Medicine and Health Sciences Commons^™

Use Of Simulation Based Technology In Pre-Clinical Years Improves Confidence And Satisfaction Among Medical Students, Muhammad Bilal Mirza, Anjiya Sulaiman, Satwat Hashmi, Samar Zaki, Rehana Rehman, Rozmeen Akbar

Medical College Documents

Objective: To determine perception of medical students about learning from integrated simulated clinical skill sessions as part of the undergraduate curriculum.
Methods: The cross-sectional study was conducted at the Centre for Innovation in Medical Education, Aga Khan University (AKU), Karachi, from July 2018 to February 2019, and comprised first year medical students undertaking the Respiration and Circulation module of the curriculum. Quantitative data was collected using a questionnaire and the responses were assessed on a five-point Likert scale. Data was analysed using SPSS 21. Qualitative data was gathered through focused group discussion with students and an in-depth interview with the …

Autism: A Deep Insight, Hemaila Tariq, Muhammad Yusuf Hafiz

Medical College Documents

No abstract provided.

Prevalence And Related Factors Of Musculoskeletal Discomfort Among Pharmacy Personnel Of King Chulalongkorn Memorial Hospital, Wiboon Jiamthubthugsin, Pornchai Sithisarankul

Chulalongkorn Medical Journal

Background: Pharmacy personnel in hospitals are exposed to workplace hazards, especially biomechanical hazards which potentially cause musculoskeletal discomfort (MSD). Understanding of MSD can help prevent and control the problem. Objective: To study the prevalence and related factors of MSD among pharmacy personnel of King Chulalongkorn Memorial Hospital (KCMH). Methods: This study was a cross-sectional descriptive study with a sample size of 197 pharmacy personnel of KCMH. The participants were asked to fill in a self-reported questionnaire comprising of individual and occupational factors and MSD assessed by the modified Nordic questionnaire. Results: The pharmacy personnel have high prevalence of MSD. The …

Pressure Differences During Foot Reflexology Affect Blood Flow To Brain And Kidneys, Kanokwan Srisupornkornkool, Titipong Kaewlak, Watchara Kaewmahanil, Sompiya Somthavil, Onuma Boonyarom, Kanjana Jittiporn

Chulalongkorn Medical Journal

Background: Foot reflexology has been re-emerging as one of the most popular forms of alternative therapy.Although the mechanisms of reflexology have not been apparently understood yet, physiological changes can be found from reflexology, e.g., reduced blood pressure, reduced heart rate, and activated brain functions.However, there are still only a small number of studies on the physiological relationships between foot reflexology and changes in blood flow. Objectives: This investigation aimed to study the effects of brain-associated and kidney-associated foot reflexology on blood flow to the brain and kidneys. The second objective was to examine the effects of pressure differences to reflex …

Effects Of Modified U-Shaped Interspinous Distraction Device On Cadaveric Intervertebral Disc Pressure, Chindanai Hongsaprabhas, Pibul Itiravivong, Pairat Tangpornprasert, Chanyaphan Virulsi

Chulalongkorn Medical Journal

Background: Adjacent syndrome is a widely concerned adverse outcome after spinal fusion. Interspinous distraction device (IDD) has become an interesting device and seems to be the solution by theoretically controlling loads to adjacent levels. Objective: To analyze the effects of a modified U-shape IDD on the intervertebral disc (IVD) pressure atm instrumented and adjacent level of a lumbar spine model. Methods: Three cadaveric specimens using lumbar vertebrae level 1 - 5 (L1 - L5) spines were loaded in neutral, flexion and extension. Needle pressure sensor was applied to measure IVD pressure at anterior annulus, nucleus pulposus, and posterior annulus of …

Depression And Sleep Quality Among Nurses In A Tertiary Hospital In Bangkok, Pariyanuch Junsatitanon, Krit Pongpirul

Chulalongkorn Medical Journal

Background: Currently, depression is a mental health problem that tends to increase. Nurses are one of the healthcare workers that are at risk of depression. The cause of which is due to their heavy workload. In addition, shift work results in decreased sleeps quality. Moreover, research studies on the relationship between sleep quality and depression including other factors are few. Objectives: To investigate the relationship between sleep quality and depression including the prevalence of depression and its associated factors. The recruited subjects of the study were nurses who worked at Nopparat Rajathanee Hospital in 2019. Methods: A cross-sectional survey of …

Factors Predicting Chemotherapy Induced Peripheral Neuropathy In Breast Cancer Patients Receiving Neurotoxic Chemotherapy, Sunet Jiwpanya, Chongjit Saneha, Wimolrat Puwarawuttipanit, Pongwut Danchaivijitr

Chulalongkorn Medical Journal

Background: Cancer is a major cause of death worldwide. Chemotherapy is an effective treatment that is widely used to increase the numbers of cancer survivors. However, it often causes side effects such as nausea, vomiting, and lack of appetite. Chemotherapy induced peripheral neuropathy (CIPN) is one of the most serious side effect leading to fatal outcomes in these patients. Objectives: To examine the influence of patient characteristics (body mass index: BMI, age, and physical activity), clinical characteristic (anemia) and treatment related factors (dosage of neurotoxic chemotherapy) on CIPN in cancer patients receiving neurotoxic chemotherapy. Methods: One hundred and twenty Thai …

Utilization Of Hearing Aids For The Underprivileged At Sisaket Hospital Under Thai Red Cross Hearing Aids Project, Kanda Limitlaohaphan

Chulalongkorn Medical Journal

Background: As the second-most prevalent disability in Thailand, mitigating the effects of hearing loss can have wide-ranging benefits. Despite the availability of hearing aids, its usage remains low. Objective: This research aimed to study factors related to utilization of hearing aids: age, gender, level of education, degree of hearing loss, understanding of usage and maintenance, and attitudes towards its use. Methods: A cross-sectional study was conducted in 30 hearing loss patients of the Thai Red Cross (TRC) Hearing Aids Project for the Underprivileged, Sisaket Hospital, Sisaket Province, Thailand (here in after referred to as “TRC Hearing Aids Project”) by face-to-face …

The Psychometric Property Testing Of The Children’S Yale-Brown Obsessive Compulsive Scale (Cy-Bocs): Thai Version, Wangsuk Wittayapanyanond, Nuttorn Pityaratstian, Napakkawat Buathong

Chulalongkorn Medical Journal

Background: Obsessive-compulsive disorder is a disease of various symptoms and severity. In Thailand, currently there is no tool to identify obsessive-compulsive disorder in children and adolescents. Objective: To evaluate the validity and reliability of the Thai version of Children’s Yale-Brown Obsessive Compulsive Scale (CY-BOCS). Methods: This study is a cross-sectional descriptive study to test the content validity of questionnaire using the index of item-objective congruence (IOC) from experts’ opinions and the internal consistency reliability in the sample of 61 child-psychiatrists in secondary, tertiary and psychiatric hospitals in Thailand that assessed children and/or adolescent patients with obsessive compulsive disorder within the …

Effects Of A Telehealth Program On The Functional Status And Rehospitalization Rates Of Patients After Coronary Artery Bypass Grafts, Nattaya Sanonoi, Usavadee Asdornwised, Kessiri Wongkongkam, Teerapong Tocharoenchok

Chulalongkorn Medical Journal

Background: Patients with coronary artery bypass graft (CABG) exhibit a decrease in functional status during the postoperative period. The rehospitalization rate within the first month is 8.0% - 21.0%. Therefore, during the first month after discharge, most patients require help from health care teams. Telehealth programs promote health monitoring and share health information remotely during transitional stages, encouraging awareness, increasing cardiac rehabilitation and physical function. As a result, the number of rehospitalizations is also reduced. Objectives: This quasi-experimental research aimed to study the effects of a telehealth program on the functional status and rehospitalization rates of patients with CABG. Methods: …

Establishing The Roadmap For The Implementation Of Genomic Medicine And Pharmacogenomics In The United Arab Emirates, Azhar Talal Mahmoud Rahma

Dissertations

The slow clinical application of genomic medicine and Pharmacogenomics (PGx) is attributed mainly to lack of knowledge of genomic medicine and PGx and confidence among healthcare professionals, scarcity of infrastructure, and absence of stakeholders’ interest. The objective of this study is to lay out a strategic plan for the implementation of genomic medicine and PGx in the United Arab Emirates (UAE) by exploring multiple areas: (1) the educational environment of genomic medicine and PGx in colleges and universities; (2) knowledge, and attitude of the medical and health sciences students, academics, and the healthcare providers; (3) the current infrastructure of genetic …

Delineating The Binding Sites Of Mason-Pfizer Monkey Virus (Mpmv) Gag Precursor Polyprotein (Pr78gag) On Genomic Rna For Its Selective Packaging, Fathima Nuzra Nagoor Pitchai

Dissertations

No abstract provided.

Role Of Nerolidol, An Aliphatic Sesquiterpene, In Colon Inflammation, Vishnu Raj

Dissertations

Inflammatory bowel diseases, which comprise Crohn’s disease (CD) and ulcerative colitis (UC), are chronic and progressive immune-mediated inflammatory conditions of the gastrointestinal (GI) tract. Both genetic and environmental factors influence this condition. Conventional therapy to suppress aberrant immune responses seen in IBD with corticosteroid or with biological agents has a high relapse rate that limits their use. Therefore, approximately 40% of IBD patients switch to alternative therapies that include dietary supplements rich in phytochemicals. Nerolidol (NED) is a naturally occurring sesquiterpene alcohol present in various plants and has potent anti-inflammatory properties. Therefore, in the current study, the role of NED …

Outcomes Of Nonsurgical Root Canal Therapy Completed In Children Aged 6-13 Years, Lauren M. Loney

Master's Theses (2009 -)

Introduction: Tooth survival following non-surgical root canal treatment (NSRCT) in adult populations has been documented as high as 97%. However, to our knowledge, no studies have examined tooth survival following NSRCT in children. The aim of this study was to determine the long-term outcomes of non-surgical root canal treatment in children aged 6-13 years provided by both endodontists and other providers.Methods & Materials: Insurance claims from the Delta Dental of Wisconsin Insurance database of 4927 anterior and molar NSRCT completed in children aged 6-13 years from the years 2002-2014 were analyzed. The teeth were followed during continuous insurance eligibility from …

Root-End Surgery Or Nonsurgical Retreatment: Are There Differences In Long Term Outcome?, Enida Haxhia

Master's Theses (2009 -)

INTRODUCTION: The decision of which modality of secondary endodontic treatment to perform is multifactorial and clinician dependent. Literature surrounding the long-term survival of nonsurgical retreatment compared to root-end surgery remain equivocal and warrant further investigation. This 7-year retrospective study seeks to compare the outcome of nonsurgical retreatments with that of root-end surgeries performed on teeth without prior nonsurgical retreatments. METHODS: Insurance claims from 1021 teeth of 987 patients in the Delta Dental of Wisconsin database were analyzed from the years 2008–2017. Tooth survival was evaluated using Cox regression models and p-value was set at 0.05. Survival time was considered from …

The Influence Of The Operator Experience On The Accuracy Of Implant Placement: An In Vitro Study, Jeffrey Garcia

Master's Theses (2009 -)

Purpose: The aim of this study is to evaluate the influence of operator experience in the fully guided placement of implants in dentate patients. Methods: Three different providers with different level of experience in implant surgery (unexperienced, moderate experienced = 2 years of experience, and experienced = more than 5 years of experience in implant surgery) placed each n=20 implants fully guided or free hand in identical replicas, produced from a CBCT of a partially edentulous patient case. The achieved implant position was digitized by using a laboratory scanner and compared with the planned position. Trueness (planned versus actual position) …

Correction Of Excessive Gingival Display: Lip Repositioning With/Without Myotomy, Austin Michael Dodge

Master's Theses (2009 -)

Background: Lip repositioning (LR) is a conservative and reversible surgical method for correcting excessive gingival display (EGD). Purpose: The study aims to compare two LR techniques. The objectives include 1) comparing the amount of gingival display reduction (GDR) after LR without (Group 1) and with (Group 2) myotomy, stratified in accordance with the etiology of the EGD 2) Comparing the gingival display rebound (GDRB) 3) compare subject satisfaction and morbidity. Methods: After obtaining IRB approval, 20 human subjects with EGD (measured apical to the CEJ of #9) were randomly allocated for surgery without and with myotomy. Pre-operative, diagnostic information were …

The Effects Of Sitting And Standing Hygiene On Posture In Dental Hygiene Students, Taylor Shay Kace

Dental Hygiene Theses & Dissertations

Problem: The purpose of this pilot study was to assess biomechanical and postural impacts of sitting and standing independently during dental hygiene practice. Methods: A convenience sample of thirty-four second-year dental hygiene students with no history of musculoskeletal disorders were enrolled in this study. Participants were randomly assigned to instrument one quadrant of the mouth on buccal or lingual surfaces while seated or standing during two independent research sessions. Two images per session, for a total of four images per participant, were taken to assess biomechanical demands of each posture using the Rapid Upper Limb Assessment (RULA) tool. The images …

Burnout, Self-Efficacy, And Coping Strategies Among College Faculty, Jordan M. Ball

Psychology Theses & Dissertations

Due to the changing college environment, university faculty are faced with a serious burden to support their university. University faculty are expected to satisfy numerous job demands, and these demands in turn lead to burnout, a chronic response to job stressors. Burnout is an essential component of occupational research as it relates to other negative outcomes, such as turnover and decreased performance. Because of this, it behooves both faculty and universities to employ methods that decrease burnout. Research concerning other populations indicates that certain personal resources can decrease burnout. Therefore, the current study seeks to determine if coping strategies and …

Biophysical Characterization Of The Par-4 Tumor Suppressor: Evidence Of Structure Outside The Coiled Coil Domain And Interactions With Platinum Chemotherapeutics, Andrea Megan Clark

Chemistry & Biochemistry Theses & Dissertations

Prostate apoptosis response-4 (Par-4) is an apoptosis-inducing tumor suppressor protein. Full-length Par-4 has previously been shown to be a predominantly intrinsically disordered protein (IDP) under neutral conditions, with significant regular secondary structure evident only within the C-terminal coiled coil domain. However, IDPs can gain ordered structure through the process of induced folding, which often occurs under non-neutral conditions. Previous work has shown that the Par-4 leucine zipper, which is a subset of the C-terminal coiled coil domain, is disordered under neutral conditions, but forms a dimeric coiled coil at acidic pH. Increase in ionic strength was also shown to increase …

Bibliometric Analysis Of Named Entity Recognition For Chemoinformatics And Biomedical Information Extraction Of Ovarian Cancer, Vijayshri Khedkar, Charlotte Fernandes, Devshi Desai, Mansi R, Gurunath Chavan Dr, Sonali Tidke Dr., M. Karthikeyan Dr.

Library Philosophy and Practice (e-journal)

With the massive amount of data that has been generated in the form of unstructured text documents, Biomedical Named Entity Recognition (BioNER) is becoming increasingly important in the field of biomedical research. Since currently there does not exist any automatic archiving of the obtained results, a lot of this information remains hidden in the textual details and is not easily accessible for further analysis. Hence, text mining methods and natural language processing techniques are used for the extraction of information from such publications.Named entity recognition, is a subtask that comes under information extraction that focuses on finding and categorizing specific …

The Human In The Middle: Artificial Intelligence In Health Care Summary Proceedings Symposium Presentation And Reactor Panel Of Experts Thomas Jefferson University December 10, 2019., Janice L. Clarke, Alexandria Skoufalos, Steven Klasko, Md, Mba

College of Population Health Faculty Papers

No abstract provided.

Preventing Colorectal Cancer: Pathway To Achieving An 80% Screening Goal In The United States: Overview And Proceedings Of A Population Health Advisory Board., David B. Nash, Raymond J. Fabius, Alexis Skoufalos

College of Population Health Faculty Papers

No abstract provided.

Gastric Volvulus In Adults In A Tertiary Care Hospital Karachi, Pakistan: A Case Series, Om Parkash, Roger Christopher Gill, Iman Qaiser, Muhammad Sharoz Rabbani, Tabish Chawla, Hasnain Zafar

Section of Gastroenterology

Gastric volvulus is a rare surgical emergency which is rare in children and occasionally presents in adults. It results due to pathological malrotation of the stomach along its longitudinal or short axis. The condition, if not treated promptly, can result in increased morbidity and carries a high risk of death. Very few cases have been reported in literature regards this important clinical condition. Early decompression and repair of anatomical defects are the corner stone of its management. There is a dire need to develop guidelines and algorithms for management and treatment of this rare condition to improve patient outcome, prevent …

Shear Bond Strength Characteristics On Surface Treatment Modalities Of Cad-Cam Resin Based Core Materials, Nikita Sinha

Master's Theses (2009 -)

Introduction: Innovations in computer aided design and computer aided manufacture (CAD-CAM) have made the manufacture of new restorative and prosthetic materials possible. They have enabled fabrication of complete arch implant supported fixed dental prosthesis (CAISFDP) in metals and polymers a reality. There are several materials which are available to fabricate a CAISFDP and it is important to find biologically, economically and aesthetically viable options for milled, cast and printed metal and non-metal structures. Objectives: The purpose of this in-vitro test was to analyze the shear bond strength of composite to Trilor material for CAISFDP restorations. Material and Methods: A total …

Resident Immune Cells Of The Avascular Lens: Mediators Of The Injury And Fibrotic Response Of The Lens., A. Menko, Jodirae Dedreu, Caitlin M. Logan, Heather Paulson, Alex V Levin, Janice L Walker

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Tissues typically harbor subpopulations of resident immune cells that function as rapid responders to injury and whose activation leads to induction of an adaptive immune response, playing important roles in repair and protection. Since the lens is an avascular tissue, it was presumed that it was absent of resident immune cells. Our studies now show that resident immune cells are a shared feature of the human, mouse, and chicken lens epithelium. These resident immune cells function as immediate responders to injury and rapidly populate the wound edge following mock cataract surgery to function as leader cells. Many of these resident …

Characterization And Clinical Significance Of Eif1ax Mutations And Co-Mutations In Cytologically Indeterminate Thyroid Nodules: A 5-Year Retrospective Analysis., Stacey Gargano, Nitika Badjatia, Yanina Nikolaus, Stephen C Peiper, Zi-Xuan Wang, Phd

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

OBJECTIVE: Mutations in the EIF1AX gene have been recently detected in a small percentage of benign and malignant thyroid lesions. We sought to investigate the prevalence and clinical significance of EIF1AX mutations and co-mutations in cytologically indeterminate thyroid nodules at our institution.

MATERIALS AND METHODS: A 5-year retrospective analysis was performed on thyroid nodules with a cytologic diagnosis of Bethesda category III or IV, which had undergone testing by our in-house next generation sequencing panel. Surgically resected nodules with EIF1AX mutations were identified, and mutation type and presence of co-mutations were correlated with histopathologic diagnosis.

RESULTS: 41/904 (4.5%) cases overall …

The Use Of Actigraphy And Its Impact On Perceived Sleep Quality And Activity Levels In Individuals With Traumatic Brain Injury In An Inpatient Rehabilitation Setting., Lina Shkokani, Amanda Reyes, Bachar Hazim, Jason Kisser, Philip T. Roskos

Conference Presentation Abstracts

No abstract provided.

Dean's Update, April 2021, Jerry L. Nadler

SOM Dean's Research Newsletter

No abstract provided.

Dean's Report - Spring 2021, Marina K. Holz

GSBMS Dean’s Report

No abstract provided.