the essential factors contributing to the spread and transmission of COVID-19 and its treatment are reviewed. Furthermore, an in-depth discussion on the epidemiological aspects, clinical symptoms …

Self-Learned Kernel Low Rank Approach To Accelerated High Resolution 3d Diffusion Mri, Abhijit Baul, Nian Wang, Choyi Zhang, Yuchou Chang, Leslie Ying, Yuchou Chang, Ukash Nakarmi

Electrical and Computer Engineering Faculty Publications

Diffusion Magnetic Resonance Imaging (dMRI) is a promising method to analyze the subtle changes in the tissue structure. However, the lengthy acquisition time is a major limitation in the clinical application of dMRI. Different image acquisition techniques such as parallel imaging, compressed sensing, has shortened the prolonged acquisition time but creating high-resolution 3D dMRI slices still requires a significant amount of time. In this study, we have shown that high resolution 3D dMRI can be reconstructed from the highly undersampled k-space and q-space data using a Kernel Low Rank method. Our proposed method has outperformed the conventional CS methods in …

Immuno-Transcriptomic Profiling Of Extracranial Pediatric Solid Malignancies., Andrew S Brohl, Sivasish Sindiri, Jun S Wei, David Milewski, Hsien-Chao Chou, Young K Song, Xinyu Wen, Jeetendra Kumar, Hue V Reardon, Uma S Mudunuri, Jack R Collins, Sushma Nagaraj, Vineela Gangalapudi, Manoj Tyagi, Yuelin J Zhu, Katherine E Masih, Marielle E Yohe, Jack F Shern, Yue Qi, Udayan Guha, Daniel Catchpoole, Rimas J Orentas, Igor B Kuznetsov, Nicolas J Llosa, John A Ligon, Brian K Turpin, Daniel G Leino, Shintaro Iwata, Irene L Andrulis, Jay S Wunder, Silvia R C Toledo, Paul S Meltzer, Ching C Lau, Beverly A Teicher, Heather Magnan, Marc Ladanyi, Javed Khan

Faculty Research 2021

We perform an immunogenomics analysis utilizing whole-transcriptome sequencing of 657 pediatric extracranial solid cancer samples representing 14 diagnoses, and additionally utilize transcriptomes of 131 pediatric cancer cell lines and 147 normal tissue samples for comparison. We describe patterns of infiltrating immune cells, T cell receptor (TCR) clonal expansion, and translationally relevant immune checkpoints. We find that tumor-infiltrating lymphocytes and TCR counts vary widely across cancer types and within each diagnosis, and notably are significantly predictive of survival in osteosarcoma patients. We identify potential cancer-specific immunotherapeutic targets for adoptive cell therapies including cell-surface proteins, tumor germline antigens, and lineage-specific transcription factors. …

Medicated-Assisted Treatment And 12-Step Programs: Evaluating The Referral Process, Candace S. Brown, Chudney Williams, Ryan E. Stephens, Jacqueline Sharp, Bobby Bellflower, Martinus T. Zeeman

Doctor of Nursing Practice Projects

Purpose/Background Overdose deaths in the U.S. from opioids have dramatically increased since the COVID-19 pandemic. Although medicated-assisted treatment (MAT) programs are widely available for sufferers of opiate addiction, many drop out of treatment prematurely. Twelve-step programs are considered a valuable part of treatment, but few studies have examined the effect of combining these approaches. We aimed to compare abstinence rates among patients receiving MAT who were referred to 12-step programs to those only receiving MAT.

Methods In this prospective study, a cohort of participants from a MAT clinic agreeing to attend a 12-step program was compared to 15 controls selected …

A Qualitative Examination Of Opioid Sparing Anesthesia Practices Among Crnas, Stephanie Knell

College of Science and Health Theses and Dissertations

The opioid epidemic has had significant consequences across the healthcare system in the United States. While anesthesia providers have historically provided quality intraoperative analgesia utilizing opioids, research to date suggests that these care experiences may have lasting implications on patients’ long term health outcomes. In contrast, opioid sparing anesthesia can provide patients superb analgesic coverage without the noxious side effects of opioids or the risk of misuse. As an emerging topic, no known study to date has described anesthesia providers’ qualitative experiences with opioid sparing anesthesia. Therefore, the purpose of this qualitative descriptive study was to conduct semi-structured interviews to …

Implementation Of An Emergency Reflex Action Drill To Improve Perceived Knowledge And Confidence In Intubation Skills Of Nurse Anesthesia Trainees, Amanda Lamacki

College of Science and Health Theses and Dissertations

Direct laryngoscopy remains the primary method for achieving intubation of the airway in general anesthesia. Novice laryngoscopists may encounter high stress and cognitive load when unexpectedly faced with a Cormack-Lehane Grade III or IV view in an unfamiliar and time-pressured environment. An Emergency Reflex Action Drill (ERAD) is a specifically designed action sequence intended to execute clinical interventions with minimal cognitive load in the setting of marked time pressure. The purpose of this study was to examine the implementation of the ERAD “Head-Neck-Reset” to improve perceived knowledge and confidence in intubation skills of nurse anesthesia trainees. A convenience sample of …

Simulation Education For Ultrasound Guided Peripheral Intravenous Catheter Insertion, Ronald Mack

College of Science and Health Theses and Dissertations

The purpose of this study was to evaluate student registered nurse anesthetist (SRNA) knowledge and confidence of ultrasound guided peripheral intravenous catheter insertion (UGPIV) before and after viewing an educational video. As a basis for developing a single group pre-test and post-test study, the dual coding theory was used. The authors hypothesize that SRNA knowledge and confidence would improve after an educational video intervention. A convenience sample of first, second, and third year SRNAs was used (N=31). The study participants completed a pre-survey to evaluate UGPIV knowledge and confidence, along with demographic questions. Participants were then instructed to view a …

Perioperative Non-Opioid Modalities (Pnom) Questionnaire Implementation And Validation Of Its Psychometric Properties, Liliya Sprisovskiy

College of Science and Health Theses and Dissertations

Introduction: The opioid epidemic and prescription opioid related deaths continue to grow in the US. Contributing factors to this epidemic include nonrestrictive opioid administration in the perioperative period. Though solutions to the epidemic has been discussed by anesthesia providers, there is no tool to quantiatively evaluate of their beliefs and practices for the perioperative management of pain. Over the past three years, there has been advancement in the science of nurse anesthesia on this front and in 2020 Tucker and Wong completed the development of a quantitative tool aimed at assessing CRNA beliefs and practices with regard to their use …

A Qualitative Examination Of Opioid Sparing Anesthesia Practices Among Crnas, Stephanie Knell

College of Science and Health Theses and Dissertations

The opioid epidemic has had significant consequences across the healthcare system in the United States. While anesthesia providers have historically provided quality intraoperative analgesia utilizing opioids, research to date suggests that these care experiences may have lasting implications on patients’ long term health outcomes. In contrast, opioid sparing anesthesia can provide patients superb analgesic coverage without the noxious side effects of opioids or the risk of misuse. As an emerging topic, no known study to date has described anesthesia providers’ qualitative experiences with opioid sparing anesthesia. Therefore, the purpose of this qualitative descriptive study was to conduct semi-structured interviews to …

The U.S. Should Expand Access To Dental Care For Older Adults, Madonna Harrington Meyer, Sarah Reilly, Julia Finan

Population Health Research Brief Series

Older adult Medicare recipients face high out-of-pocket dental expenses due to a lack of appropriate dental care coverage. Older adults with lower socioeconomic status tend to have worse oral health, less dental insurance coverage, greater difficulties finding a dentist, and low-quality care. This brief details the experiences socioeconomically disadvantaged older adults face in obtaining appropriate and affordable dental care and calls on Congress to include preventative and restorative dental care as part of the federal funding agenda.

Implications Of An Education Tool As A Noise Reduction Strategy In The Operating Room, Sona Wardius, Amanda Parker

College of Science and Health Theses and Dissertations

Noise in the operating room (OR) can be from many sources, including personnel and medical equipment. Excessive noise is prevalent in the OR and can lead to distractions, interruptions, stress, and medical errors. These distractions have been well-documented in the literature and can reduce the quality of patient care. Awareness and education have proven to be solutions to noise reduction, but there is little evidence in the literature regarding the adoption of a clinical guideline. The goal of this study is to bring awareness of noise levels in the OR, the most common noise distractions, and how these relate to …

Return-To-Play Rates And Clinical Outcomes Of Baseball Players After Concomitant Ulnar Collateral Ligament Reconstruction And Selective Ulnar Nerve Transposition., Somnath Rao, Taylor D'Amore, Donald P. Willier, Richard J. Gawel, Robert A Jack, Steven B. Cohen, Michael G. Ciccotti

Rothman Institute Papers

Background: Injury to the ulnar collateral ligament (UCL) leading to medial elbow instability and possible ulnar neuritis is common in overhead-throwing athletes. Treatment may require UCL reconstruction (UCLR) and concomitant ulnar nerve transposition (UNT) for those with preoperative ulnar neuritis.

Purpose: To evaluate the return-to-play (RTP) rates, clinical outcomes, and rates of persistent ulnar neuritis after concomitant UCLR and UNT in a cohort of baseball players with confirmed preoperative ulnar neuritis.

Study Design: Case series; Level of evidence, 4.

Methods: Eligible patients were those who underwent concomitant UCLR and UNT at a single institution between January 2008 and June 2018 …

Multi-Vendor And Multisite Evaluation Of Cerebrovascular Reactivity Mapping Using Hypercapnia Challenge, Peiying Liu, Dengrong Jiang, Marilyn Albert, Christopher E. Bauer, Arvind Caprihan, Brian T. Gold, Steven M. Greenberg, Karl G. Helmer, Kay Jann, Gregory A. Jicha, Pavel Rodriguez, Claudia L Satizabal, Sudha Seshadri, Herpreet Singh, Jeffrey F. Thompson, Danny J. J. Wang, Hanzhang Lu

Neuroscience Faculty Publications

Cerebrovascular reactivity (CVR), which measures the ability of cerebral blood vessels to dilate or constrict in response to vasoactive stimuli such as CO2 inhalation, is an important index of the brain's vascular health. Quantification of CVR using BOLD MRI with hypercapnia challenge has shown great promises in research and clinical studies. However, in order for it to be used as a potential imaging biomarker in large-scale and multi-site studies, the reliability of CO2-CVR quantification across different MRI acquisition platforms and researchers/raters must be examined. The goal of this report from the MarkVCID small vessel disease biomarkers consortium is to evaluate …

Enhancing Cancer Care Of Rural Dwellers Through Telehealth And Engagement (Encore): Protocol To Evaluate Effectiveness Of A Multi-Level Telehealth-Based Intervention To Improve Rural Cancer Care Delivery, Tuya Pal, Pamela C. Hull, Tatsuki Koyama, Phillip Lammers, Denise Martinez, Jacob Mcarthy, Emma Schremp, Ann Tezak, Anne Washburn, Jennifer G. Whisenant, Debra L. Friedman

Markey Cancer Center Faculty Publications

BACKGROUND: Despite lower cancer incidence rates, cancer mortality is higher among rural compared to urban dwellers. Patient, provider, and institutional level factors contribute to these disparities. The overarching objective of this study is to leverage the multidisciplinary, multispecialty oncology team from an academic cancer center in order to provide comprehensive cancer care at both the patient and provider levels in rural healthcare centers. Our specific aims are to: 1) evaluate the clinical effectiveness of a multi-level telehealth-based intervention consisting of provider access to molecular tumor board expertise along with patient access to a supportive care intervention to improve cancer care …

High-Fructose, High-Fat Diet Alters Muscle Composition And Fuel Utilization In A Juvenile Iberian Pig Model Of Non-Alcoholic Fatty Liver Disease, Heather C Spooner, Stefani A Derrick, Magdalena Maj, Rodrigo Manjarín, Gabriella V Hernandez, Deepali S Tailor, Parisa S Bastani, Rob K Fanter, Marta L Fiorotto, Douglas G Burrin, Michael R La Frano, Angelos K Sikalidis, Jason M Blank

Children’s Nutrition Research Center Staff Publications

Non-alcoholic fatty liver disease (NAFLD) is a serious metabolic condition affecting millions of people worldwide. A “Western-style diet” has been shown to induce pediatric NAFLD with the potential disruption of skeletal muscle composition and metabolism. To determine the in vivo effect of a “Western-style diet” on pediatric skeletal muscle fiber type and fuel utilization, 28 juvenile Iberian pigs were fed either a control diet (CON) or a high-fructose, high-fat diet (HFF), with or without probiotic supplementation, for 10 weeks. The HFF diets increased the total triacylglycerol content of muscle tissue but decreased intramyocellular lipid (IMCL) content and the number of …

Aberrant Crosstalk Between Insulin Signaling And Mtor In Young Down Syndrome Individuals Revealed By Neuronal-Derived Extracellular Vesicles, Marzia Perluigi, Anna Picca, Elita Montanari, Riccardo Calvani, Federico Marini, Roberto Matassa, Antonella Tramutola, Alberto Villani, Giuseppe Familiari, Fabio Di Domenico, D. Allan Butterfield, Kenneth J. Oh, Emanuele Marzetti, Diletta Valentini, Eugenio Barone

Chemistry Faculty Publications

INTRODUCTION: Intellectual disability, accelerated aging, and early-onset Alzheimer-like neurodegeneration are key brain pathological features of Down syndrome (DS). Although growing research aims at the identification of molecular pathways underlying the aging trajectory of DS population, data on infants and adolescents with DS are missing.

METHODS: Neuronal-derived extracellular vesicles (nEVs) were isolated form healthy donors (HDs, n = 17) and DS children (n = 18) from 2 to 17 years of age and nEV content was interrogated for markers of insulin/mTOR pathways.

RESULTS: nEVs isolated from DS children were characterized by a significant increase in pIRS1^Ser636, a marker of …

A Biocultural Analysis Of The Impacts Of Interactions Between West Africans And Europeans During The Trans-Atlantic Trade At Elmina, Ghana, Heidi Ellen Miller

USF Tampa Graduate Theses and Dissertations

This project utilizes a biocultural approach to assess the demographics and health of the West African population from Elmina, Ghana. Elmina, selected by the Portuguese in 1482 as the site of the first European trade fort in sub-Saharan Africa, grew from a small coastal fishing village to a large settlement over the course of more than 400 years of trade and cultural entanglement. Taken over by the Dutch and then ceded to the British, the people of Elmina navigated significant cultural changes, changes and experiences that can be detected in their skeletal remains. Bioarchaeological research concerned with the effects of …

Social Determinants Of Health Related To Stay-At-Home Order Adherence And Social Distancing Attitudes Among A Diverse Deep South Population, Jennifer L. Lemacks, Tammy Greer, Sermin Aras, Laurie Abbott, Darlene Willis, June Gipson, Mohamed O. Elasri

Faculty Publications

Objective: To describe COVID-19 related symptoms and medical care experienced in the first six months of the pandemic as well as stay-at-home order adherence, and attitudes related to COVID-19 risk and social distancing among a diverse sample of adults in the Deep South.

Methods: Survey data were collected from 411 Louisiana and Mississippi residents for three weeks in June 2020 through social media.

Results: Over half (52.5%) of participants who experienced COVID-19 related symptoms (with 41.5% experiencing at least one symptom) did not feel the severity of symptoms warranted seeking medical care. 91.6% of the Deep South …

Using Culture Independent Approaches To Gain Insights Into Human Urinary Tract Microbiome In Healthy Male And Female Individuals, Sarah Hussein El-Alawi

Archived Theses and Dissertations

No abstract provided.

Copycat Mass Killings: How Personality Might Moderate Identification With Antisocial Characters, Emily R. Mazzurco

Kean Quest

Research indicates that certain personality traits are prevalent within mass killers. Aggression, social rejection, narcissism, fame-seeking, low self-esteem, and depression are commonalities with mass killers, specifically mass shooters. Identification or idolizing antisocial fictional characters is also a common behavior within these types of offenders. These types of killers often draw inspiration for their own crimes from past criminals or from film and TV, thus committing what is known as a copycat crime. The purpose of the current study will be to examine the effects of social rejection and instigation on the likelihood of identifying with an antisocial character in young …

2021-11-22_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.

2021-11-22_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Treatment Considerations For Obstructive Sleep Apnea In Pediatric Down Syndrome, Erica Gastelum, Marcus Cummins, Amitoj Singh, Manuel Montoya, Gino Luis Urbano, Mary Anne Tablizo

Goal 3: Good Health and Well-Being

Children with Down syndrome (DS) are at high risk for developing obstructive sleep apnea (OSA) compared to children without DS. The negative impact of OSA on health, behavior, and cognitive development in children with DS highlights the importance of timely and effective treatment. Due to the higher prevalence of craniofacial and airway abnormalities, obesity, and hypotonia in patients with DS, residual OSA can still occur after exhausting first-line options. While treatment commonly includes adenotonsillectomy (AT) and continuous positive airway pressure (CPAP) therapy, additional therapy such as medical management and/or adjuvant surgical procedures need to be considered in refractory OSA. Given …

Nitrous Oxide Adaptation On Gene Expression In Breast Cancer Cells, Harsh Chheda, Estevan Ruiz Limón López, Zainab Mahmood, Ankit Sharma, Tina Tran, Uzma Abdulbaseer, Farouk Alshatti, James A. Radosevich

Chemistry and Physics Faculty Proceedings, Presentations, Speeches, Lectures

Hypothesis and Objective: Genes participating in the notch signaling pathway are influenced by exposure to high nitrous oxide (HNO) levels. Notch signaling pathway genes are responsible for regulating cell fate, differentiation, and apoptosis. Dysregulation of these genes can contribute to tumorigenesis. Alterations in the expression of these genes in MCF7 breast cancer cells could help determine the effects of the notch signaling pathway on tumorigenesis as a result of exposure to nitrous oxide.

Methods: Samples of cDNA from MCF7 and MCF7-HNO cells were used in DNA microarray analysis. Qualifying genes of interest provided a p value < .05. Differentially expressed genes (DEGs) were defined and categorized using the Gene Oncology Uniprot (GO) Molecular Function database. These cells were further analyzed using a proprietary bioinformatics analysis created by our laboratory.

Results: Exposure to HNO …

2021-11-22 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.