Medicine and Health Sciences Commons^™

Vitamin D3 Induces Mesenchymal-To-Endothelial Transition And Promotes A Proangiogenic Niche Through Igf-1 Signaling, Lei Chen, Anweshan Samanta, Lin Zhao, Nathaniel R. Dudley, Tanner Buehler, Robert J. Vincent, Jeryl Hauptman, Magdy Girgis, Buddhadeb Dawn

School of Medicine Faculty Research

Biological Sciences; Physiology; Molecular Biology; Cell Biology

Transmission Of Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) In A Patient Transport Van, Lucas D. Jones, Ernest R. Chan, Sarah N. Redmond, Jeffrey D. Kovach, Marlin Linger, Peter A. Zimmerman, Curtis J. Donskey

Faculty Scholarship

We report 2 episodes of potential SARS-CoV-2 transmission from infected van drivers to passengers despite masking and physical distancing. Whole-genome sequencing confirmed relatedness of driver and passenger SARS-CoV-2. With the heater operating, fluorescent microspheres were transported by airflow >3 meters from the front to the back of the van.

Service Use By Medicaid Recipients With Serious Mental Illness During An Rct Of The Bridge Peer Health Navigator Intervention, Erin L Kelly, Benjamin Hong, Lei Duan, Laura Pancake, Heather Cohen, John S Brekke

Department of Family & Community Medicine Faculty Papers

OBJECTIVE: Integration of general medical care and mental health care is a high priority for individuals with serious mental illnesses because of their high risk of morbidity and early mortality. The Bridge is a peer-led, health navigator intervention designed to improve access to and use of health care and self-management of medical services by individuals with serious mental illnesses. This study expands on a previous study in which the authors examined participants' self-reported outcomes from a 12-month randomized controlled trial of the Bridge. In the study reported here, Medicaid data were used to assess the impact of the intervention on …

Primary And Secondary Interventions To Address Common Female Reproductive Health Issues On College Campuses, Alison Yelsma

Honors Theses

My public health capstone/honors thesis was about primary and secondary interventions for college students on the topic of, and surrounding, common female reproductive health issues. I requested current female college students to complete a questionnaire with questions that addressed their knowledge, attitudes and practices in this area. Responses from process and content questions were used to develop suggested peer support and educational sessions for college campuses surrounding endometriosis and polycystic ovarian syndrome (PCOS).

Prebiotic And Probiotic Knowledge And Consumption In Collegiate Athletes, Hannah Kahn

Honors Theses

The purpose of this study was to investigate gastrointestinal disturbances in collegiate athletes and their knowledge of gastrointestinal health, or lack thereof, specifically pertaining to nutrition choices including prebiotic fiber and probiotic foods, sources, and supplements. Student-athletes at the division one level endure rigorous training for competition. Although one may have competent knowledge on the importance of fueling their body for their sport, there may be gaps in understanding the digestive mechanisms of their diet, importance of a diverse gut microbiome, and subsequent nutrient uptake. This study and questionnaire explored the relationship between gastrointestinal (GI) disturbances a student-athletes may experience …

Pain Response Of Transcutaneous Electrical Nerve Stimulation To Different Grades Of Knee Osteoarthritis, Emily Beer

Honors Theses

Knee osteoarthritis (OA) is diagnosed worldwide and affects nearly 250 million people (Wallace et al., 2017, pg. 1). Additionally, people who are 45 years and over are prone to this degrative disease (Wallace et al., 2017, pg. 1). Knee OA can be graded into five categories (0-4) levels associated with the Kellgren-Lawrence grading scales (Kellgren & Lawrence, 1957, pg. 494). Symptoms will develop overtime; thus, it is important to find non-pharmacological ways to help alleviate pain for individuals affected. A non-pharmacological modality of interest is the transcutaneous electrical nerve stimulation (TENS) units, which can be tailored to a patient’s specific …

Hiv Tat Protein Activates Plasma Kallikrein-Kinin System In Hiv-1 Tat Transgenic Mice, Logan Sneed

Honors Theses

Human Immunodeficiency Viruses are a group of lentiviruses that have seen a lot of study ever since their discovery. HIV-1, the most common and virulent form of the virus, has proven to be quite deadly when untreated, so any research into the mechanisms of HIV pathogenesis and replication could have major medical applications all over the world. HIV-1 is a sexually transmitted virus that compromises the hosts immune system and eventually leads to the patient developing AIDS, a life-threatening condition that nearly half of people infected with HIV will develop within ten years. Our study sets out to determine exactly …

Suicide Risk And School Related Stressors In Veterinary Students, Deanna Nicole Arnold

Honors College Theses

Compared to the general population of the United States, veterinarians are at an increasingly higher risk for suicide. This is commonly associated with stressful work environments, long work hours, poor work-life balance, client demands and complaints, and large amounts of euthanasia procedures. While many studies have been performed to confirm the above statements, few to no studies have been done on students currently enrolled in veterinary school to assess their mental health. This study will survey graduate school students in this field and will evaluate their mental health state and risk factors towards suicide. Through comparing the results of this …

Mental Health Among Nursing Students Amid The Coronavirus Pandemic, Cheydan Crump

Honors College Theses

The purpose of this study was to determine the effects of the current pandemic on the mental health of nursing students at a rural university. This study examined various risk factors and potential indicators for mental health, such as changes in physical activity, sleep behaviors, and differing perceptions of support they have received from the nursing program and the participating university, throughout the spread of COVID-19. This study was a non-experimental, analytical study conducted in a rural university in the southern region of the United States. This convenience sample consisted of 21 students, all of which were enrolled in the …

Exploring Willingness To Pay For Health Insurance And Preferences For A Benefits Package From The Perspective Of Women From Low-Income Households Of Karachi, Pakistan, Shifa Salman Habib, Shehla Zaidi

Community Health Sciences

Background: Achieving universal health coverage (UHC) and reduction in out of pocket (OOP) expenditures on health, is a critical target of the Sustainable Development Goals (SDG). In low-middle income countries, micro-health insurance (MHI) schemes have emerged as a useful financing tool for laying grounds for Universal Health Coverage. The aim of this study was to provide evidence for designing a feasible health insurance scheme targeted at urban poor, by exploring preferences for an insurance benefits package and co-payments among women from low-income households in Karachi, Pakistan.
Methods: This was a descriptive cross-sectional study, conducted using household surveys between July-August 2015. …

Maternal And Neonatal Morbidity And Mortality Among Pregnant Women With And Without Covid-19 Infection: The Intercovid Multinational Cohort Study, José Villar, Shabina Ariff, Robert B. Gunier, Ramachandran Thiruvengadam, Stephen Rauch, Alexey Kholin, Paola Roggero, Federico Prefumo, Marynéa Silva Do Vale, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Importance: Detailed information about the association of COVID-19 with outcomes in pregnant individuals compared with not-infected pregnant individuals is much needed.
Objective: To evaluate the risks associated with COVID-19 in pregnancy on maternal and neonatal outcomes compared with not-infected, concomitant pregnant individuals.
Design, setting, and participants: In this cohort study that took place from March to October 2020, involving 43 institutions in 18 countries, 2 unmatched, consecutive, not-infected women were concomitantly enrolled immediately after each infected woman was identified, at any stage of pregnancy or delivery, and at the same level of care to minimize bias. Women and neonates were …

In Men With Obesity, T2dm Is Associated With Poor Trabecular Microarchitecture And Bone Strength And Low Bone Turnover, Francesca Vigevano, Giulia Gregori, Georgia Colleluori, Rui Chen, Vimlin Autemrongsawat, Nicola Napoli, Clifford Qualls, Dennis T Villareal, Reina Armamento-Villareal

Faculty, Staff and Students Publications

INTRODUCTION: Obesity and type 2 Diabetes (T2D) are both associated with greater bone mineral density (BMD) but increased risk of fractures. The effect of the combination of both conditions on bone metabolism, microarchitecture, and strength in the obese population remains unknown.

METHODS: Data from 112 obese men were collected. Bone turnover and biochemical markers were measured by enzyme-linked immunosorbent assay, body composition and BMD at all sites were assessed by dual energy X-ray absorptiometry, whereas bone microarchitecture and strength (stiffness and failure load) were measured by high-resolution peripheral computed tomography. Data were compared among metabolically healthy obese (MHO) and metabolically …

Muscle Performance Changes With Age In Active Women, Ryan M. Miller, Eduardo D. S. Freitas, Aaron D. Heishman, Keldon M. Peak, Samuel R. Buchanan, J. Mikhail Kellawan, Hugo M. Pereira, Debra A. Bemben, Michael G. Bemben

Health & Human Performance Faculty Publications

The purpose of this study was to examine age-related differences in muscle performance in women divided into young (YW, 20–39 years, n = 29) middle-aged (MAW, 40–59 years, n = 33), and older (OW, ≥60 years, n = 40) age groups. Methods: Hand grip strength, vertical jump performance, and knee extensor (KE) strength (0 deg/s, 60 deg/s, and 240 deg/s), speed of movement (SoM; at 1 Nm, 20%, 40%, and 60% isometric strength), and endurance (30-repetition test at 60 degs/s and 240 deg/s) were assessed. Computed tomography-acquired muscle cross-sectional area (mCSA) was measured and included to determine specific strength (KE …

Challenges And Opportunities In Food Safety-A Review, Iram Asim, Humaira Yasmeen

Journal of Bioresource Management

Food-borne diseases are the group of disorders that are caused by consuming food having microbial existence in it. So safe food handling is to make sure the lessening of detrimental effects in growth to the packaging of food to minimize health issues on consumers which otherwise can lead to large scale disease outburst. This review concludes the findings of the studies on how food is being handled from farm to fork, how airlines are contributing towards the spreading of diseases, how any negligence in any one of the steps can cause havoc to mankind in the light of the recent …

Intrauterine Blood Plasma Platelet-Therapy Mitigates Persistent Breeding-Induced Endometritis, Reduces Uterine Infections, And Improves Embryo Recovery In Mares, Lorenzo G. T. M. Segabinazzi, Igor F. Canisso, Giorgia Podico, Lais L. Cunha, Guilherme Novello, Michael F. Rosser, Shavanh C. Loux, Fabio S. Lima, Marco A. Alvarenga

Maxwell H. Gluck Equine Research Center Faculty Publications

Microorganisms, including pathogenic or opportunistic bacteria and fungi, may gain access to the uterus during breeding, and infectious endometritis plays a major role in equine subfertility. This study aimed to assess the post-breeding inflammatory response, endometrial culture, and embryo recovery of mares susceptible to persistent breeding-induced endometritis (PBIE) treated with plasma-rich (PRP) or -poor (PPP) plasma. Mares (n = 12) susceptible to PBIE had three cycles randomly assigned to receive intrauterine infusions of lactate ringer solution (LRS, control), or autologous PRP or PPP pre- (−48 and −24 h) and post-breeding (6 and 24 h). Mares were bred with fresh …

A Retrospective Look At The Predictions And Recommendations From The 2009 Amia Policy Meeting: Did We See Ehr-Related Clinician Burnout Coming?, Justin B Starren, William M Tierney, Marc S Williams, Paul Tang, Charlene Weir, Ross Koppel, Philip Payne, George Hripcsak, Don E Detmer

2020-Current year OA Pubs

Clinicians often attribute much of their burnout experience to use of the electronic health record, the adoption of which was greatly accelerated by the Health Information Technology for Economic and Clinical Health Act of 2009. That same year, AMIA's Policy Meeting focused on possible unintended consequences associated with rapid implementation of electronic health records, generating 17 potential consequences and 15 recommendations to address them. At the 2020 annual meeting of the American College of Medical Informatics (ACMI), ACMI fellows participated in a modified Delphi process to assess the accuracy of the 2009 predictions and the response to the recommendations. Among …

Dnp Final Report: The Impact Of The Care Coordination Management Tool On Children With Special Health Care Needs, Keisia N. Sobers-Butler, Ms, Bsba, Rn, Cmcn

DNP Final Reports

Children with Special Health Care Needs (CSHCN) population, account for 30% of spending or $233.5 billion of the costs (Bui et al., 2017). Identifying barriers to care in the CSHCN population can be multi-faceted and complex incorporating high utilization of time, and clinical resources. This project aims to evaluate the impact of care coordination, and utilization on the CSHCN population through a Patient-centered Medical Home, use of embedded case management assessing this population through using the evidence-based Care

Coordination Management Tool (CCMT). CSHCN (N=117) and families were assessed using the CCMT at every interaction from September 1, 2020 – November …

The Danger Of Apathy: College Students' Receipt Of Mumps Vaccine During An Outbreak, Laura A. Keane

James Madison Undergraduate Research Journal (JMURJ)

A mumps outbreak occurred on the James Madison University campus in Harrisonburg, Virginia, during the Spring 2018 semester. For many of the students, it was probably the first time they had to decide on their own whether or not to receive a vaccine. This study examined the relationships between students’ general vaccine acceptance; measles, mumps, and rubella (MMR) vaccine acceptance; vaccine knowledge; and intent to receive/receipt of the MMR booster. An explanatory, cross-sectional study was distributed in Fall 2019 to students in two health courses (n = 243). For students who were enrolled during the Spring 2018 semester, the …

2021-04-22_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Limited Pfizer-Biontech Vaccine Available Next Week, April 22, 2021, University Of Northern Iowa

UNI Response to COVID-19

Announces the availablility of the Pfizer vaccine for clinics held the week of April 26th.

2021-04-22_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102057---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

Early Mobility In The Intensive Care Unit: An Integrative Review On Safe Practices, Jessica Poehler

Nursing Masters Papers

The effects of immobility in the intensive care unit (ICU) lead to significant short and long-term complications among patients. Early mobility practices positively impact patients’ cognitive and physical outcomes while in the ICU and post ICU discharge; however, patient safety barriers exist with implementing early mobility interventions. An integrative literature review was completed to summarize early mobility practices among individuals in the ICU, adverse safety events that occurred during mobilizing, and best practices to prevent adverse safety events from occurring. Using CINAHL, PubMed, OVID, and ProQuest, eleven articles were analyzed for level and quality of evidence, including two randomized controlled …

How Do Canadian Public Health Agencies Respond To The Covid-19 Emergency Using Social Media: A Protocol For A Case Study Using Content And Sentiment Analysis, Anita Kothari, Lyndsay Foisey, Lorie Donelle, Michael Bauer

Nursing Publications

Introduction Keeping Canadians safe requires a robust public health (PH) system. This is especially true when there is a PH emergency, like the COVID-19 pandemic. Social media, like Twitter and Facebook, is an important information channel because most people use the internet for their health information. The PH sector can use social media during emergency events for (1) PH messaging, (2) monitoring misinformation, and (3) responding to questions and concerns raised by the public. In this study, we ask: what is the Canadian PH risk communication response to the COVID-19 pandemic in the context of social media? Methods and analysis …

The Quandary Of Dna-Based Treatment Assessment In De Novo Metastatic Prostate Cancer In The Era Of Precision Oncology., Sigve Nakken, Wolfgang Lilleby, Marta D. Switlyk, Karen E Knudsen, Oscar Lilleby, Sen Zhao, Fatemeh Kaveh, Per O. Ekstrøm, Alfonso Urbanucci, Eivind Hovig

Department of Cancer Biology Faculty Papers

Guidelines for genetic testing have been established for multiple tumor types, frequently indicating the most confident molecularly targeted treatment options. However, considering the often-complex presentation of individual cancer patients, in addition to the combinatorial complexity and inherent uncertainties of molecular findings, deriving optimal treatment strategies frequently becomes very challenging. Here, we report a comprehensive analysis of a 68-year-old male with metastatic prostate cancer, encompassing pathology and MRI findings, transcriptomic results, and key genomics findings from whole-exome sequencing, both somatic aberrations and germline variants. We identify multiple somatic aberrations that are known to be enriched in prostate cancer, including a deletion …

2021-04-22_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-04-22_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Exploring The Impact Of Care Delivery On Families Of Children With Medical Complexity, Shelby Pawlowski

DNP Projects

Background: Children with medical complexity (CMC) are considered most medically fragile and require the most health care needs. Medical care for CMC is described as fragmented, uncoordinated, and crisis-driven with a tendency to over-medicalize the child and under-support the family. The intimate link between caregiver and child health supports further exploration of factors that may influence family health-related quality of life (FHRQOL) in families of CMC. Purpose: The purpose was description of the population of CMC receiving rehabilitation services in the community setting and exploration of the impact of a comprehensive outpatient rehabilitation facility (CORF) on FHRQOL. Review of Evidence: …

A Quality Improvement Project To Improve Communication And Reduce Hospital Readmissions, Mackenzie Thomas

DNP Projects

Background: More than 25 million people are readmitted to the hospital within 30 days of nursing home admission. With most nursing home patients receiving Medicare, Medicaid, or other publicly funded services, readmissions significantly burden the healthcare system. Poor communication within nursing homes may contribute to poor health outcomes and unplanned hospital readmissions. Purpose: To reduce readmission rates at two skilled nursing facilities by improving staff communication through consistent use of the INTERACT STOP AND WATCH (SW) tool. Design: The quality improvement project reviewed all admissions, transfers, and readmissions occurring before and during the project to determine the impact of the …

Rn Perception Of Resources, Communication, And Leadership During Covid-19 And The Impact On Rn Satisfaction And Turnover In A Multi-Hospital System, Gina Bullington

DNP Projects

Abstract

While RN retention has been a perennial challenge, COVID-19 has exacerbated the problem. The project’s purpose was to study RNs’ perception of communication, resources, and leadership during COVID-19, and the impact on RN turnover in a multi-hospital system. 3280 RNs’ engagement survey responses and turnover percentages from pre-COVID-19 (November 2019) were compared to engagement survey responses and turnover percentages 12 months later (November 2020). 90% (n = 2963) were female and 43% (n = 1396) were between the ages of 25 and 39 years. The majority of RN respondents were employed 1-9 years (59%, n = 1934). …

The Health Impact Of Intensive Case Management On Women With Oud And Their Infants, Shannon Rappe

DNP Projects

Postpartum women with an opioid use disorder (OUD) are at high risk for treatment disengagement, leaving them vulnerable to overdose and death between seven and twelve months postpartum. Intensive case management programs have been proposed as an effective strategy to reduce barriers and increase treatment engagement among postpartum women. The purpose of this study was to evaluate program outcomes of postpartum women with OUD and the health outcomes of their infants when engaged in an intensive case management program postpartum. The study was a retrospective review of secondary data collected on 221 postpartum mothers and 225 infants of mothers who …