Medicine and Health Sciences Commons^™

A Survey Regarding Awareness And Beliefs About Homoeopathy Among General Population During Magh Mela At Allahabad, Uttar Pradesh, India, Manas Sarangi, Pramanik Abhishek, Jaya Gupta, Ramesh Prasad, Pramodji Singh, Mahesh Shah, Alok Upadhyay, Saurabh Jain, Ambreesh Pandey

Indian Journal of Research in Homoeopathy

Background and Objective: Homoeopathy is one of the various alternative systems of medicine prevalent in India. A survey was conducted during the month of January–February 2017 in a congregation at Sangam, Allahabad, to know about the awareness of general population about Homoeopathy. Methods: A cross-sectional survey was conducted on patients and people visiting the health check-up camp and exhibition stall set-up during Magh Mela at Sangam, Allahabad. A self-administered questionnaire was used during the survey, devised by the Central Council for Research in Homoeopathy. Results: Of 1144 total respondents, 68.1% had knowledge about Homoeopathy. About 46.6% of respondents believed that …

Effect Of 10-Valent Pneumococcal Conjugate Vaccine On The Incidence Of Radiologically-Confirmed Pneumonia And Clinically-Defined Pneumonia In Kenyan Children: An Interrupted Time-Series Analysis, Micah Silaba, Michael Ooko, Christian Bottomley, Joyce Sande, Rachel Benamore, Kate Park, James Ignas, Kathryn Maitland, Neema Mturi, Anne Makumi

Imaging & Diagnostic Radiology, East Africa

Background: Pneumococcal conjugate vaccines (PCV) are highly protective against invasive pneumococcal disease caused by vaccine serotypes, but the burden of pneumococcal disease in low-income and middle-income countries is dominated by pneumonia, most of which is non-bacteraemic. We examined the effect of 10-valent PCV on the incidence of pneumonia in Kenya.

Methods: We linked prospective hospital surveillance for clinically-defined WHO severe or very severe pneumonia at Kilifi County Hospital, Kenya, from 2002 to 2015, to population surveillance at Kilifi Health and Demographic Surveillance System, comprising 45000 children younger than 5 years. Chest radiographs were read according to a WHO standard. A …

Development Of A Real-Time Pcr Assay For Pneumocystis Jirovecii On The Luminex Aries® Platform, Subathra Marimuthu, Kuldeep Ghosh, Leslie A Wolf

The University of Louisville Journal of Respiratory Infections

Pneumocystis pneumonia (PCP) is an opportunistic infection caused by the fungus Pneumocystis jirovecii. Infection with P. jirovecii can result in serious illness in patients with a weakened immune system, and can lead to death if it is not properly diagnosed and treated. Direct detection of P. jirovecii in lower respiratory tract specimens such as bronchoalveolar lavage (BAL) is preferred for rapid diagnosis, a laboratory service currently not available locally. We report here the development of a diagnostic real-time Polymerase Chain Reaction (PCR) assay using BAL specimens to detect P. jirovecii. By targeting the multi-copy mitochondrial large subunit ribosomal …

An Atypical Presentation Of A Rare Disease, Elizabeth Schoenberg, Kathleen P. Mcguinn, Deirdre Connolly, Sherry Yang

Department of Dermatology and Cutaneous Biology Faculty Papers

A 76-year-old white woman presented for evaluation of asymptomatic skin lesions on her right shin, right buttock, and left arm. All lesions initially underwent slow growth and plateaued and then remained stable in size. A complete review of systems revealed normal results. She had 3 well-demarcated erythematous round plaques ranging from 1.5 to 3 cm, all with a central depression, yellow hue, and prominent telangiectasias (Figs 1 and 2). An excisional biopsy was performed. Histologically, there were palisading granulomas within the papillary and reticular dermis, predominantly composed of a histiocytic cell population with multiple large giant cells (S100^-; …

Epithelioid Glioblastoma Presenting As Aphasia In A Young Adult With Ovarian Cancer: A Case Report, Megan M. Finneran, Joseph Georges, Michael Kakareka, Ryan Moncman, Miriam Enriquez, Todd Siegal, Gregory Kubicek, Alan Turtz, Steven S. Yocom, H Warren Goldman

PCOM Scholarly Works

Our patient's clinical history and preoperative radiographic evaluation suggested central nervous system (CNS) metastatic disease. Ultimately, final pathology revealed epithelioid glioblastoma (eGBM), a newly classified CNS primary tumor. This reinforces the importance of direct tissue sampling and including eGBM on the differential for young patients with histories of systemic cancer presenting with new CNS lesions.

Young Women’S Knowledge About Fertility And Their Fertility Health Risk Factors, Qiyan Mu, Lisa Hanson, James B. Hoelzle, Richard J. Fehring

College of Nursing Faculty Research and Publications

Objective

To explore the relationships among young women’s demographic characteristics, their self-perceived and actual knowledge about fertility, and their fertility health risk factors.

Design

A quantitative, cross-sectional study.

Setting

Online survey.

Participants

Young women between the ages of 18 and 24 years (N = 342).

Methods

We used an online survey to collect data from young women regarding their demographic characteristics, their self-perceived and actual knowledge about fertility, and their fertility health risk factors. We used multiple linear regression to explore the relationships among these factors.

Results

Participants were mainly White, had some form of college education, and used …

Use Of 3d Imaging For Providing Insights Into High-Order Structure Of Mitotic Chromosomes, Mohammad Yusuf, Kohei Kaneyoshi, Kiichi Fukui, Ian Robinson

Centre for Regenerative Medicine & Stem Cell Research

The high-order structure of metaphase chromosomes remains still under investigation, especially the 30-nm structure that is still controversial. Advanced 3D imaging has provided useful information for our understanding of this detailed structure. It is evident that new technologies together with improved sample preparations and image analyses should be adequately combined. This mini review highlights 3D imaging used for chromosome analysis so far with future imaging directions also highlighted.

Combination Of Rock Inhibitor, Hypoxia And Melatonin Improved Differentiation Of Rabbit Induced Pluripotent Stem Cells Into Cardiac Progenitor Cells, Praopilas Phakdeedindan, Piyathip Setthawong, Mongkol Techakumphu, Theerawat Tharasanit

The Thai Journal of Veterinary Medicine

Cardiac progenitors are a promising cell source for treating myocardial infarction. In this study, we improved the protocol for cardiac differentiation of rabbit induced pluripotent stem cells (iPSC) using Rho-associated protein kinase (ROCK) inhibitor (Y-27632), low O2 tension (hypoxia) and melatonin treatments. In experiment 1, the rabbit iPSCs were differentiated into cardiac cell fate via embryoid body (EB) formation with or without ROCK inhibitor. EB diameters were measured on day 3 of differentiation. In experiment 2, the EBs were plated on gelatin-coated dishes and further cultured in different oxygen tensions, hypoxia (5% oxygen) and normoxia (20% oxygen). The plated EBs …

Effect Of A Rapid Heat Treatment On Thai Qx-Like Infectious Bronchitis Virus And Evaluation Of Protection Induced By A Heat-Treated Virus, Tawatchai Pohuang, Sucheeva Junnu

The Thai Journal of Veterinary Medicine

The purpose of this study was to evaluate the effect of a rapid heat-treatment method on Thai QX-like infectious bronchitis virus (IBV) and the efficacy on protection from the virus after heat treatment. QX-like IBV isolate THA46 was incubated at 56 oC. The incubated virus was collected every 5 min for up to 1 h and then they were inoculated into embryonated chicken eggs. At 6 days post-inoculation, allantoic fluid was harvested from the embryonated eggs which were inoculated with virus of the longest heat-treatment time that induced lesions in the embryos. That allantoic fluid was used in a subsequent …

Self-Reported Addiction To Pornography In A Nationally Representative Sample: The Roles Of Use Habits, Religiousness, And Moral Incongruence, Joshua B. Grubbs, Shane W. Kraus, Samuel L. Perry

Psychology Faculty Research

Background and aims: Despite controversies regarding its existence as a legitimate mental health condition, self-reports of pornography addiction seem to occur regularly. In the United States, prior works using various sampling techniques, such as undergraduate samples and online convenience samples, have consistently demonstrated that some pornography users report feeling dysregulated or out of control in their use. Even so, there has been very little work in US nationally representative samples to examine self-reported pornography addiction. Methods: This study sought to examine self-reported pornography addiction in a US nationally representative sample of adult Internet users (N = 2,075). Results: The results …

Feeling Green: The Benefits Of Green Space On Urbanites' Mental Health, Kathryn A. Hoagland

Liberal Arts and Engineering Studies

This investigation intends to determine the best methods for incorporating public green space into dense urban areas, for the betterment of residents' mental health. Data from studies showing differences in the prevalence of anxiety and depression in urban and rural areas are discussed alongside data from studies looking at the effect that certain types of green space might have on mental health. While there is no exact consensus on the extent to which nature has positive effects on mental health there is enough of a correlation to argue for the implementation of public green spaces in urban design, in order …

Stressed Out With Sepsis., Robert Hilton, Michael Baram

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

No abstract provided.

Cyto-Histologic Discordancy In Patients Undergoing Thyroidectomy At Aga Khan University Hospital, Moses Barasa, Abdulkarim Abdallah

General Surgery, East Africa

Fine needle aspiration cytology (FNAC) findings are the basis upon which decision and type surgery is made. Therefore the diagnostic accuracy and utility of FNAC being such an integral tool in management of thyroid lesions must be evaluated for cyto-histologic discrepancy from time to time as a quality assurance measure. The objective was to compare thyroid fine-needle aspiration cytology (FNAC) with final histopathological findings at in patients undergoing thyroidectomy. This was a cross-sectional retrospective study at Aga Khan university hospital, Nairobi. Cyto-histologic discrepancy was found in 19(25%) of cases with false positive and negative rates at 9% and 16%. False …

Establishing Cohorts To Generate The Evidence Base To Reduce The Burden Of Breast Cancer In Sub-Saharan Africa: Results From A Feasibility Study In Kenya, Sujha Subramanian, Robai Gakunga, Madeleine D. Jones, Asaph Kinyanjui, Emily' Ochieng, Nancy Gikaara, Florence Maluni, David Wata, Anne Korir, Miriam Mutebi, Zipporah Ali

General Surgery, East Africa

Purpose: By 2025, Kenya is estimated to experience a two-thirds increase in the incidence of breast cancer. Local research is necessary to generate evidence to inform policy, public health, and medical practice. There have been no longitudinal cohort studies in sub-Saharan Africa of women with and without breast cancer. Our aim is to assess the feasibility of conducting cohort studies in Kenya that consider clinical characteristics, socioeconomic factors, and self-care behaviors.

Methods: We initiated a short-term follow-up cohort study of women with and without a diagnosis of breast cancer with baseline face-to-face data collection and one follow-up interview …

Healthy Heart Africa-Kenya: A 12-Month Prospective Evaluation Of Program Impact On Health Care Providers' Knowledge And Treatment Of Hypertension, Elijah N. Ogola, Francis O. Okello, Jane L. Herr, Elizabeth Macgregor-Skinner, Ashling Mulvaney, Gerald Yonga

Internal Medicine, East Africa

Background: Given the rising burden of hypertension in Africa, the Healthy Heart Africa program was developed to improve access to quality hypertension care in the primary care setting. The Healthy Heart Africa program provides a comprehensive, coordinated intervention directed at health care providers (HCPs) and the general public.

Objective: The impact of Healthy Heart Africa on HCPs' knowledge of hypertension and facility-level services in Kenya was evaluated by a 12-month prospective study.

Methods: Intervention facilities were selected by stratified random sampling and matched to similar control facilities. Intervention facilities received a hypertension treatment protocol, equipment, training and patient education materials, …

Improving Narrative And Expository Language: A Comparison Of Narrative Intervention To Shared Storybook Reading, Karee Douglas

Theses and Dissertations

The purpose of this study was to explore the impact of oral narrative intervention delivered in a multi-tiered system of support format on proximal narrative retell outcomes, and more distal personal story generation and expository language outcomes of preschool and kindergarten students. Participants included 241 preschool and kindergarten students. Students were divided into 3 different groups (treatment, alternate treatment, and no-treatment control). The treatment group received Story Champs Tier 1 oral narrative language intervention from their classroom teacher twice a week for 15-20 minutes over 14 weeks. A sub-sample of students from the Story Champs group who did not meet …

Survival Probability In Patients With Sickle Cell Anemia Using The Competitive Risk Statistical Model., Emilia Matos Do Nascimento, Clarisse Lopes De Castro Lobo, Basilio De Bragança Pereira, Samir K. Ballas

Cardeza Foundation for Hematologic Research

The clinical picture of patients with sickle cell anemia (SCA) is associated with several complications some of which could be fatal. The objective of this study is to analyze the causes of death and the effect of sex and age on survival of Brazilian patients with SCA. Data of patients with SCA who were seen and followed at HEMORIO for 15 years were retrospectively collected and analyzed. Statistical modeling was performed using survival analysis in the presence of competing risks estimating the covariate effects on a sub-distribution hazard function. Eight models were implemented, one for each cause of death. The …

March 2019, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

The Bulldog Wellness Committee has 1 standing desk available to be loaned out for a 4 month trial basis. The desk has a two-tiered design with separate keyboard/mouse deck and a spring-assisted lift mechanism that allows for easy access when either sitting or standing. Contact Christina Darras at (580) 774-3159 or email [email protected] to reserve your desk today.

Pharmacological Aspects Of Resveratrol, Raisa Ramirez, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Resveratrol [(E)-5-(4-hydroxystyryl) benzene-1,3-diol], also known as 3,4′,5-trihydroxystilbene also known as resveratrol is classified as a phytoalexin in plants such as nuts, cocoa, berries and grapes for self-defense against injury and pathogenic attacks by bacteria and fungi. Research on this compound did not gain popularity until the 1990s when a published paper implied the relationship between resveratrol and the decrease in cardiovascular complications due to the consumption of grape fermented wine in French populations. This observation sparked research on resveratrol even though its concentration in wine is relatively low, leading to the realization that resveratrol has potential for benefits in other …

A Case Report Of Massive Acetaminophen Poisoning Treated With A Novel “Triple Therapy”: N-Acetylcysteine, 4-Methylpyrazole, And Hemodialysis, Emily A. Kiernan Do, Julie A. Fritzges Do, Kathryn Henry Do, Kenneth D. Katz Md

Department of Emergency Medicine

Massive acetaminophen (N-acetyl-p-aminophenol; APAP) ingestion is characterized by a rapid onset of mitochondrial dysfunction, including metabolic acidosis, lactemia, and altered mental status without hepatotoxicity which may not respond to the standard doses of N-acetylcysteine (NAC). A 64-year-old woman without medical history presented comatose after an ingestion of 208 tablets of Tylenol PM™ (APAP 500 mg and diphenhydramine 25 mg). The initial APAP concentration measured 1,017 µg/mL (therapeutic range 10-30 µg/mL), and elevated anion gap metabolic acidosis, lactemia, and 5-oxoprolinemia were detected. High-dose intravenous (IV) NAC, 4-methylpyrazole (4-MP), and hemodialysis (HD) were initiated. She was transferred to a liver …

Law Library Blog (March 2019): Legal Beagle's Blog Archive, Roger Williams University School Of Law

Law Library Newsletters/Blog

No abstract provided.

Investigating The Role Of Free Radicals In Huntington's Disease Using Drosophila Melanogaster, Jennifer Libov

Honors Program: Senior Projects (Public)

During normal cell metabolism, reactive oxygen species (ROS) are produced as a byproduct of oxidative phosphorylation. ROS are utilized in the cell as a signaling molecule and can be maintained at healthy levels by cellular antioxidants. However, when the cell experiences oxidative stress due to environmental or genetic conditions, levels of ROS can exceed healthy levels and inhibit necessary life functions by damaging biomolecules and cellular structures. This loss of function can lead to physiological decline and neurodegeneration, such as in diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and, potentially, Huntington’s disease. The following experiments use the model genetic organism …

Implementation Science Research Examining The Integration Of Evidence-Based Practices Into Hiv Prevention And Clinical Care: Protocol For A Mixed-Methods Study Using The Exploration, Preparation, Implementation, And Sustainment (Epis) Model, April Idalski Carcone, Karin Coyle, Sitaji Gurung, Demetria Cain, Rafael E. Dilones, Laura Jadwin-Cakmak, Jeffrey T. Parsons, Sylvie Naar

Publications and Research

BACKGROUND: The Exploration, Preparation, Implementation, and Sustainment (EPIS) model is an implementation framework for studying the integration of evidence-based practices (EBPs) into real-world settings. The EPIS model conceptualizes implementation as a process starting with the earliest stages of problem recognition (Exploration) through the continued use of an EBP in a given clinical context (Sustainment). This is the first implementation science (IS) study of the integration of EBPs into adolescent HIV prevention and care settings.

OBJECTIVE: This protocol (ATN 153 EPIS) is part of the Scale It Up program, a research program administered by the Adolescent Medicine Trials Network for HIV/AIDS …

High Glucose, High Fatty Acid-Induced Toxicity, Oxidative And Metabolic Stress And Alterations In Cell Signalling In Pancreatic Rin-5f Cells: Attenuation By N-Acetylcysteine, Arwa Munassar Ali Thabet Alnahdi

Medical Education Dissertations

Hyperglycaemia and hyperlipidaemia are the main causes of diabetes and obesity-associated complications. Increased oxidative stress, inflammatory responses and altered energy metabolism have been associated with hyperglycaemia and hyperlipidaemia. The concept of ‘glucolipotoxicity’ has arisen from the combination of the deleterious effects of the chronic elevation of levels of glucose and fatty acids on pancreatic β-cells’ function and/or survival. The synergistic effect of both nutrients exacerbates β-cells’ dysfunction over time and creates a vicious cycle of impaired insulin secretion and metabolic disturbances. Though numerous studies have been conducted in this field, the exact molecular mechanisms and causative factors still need to …

Assessment Of Clinical Outcomes In Patients Presenting With Transverse Myelitis: A Tertiary Care Experience From A Developing Country, Aijaz Ali, Syeda Beenish Bareeqa, Amir Riaz, Syed Ijlal Ahmed,, Muhammad Hassan Shaikh, Muhammad Ishaq Ghauri

Department of Medicine

Background: Transverse myelitis (TM) is an inflammatory disorder of spinal cord, characterized by acute or sub-acute dysfunction of spinal cord affecting the motor, sensory, and autonomic systems. It may be idiopathic or related to other diseases. Although some patients recover from TM with minor or no residual problems, others suffer permanent impairments that affect their ability to perform ordinary tasks of daily living. Our objective was to determine the frequency of different clinical outcomes in patients presenting with TM.

Methods: It was a prospective cohort clinical study conducted from May 2018 till October 2018. Study was conducted in the Department …

Prevalence, Patterns And Factors Associated With Hypertensive Crises In Mulago Hospital Emergency Department; A Cross-Sectional Study, Martha Sajatovic

Faculty Scholarship

Background: Hypertension is increasing in sub-Saharan Africa (SSA) and it’s the single most important modifiable stroke risk factor, yet it’s control is not routinely emphasized. The prevalence, pattern and factors associated with hypertensive urgencies and emergencies in Uganda is not well established. A cross-sectional study, was conducted between November 2015 and February 2016, using a complete clinical examination and pre-tested standardized questionnaire subjects were enrolled. The prevalence of hypertensive crises and associations of demographic and clinical factors determined using logistic regression. Results: The prevalence of hypertensive crises was 5.1%, (203/4000) of all admissions at the medical section of the accident …

Early Neonatal Vitamin A Supplementation And Infant Mortality: An Individual Participant Data Meta-Analysis Of Randomised Controlled Trials, Rajiv Bahl, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Background: Biannual vitamin A supplementation is a well-established survival tool for preschool children 6 months and older in vitamin A deficient populations but this schedule misses the opportunity to intervene on most young infant deaths. Randomised trials of neonatal vitamin A supplementation (NVAS) in the first few days of life to assess its impact on under 6-month mortality in low/middle-income countries have had varying results.
Methods: Investigators of 11 published randomised placebo-controlled NVAS trials (n=163 567 children) reanalysed their data according to an agreed plan and pooled the primary outcomes of mortality from supplementation through 6 and 12 months of …

A Therapeutic Pastoral Counseling Program Designed To Reveal And Treat Combat Events Of Homeless Veterans In Wake County, North Carolina, Earnest Lee Shannon Jr

Doctoral Dissertations and Projects

This thesis project researched homelessness among male veterans in Wake County, North Carolina to determine if they experienced a combat event that caused spiritual injury caused by moral injury and shame, which contributed to their homelessness. Joshua’s Conquest, the spiritual formation treatment program is used to treat the spiritual injury. The need for this program is explicated, along with the development of Joshua’s Conquest, and how it will treat this odious event, so the homeless male veteran will be able to obtain housing normalcy. Personally, this thesis project was fueled by experiences with homelessness and limited service in the military. …

Increase In Pneumococcal Immunization In Adults Over 65 Years Of Age In A Federally Qualified Health Center, Mara J. Dominguez

Doctoral Dissertations and Projects

Pneumococcal disease is a healthcare concern with increasing financial and societal burden for adults over the age of 65 years and their caretakers. The Center for Disease Control and Prevention (CDC) recommends the use of pneumococcal vaccines in this population as a preventive measure helping minimize the mortality and morbidity. This project aimed at increasing the rate of pneumococcal vaccines in a Federally Qualified Health Center (FQHC). The interventions implemented included the use of audit, feedback and provider educational intervention aimed at increasing the knowledge and the intent to change and improve their practice. The key results indicated an increase …

Comparing The Causal Implications Of Clinical Unit Placements On Senior Bachelor Of Science In Nursing Students' Cognitive Decision-Making Processes, Shelley Layne Blackwood

Doctoral Dissertations and Projects

Evidence suggests that new nursing graduates entering the workforce struggle with decision making. Poor clinical decisions often lead to undesirable patient outcomes. Utilizing quantitative, causal-comparative, pretest-posttest design, this research explored the effect of four categories of clinical unit placements (specialty units, acute care, critical care, and emergency departments) on senior bachelor of science in nursing (BSN) students’ cognitive decision-making processes to explore which type of unit, if any, significantly changes nursing student cognitive processes while making decisions. A convenience sample of 30 senior BSN students from a private, faith-based university completed both a demographic survey and the Nurse Decision Making …