Medicine and Health Sciences Commons^™

Comparison Of Third Year Medical Student Wellness Before And During The Sars-Cov2 Pandemic, Jenna Scholl, Oladapo Akinmoladun, Amissabah Kanley, Nathan Gollehon, Jason Burrows

Child Health Research Institute Pediatric Research Forum

Introduction

Depression and suicidal ideation have a higher prevalence in medical students when compared to other age-matched populations.^1,2 The SARS-CoV2 pandemic has further threatened medical trainee well-being with increased stress and risk of mental illness.^3,4

Objective

To compare medical student well-being at a single institution before and during the SARS-CoV2 pandemic.

Methods

Third year medical students at a single institution voluntarily completed a survey during pediatric clerkship orientation as part of an ongoing, non-pandemic longitudinal wellness study. The survey instrument includes basic demographic information, the validated World Health Organization (WHO) (FIVE) Well-Being Index (WHO-5), and questions about physical …

Expanding The Phenotype Of Hnrnpu-Related Disorders To Include Brief, Resolved, Unexplained Events (Brue), Jonah Scheffler, Kristen P. Fishler, Lois J. Starr

Child Health Research Institute Pediatric Research Forum

hnRNP-U deficiency is caused by pathogenic variants in HNRNPU, which encodes the heterogeneous nuclear ribonucleoprotein U (HNRNPU), a highly conserved protein responsible for assisting spliceosomes in mediating transcription and alternative splicing activity. HnRNPs are responsible for the regulation of translation at the presynaptic sites as well as the transportation of stabilized mRNAs along the axonal cytoskeleton. Here, we report a 2-year-old-male with a HNRNPU variant with a new presentation of apparent recurrent apneic spells with an underlying epileptic origin. These were described as apnea followed by desaturation and tachycardia in the 180's-200 range prior to resolution of symptoms. He also …

Relationship Between Mir-335 And Sterol Levels After In Vitro Hypoxia-Ischemia Of Primary Brain Cells, Namood-E Sahar, Zeljka Korade, Eric Peeples

Child Health Research Institute Pediatric Research Forum

Background/Purpose: Cholesterol homeostasis is vital for synaptogenesis and myelination during fetal and neonatal brain development. Both brain and plasma sterol levels have been shown to be associated with outcomes in adult stroke, and animal studies have suggested brain and plasma sterol changes in neonatal hypoxic-ischemic brain injury. MicroRNA-335 (miR-335) has been associated with brain sterol metabolism and our preliminary data showed that sterol metabolism is dysregulated in the brain after hypoxic-ischemic injury in a mouse model. This study sought to describe the effect of oxygen-glucose deprivation in vitro on individual brain cell populations and to validate the associations between sterol …

Postnatal Diagnosis Of Dandy Walker Malformation With Encephalocele, Heerali Patel

Child Health Research Institute Pediatric Research Forum

Encephalocele is a defect of the neural tube. Dandy Walker malformation (DWM) is a defect involving agenesis or hypoplasia of the cerebellar vermis, cystic dilation of the fourth ventricle, and enlargement of the posterior fossa. This is a case of a female preterm infant born at 36 weeks’ gestation who presented with DWM and an encapsulated occipital encephalocele at birth. The pregnancy was complicated by poorly controlled maternal diabetes. Prenatal ultrasound indicated a central nervous system anomaly. Amniocentesis did not show chromosomal abnormality. The infant also presented with polydactyly of the right thumb. MRI showed evidence of soft tissue within …

3d Printed Adjustable Glasses: A New Model Of Corrective Lens Delivery For Pediatric Refractive Error In Underserved Communities, Nathan Ostlie, Mari Ogino, Donny Suh, Gabe Linke, James Hermsen

Child Health Research Institute Pediatric Research Forum

Purpose:

Uncorrected refractive error (URE) remains a major cause of preventable vision impairment in the pediatric population with large inequities in disease burden. The present study aims to elucidate the global burden of pediatric URE and explore the current lens delivery systems which address this problem. Within this framework, we introduce a new model of corrective lens delivery that may improve upon existing models.

Methods:

The present study involved an extensive literature review of epidemiological data to determine the global prevalence of URE. Prevalence data was then compared against WHO data on refractionist coverage gaps divided by region. …

Perceptions Of Pediatricians On The Sars-Cov2 Vaccine, Karl Khandalavala, Kari Simonsen, Jeffrey A. Robinson

Child Health Research Institute Pediatric Research Forum

Introduction: The novel SARs-CoV2 coronavirus has infected approximately 30,000,000 people in the USA. To date, approximately 146 million doses of SARs-CoV2 vaccines have been administered. Perceptions of rapid vaccine development have resulted in reported vaccine hesitancy and refusal. Though not currently FDA approved for use in pediatric populations, but pediatric vaccination may contribute to herd immunity. Previous study demonstrates that physician recommendations significantly impact perceptions of routine pediatric immunizations among parents. Given this historical data, this study aimed to describe the strength of recommendation by pediatricians for the SARs-CoV2 vaccine for pediatric patients and their parents.

Methods: A …

To Addend Or Not To Addend? Exploring Pediatric Residents' Perceptions Of Using Medical Students’ Notes For Documentation, A Mixed Methods Approach, Shannon Haines, Kari Nelson, Kaeli Samson, Nathan Gollehon

Child Health Research Institute Pediatric Research Forum

Background

Clinical documentation is an essential skill for practicing physicians, yet many medical students are not prepared for documentation required during residency.^1,2 CMS rule changes now allow medical students’ notes to be used for billing.³ Residents are often the primary authors of notes and provide medical student supervision and instruction. However, little is known about how the use of medical student notes in patient documentation would impact residents. We utilized Constructivist Learning Theory to frame our work, where students construct their knowledge as residents and subsequently faculty facilitate the process.⁴

Objectives

To evaluate how utilizing clerkship medical …

Unsolicited Advice, Kara Arnold

Child Health Research Institute Pediatric Research Forum

This piece was written with the phrases that have been said to me or to other female colleagues throughout my year of clinical rotations. Although women in medicine have come a long way, I want this to illustrate the pain that is still inflicted towards female professionals through words like these.

Life As Medical Student On Rotation, Amanda Goodwin

Child Health Research Institute Pediatric Research Forum

A reflection of the stress and wonder surrounding M3 year

Identification Of Transcription Regulators Of The Algz/R Two-Components Regulatory System In Pseudomonas Aeruginosa, Kwasi Yeboah

Electronic Theses and Dissertations

Pseudomonas aeruginosa is an opportunistic pathogen that express a plethora of virulence components controlled through two-component regulatory systems that allow for sensing and responding to environmental stimuli. This study was aimed at identifying transcription regulators of algZ that encodes the histidine sensor kinase (AlgZ) of the AlgZR two-component regulatory system. To understand how the algZ gene is transcriptionally controlled, transposon mutagenesis was used to create a mutant library with varying algZ expression based on their b-Galactosidase activity. The gene PA3327 was identified as a potential regulator of algZ expression using arbitrary PCR. This gene encodes a probable non-ribosomal peptide synthetase …

A New All-Natural Wound Treatment Gel Shows Strong Inhibitory Activity Against Staphylococcus Aureus And Other Wound Pathogens, Tasha K. Nelson

Electronic Theses and Dissertations

Skin related injuries are some of the most dangerous forms of wounds. In addition to treating the wound itself, health care providers must be cautious of microbial infections. In this study, we evaluate a novel all-natural antimicrobial gel compound (AMG) designed to kill planktonic bacteria, penetrate bacterial biofilms, and accelerate wound healing. In -vitro experiments demonstrate that AMG is effective in inhibiting planktonic growth and biofilm development of eight common pathogens. LIVE/DEAD staining and confocal microscopy reveal that planktonic growth and three-dimensional structure of biofilms were significantly reduced. Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) was used to investigate a small …

Investigating The Association Between Adolescent Polysubstance Use, Crime, And Violence In The United States, Christian Nwabueze

Electronic Theses and Dissertations

The lifetime prevalence of alcohol in the United States is 8% and lifetime prevalence of illicit drug use is about 2-3%. Substance use is common among adolescents and polysubstance use is becoming a public health threat.

The prevalence of adolescent physical dating violence was 8.2%, the prevalence of adolescent sexual violence was also 8.2% while the prevalence of dual adolescent physical and sexual violence was 2.6%. Compared to those who used only single substances, adolescents who did not use any substance were 60% less likely (OR = 0.42, 95% CI = 0.24 – 0.74) to experience physical dating violence, 50% …

Investigating Bmp7 Expression In Glioblastoma Multiforme, Yajaira Janett Macias

Theses and Dissertations

The PI3K/AKT/mTOR pathway regulates important cell processes such as growth, survival, motility, inflammation, proliferation, and apoptosis. In Glioblastoma multiforme (GBM) the PI3K/AKT/mTOR pathway is aberrant as it is almost always active. This results in the deregulation of downstream molecules and ultimately leads to cancer progression and maintenance in GBM tumors. In this study, we used RNA-sequencing to identify differentially expressed genes (DEGs) in U87MG GBM cells treated with NVP-BEZ235, a dual inhibitory drug targeting PI3K and mTOR. A total of 7,803 differentially expressed genes were identified via RNA-seq. GEPIA2 online tool was used to assess differential gene expression …

Intravenous Smart Pumps During Actual Clinical Use: A Descriptive Comparison Of Primary And Secondary Infusion Practices., Karen K Giuliano, Daleen Penoyer, Rebecca S. Mahuren, Melody Bennett

Parkview Pharmacy Department

This descriptive observational study was conducted to increase understanding of medication administration practices during actual clinical use between 2 commonly used, different types of intravenous (IV) smart pumps. Compliance with manufacturer-recommended setup requirements for both primary and secondary infusions and secondary medication administration delay was compared between a head-height differential system and a cassette system. A total of 301 medication administration observations were included in this study: 102 (34%) for the linear peristaltic IV smart pump (medical-surgical: N = 51; critical care: N = 51) and 199 (66%) for the cassette pump (medical-surgical: N = 88; critical care: N = …

May 2021, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

National Osteoporosis Month

About 54 million Americans have osteoporosis and low bone mass, placing them at increased risk for osteoporosis.

American Stroke Awareness Month

Stroke is dangerous and deadly, but you can control and treat several risk factors for it.

Emotion Regulation Among Adults With Asthma: Links With Short-Acting Inhaler Medication Overuse And Utilization Of Acute Medical Care, Victoria A. Green

Honors Theses

Effective control of asthma symptoms requires daily self-management activities, including use of short-acting or “rescue” inhaled medications. Overuse of short-acting inhaled medications, such as albuterol, can have negative side-effects, including respiratory infections and worse asthma symptom control. Existing research suggests that emotion plays an important role in airway inflammation and asthma symptom control. The objective of this study was to determine whether difficulties regulating emotion was associated with overuse of short-acting inhaled medications and acute medical care usage in adults with asthma. The sample included 401 adults with asthma recruited from an online panel of adults with chronic respiratory disease. …

Implementation Evaluation Of Blood Flow Restriction In The Clinical Setting, Madison Mccall

Honors Theses

Blood flow restriction (BFR) refers to a relatively new training/rehabilitation method consisting of a tourniquet system applied to a limb to partially inhibit blood flow to the muscles distal to the tourniquet. Though much research has been conducted concerning its use, there is little information addressing why clinicians may or may not implement it. Diffusion of Innovation (DOI) theory explains how a product or idea can spread to specific population groups, ending in adoption of it. The Consolidated Framework for Implementation Research (CFIR) consists of a set of constructs which can be used to determine the specific factors involved in …

Light And Heavy Verb Productions Between Single And Sequential Picture Description Tasks In People With And Without Non-Fluent Aphasia, Jessica Hall

Honors Theses

Background: Previous research has shown that persons with non-fluent aphasia (PWNFA) suffer from the inability to retrieve words, specifically more of a difficulty with verb productions. Various discourse elicitation tasks have shown to have differing effects on verb retrievals in this population. However, there is a lack of research on the relationship between single vs. sequential picture description tasks and the productions of heavy and light verbs in persons with non-fluent aphasia.

Purpose: The purpose of this study was to analyze the ratios of heavy and light verbs produced in both single picture description tasks and sequential picture description tasks …

Effectiveness Of Visual Representations In Undergraduate Human Anatomy And Physiology I & Ii, Mary Agnes Mestayer

Honors Theses

The objective of this project was to explore intersections between student preferences and student performance on anatomical visual representations in Human Anatomy and Physiology I and II. Visual representations are a critical resource for the formation of relationships between function and structure furthermore; students interpret these representations uniquely based on specific factors (learning objective, prior knowledge, the diagram studied, etc.). Phase I of this project gathered undergraduate responses to ten Likert-style questions on their opinions on diagrams and their use in the A&P classroom. Phase II of this project presented participants with twelve manipulated diagrams sourced from three diagram with …

The Role Of Cannabinoid Receptor 2 In Zebrafish Toxicities Following Developmental Exposure To Thc Or Cbd, Haley Watts

Honors Theses

As the laws concerning the regulation of Cannabis Sativa change across the globe, maternal use of cannabinoid-containing products during pregnancy is a greater concern than ever before. Little research has been conducted on the consequences of maternal use and developmental exposure to ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD. In this study, larval zebrafish (Danio rerio) were used to measure CBD and THC-mediated adverse outcomes including effects on larval length, eye area, and behavior in the cnr^+/+ and cnr2^-/- zebrafish strains where we discovered that cannabinoid exposure results in a decrease in each of these endpoints. Adult …

Using Deep Learning To Automate The Diagnosis Of Skin Melanoma, Akhil Reddy Alasandagutti

Honors Theses

Machine learning and image processing techniques have been widely implemented in the field of medicine to help accurately diagnose a multitude of medical conditions. The automated diagnosis of skin melanoma is one such instance. However, a majority of the successful machine learning models that have been implemented in the past have used deep learning approaches where only raw image data has been utilized to train machine learning models, such as neural networks. While they have been quite effective at predicting the condition of these lesions, they lack key information about the images, such as clinical data, and features that medical …

Proficiency Of Mississippi Pharmacy Staff In Communicating With Spanish-Speaking Patients, Caroline Kreh

Honors Theses

Pharmacists play a crucial role in patient care; they must be able to communicate effectively with patients to convey health information. Given the linguistic diversity of Mississippi, pharmacists will likely encounter Spanish-speaking patients in the course of their practice. Previous studies have investigated various indicators of pharmacists’ ability to communicate with Spanish-speaking patients; however, no existing studies regarding Mississippi pharmacy staff members’ ability to communicate with Spanish-speaking patients were found. The objectives of this study were to measure Mississippi pharmacists’ confidence, satisfaction, proficiency, use of resources, and level of education related to communicating with Spanish-speaking patients. The sample was composed …

Fine Particulate Matter And Low Weight Births In Mexico City, Mexico, Kennedy Cohn

Honors Theses

Fine particulate matter (PM2.5) exposure has been associated with several negative health consequences, and recent studies suggest a potential relationship between PM2.5 exposure and adverse birth outcomes, including low birth weight (LBW). This thesis investigated a potential relationship between fine particulate matter concentration and low birth weight in Mexico City, Mexico between 2008-2016. Maternal pollution exposure was estimated at the city-wide level by averaging PM2.5 measurements from various monitoring stations. Birth weight was collected from the SINAC database. Logistic regression models were run for different temporal scales (by trimester, and 10-month periods); however, there were no significant relationships found between …

Social Environment Changes During Covid-19 Quarantine, Aileen Jimenez

Honors Theses

The purpose of this research project is to understand perceptions of the psychological, behavioral, and social impacts of COVID-19. Students at the University of Mississippi were invited to participate in an online questionnaire administered through Qualtrics. The questionnaire was composed of questions concerning health behaviors, including questions from the Depression, Anxiety and Stress Scale-21, Perceived Vulnerability to Disease Scale, Fear of Coronavirus-19 Scale, and the World Health Organization’s COVID-19 Snapshot Monitoring study. 274 students participated in the study. Overall, the results of this study suggested moderate distress across the sample, differences in sleep, exercise, and alcohol consumption during quarantine conditions, …

Nursing Student Perceptions Of Health Care Worker Appearance And Compassion, Skill, Knowledge, And Trustworthiness, Sophia Quick

Undergraduate Honors Theses

Background: Many health care facilities enforce strict dress code policies prohibiting visible body modifications, including tattoos, piercings, and vibrant hair colors. As popularity of body modifications among young adults surges, facilities may be forced to adapt policies as these workers enter the workforce. While some evidence exists related to patient perceptions of health care workers with body modifications, there is little about how nursing students perceive them. This study aimed to describe undergraduate, pre-licensure nursing students’ perceptions of health care worker appearance on compassion, skill, knowledge, and trustworthiness.

Methods: Using cross-sectional design, an on-line Likert-type survey was used to collect …

A Pilot Study Comparing Over And Under Triage Systems At A Center Pursuing Trauma Accreditation, Caitlyn N. Balsay Bs, Mr, Bree A. Harrison Bsn, Rn, Tcrn, Joseph J. Stirparo Md, Michael T. Crowley Md, Nicholas P. Johnson Do, Bryan G. Kane Md, Kathleen E. Kane Md

USF-LVHN SELECT

No abstract provided.

Muc13 Enhances Colorectal Cancer Metastasis, Kyle Doxtater

Theses and Dissertations (ETD)

Colorectal cancer (CRC) is one of the most prevalent cancer worldwide with a 5% lifetime incidence in developed countries. It is third most common cause of cancer related death in the United States and the second deadliest when men and women are combined. Encouragingly due to changes in dietary lifestyle, screening colonoscopy, and advancement in treatments the mortality has decreased in recent years. Most sporadic CRCs develop from polyploid adenomas and are preceded by intramucosal carcinomas (stage 0), which can progress into more malignant forms. This developmental process is known as the adenoma-carcinoma sequence. Early detection and endoscopic removal are …

Delineating The Upc2a Regulon In Candida Glabrata, Yu Li

Theses and Dissertations (ETD)

Candida glabrata is the second most common cause of invasive candidiasis. Intrinsic resistance has greatly limited the utility of the triazole antifungal, fluconazole, in the treatment of invasive fungal infection. The transcription factor Upc2 regulates the expression of sterol biosynthesis genes in yeast. Disrupting UPC2A in C. glabrata greatly increases its susceptibility to fluconazole (FLU) in both FLU-susceptible and -resistant clinical isolates. Therefore, the Upc2A and its target genes represent a potential pathway for overcoming FLU resistance in C. glabrata. We aimed to delineate the Upc2A regulon to determine its target genes involved in FLU resistance. Transcriptome sequencing (RNA-seq) analysis …

Multi-Response Surface Optimisation Of Extrusion Cooking To Increase Soluble Dietary Fibre And Polyphenols In Lupin Seed Coat, Liezhou Zhong, Zhongxiang Fang, Mark L. Wahlqvist, Jonathan M. Hodgson, Stuart K. Johnson

Research outputs 2014 to 2021

The seed coat of the legume lupin which is rich in insoluble dietary fibre is a major by-product in human food applications. Extrusion cooking has been demonstrated to increase desirable soluble dietary fibre in the Australian sweet lupin seed coat. In this study, processing condition of twin-screw extrusion cooking was optimised using a central composite rotatable design to increase soluble dietary fibre in lupin seed coat from 44.17 g/kg up to 113.69 g/kg dry basis. The high levels of polyphenols in the seed coat were retained. The optimal extrusion conditions which achieved maximum levels of soluble dietary fibre, total free …

Keeping Count: Studying The Effects Of Previous Sexual History On A Current Coupling, Kaelyn D. Pate

Electronic Theses and Dissertations

The following thesis details a quantitative study focusing on the sexual double standard and how its impact on sexual attitudes and behaviors has a possible influence on relationship satisfaction. The purpose of this research is to understand how attitudes regarding the prevailing double standard reflect the hesitancy towards having a partner with a previous sexual history as the discussion suggests. There will be a review of previous literature for the traditional, cultural, and even paradoxical aspects that make up the standard. Findings of the study showed that there was no significant relationship found between a respondent’s acceptance of the sexual …