Medicine and Health Sciences Commons^™

Analysis Of Secondary Data To Determine The Relationship Between Age And Power Toothbrush Use, Kimberly Milleman

Health Sciences Program Student Theses, Dissertations and Capstones

The purpose of this research is to determine the relationship between power toothbrush use and a person's chronological age. Additionally, the relationship between the gingival bleeding index (GBI) scores with relation to manual and electronic toothbrush use based on age group was determined. The Diffusion of Innovation and Social Cognitive theories were used to predict and interpret the study results. After approval was received from the Institutional Review Board at Nova Southeastern University, a retrospective de-identified data set was assembled and analyzed. Secondary data was analyzed to look for a relationship betweenchronological age and power toothbrush use and GBI scores. …

A Propensity-Matched, Mortality-Adjusted Study Of Palliative Care Consult To Reduce 90-Day Hospital Readmission In A Heart Failure Cohort, Janice Shirley

Health Sciences Program Student Theses, Dissertations and Capstones

Centers for Medicare and Medicaid Services (CMS) instituted the Hospital Readmission Reduction Program (HRRP) to reduce the frequency of heart failure (HF) 30-day hospital readmissions. To meet the needs of patients with end-stage HF, palliative care (PC) is promoted to provide additional support to patients and reduceunnecessary hospital readmission. While PC is a plausible and logical intervention, effectiveness in achieving reductions in readmissions has not been assessed ina HF population with adequate controls to assess confounding.

The goal of this research was to assess the effectiveness of Palliative care for HF (HFPC) consult to effect change in 90-day hospital readmissions …

Job-Related Attitudes And Burnout Amongst Medical Physicists In The United States, Deborah L. Schofield

Health Sciences Program Student Theses, Dissertations and Capstones

In the last forty-five years, burnout has evolved from a psychological fad to a validated syndrome included in both the 10th and 11th editions of the International Classification of Diseases by the World Health Organization. Numerous studies have been conducted to determine the prevalence and toll of burnout within the health care sector including within the field of oncology. However, the impact of this syndrome on medical physicists has been largely unevaluated. This dissertation study aims to fill the gap in the literature by examining job-related attitudes and burnout amongst medical physicists in the United States. Themulti-dimensional theory of burnout …

Population Level Impact Of Self-Immolation On Burn Unit Resources: A Retrospective Case-Matched Study, Kristina Rosa Cruz Bolling

Health Sciences Program Student Theses, Dissertations and Capstones

Background: This investigator sought to enhance medical knowledge and clinical care by distinguishing the population level characteristics of patients who attempted self-immolation within the burn population and determine the impact these patients have on health-care related resource utilization. Methods: Patients who met the inclusion criteria and were admitted for a documented attempt of self-immolation were case-matched based on age, gender, total body surface area burn, inhalation injury, and burn mechanism to individuals who experienced accidental burn injuries and were admitted to the burn unit during the same time-period. To compare patients, this investigator matched patient groups using a propensity score …

Exploring Living Conditions And Asthma Among Migrant Farmworkers, Jenelle Williams

Health Sciences Program Student Theses, Dissertations and Capstones

Migrant farmworkers are exposed to many physical, chemical, and biological hazards that pose human health risks. Quality of housing is a major factor that contributes to asthma disparities around the world; however, no study to date has explored the factors associated with the high rates in this population. Poor housing conditions are associated with a wide range of health conditions, including respiratory infections and asthma. Addressing housing issues offers public health practitioners an opportunity to address an important social determinant of health. Using the Social Ecological Model, the objective of this quantitative, cross-sectional dissertation study is to examine the presence …

Relationship Between Electronic Health Literacy, Locus Of Control, Trust In Physicians, Attitudes Towards Providers, And Medication Adherence, Donrie Purcell

Health Sciences Program Student Theses, Dissertations and Capstones

Health literacy is related to a variety of health outcomes, including diseases, quality of life, and even death. Few studies have investigated the relation of e-health literacy to outcomes or the mechanism by which they may be related. The purpose of this study was to evaluate the relation of e-health literacy to patients' attitudes toward health care providers, trust in physicians, and medication adherence as well as theextent to which these relations were mediated by locus of control. Data were collected on participants 40 years and older having at least one chronic health condition from the Fostering Literacy for Good …

Applying An Ecological Perspective To Interprofessional Education: Attitude Changes In Students Of The Tri-Alliance, Angela M. Cecil

Health Sciences Program Student Theses, Dissertations and Capstones

In spring 2020, three partnering academic programs of the "tri-alliance"—occupational therapy, physical therapy, and speech-language pathology—immediately transitioned from hybrid interprofessional education(IPE) to uniprofessional, online learning experiences due to the COVID-19 pandemic. This transition presented opportunity to compare attitude changes and understand student perceptions about interprofessionalcollaboration between two tri-alliance student groups: Case 2018, N = 119 and Case 2020, N = 95. By incorporating the Bioecological Theory of Human Development (BTHD) and the Ecology of Human Performance (EHP), a comparative mixed methods case study merged quantitative results from a natural experiment and qualitative findings from a case study to learn about …

Cis-Trimethoxystilbene, Exhibits Higher Genotoxic And Antiproliferative Effects Than Its Isomer Trans-Trimethoxystilbene In Mcf-7 And Mcf-10a Cell Lines, Natália Dos Santos Gonçalves, Tamires Maria Silva Pereira De Mello, Cássia Suemi Mizuno, Saqlain Haider

Faculty and Student Publications

Stilbenes are a class of natural compounds with a wide variety of biological effects, such as antitumor activity. The best-known stilbene is resveratrol, whose clinical application is limited due to its low bioavailability. Methoxylated derivatives of this stilbene, including cis-trimethoxystilbene (cis-TMS) and trans-trimethoxystilbene (trans-TMS) have demonstrated more pronounced cytotoxic and anti-proliferative effects than resveratrol. Thus, the objective of this study is to evaluate and compare the cytotoxicity and antiproliferative effects of cis-and trans-TMS in MCF-7 and its normal counterpart MCF-10A. Both compounds were cytotoxic, genotoxic, and induced G2-M accumulation and cell death in the two cell lines. These results suggested …

The Effect Of Paternal Age On Intracytoplasmic Sperm Injection Outcome In Unexplained Infertility, Haitham Elbardisi, Mohamed Arafa, Neha Singh, Bridget Betts

Faculty and Student Publications

Objective: : To examine the effect of paternal age on intracytoplasmic sperm injection (ICSI) outcomes in unexplained infertility Subjects and Methods: : This retrospective study, done at the Hamad Medical Corporation, Doha, Qatar screened infertile couples who underwent ICSI between 2014 and 2019 for the inclusion and exclusion criteria defining ‘unexplained infertility’. Couples recruited were allocated into two groups: Group A (paternal age <35 years) and Group B (paternal age ≥35 years). Baseline characteristics, investigations including semen and advanced sperm function tests and ICSI records were compared for primary outcomes such as fertilisation, cleavage, clinical pregnancy, miscarriage and live birth; and secondary outcomes such as semen parameters and advanced sperm functions (DNA fragmentation index and oxidation reduction potential). Results: : We found that final pregnancy outcomes including clinical pregnancy rate (P = 0.231), live-birth rate (P = 0.143), and miscarriage rates (P = 0.466) were not significantly different between the two age groups. Normal fertilisation (P = 0.01) and cleavage rate after ICSI (P = 0.001) were statistically significant when the age groups were compared. Also, normal sperm morphology was found to be significantly different (P = 0.041). Conclusions: : Advanced paternal age affects sperm morphology, fertilisation and embryo cleavage in ICSI but does not appear to affect clinical pregnancy, miscarriage or live-birth rates. ICSI appears to be a valid fertility treatment option in advancing paternal age.

Eucalyptus Cinerea: Microscopic Profile, Chemical Composition Of Essential Oil And Its Antioxidant, Microbiological And Cytotoxic Activities, Matheus Saukoski Pauzer, Thais De Oliveira Borsato, Valter Paes De Almeida, Vijayasankar Raman

Faculty and Student Publications

Eucalyptus species possess anti-inflammatory, antifungal, antibacterial, and insecticidal properties. In this study, the chemical composition and biological activities of Eucalyptus cinerea essential oil (EO) and the leaf and stem anatomy were investigated. EO was extracted by Clevenger apparatus and the compounds were identified by GC/MS. The antioxidant activity was evaluated by DPPH, ABTS, and reducing phosphomolybdenum complex. Broth microdilution was used to determine antimicrobial activity. Cytotoxicity was verified against HeLa, HRT-18, and Calu-3 cells by MTT assay. The cytotoxic mechanism was studied by cell DNA content, cell cycle, and DNA fragmentation. The microscopic analyzes of the leaves and the stems …

The Impact Of The Covid-19 Pandemic On Self-Reported Management Of Chronic Conditions, Hyllore Imeri, Erin Holmes, Shane Desselle, Meagen Rosenthal

Faculty and Student Publications

Chronic conditions (CCs) management during the COVID-19 pandemic and the impact of the pandemic on patient activation (PA) and health locus of control (HLOC) remain unknown. This cross-sectional online survey study examined the role of COVID-19 pandemic-related worry or fear in PA and HLOC among patients with CCs. Individuals with CCs (n = 300) were recruited through MTurk Amazon. The questionnaire included sociodemographic questions, the Patient Activation Measure, and the Multidimensional Health Locus of Control–Form B. Out of the 300 participants, 9.7% were diagnosed with COVID-19, and 7.3% were hospitalized. Patients with cancer, chronic kidney disease, chronic obstructive pulmonary disease, …

Simultaneous Estimation Of Cinnamaldehyde And Eugenol In Essential Oils And Traditional And Ultrasound-Assisted Extracts Of Different Species Of Cinnamon Using A Sustainable/Green Hptlc Technique, Ahmed I. Foudah, Faiyaz Shakeel, Mohammed H. Alqarni, Samir A. Ross

Faculty and Student Publications

A wide range of analytical techniques are reported for the determination of cinnamaldehyde (CCHO) and eugenol (EOH) in plant extracts and herbal formulations either alone or in combination. Nevertheless, sustainable/green analytical techniques for the estimation of CCHO and EOH either alone or in combination are scarce in the literature. Accordingly, the present research was carried out to establish a rapid, highly sensitive, and sustainable high-performance thin-layer chromatography (HPTLC) technique for the simultaneous estimation of CCHO and EOH in the traditional and ultrasound-assisted methanolic extracts of Cinnamomum zeylanicum, C. burmannii, and C. cassia and their essential oils. The simultaneous estimation of …

Isolation Of Catechins From Cycas Armstrongii Miq. Of An Egyptian Origin, Ahmed Ismail, Mohamed M. Radwan, Hossam M. Hassan, Abeer S. Moawad

Faculty and Student Publications

The phytochemical investigation of Cycas armstrongii Miq. leaves and twigs using different chromatographic techniques led to the isolation of three catechin monomers; catechin (1), epicatechin (2), and epigallocatechin-3-gallate (3), for the first time from this species. The chemotaxonomic significance of the isolated compounds is discussed in the rest of this article.

Hiv-1 Tat And Morphine Differentially Disrupt Pyramidal Cell Structure And Function And Spatial Learning In Hippocampal Area Ca1: Continuous Versus Interrupted Morphine Exposure, William D. Marks, Jason J. Paris, Aaron J. Barbour, Jean Moon

Faculty and Student Publications

About half the people infected with human immunodeficiency virus (HIV) have neurocognitive deficits that often include memory impairment and hippocampal deficits, which can be exacerbated by opioid abuse. To explore the effects of opioids and HIV on hippocampal CA1 pyramidal neuron structure and function, we induced HIV-1 transactivator of transcription (Tat) expression in transgenic mice for 14 d and co-administered time-release morphine or vehicle subcutaneous implants during the final 5 d (days 9–14) to establish steady-state morphine levels. Morphine was withheld from some ex vivo slices during recordings to begin to assess the initial pharmacokinetic consequences of opioid withdrawal. Tat …

An Evaluation Of Antipseudomonal Dosing On The Incidence Of Treatment Failure, Brandon K. Hawkins, Mary Joyce B. Wingler, David A. Cretella, Katie E. Barber

Faculty and Student Publications

Introduction: Significant mortality is associated with delays in appropriate antibiotic therapy in Pseudomonas aeruginosa infections. The impact of empiric dosing on clinical outcomes has been largely unreported. Methods: This retrospective cohort compared treatment failure in patients receiving guideline-concordant or guideline-discordant empiric therapy with cefepime, meropenem, or piperacillin/tazobactam. Patients with culture-positive P. aeruginosa between 1 July 2013 and 31 July 2019 were eligible for inclusion. Patients with cystic fibrosis, polymicrobial infection, and urinary or pulmonary colonization were excluded. The composite primary outcome was treatment failure, defined as (1) therapy modification due to resistance/perceived treatment failure, (2) increased/unchanged qSOFA, or (3) persistent …

Understanding Of Pharmacy Students Towards Antibiotic Use, Antibiotic Resistance And Antibiotic Stewardship Programs: A Cross-Sectional Study From Punjab, Pakistan, Khezar Hayat, Shazia Jamshed, Meagen Rosenthal, Noman Ul Haq

Faculty and Student Publications

Antibiotic resistance (ABR) is a significant issue for public health globally. An adequate understanding of ABR and the approaches used to tackle ABR, including antibiotic stewardship programs, are vital. This study aimed to get an insight into antibiotic use, ABR, and antibiotic stewardship programs among pharmacy students of Punjab, Pakistan. This multicenter study was undertaken among final (fifth) year undergraduate pharmacy students of 7 universities of Punjab, Pakistan. A paper-based self-administered questionnaire comprising 48-items was utilized for data collection. Descriptive and inferential statistics were employed for data analysis. This study included a total of 296 respondents with a response rate …

A Modified Delphi Involving Laboratory Faculty To Define Essential Skills For Pharmacy Graduates, Jeanne E. Frenzel, Brandon T. Nuziale, Courtney L. Bradley, Jordan M. Ballou

Faculty and Student Publications

Objective. To define essential skills for Doctor of Pharmacy (PharmD) graduates that are needed in the four most common sectors of pharmacy practice as determined by expert faculty who instruct within pharmacy skills laboratories. Methods. A three-round Delphi method was used to establish consensus. In the first round, participants were asked what skills were needed by students at entry to practice in community, health-system, ambulatory care, and managed care pharmacy settings. In rounds two and three, participants were asked to rate each skill with a level of importance using a 10-point Likert scale (1=not important to 10=very important). Results. In …

Expression Of Trefoil Factor 3 Is Decreased In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Amit Reddy, Veena Shenoy

Faculty and Student Publications

In colorectal cancer (CRC), high expression of trefoil factor 3 (TFF3) is associated with tumor progression and reduced patient survival; however, bioinformatics analyses of public 'omics' databases show low TFF3 expression in CRCs as compared to normal tissues. Thus, we examined TFF3 expression in CRCs and matching normal tissues to evaluate its role in CRC progression. TFF3 gene expression was char- acterized using the bioinformatics portal UALCAN (http:// ualcan.path.uab.edu). Tissue microarrays (TMAs) of archival CRC specimens (n=96) were immunostained with anti-human TFF3 antibodies. Immunohistochemical (IHC) staining intensity was semi-quantitatively scored. For this cohort, the median follow-up was 5.4 years. Associations …

Exploring The Chemical Space Of 1,2,3-Triazolyl Triclosan Analogs For Discovery Of New Antileishmanial Chemotherapeutic Agents, Julia Fernández De Luco, Alejandro I. Recio-Balsells, Diego G. Ghiano, Ana Bortolotti

Faculty and Student Publications

Triclosan and isoniazid are known antitubercular compounds that have proven to be also active againstLeishmaniaparasites. On these grounds, a collection of 37 diverse 1,2,3-triazoles based on the antitubercular molecules triclosan and 5-octyl-2-phenoxyphenol (8PP) were designed in search of novel structures with leishmanicidal activity and prepared using different alkynes and azides. The 37 compounds were assayed againstLeishmania donovani, the etiological agent of leishmaniasis, yielding some analogs with activity at micromolar concentrations and againstM. tuberculosisH37Rv resulting in scarce active compounds with an MIC of 20 μM. To study the mechanism of action of these catechols, we analyzed the inhibition activity of the …

Multisite Study Assessing The Effect Of Cognitive Test Anxiety On Academic And Standardized Test Performance, Adam N. Pate, Stephen Neely, Daniel R. Malcom, Kimberly K. Daugherty

Faculty and Student Publications

Objective. To evaluate the degree of cognitive test anxiety (CTA) present in student pharmacists at multiple pharmacy programs in the United States and to determine if there are associations between self-reported CTA and relevant academic outcomes. Methods. All 2018-2019 advanced pharmacy practice experience (APPE) students from three US Doctor of Pharmacy (PharmD) programs (N=260) were invited to participate in the study. Participants completed a validated 37-question survey that included the Cognitive Test Anxiety Scale-2 (CTAS-2) along with demographics-related questions. Responses were analyzed using analysis of variance (ANOVA), Kruskal Wallace, and multiple linear regression where appropriate. Results. One hundred twenty-four students …

The Impact Of Two Longitudinal Professionalism Courses On Student Pharmacists’ Empathy, Brent N. Reed, Stuart T. Haines, Erin R. Holmes

Faculty and Student Publications

Objective. To determine whether empathy increased in first-year student pharmacists after completing longitudinal professionalism courses at two schools of pharmacy, identify potential moderators, and assess whether students’ conceptualization of empathy changed with time. Methods. Surveys to assess empathy and other variables were administered to student pharmacists at baseline and at the end of two professionalism courses. Baseline and follow-up scores were compared to detect changes over time. Multivariable analysis was used to identify predictors of empathy scores. Factor analysis was performed to ascertain changes in the dimensionality of empathy. Results. Students’ demographics and baseline empathy scores differed between the two …

The Association Of Self-Reported Physical Activity On Human Sensory Long-Term Potentiation, Damien Moore, Paul D. Loprinzi

Faculty and Student Publications

Exercise has been shown to enhance synaptic plasticity, therefore, potentially affecting memory. While the mechanism(s) responsible for this relationship have been explored in animal models, current research suggests that exercise may possess the ability to induce synaptic long-term potentiation (LTP). Most of the LTP mechanistic work has been conducted in animal models using invasive procedures. For that reason, the purpose of the present experiment was to investigate whether self-reported exercise is related to human sensory LTP-like responses. Nineteen participants (MAGE= 24 years; 52.6% male) completed the study. Long-term potentiation-like responses were measured by incorporating a non-invasive method that assess the …

Fit For Fire: A 10-Week Low-Cost Hift Experiential Learning Initiative Between Underrepresented Kinesiology Undergraduates And Hypertensive Deconditioned Firefighters Improves Their Health And Fitness, Melanie Poudevigne, Christina Day, Eon Campbell, Da’Lynn Mills, Reginald Porter, Ximena Zornosa, Thomas Andre

Faculty and Student Publications

The aims of this study were to investigate the feasibility of an experiential learning initiative led by minority exercise science undergraduates and to observe the adaptations after a 10-week high-intensity functional training (HIFT) program in 34 underrepresented, hypertensive, and overweight/obese professional firefighters (PFF; age: 36.8 ± 11.0 years, body weight: 97.3 ± 21.5 kg, height: 181.7 ± 6.6 cm; BMI: 29.2 ± 4.9 kg/m2). Data were analyzed for muscular strength and endurance, cardiorespiratory endurance, body composition, agility, flexibility, and readiness for change. The PFFs trained two to three times weekly during their work shifts at vigorous intensity for 40 min. …

The Evolution And Future Of Targeted Cancer Therapy: From Nanoparticles, Oncolytic Viruses, And Oncolytic Bacteria To The Treatment Of Solid Tumors, Kyle M. Pierce, William R. Miklavcic, Kyle P. Cook, Mikayla Sweitzer Hennen, Kenneth W. Bayles, Michael A. Hollingsworth, Amanda E. Brooks, Jessica E. Pullan, Kaitlin M. Dailey

Journal Articles: Pathology and Microbiology

While many classes of chemotherapeutic agents exist to treat solid tumors, few can generate a lasting response without substantial off-target toxicity despite significant scientific advancements and investments. In this review, the paths of development for nanoparticles, oncolytic viruses, and oncolytic bacteria over the last 20 years of research towards clinical translation and acceptance as novel cancer therapeutics are compared. Novel nanoparticle, oncolytic virus, and oncolytic bacteria therapies all start with a common goal of accomplishing therapeutic drug activity or delivery to a specific site while avoiding off-target effects, with overlapping methodology between all three modalities. Indeed, the degree of overlap …

Understanding Cyanide Toxicity In Victims Of Smoke Inhalation, Jessica L. Wyman

Doctor of Nursing Practice Projects

Every day in the United States forty-two people are killed or injured as a direct result of fire. Building construction materials and furnishings have evolved from natural textiles to synthetic plastic-based goods that release excessive lethal toxic gases when heated. Rapid release of gas results in critical levels of hydrogen cyanide and carbon monoxide leading to fatal toxic exposures. Nursing knowledge and confidence can improve victim survivability by improving rapid recognition and assessment of these complex patients. The purpose of this DNP project was to increase emergency department nursing knowledge, confidence and ability in assessing and appropriately triaging smoke inhalation …

Case Management Of Primary Care Patients, Bernadette Webster

Doctor of Nursing Practice Projects

Case management (CM) offered in primary care is a collaboration, guided by the registered nurse, working to coordinate all aspects of care for the patient and the family. The purpose of this quality improvement/assurance project was to provide nurses in primary care with the education and methods of CM to assist in more effectively managing care for a patient after testing positive for COVID-19. An intervention was delivered to registered nurses (RN) in the primary care setting designed to improve knowledge and skill with case management for patients with high care needs or recently diagnosed with COVID-19. A templated note …

Guideline Utilization To Promote De-Escalation Of Benzodiazepine Use In Adults With Generalized Anxiety Disorder, Magdalena A. Malloy

Doctor of Nursing Practice Projects

Benzodiazepines are commonly used as the first line treatment for adults diagnosed with Generalized Anxiety Disorder (GAD) despite clinical guidelines that recommend otherwise. This can lead to misuse, abuse, addiction, and dependence. To de-escalate use of benzodiazepines as first-line treatment, this DNP Project seeks to reinforce use of evidence-based practice via a reminder card. The guideline compliance program was assessed by chart review to determine impact on GAD-7 scores and benzodiazepine prescriptions. Total of 69 patients’ charts were audited by six prescribers, over the period of eight weeks, to determine if outcomes were met. When analyzed pre and post intervention …

Intervention Of Mindfulness With Students To Identify Mental Health Problems And Enhance Coping Strategies, Aileen M. Jones

Doctor of Nursing Practice Projects

When mental health care is delayed, a young person may have more difficulty in academia and social situations. Therefore, it is important to reach young people to provide them with the skills to deal with stressors and mental health issues. The purpose of this project is to use mindfulness techniques to increase mental health literacy (MHL) and strengthen coping skills which can possibly assist students in building resilience to cope with stressors. By utilizing available mental health resources and learning coping skills, there can be a drastic change in the trajectory of a young persons’ life who struggles with stressors …

Improving Psychological Trauma Awareness For Culturally Responsive Care: A Dnp Project, Jose M. Cruz

Doctor of Nursing Practice Projects

Racism and racial discrimination occur in a variety of forms (Kendi, 2017). Both can contribute to poor mental health outcomes in the United States (Alvarez, Liang, & Neville, 2016; Comas-Diaz, Hall, & Neville, 2019; Levy, 2019; Malott & Schaefle, 2015; Williams, Lawrence, Davis, & Vu, 2019). These social conditions have been identified as chronic stressors that can illicit trauma symptoms, result in post-traumatic stress disorder (PTSD), and contribute to increased suicidality (French et al., 2020). Providers should understand the ramifications of the psychological trauma that can occur and endeavor to deliver evidence-based solutions. This doctoral project was designed to develop, …

A Protocol For Improving Early Recognition And Treatment Of Bipolar Disorder, Zelluyah Gaitho

Doctor of Nursing Practice Projects

In bipolar disorder, patients present to a clinician during depressive episodes often leading to a misdiagnosis. In turn, this could lead to inappropriate treatment. This failure to diagnose could be attributed to lack of use of validated screening tools and deviation from clinical guidelines. The purpose of this quality improvement project was to develop a protocol that will help improve early recognition and treatment of bipolar disorder by using the Mood Disorder Questionnaire. A training program was developed to increase knowledge on the proper use of the Mood Disorder Questionnaire (MDQ) and the Quality-of-Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF). …