Medicine and Health Sciences Commons^™

Polymeric Nanoparticles For Nasal Drug Delivery To The Brain: Relevance To Alzheimer's Disease, Navid Rabiee, Sepideh Ahmadi, Ronak Afshari, Samira Khalaji, Mohammad Rabiee, Mojtaba Bagherzadeh, Yousef Fatahi, Rassoul Dinarvand, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin, Thomas J. Webster

School of Dentistry Faculty Research and Publications

Currently, Alzheimer's disease (AD) accounts for more than half of all dementia cases. Although genetics, age, and environmental factors affect the disease, the cause of AD is not yet fully known. Various drugs have been proposed for the prevention and treatment of AD, but the delivery of these therapeutic agents to the brain is difficult. The blood–brain barrier prevents systemic drugs from accessing the central nervous system and designing a suitable system to overcome this barrier has attracted much attention. The intranasal pathway, given its proximity to the brain, provides a great opportunity for drug delivery. Understanding the physiological characteristics …

Autism And/Or Developmental Delay, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Week Of March 1, 2021, New York Medical College

InTouch

• NYMC Commences Energy Performance Project
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Detection Of Bacillus Cereus And Gram-Negative Bacteria Communities In Commercial Sesame In Japan, Kazuko Kato, Noriko Komagome, Machiko Mineki, Sumalee Boonmar, Yukio Morita

The Thai Journal of Veterinary Medicine

Sesame seeds are used in many traditional Japanese foods for their flavor and taste but commercial sesame can be highly contaminated with bacteria. We therefore examined the bacterial populations, including Bacillus spp., Enterobacteriaceae bacteria and standard plate count bacteria in sesame samples purchased from markets in Japan. A total of 8 sesame samples were tested, of which 4 (50.0%) harbored 4.3–5.6 log cfu/g standard plate count and 2.7–4.3 log cfu/g Enterobacteriaceae bacilli. Pantoea dispersa, P. septica and P. agglomerans were identified by a MALDI-TOF MSbased test. One (12.5%) sample harbored 3.6 log cfu/g Bacillus cereus, but this strain lacked the …

Evaluation Of Tear Quantity And Quality Treated With Gintonin Eye Drops In Labrador Retrievers And English Springer Spaniels, Ji-Seung Choi, Joon-Young Kim, Soon-Wuk Jeong

The Thai Journal of Veterinary Medicine

The aims of this study were to determine the relationship between tear osmolarity (TO), Schirmer tear test-1 (STT- 1) and tear film break-up time (TBUT) values in canines and to determine the impact of eye drops containing gintonin - a ginseng-derived lysophosphatidic acid (LPA) receptor ligand - on these indices. Fourteen canines (four English springer spaniels and ten Labrador retrievers) were randomized into two groups: the control group received only placebo eye drops (carboxymethylcellulose), while the experimental group received carboxymethylcellulose eye drops containing 5 µg of gintonin. Treatment was applied twice per day for a period of four weeks and …

Pharmacokinetics Of Oxfendazole Nanosuspension In Sheep, Yuzhu Sun, Xiaofang Wang, Aoxue Zhang, Bao Zhang, Liwei Shao, Yue Liu, Haiting Wang, Wanhe Luo, Dongmei Chen, Shuyu Xie

The Thai Journal of Veterinary Medicine

The pharmacokinetics of our previous prepared oxfendazole nanosuspension was studied in sheep to understand its enhancement of bioavailability. Ten sheep were randomly divided into two groups, each of which received a singledose (5mg/kg) oral oxfendazole nanosuspension and oxfendazole granules. After intragastric administration, oxfendazole rapidly reached peak concentrations of 11.25 μg/mL and 5.50 µg/mL at 5.6 h and 6.6 h in the nanosuspension group and granules group and the concentrations gradually reduced to below the detection limit at 96 h and 72h, respectively. The main pharmacokinetic parameters of oxfendazole after administration to the sheep: The Tmax, Cmax, AUClast, MRTlast, T1/2 and …

Prevalence Of Canine Vector-Borne Blood Parasites In The Plain Regions Of Cambodia, Koemseang Nhuong, Samut Sum, Piyanan Taweethavonsawat

The Thai Journal of Veterinary Medicine

Canine vector-borne blood parasites (CVBP) cause various diseases in dogs. The aim of this study was to survey canine blood parasites in the plain regions of Cambodia. The study was conducted from November 2014 to September 2015. A total of 455 blood samples were collected from rural and urban areas in the plain regions of Cambodia. Six infected dogs were found (1.32%), with the following parasites: Dirofilaria immitis (2/6), Brugia pahangi (1/6), Babesia vogeli (1/6) and two co-infections of Ehrlichia canis with Anaplasma platys (1/6) and Babesia vogeli with Anaplasma platys (1/6). However, the rate of detection of blood parasitic …

Reverse Transcription Loop-Mediated Isothermal Amplification Combined With Lateral Flow Device (Rt-Lamp-Lfd) For Swine Influenza Virus Detection, Albarriyati Ummi Asih, Taveesak Janetanakit, Chanakarn Nasamran, Napawan Bunpapong, Supanat Boonyapisitsopa, Alongkorn Amonsin

The Thai Journal of Veterinary Medicine

Swine influenza virus (SIV) causes respiratory disease in pigs leading to economic losses in swine production. Some SIV subtypes can also infect human and considered as a zoonotic pathogen. The importants of swine influenza are not only impact on the economic losses but also the human health. The objectives of this study were to develop a reverse transcription loop-mediated isothermal amplification combined with lateral flow device assay (RT-LAMP-LFD) for the detection of SIVs and to evaluate the performance, sensitivity and specificity of the assay. Our result showed that RTLAMP-LFD assay was developed with six newly designed primers and with optimum …

Retrospective Evaluation Of The Patterns Of Clinical Use Of Anti-Parasitic Agents On Animals Presented For Veterinary Care At An Animal Hospital In Nigeria, Thelma Ebele Ihedioha, Isaac Uzoma Asuzu, John Anaelom Nwanta

The Thai Journal of Veterinary Medicine

Patterns of use of anti-parasitic agents (APAs) on animals presented for veterinary care at the Veterinary Teaching Hospital, Nsukka, Nigeria, from January 2013 to December 2017 were surveyed. Animals presented were predominantly dogs (84.0%) and goats (8.1%). A total of 4851 cases were evaluated, out of which 3196 (65.9%) were treated with APAs. There was a significant variation (p=0.002) in the annual frequency of use of APAs across the study period, but the effect size of the variation was small (ɸc=0.06). Ivermectin was the most frequently used APA (1479 out of the 3196 = 46.3%); followed by praziquantel-pyrantel-fenbendazole combined formulation …

Clinical Evaluation Of The Accuracy Of Foetal Radiographic Findings In Parturition Date Prediction Of Small Size Dogs, Panthipa Borikappakul, Nardtiwa Chaivoravitsakul, Rampaipat Penchome, Suppawiwat Ponglowhapan

The Thai Journal of Veterinary Medicine

Ultrasonographic measurements of extra-foetal or foetal structures have been reported as an accurate means of predicting the date of parturition in the bitch. However, for many years, radiography has been clinically useful for pregnancy diagnosis, determining the number of foetuses and prolonged foetal death. Guidelines for estimating the canine parturition date based on foetal skeletal mineralization in relation to gestational age and preovulatory LH surge have been applied in small animal practice. The aims of this retrospective study were to evaluate the accuracy of parturition date prediction using foetal radiographic findings in small size dogs (1-10 kg), and to determine …

Production Performance, Carcass Traits And Meat Quality Of Growing Naemi Lambs Fed A Diet Containing Palm Kernel Meal, Gamaledin M. Suliman, Hanee H. Al-Baadani, Mutassim M. Abdelrahman, Ibrahim A. Alhidary

The Thai Journal of Veterinary Medicine

Palm kernel meal (PKM) is a byproduct produced after oil extraction from palm kernels. It is a valuable source of fiber, energy and protein which can reduce the cost of total mixed ration (TMR). This study was conducted to assess the growth performance, carcass characteristics and meat quality of lambs fed TMR pellet with PKM. A total of 32, three-month-old male lambs were randomly distributed into two diets (PTMR1= 0; PTMR2= 200 kg PKM/ton TMR). Results of the study showed that the production performance and the characteristics, composition and fat content of carcasses, as well as meat quality traits were …

The Occurrence Of Gastrointestinal Parasitic Infections Of Goats In Ratchaburi, Thailand, Witchuta Junsiri, Pulice Tapo, Runglawan Chawengkirttikul, Amaya Watthanadirek, Napassorn Poolsawat, Sutthida Minsakorn, Panat Anuracpreeda

The Thai Journal of Veterinary Medicine

Gastrointestinal (GI) parasitic diseases play an important role in the major constraints on goat production in Thailand and worldwide. The aim of this study was to assess the occurrence of GI parasitic infections among goats in Ratchaburi province of Thailand. In this study, fecal samples (394) were collected and tested by means of the floatation, sedimentation and direct smear methods to discriminate eggs or oocyst of the parasites. The overall occurrence of GI parasitic infections was 86.54%. The respective occurrences for the raising distance, farm system, water source nearby, type of feed and aquatic plants were found to vary significantly …

Infectious Endometritis In Arabian Mares: An Updated Clinical Investigation Of Uterine Microbial Isolates, Antimicrobial Sensitivities And Fertility In Egypt, Amr S. El-Shalofy, Mohamed K. Derbala, Hanaa A. Asfour, Hany M. Eissa, Aly B. Aly

The Thai Journal of Veterinary Medicine

The present study aimed to survey the prevalence of microbial isolates in the uterus of sub-fertile Arabian mares and to identify their existing antimicrobial sensitivities. In addition, to evaluate the efficacy of antimicrobial therapy based on the fertility outcomes determined by sonographic pregnancy diagnosis. Double guarded uterine swabs were collected from (barren) Arabian mares during mid-estrus. Based on the laboratory findings of microbial culture and antimicrobial sensitivity, mares were treated, inseminated and tested for pregnancy two weeks after ovulation. The predominant microbial isolates were Beta-hemolytic streptococci (BHS) (38.9%), Escherichia coli (E. coli) (33.3%), Staphylococcus aureus (S. aureus) (20.4%) and Candida …

Molecular Evolutionary Analysis Of Orf3 And M Genes Of Porcine Epidemic Diarrhea Virus In Heilongjiang Province Of China, Yulong Zhou, Guoqiang Gao, Liang Zheng, Zhijun Wu, Hongwei Cao, Hua Zhang, Yanlong Cong

The Thai Journal of Veterinary Medicine

In this present study, 11 porcine epidemic diarrhea viruses (PEDVs) were isolated from the fecal samples of piglets infected with PEDV in HeiLongJiang province of China. In order to analyze the molecular evolution of these reemerging PEDVs, the ORF3 and M genes of 11 PEDVs were amplified by reverse transcriptase polymerase chain reaction, cloned, sequenced, and analyzed with each other as well as other PEDV reference strains. The complete nucleotide sequence comparison was performed with Bioedit software, and the results showed that the similarity of 11 ORF3 and M genes ranged from 97% to 100%. Nucleotides and amino acids were …

Management Of Difficult Airway In A Pregnant Patient With Severely Reduced Mouth Opening, Faisal Shamim, Aly Bahadur, Dinaz Ghandhi, Anum Aijaz

Department of Anaesthesia

Pregnancy is associated with a wide variety of oral and dental changes ranging from gingivitis to odontogenic infections. If left untreated, severe dental abscess can progress to Ludwig's angina, which is a potentially lethal cellulitis that rapidly extends to the neck region and may lead to life-threatening upper airway obstruction. We report the case of a pregnant woman who presented with intense throbbing pain, trismus and severely reduced mouth opening due to dental abscess for the last one week. She required incision and drainage of abscess with extraction of third molar under general anaesthesia. There are some significant challenges to …

Persistent Post-Surgical Pain Following Breast Cancer Surgery: An Observational Study In A Tertiary Care Hospital, Ali Sarfraz Siddiqui, Sana Zeeshan, Aliya Ahmed, Shaista Khan

Department of Anaesthesia

Objective: To determine the frequency of persistent pain in patients after breast cancer surgery, and to assess the distribution and characteristics of pain in such patients.
Methods: The prospective observational single cohort study was conducted at the Department of Anaesthesiology and in the Breast Clinic of the Department of Surgery, Aga Khan University Hospital, Karachi, from August 2016 to January 2017, and comprised adult female patients with biopsy-proven carcinoma of breast who were scheduled for elective definitive breast cancer surgery. The patients were followed up for up to three months post-surgery and those with persistent pain were followed up for …

Detection Of Oxa-23, Ges-11 And Ndm-1 Among Carbapenem-Resistant Acinetobacter Baumannii In Dubai: A Preliminary Study, Carole Ayoub Moubareck, Dalal Hammoudi Halat, Anju Nabi, Mouza A. Alsharhan, Zulfa O. Aldeesi, Aaron Han, Handan Celiloglu, Dolla Karam Sarkis

All Works

No abstract provided.

Heterogeneous Contributions Of Change In Population Distribution Of Body Mass Index To Change In Obesity And Underweight, Maria L.C. Iurilli, Bin Zhou, James E. Bennett, Rodrigo M. Carrillo-Larco, Marisa K. Sophiea, Andrea Rodriguez-Martinez, Honor Bixby, Bethlehem D. Solomon, Cristina Taddei, Goodarz Danaei, Mariachiara Di Cesare, Gretchen A. Stevens, Leanne M. Riley, Stefan Savin, Melanie J. Cowan, Pascal Bovet, Albertino Damasceno, Adela Chirita-Emandi, Alison J. Hayes, Nayu Ikeda, Rod T. Jackson, Young Ho Khang, Avula Laxmaiah, Dimitrios Papandreou

All Works

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape …

Impact Of Covid-19 On Mental Health And Quality Of Life: Is There Any Effect? A Crosssectional Study Of The Mena Region, Ayesha S. Al Dhaheri, Mo'ath F. Bataineh, Maysm N. Mohamad, Abir Ajab, Amina Al Marzouqi, Amjad H. Jarrar, Carla Habib-Mourad, Dima O.Abu Jamous, Habiba I. Ali, Haleama Al Sabbah, Hayder Hasan, Lily Stojanovska, Mona Hashim, Osama A.Abd Elhameed, Reyad R.Shaker Obaid, Samar Elfeky, Sheima T. Saleh, Tareq M. Osaili, Leila Cheikh Ismail

All Works

The COVID-19 pandemic is a major health crisis that has changed the life of millions globally. The purpose of this study was to assess the effect of the pandemic on mental health and quality of life among the general population in the Middle East and North Africa (MENA) region. A total of 6142 adults from eighteen countries within the MENA region completed an online questionnaire between May and June 2020. Psychological impact was assessed using the Impact of Event Scale-Revised (IES-R) and the social and family support impact was assessed with questions from the Perceived Support Scale (PSS). The IES-R …

Phenotype Expression Variability In Children With Gabrb3 Heterozygous Mutations., Abdulhafeez M. Khair, Alana E. Salvucci

Department of Pediatrics Faculty Papers

GABRB3 gene is a recently identified gene located in 15q12 chromosome and encodes for gamma-aminobutyric acid (GABA) receptor subunit beta-3 protein, which is linked to the GABAA receptor. The gene is believed to share a role in inhibitory GABAergic synapses, GABA iron-gated channel function, and possible cellular response to histamine. The β3 subunit is expressed in cerebral grey matter, thalami, hippocampi, and cerebellum, among other structures. Faulty GABRB3 function is linked to several neurological disorders and clinical syndromes. However, the spectrum of such disorders is not yet well known. We present three case reports highlighting the potentially expanding clinical phenotype …

Figo (International Federation Of Gynecology And Obstetrics) Initiative On Fetal Growth: Best Practice Advice For Screening, Diagnosis, And Management Of Fetal Growth Restriction, Nir Melamed, Ahmet Baschat, Yoav Yinon, Apostolos Athanasiadis, Federico Mecacci, Francesc Figueras, Vincenzo Berghella, Amala Nazareth, Muna Tahlak, H David Mcintyre, Fabrício Da Silva Costa, Anne B Kihara, Eran Hadar, Fionnuala Mcauliffe, Mark Hanson, Ronald C Ma, Rachel Gooden, Eyal Sheiner, Anil Kapur, Hema Divakar, Diogo Ayres-De-Campos, Liran Hiersch, Liona C Poon, John Kingdom, Roberto Romero, Moshe Hod

Department of Obstetrics and Gynecology Faculty Papers

No abstract provided.

Comparison Of Short-Leg And Long-Leg Casts For The Treatment Of Distal Third Tibial Shaft Fractures In Children, Scott A. Barnett, Bailli Fontenot, Claudia Leonardi, Joseph A. Gonzales, Dominic Gargiulo, Michael J. Heffernan

School of Medicine Faculty Publications

Background:Long-leg casts (LLCs) are an established treatment for pediatric tibial shaft fractures including fractures involving the distal third. There is a paucity of literature assessing the use of short-leg cast (SLC) for tibial shaft fractures. The purpose of this study was to determine if SLC were as effective as LLC for the treatment of pediatric distal third tibial shaft fractures.Methods:A retrospective review was conducted on consecutive distal third tibial shaft fractures treated at a tertiary pediatric hospital from 2013 to 2018. Exclusion criteria included midshaft and proximal fractures of the tibia, distal fractures that violated the tibial physis or plafond, …

Can Caregivers Trust Information Technology In The Care Of Their Patients? A Systematic Review, Alice Noblin, Barbara Hewitt, Murad Moqbel, Scott Sittig, Lakesha Kinnerson, Vera Rulon

Information Systems Faculty Publications

The Health Insurance Portability and Accountability Act of 1996 (HIPAA) requires that healthcare providers allow patients to engage in their healthcare by allowing access to their health records. Often patients need informal caregivers including family members or others to help them with their care. This paper explores whether trust is a key factor for informal caregivers’ decision to use health information technologies (HIT) including electronic health records (EHR), patient portals, mobile apps, or other devices to care for their patient. Six reviewers conducted a comprehensive search of four literature databases using terms that pertained to a caregiver and trust to …

Elaborating The Science Of Food Choice For Rapidly Changing Food Systems In Low-And Middle-Income Countries, Christine E. Blake Ph.D., Rd, Edward A. Frongillo Jr. Ph.D., Andrea M. Warren, Shilpa V. Constantinides, Krystal K. Rampalli, Shiva Bhandari

Faculty Publications

The world’s food systems and environments have been changing dramatically, concomitant with changes in overand undernutrition. We elaborate the science of food choice to better understand, analyze, and respond to relationships between changing food environments and food choice. The science of food choice is concerned with generating knowledge about causal drivers of food choice decision making processes and behavior within immediate food and social environments. Three fundamental and interconnected questions undergird this science; 1) what do people eat from the options available and accessible?; 2) how do people interact with food environments?; and 3) why do people decide to acquire, …

Reliability Of A Barre-Mounted Dynamometer-Stabilizing Device In Measuring Dance-Specific Muscle Performance, Melissa Strzelinksi, Lori Thein Brody, Jo Armour Smith, Shaw Bronner

Physical Therapy Faculty Articles and Research

BACKGROUND: Hand-held dynamometry is considered an efficient, effective, and portable means of objectively measuring lower extremity strength; however, it has yet to be studied specific to dance-relevant muscle performance. Also, dynamometry is often criticized for variability in results based on tester strength and sex. Use of an external stabilizing device has been suggested to minimize differences in outcomes between male and female testers by reducing variability associated with tester strength limitations. Therefore, this study used a barre-mounted, portable dynamometer stabilizing device to improve consistency of results among different testers for assessing hip and lower extremity muscle performance in dance-relevant positions. …

The Scoop, Vol. 7 Issue 12, March 2021, Health Sciences Library

Volume 7

Latest news and updates from the Health Sciences Library in our monthly newsletter for March 2021..

Homoeopathy For Management Of Type 2 Diabetes Mellitus In A Patient Of Major Depressive Disorder - A Case Report, Karanpreet Nahar, Subhash Kaushik

Indian Journal of Research in Homoeopathy

Introduction: Major depressive disorder in diabetic individuals represents a multifactorial phenomenon resulting from interactions between biological and psychosocial factors, which may intensify the probability of developing type 2 diabetes mellitus (T2DM) in otherwise healthy individuals. Case Summary: A case of T2DM is reported in a 38-year-old woman suffering from major depressive disorder who was treated successfully with individualised homoeopathic medicines. The patient reported to the Lifestyle Disorders clinic of Homoeopathic Hospital, Noida, with recently diagnosed diabetes of 8 months. After individualised homoeopathic treatment, the patient's fasting plasma glucose, postprandial glucose, HbA1c levels, fasting plasma insulin and Hamilton Depression Rating Scale …

Are We At The Crossroads For Integrative Medicine?, Anil Khurana

Indian Journal of Research in Homoeopathy

No abstract provided.

Homoeopathic Treatment Of Women With Polycystic Ovarian Syndrome: A Prospective Observational Study, Girish Gupta, Naveen Gupta, Santosh Singh, Varanasi Roja, Dewan Deepti

Indian Journal of Research in Homoeopathy

Background: Polycystic ovarian syndrome (PCOS) is one of the most common hormonal disorders among women of reproductive age group and a leading cause of female sub-fertility. Objectives: This study was conducted to evaluate the effect of individualised homoeopathy on clinical and hormonal profile in women suffering from PCOS. Materials and Methods: A prospective, observational study was conducted from July 2015 to June 2017 at Homoeopathic Research Foundation, Lucknow, in which 80 cases were screened, and 38 cases fulfilling the eligibility criteria were enrolled. Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (PCOSQ) was used to evaluate the quality of life. …

Usefulness Of Individualised Homoeopathic Medicine In Manic Episode - A Case Report, S Moorthi, P Radhika, K Muraleedharan

Indian Journal of Research in Homoeopathy

Introduction: Mania is a form of mood disorder initially, characterised by elevated mood, insomnia, increased libido and grandiosity. More severe forms develop elation and grandiose delusions. Case Summary: A patient reported in the Out Patient Department with symptoms of increased delusions for 3 weeks. The consultant psychiatrist diagnosed it as a case of bipolar affective disorder, current episode manic with psychotic features. Young mania rating scale (YMRS) scored 38 at the time of admission. Lachesis mutus 200 was prescribed initially and later Lycopodium clavatum 200 was prescribed, as the symptom picture changed. Overall improvement was noticed clinically and in YMRS …