Medicine and Health Sciences Commons^™

Com Outlook_Winter_2021, Nova Southeastern University

COM Outlook

No abstract provided.

Biosimilars Use In Medicine For Inflammatory Diseases, Inderbir S. Padda, Rajat Bhatt, Obaid Rehman, Mayur S. Parmar

HPD Articles

No abstract provided.

Experiences Of Incarcerated Young Men In Equine-Facilitated Psychotherapy: An Interpretative Phenomenological Analysis, Cynthia Vanessa Penalva

Department of Family Therapy Dissertations and Applied Clinical Projects

In 2018, 14,000 young people between the ages of 11 and 18 were incarcerated in the United States (Fosler, 2018). Incarcerated are more likely than non-incarcerated youth to experience anxiety, depression, violence, and behavior issues. While mental health treatment facilities often provide resources such as continuing education, General Education Development, vocational training, and talk therapy services (Florida Department of Juvenile Justice, 2019), Equine-FacilitatedPsychotherapy (EFP) is a relatively unexplored intervention for this population. The increasing need for innovative mental health services tailored to specific client populations has inspired collaborations among community professionals seeking to deliver high-impact interventions. One such community effort …

Long-Term Sobriety From Opioid Use: An Interpretive Phenomenological Analysis, Claire C. Loucka

Department of Family Therapy Dissertations and Applied Clinical Projects

Opioid addiction is a current health crisis in the United States. According to the National Institute on Drug Abuse 1.7 million Americans were addicted to opioids in 2017 (NIH, 2020, para 2). According to the Centers for Disease Control and Prevention, 130 Americans die every day due to an opioid overdose (CDC, 2019, para.1). Those in treatment are 60% more likely to relapse within the first 90 days post-treatment (Weich, 2010). Marriage and Family Therapists may often work in treatment settings addressing addiction and recovery. This study utilized a Solution Focused Brief Therapy lens to seek to understand the life …

Specialists In Name Or Practice? The Inclusion Of Transgender And Gender Diverse Identities In Online Materials Of Gender Specialists, Natalie Holt, Robyn E. King, Richard Mocarski, Nathan Woodruff, Debra A. Hope

Trans Collaborations Academic Papers

Recommendations for health care providers working with transgender and gender diverse (TGD) individuals emphasize affirming clients’ identities, such as using correct pronouns and name, however it is unknown how often gender specialists adhere to such recommendations. Websites and intake forms of gender specialists were coded for use of affirming language, asking for pronouns and chosen name, and mention of TGD specialties and resources. Most websites identified the provider’s specialty to work with TGD individuals, though much fewer provided additional resources concerning TGD issues and only half of intake forms included affirming language. Given previous research that has demonstrated providers working …

Psychometric Evaluation Of The Transgender Congruence Scale, T. Zachary Huit, Allura L. Ralston, J, Kyle Haws, Natalie Holt, Debra A. Hope, Jae Puckett, Richard Mocarski, Nathan Woodruff

Trans Collaborations Academic Papers

Introduction Despite increased attention to transgender and gender diverse (TGD) issues in psychological literature during the past decade, gaps remain for psychometric validation of TGD-specific measures. Kozee et al. (Psychology of Women Quarterly 36(2):179–196, 2012) addressed such gaps by creating the Transgender Congruence Scale (TCS), measuring gender acceptance and feelings of gender congruence between internal and external attributes across a broad range of gender identities. The current study extended Kozee and colleagues’ work by further examining the psychometric properties of the TCS.

Methods Between October and November of 2017, 210 transmasculine, transfeminine, and gender diverse adults between ages 19 …

Antibiotics And Antimicrobial Resistance In The Covid-19 Era: Perspective From Resource-Limited Settings, Mentor Ali Ber Lucien, Michael F. Canarie, Paul E. Kilgore, Gladzin Jean-Denis, Natael Fénélon, Manise Pierre, Mauricio Cerpa, Gerard A. Joseph, Gina Maki, Marcus J. Zervos, Patrick Dely, Jacques Boncy, Hatim Sati, Ana Del Rio, Pilar Ramon-Pardo

Department of Pharmacy Practice

The dissemination of COVID-19 around the globe has been followed by an increased consumption of antibiotics. This is related to the concern for bacterial superinfection in COVID-19 patients. The identification of bacterial pathogens is challenging in low and middle income countries (LMIC), as there are no readily-available and cost-effective clinical or biological markers that can effectively discriminate between bacterial and viral infections. Fortunately, faced with the threat of COVID-19 spread, there has been a growing awareness of the importance of antimicrobial stewardship programs, as well as infection prevention and control measures that could help reduce the microbial load and hence …

Improved De Novo Alignment Of A Girardia Dorotocephala Ma-C2 (2n = 24) Transcriptome, Labib Rouhana, J F. Ryan, Eugene M. P. Almazan

Biological Sciences Faculty Publications

Improved De novo alignment of a Girardia dorotocephala MA-C2 (2n = 24) transcriptome.

Splenic Artery Pseudo-Aneurysm Secondary To Necrotizing Pancreatitis – A Rare Lethal Complication., Vinay Raj Dr, Divya Vishwanatha Kini Dr

Radiology Teaching Files

CLINICAL HISTORY:

A 35-year-old male patient presented with history of massive hemoptysis associated with pain abdomen and breathlessness since the past 3 days. Patient had no prior co-morbidities; however was a chronic alcoholic and smoker since the past 15 years. No hospital admissions in the past

Relationship Between Treatment Comorbidities And Viral Suppression Of Hiv Infections In Johannesburg, Nwogo Ekeji, Nwogo Immaculata Ekeji

School of Health Sciences Publications

HIV has globally infected 37.9 million people, of which 23.3 million (62%) are on antiretroviral treatment (ART). In South Africa, low rate of viral suppression among people living with HIV (PLWHIV) is a major health problem that has continued to fuel HIV persistence. A cross-sectional quantitative research design was used to investigate the relationship between treatment of comorbidities and viral suppression among HIV-infected adults aged 18 – 49 who were diabetic, had cancer, or tuberculosis (TB) in Johannesburg. The HIV care continuum formed the framework for this research. A secondary dataset from the national level survey 2017 was used for …

Cross-Sectional Nutrition Profile Of Palliative Home Care Clients In Ontario And Performance Of The Interrai Palliative Care Nutrition Clinical Assessment Protocol, Tara Stevens, Heather Keller, Nicole Williams, James Downar, Dawn M. Guthrie

Health Sciences Faculty Publications

Background: The nutrition profile of palliative home care clients is unknown. This study describes this group and their nutrition issues and evaluates the performance of the interRAI nutrition Clinical Assessment Protocol (CAP).

Methods: This was a cross-sectional secondary analysis using Ontario interRAI Palliative Care (interRAI PC) Assessment data. The sample represents 74,963 unique Ontario home care clients assessed between 2011 and 2018. Frequencies and standardized differences (stdiffs) of nutrition characteristics were presented for cancer (n = 62,394) and noncancer (n = 12,569) diagnostic subgroups. Rates of triggering the nutrition CAP were presented by nutrition issue to evaluate its performance.

Results: …

Brief Communication: A Radiology Resident's Experience With Covid-19 In New York City, A. Ramjit, A. Gokli

Journal Articles

© 2020 Elsevier Inc. The COVID-19 pandemic impacted New York City severely. As a radiology resident, I was unsure how my role would change as the pandemic unfolded. Like many hospital systems in New York City, my department was asked to assist in the clinical care of patients during the dramatic surge of admissions related to COVID-19. I placed invasive central lines for critically ill patients in the intensive care unit to help reduce the workload on already overwhelmed critical care teams. I also performed direct patient care within dedicated COVID-19 inpatient floors.

A Case-Control Study Of Prone Positioning In Awake And Nonintubated Hospitalized Coronavirus Disease 2019 Patients., P. C. Nauka, S. Chekuri, M. Aboodi, A. A. Hope, M. N. Gong, J.T. Chen

Journal Articles

To determine the association between prone positioning in nonintubated patients with coronavirus disease 2019 and frequency of invasive mechanical ventilation or inhospital mortality.

Design

A nested case-matched control analysis.

Setting

Three hospital sites in Bronx, NY.

Patients

Adult coronavirus disease 2019 patients admitted between March 1, 2020, and April 1, 2020. We excluded patients with do-not-intubate orders. Cases were defined by invasive mechanical ventilation or inhospital mortality. Each case was matched with two controls based on age, gender, admission date, and hospital length of stay greater than index time of matched case via risk-set sampling. The presence of nonintubated proning …

Inclusion Of Pregnant Individuals Among Priority Populations For Coronavirus Disease 2019 Vaccination For All 50 States In The United States., A. Grünebaum, L. B. Mccullough, A. Litvak, F. A. Chervenak

Journal Articles

No abstract provided.

Atrial Fibrillation Is An Independent Predictor For In-Hospital Mortality In Patients Admitted With Sars-Cov-2 Infection., S. E. Mountantonakis, M. Saleh, J. Fishbein, A. Gandomi, M. Lesser, J. Chelico, J. Gabriels, M. Qiu, L. M. Epstein, Northwell Covid-19 Research Consortium

Journal Articles

Background

Atrial fibrillation (AF) is the most encountered arrhythmia and has been associated with worse in-hospital outcomes.

Objective

This study was to determine the incidence of AF in patients hospitalized with coronavirus disease 2019 (COVID-19) as well as its impact on in-hospital mortality.

Methods

Patients hospitalized with a positive COVID-19 polymerase chain reaction test between March 1 and April 27, 2020, were identified from the common medical record system of 13 Northwell Health hospitals. Natural language processing search algorithms were used to identify and classify AF. Patients were classified as having AF or not. AF was further classified as new-onset …

The Impact Of Confirmed Coronavirus Disease 2019 (Covid-19) Infection On Ambulatory Procedures And Associated Delays In Care For Asymptomatic Patients, C. G. Larsen, C. D. Bub, B. C. Schaffler, T. Walden, J. M. Intravia

Journal Articles

© 2021 Elsevier Inc. Background: Since the reopening of ambulatory centers, minimal data has been reported regarding positive tests among patients undergoing ambulatory procedures, associated delays in care, and outcomes of patients previously positive for coronavirus disease 2019. Methods: A retrospective observational case series of ambulatory procedures was performed. Records since the reopening of ambulatory centers in New York were searched for patients with positive coronavirus disease 2019 nasal swab results who underwent ambulatory procedures. Chart reviews were conducted to determine coronavirus disease history and hospitalizations, demographic information, procedure details, and 30-day admissions. Results: A total of 3,762 patients underwent …

Utilization Of Extracorporeal Membrane Oxygenation During The Covid-19 Pandemic., A. Kichloo, A. Kumar, R. Amir, M. Aljadah, N. Farooqi, M. Albosta, J. Singh, S. Jamal, Z. El-Amir, N. Lone, +1 Additional Author

Journal Articles

The ongoing outbreak of severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2, or coronavirus disease 2019 (COVID-19)] was declared a pandemic by the World Health Organization on March 11, 2020. Worldwide, more than 65 million people have been infected with this SARS-CoV-2 virus, and over 1.5 million people have died due to the viral illness. Although a tremendous amount of medical progress has been made since its inception, there continues to be ongoing research regarding the pathophysiology, treatments, and vaccines. While a vast majority of those infected develop only mild to moderate symptoms, about 5% of people have severe forms of infection …

Rationale And Design For The Study Of Rivaroxaban To Reduce Thrombotic Events, Hospitalization And Death In Outpatients With Covid-19: The Prevent-Hd Study, W. H. Capell, E. S. Barnathan, G. Piazza, A. C. Spyropoulos, J. Hsia, S. Bull, C. Lipardi, C. Sugarmann, E. Suh, M. P. Bonaca, +2 Additional Authors

Journal Articles

© 2021 Elsevier Inc. Background: COVID-19 is associated with both venous and arterial thrombotic complications. While prophylactic anticoagulation is now widely recommended for hospitalized patients with COVID-19, the effectiveness and safety of thromboprophylaxis in outpatients with COVID-19 has not been established. Study Design: PREVENT-HD is a double-blind, placebo-controlled, pragmatic, event-driven phase 3 trial to evaluate the efficacy and safety of rivaroxaban in symptomatic outpatients with laboratory-confirmed COVID-19 at risk for thrombotic events, hospitalization, and death. Several challenges posed by the pandemic have necessitated innovative approaches to clinical trial design, start-up, and conduct. Participants are randomized in a 1:1 ratio, stratified …

The Use Of Oxygen Hoods In Patients Failing On Conventional High-Flow Oxygen Delivery Systems, The Effects On Oxygenation, Mechanical Ventilation And Mortality Rates In Hypoxic Patients With Covid-19. A Prospective Controlled Cohort Study, D. Dayya, O. J. O'Neill, T. D. Feiertag, R. Tuazon-Boer, J. Sullivan, L. Perez, S. Gurash, M. Eaton, T. Bodley, T. Hall, +2 Additional Authors

Journal Articles

© 2021 Introduction: Efforts to meet increased oxygen demands in COVID-19 patients are a priority in averting mechanical ventilation (MV), associated with high mortality approaching 76.4–97.2%. Novel methods of oxygen delivery could mitigate that risk. Oxygen hoods/helmets may improve: O2-saturation (SaO2), reduce in-hospital mechanical ventilation and mortality rates, and reduce length of hospitalization in hypoxic Covid-19 patients failing on conventional high-flow oxygen delivery systems. Methods: DesignProspective Controlled Cohort Study. SettingSingle Center. ParticipantsAll patients admitted with a diagnosis of COVID-19 were reviewed and 136/347 patients met inclusion criteria. Study period3/6/2020 to 5/1/2020. 136 participants completed the study with known status for …

Transitioning Trainees From The Operating Room To The Covid-19 Intensive Care Unit In New York – Correspondence, M. A. Catalano, G. F. Coppa, V. M. Patel

Journal Articles

No abstract provided.

Professionally Responsible Coronavirus Disease 2019 Vaccination Counseling Of Obstetrical And Gynecologic Patients, F. A. Chervenak, L. B. Mccullough, E. Bornstein, L. Johnson, A. Katz, R. Mcleod-Sordjan, M. Nimaroff, B. L. Rochelson, A. Tekbali, A. Warman, K. Williams, A. Grünebaum

Journal Articles

© 2021 Elsevier Inc. The development of coronavirus disease 2019 vaccines in the current and planned clinical trials is essential for the success of a public health response. This paper focuses on how physicians should implement the results of these clinical trials when counseling patients who are pregnant, planning to become pregnant, breastfeeding or planning to breastfeed about vaccines with government authorization for clinical use. Determining the most effective approach to counsel patients about coronavirus disease 2019 vaccination is challenging. We address the professionally responsible counseling of 3 groups of patients—those who are pregnant, those planning to become pregnant, and …

Should Covid-19 Patients > 75 Years Be Ventilated? An Outcome Study., H. Raheja, N. Chukwuka, C. Agarwal, D. Sharma, A. Munoz-Martinez, J. Fogel, M. Khalid, A. T. Hashmi, S. Ehrlich, G. R. Rojas-Marte, +11 Additional Authors

Journal Articles

Background

Elderly patients with COVID-19 disease are at increased risk for adverse outcomes. Current data regarding disease characteristics and outcomes in this population is limited.

Aim

To delineate the adverse factors associated with outcomes of COVID- 19 patients ≥75 years of age.

Design

Retrospective cohort study.

Methods

Patients were classified into mild/moderate, severe/very severe, and critical disease (intubated) based on oxygen requirements. The primary outcome was in-hospital mortality.

Results

355 patients aged ≥75 years hospitalized with COVID-19 between March 19th and April 25th, 2020 were included. Mean age was 84.3 years. One-third of the patients developed critical disease. Mean length …

Disposable Lives: Covid-19, Vaccines, And The Uprising, Matiangai Sirleaf

Faculty Scholarship

Two French doctors appeared on television and publicly discussed potentially utilizing African subjects in experimental trials for a tuberculosis vaccine as an antidote to the novel coronavirus (COVID-19). Tedros Adhanom Ghebreyesus, the Director-General of the World Health Organization (WHO), denounced these kinds of racist remarks as a “hangover from ‘colonial mentality’” and maintained that “Africa can’t and won’t be a testing ground for any vaccine.” The fallout on social media was similarly swift, with Samuel Eto’o, a Cameroonian football legend, referring to the doctors as “[d]es assasins” and several others questioning the motives behind testing a vaccine on the African …

Application Of Big-Data For Epidemiological Studies Of Refractive Error, Michael Moore, James Loughman, John Butler, Arne Ohlendorf, Siegfried Wahl, Daniel Ian Flitcroft

Articles

Purpose

To examine whether data sourced from electronic medical records (EMR) and a large industrial spectacle lens manufacturing database can estimate refractive error distribution within large populations as an alternative to typical population surveys of refractive error.

Subjects

A total of 555,528 patient visits from 28 Irish primary care optometry practices between the years 1980 and 2019 and 141,547,436 spectacle lens sales records from an international European lens manufacturer between the years 1998 and 2016.

Methods

Anonymized EMR data included demographic, refractive and visual acuity values. Anonymized spectacle lens data included refractive data. Spectacle lens data was separated into lenses …

In Situ Water Quantification In Natural Deep Eutectic Solvents Using Portable Raman Spectroscopy, Suha Elderderi, Laura Wils, Charlotte Leman-Loubière, Hugh Byrne, Igor Chourpa, Cécile Enguehard-Gueiffier, Emilie Munnier, Abdalla A. Elbashir, Leslie Boudesocque-Delaye, Franck Bonnier

Articles

Raman spectroscopy is a cost-effective, label free and non-destructive analytical tool [1] that delivers specific molecular information to enable the determination of the chemical composition of samples within seconds, with minimum or no requirements for sample preparation. The technique is based on the illumination of samples with a monochromatic laser source, resulting in a fraction of the light being inelastically scattered (the Raman effect) which can be collected as spectral signatures [2]. Raman spectroscopy is considered as an approach well suited for the monitoring and control of chemical and pharmaceutical processes [3,4], end point prediction of chemical synthesis reactions [5] …

Praseodymium Mid-Infrared Emission In Alf3-Based Glass Sensitized By Ytterbium, Jiquan Zhang, Mo Liu, Jin Yu, Ruicong Wang, Shijie Jia, Zijun Liu, Gerald Farrell, Shunbin Wang, Pengfei Wang

Articles

Broadband emission was obtained over 2.6 to 4.1 μm (Pr3+: 1G4→3F4, 3F3) in AlF3-based glass samples doped with different concentrations of praseodymium and 1 mol% ytterbium using a 976 nm laser pump. An efficient energy transfer process from Yb3+: 2F5/2 to Pr3+: 1G4 was analyzed through emission spectra and fluorescence lifetime values. The absorption and emission cross-sections were calculated by Füchtbauer-Ladenburg and McCumber theories and a positive gain can be obtained when P>0.3. To the best of the authors’ knowledge, this work represents the first report of broadband mid-infrared emission of Pr3+ in an AlF3-based glass. The results show …

Disentangling Social-Genetic From Rearing-Environment Effects For Alcohol Use Disorder Using Swedish National Data, Aiman Hanif, Han Tran

VCU's Medical Journal Club: The Work of Future Health Professionals

The presentation introduces Dr. Jessica Salvatore and colleagues’ work, Disentangling Social-Genetic From Rearing-Environment Effects for Alcohol Use Disorder Using Swedish National Data, on the social-genetic effects of having a spouse whose parent(s) is/are affected by alcohol use disorder (AUD). After collecting personal data of over 300,000 Swedish opposite-sex couples, the study used actor-partner interdependence model and logistic regression model to examine the association between a spouse’s AUD predisposition and the proband’s risk of developing AUD. The results showed that the proband is at a high risk of developing AUD upon marrying an AUD-predisposed spouse. The authors concluded that this relationship …

Mesenchymal Stem Cell Therapy For Knee Osteoarthritis: 5 Years Follow- Up Of Three Patients, Shahad Musa

VCU's Medical Journal Club: The Work of Future Health Professionals

This presentation is on the effects of mesenchymal stem cells on osteoarthritis in the knees. Osteoarthritis is the degeneration of cartilage and has very little long-term treatments. Most treatments are geared towards pain management and surgery is an option, but no cure exists to reverse or stop degeneration. Embryonic stem cell research is severely limited, meaning mesenchymal stem cells (adult-derived stem cells) are more accessible to research. In this study, stem cells from the patient’s bone marrow were derived and then injected into the severely damaged knees. Results were conducted six months and five years after. Six months after the …

Β-Amyloid Accumulation In The Human Brain After One Night Of Sleep Deprivation, Shahad Musa

VCU's Medical Journal Club: The Work of Future Health Professionals

This presentation is on the effects of sleep deprivation on β-amyloid accumulation in the brain. During sleep, the glymphatic system is involved in the clearance of metabolic including metabolic wastes. β-amyloid accumulation is directly correlated to impairment of brain function and Alzheimer's disease. Increased sleep or ways to decrease β-amyloid accumulation could be beneficial in the prevention of Alzheimer's. Data collected in the article published by Shokri-Kojori, E. et al. suggests that sleep deprivation negatively affected mood and was correlated with increases in amyloid- β burden in the right hippocampal cluster. Further research on how sleep impacts β-amyloid accumulation should …

Diacylglycerol Lipase-Β Knockout Mice Display A Sex-Dependent Attenuation Of Traumatic Brain Injury-Induced Mortality With No Impact On Memory Or Other Functional Consequences, Jefin Jose

VCU's Medical Journal Club: The Work of Future Health Professionals

Traumatic brain injury has been a concern in recent years with a greater understanding of its effects on the brain. The endocannabinoid system leads to inflammation when activated, leading to a poorer prognosis in vivo for traumatic brain injury patients. In the present study, the researchers wanted to identify the potentially neuroprotective effects of DAGL-β knockout when mice were exposed to traumatic brain injury. Using a variety of different techniques, the researchers were able to conclude that DAGL-β knockout did not lead to neuroprotective benefits but was associated with lower levels of mortality immediately following the injury. In addition, the …