Medicine and Health Sciences Commons^™

Affiliation, Aggression, And Selectivity Of Peer Relationships In Meadow And Prairie Voles, Nicole S. Lee, Nastacia L. Goodwin, Katherine E. Freitas, Annaliese K. Beery

Psychology: Faculty Publications

Relationships between adult peers are central to the structure of social groups. In some species, selective preferences for specific peers provide a foundation for consistent group composition. These preferences may be shaped by affiliation toward familiar individuals, and/or by aversion to unfamiliar individuals. We compared peer interactions in two vole species that form selective preferences for familiar same-sex individuals but differ in mating system. Prairie voles (Microtus ochrogaster) form pair bonds with mates and may reside in family groups. Meadow voles (Microtus pennsylvanicus) are promiscuous breeders that form communal winter groups in the wild, and exhibit …

Unusual Substrate And Halide Versatility Of Phenolic Halogenase Pltm, Shogo Mori, Allan H. Pang, Nishad Thamban Chandrika, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov

Pharmaceutical Sciences Faculty Publications

Controlled halogenation of chemically versatile substrates is difficult to achieve. Here we describe a unique flavin-dependent halogenase, PltM, which is capable of utilizing a wide range of halides for installation on a diverse array of phenolic compounds, including FDA-approved drugs and natural products, such as terbutaline, fenoterol, resveratrol, and catechin. Crystal structures of PltM in complex with phloroglucinol and FAD in different states yield insight into substrate recognition and the FAD recycling mechanism of this halogenase.

Identifying Areas With Disproportionate Local Health Department Services Relative To Opioid Overdose, Hiv And Hepatitis C Diagnosis Rates: A Study Of Rural Illinois, Collen Mcluckie, Mai T. Pho, Kaitlin Ellis, Livia Navon, Kelly Walblay, Wiley D. Jenkins, Christofer Rodriguez, Marynia A. Kolak, Yen-Tyng Chen, John A. Schneider, Whitney E. Zahnd

Faculty Publications

Background: U.S. rural populations have been disproportionately affected by the syndemic of opioid-use disorder (OUD) and the associated increase in overdoses and risk of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) transmission. Local health departments (LHDs) can play a critical role in the response to this syndemic. We utilized two geospatial approaches to identify areas of discordance between LHD service availability and disease burden to inform service prioritization in rural settings.Methods: We surveyed rural Illinois LHDs to assess their OUD-related services, and calculated county-level opioid overdose, HIV, and hepatitis C diagnosis rates. Bivariate choropleth maps were created to …

H3k27m Induces Defective Chromatin Spread Of Prc2-Mediated Repressive H3k27me2/Me3 And Is Essential For Glioma Tumorigenesis., Ashot S. Harutyunyan, Brian Krug, Haifen Chen, Simon Papillon-Cavanagh, Michele Zeinieh, Nicolas De Jay, Shriya Deshmukh, Carol C L Chen, Jad Belle, Leonie G. Mikael, Dylan M. Marchione, Rui Li, Hamid Nikbakht, Bo Hu, Gael Cagnone, Warren A. Cheung, Abdulshakour Mohammadnia, Denise Bechet, Damien Faury, Melissa K. Mcconechy, Manav Pathania, Siddhant U. Jain, Benjamin Ellezam, Alexander G. Weil, Alexandre Montpetit, Paolo Salomoni, Tomi Pastinen, Chao Lu, Peter W. Lewis, Benjamin A. Garcia, Claudia L. Kleinman, Nada Jabado, Jacek Majewski

Manuscripts, Articles, Book Chapters and Other Papers

Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines and isogenic CRISPR-edited controls to assess H3K27M effects in vitro and in vivo. We find that whereas H3K27me3 and H3K27me2 are normally deposited by PRC2 across broad regions, their deposition is severely reduced in H3.3K27M cells. H3K27me3 is unable to spread from large unmethylated CpG islands, while H3K27me2 can be deposited outside these PRC2 high-affinity sites but to levels corresponding to H3K27me3 deposition in wild-type cells. Our findings indicate that PRC2 recruitment and propagation on …

Glucagon - Like Peptide – 1 Receptor Agonists To Reduce The Risk Of Nephropathy In The Uncontrolled Type 2 Diabetic Patient, Rebecca Fee

Nursing Capstones

No abstract provided.

Association Of Reported Fish Intake And Supplementation Status With The Omega-3 Index, Kristina H. Jackson, Jason M. Polreis, Nathan L. Tintle, Penny M. Kris-Etherton, William S. Harris

Faculty Work Comprehensive List

Background: An Omega-3 Index (O3I; EPA+DHA as a % of erythrocyte total fatty acids) in the desirable range (8%-12%) has been associated with improved heart and brain health.

Objective: To determine the combination of fish intake and supplement use that is associated with an O3I of >8%.

Design: Two cross-sectional studies comparing the O3I to EPA+DHA/fish intake.

Participants/setting: The first study included 28 individuals and assessed their fish and EPA+DHA intake using both a validated triple-pass 24-hr recall dietary survey and a single fish-intake question. The second study used de-identified data from 3,458 adults (84% from US) who self-tested their …

Environmental Transmission Of Toxoplasma Gondii: Oocysts In Water, Soil And Food, Karen Shapiro, Lillian Bahia-Oliveira, Brent Dixon, Aurélien Dumètre, Luz A. De Wit, Elizabeth Vanwormer, Isabelle Villena

School of Veterinary and Biomedical Sciences: Faculty Publications

Toxoplasma gondii is a zoonotic protozoan parasite that can cause morbidity and mortality in humans, domestic animals, and terrestrial and aquatic wildlife. The environmentally robust oocyst stage of T. gondii is fundamentally critical to the parasite's success, both in terms of its worldwide distribution as well as the extensive range of infected intermediate hosts. Despite the limited definitive host species (domestic and wild felids), infections have been reported on every continent, and in terrestrial as well as aquatic environments. The remarkable resistance of the oocyst wall enables dissemination of T. gondii through watersheds and ecosystems, and long-term persistence in diverse …

Improving Health Data For Indigenous Populations: The International Group For Indigenous Health Measurement, Michelle Chino, Ian Ring, Lisa Jackson Pulver, John Waldon, Malcolm King

School of Public Health Faculty Research

Health disparities between Indigenous and non-Indigenous populations exist in many countries, including those with well-developed statistical systems. The need to improve the measurement and understanding of Indigenous health disparities led to the formation of the International Group for Indigenous Health Measurement (IGIHM), composed of Indigenous and non-Indigenous, government and non-government, statisticians, researchers and health professionals. Since its founding in 2005, the IGIHM has pursued activities to improve health measurement, which in turn have been used for improving the health of Indigenous populations and enhancing Indigenous health knowledge and data.

Rethinking Health Services Measurement For Indigenous Populations, Michelle Chino Dr, Angela Mashford-Pringle, Ian Ring, Fadwa Al-Yaman, John Waldon

School of Public Health Faculty Research

Indigenous people around the world experience shorter life expectancy, poorer health outcomes, and on average have less social capital, than non-Indigenous people in their respective countries. While national goals are to lower mortality and morbidity rates of Indigenous people, much evidence exists that indicates there is almost no Indigenous involvement in data collection, policy development, program implementation and development and measurement of services. A more holistic and culturally relevant framework is presented to improve services and outcomes for Indigenous populations.

The Moderating Effect Of Employee Bottom-Line Mentality On The Relation Between Personality And Unethical Pro-Organizational Behaviors, Jordan Thomas

Theses and Dissertations

Unethical pro-organizational behavior (UPB) refers to unethical actions that employees engage in to benefit the company they work for. The issue of employees engaging in UPB has been high-lighted in various high-profile scandals, such as the Volkswagen emissions scandal. The current study examined the interaction between employees’ personality traits, perceptions of bottom-line mentality (BLM), and UPB. The results suggested that when employees who are low on trait conscientiousness and honesty-humility are placed in an environment in which they perceive to have high levels of BLM, they are more likely to engage in UPB than those individuals who had higher levels …

Self-Collected Sampling Methods For Chlamydia And Gonorrhea Screening Among College Women: Exploring Patient-Centered Intervention Characteristics, Stacey B. Griner

USF Tampa Graduate Theses and Dissertations

Background: Young adults are disproportionately burdened by sexually transmitted infections (STIs) such as chlamydia and gonorrhea; however, STI screening rates are low among this population. Given the barriers associated with screening, self-sampling methods used at home may be an innovative solution to improve STI screening rates.

Purpose: The purpose of this study was to explore factors influencing chlamydia and gonorrhea screening among college women. This study had two aims: (1) assess factors associated with STI screening among college women and (2) identify informational needs and key intervention characteristics to inform the development of a patient-centered STI screening intervention.

Methods: Guided …

Improving The Quality Of Consumer Health Information On Wikipedia: Case Series., Shira Schecter Weiner, Jill S. Horbacewicz, Lane Rasberry, Yocheved Bensinger-Brody

The School of Health Sciences Publications and Research

BACKGROUND: Wikipedia is one of the most consulted health resources in the world. Since the public is using health information from Wikipedia to make health care decisions, improving the quality of that health information is in the public interest. The open editable content design of Wikipedia and quality control processes in place provide an opportunity to add high-value, evidence-based information and take an active role in improving the health care information infrastructure.

OBJECTIVE: The aim of this project was to enhance Wikipedia health pages using high-quality, current research findings and track the persistence of those edits and number of page …

Ada News - 03/18/2019, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

What's Happening: March 18, 2019, Maine Medical Center

What's Happening

No abstract provided.

Apixaban Discontinuation Prior To Major Surgery: Results From A Prospective Single Center Study, Edwin Lam, Luis Eraso, Taki Galanis, Walter K. Kraft, Geoffrey Ouma, Lynda Thomson, Eugene Viscusi, Douglas Stickle, Jerald Z. Gong, Suzanne Adams, Geno Merli

Department of Pharmacology and Experimental Therapeutics Posters

Primary Objective

• Estimate the proportion of patients who achieve a plasma apixaban concentration of/mL following at least 48 hours of discontinuation prior to surgery or invasive procedure

Secondary Objective

• Perioperative and follow up arterial or venous thromboembolic events, major bleeding, clinically significant non-major bleeding complications. Correlation of apixaban anti-Factor Xa (FXa) activity and plasma apixaban concentrations at pre-admission and prior to surgery

Antibacterial Activity Of Polymers: Discussions On The Nature Of Amphiphilic Balance, Edmund F. Palermo, Karen Lienkamp, Elizabeth R. Gillies, Paul J. Ragogna

Bone and Joint Institute

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The purpose of this Viewpoint is to discuss the molecular design principles that guide development of synthetic antimicrobial polymers, especially those intended to mimic the structure of host defense peptides (HDPs). In particular, we focus on the principle of “amphiphilic balance” as it relates to some recently developed polyphosphoniums with somewhat atypical structure. We find that the fundamental concept of amphiphilic balance is still applicable to these new polymers, but that the method to achieve such balance is somewhat unique. We then briefly outline the future challenges and opportunities in this …

Hard Choices And Deficient Choosers, Mark Kelman

Northwestern Journal of Law & Social Policy

No abstract provided.

Weight Gain In Patients With Hiv Infection Who Are Virologically Suppressed On Antiretroviral Therapy And Switch To Integrase Inhibitor Containing Regimens, Matty Zimmerman, Jason Schafer, Pharmd, Mph, Bcps, Bcidp, Aahivp

College of Pharmacy Posters

Objective

To determine the prevalence and extent of weight gain among virologically suppressed PLWH whose antiretroviral therapy (ART) has been switched to an integrase inhibitor (INSTI) containing regimen.

Factors Associated With Anemia Among Women Of The Reproductive Age Group In Thatta District: Study Protocol, Sumera Aziz Ali, Zahid Abbasi, Anam Feroz, K Michael Hambidge, Nancy F. Krebs, Jamie E. Westcott, Sarah Saleem

Community Health Sciences

Background: Maternal anemia is a leading public health issue placing pregnant women at higher risk of low birth weight, preterm birth, perinatal mortality, and neonatal mortality. Women in developing countries are at higher risk of anemia which could be either due to micronutrient deficiencies, hemoglobinopathies, infections or other socio-demographic factors. Thus, it is highly essential to explore the factors of anemia among women of the reproductive age group in order to design suitable interventions. The primary objective of this study is to assess the biological and socio-demographic factors that are associated with anemia among the women of the reproductive age …

Community-Led Data Collection Using Open Data Kit For Surveillance Of Animal African Trypanosomiasis In Shimba Hills, Kenya, Sarah A.O. Wamwenje, Ibrahim I. Wangwe, Nicodemus Masila, Caroline K. Mirieri, Lillian Wambua, Benard W. Kulohoma

All Peer-Reviewed Publications

Objective: In Sub-Saharan Africa, there is an increase in trypanosome non-susceptibility to multiple trypanocides, but limited information on judicious trypanocide use is accessible to smallholder farmers and agricultural stakeholders in disease endemic regions, resulting in widespread multi-drug resistance. Huge economic expenses and the laborious nature of extensive field studies have hindered collection of the requisite large-scale prospective datasets required to inform disease management. We examined the efficacy of community-led data collection strategies using smartphones by smallholder farmers to acquire robust datasets from the trypanosomiasis endemic Shimba hills region in Kenya. We used Open Data Kit, an open-source smartphone application development …

Can Prolaris Score Be Used To Predict Change In Gleason Score From Biopsy To Post-Radical Prostatectomy Pathology?, Benjamin Croll Ms4

USF-LVHN SELECT

No abstract provided.

Adapting To Hospital Culture And Improving Patient Care: Development And Implementation Of A Pediatric Gastrostomy Tube Medical Home Program, Heather Geist Bs, Marybeth Browne Md

USF-LVHN SELECT

No abstract provided.

Improving The Effectiveness Of Remote Patient Monitoring Reports In Heart Failure Patients, Jamaal Hardee, Eric W. Bean Do, Lorraine Valeriano Bsn, Rn, Cnrn, Mindy Brosious Bsn, Rn

USF-LVHN SELECT

No abstract provided.

Mohs Patient Demographics: A Quality Improvement Study Analyzing Patient Demographics And Access To Mohs Surgery For Basal Cell Carcinoma And Squamous Cell Carcinoma, Chelsea Kesty Bsc, Deborah Dorrell Bsc, Katarina Kesty Md, Phillip Williford Md

USF-LVHN SELECT

No abstract provided.

Implementing A Hyperbilirubinemia Pathway For The Inpatient Pediatrics Unit At Lehigh Valley Health Network, Daphne Porat Ms4

USF-LVHN SELECT

No abstract provided.

Starting Off On The Right Food: The Role Of Lactation Support In Breastfeeding Initiation And Continuation, Preethi Rajan, C Lenhart Phd, Kimberly C. Brown Md

USF-LVHN SELECT

No abstract provided.

Empathy, Burnout, And Emotional Intelligence In Usf Pharmacy Students, Pranav Reddy

USF-LVHN SELECT

No abstract provided.

Cost Savings Achieved Through Introduction Of Holmium Laser Enucleation Of The Prostate (Holep), Jacob Rust Ms4, James Johannes Md, Benjamin Croll Ms4, Rohan Shah Ms4, Andrew Lai Md

USF-LVHN SELECT

No abstract provided.

Evaluation Of Variability In A Surgical Spine Pathway, William Schertzing Ms4, Matthew Mccambridge Md

USF-LVHN SELECT

No abstract provided.

Analyzing Patient Risk Factors In Ambulatory Surgery Complications, Meg Scott, Matthew Mccambridge Md, Beatrice Oertner

USF-LVHN SELECT

No abstract provided.